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Schizophrenia in Biological News

LSUHSC research helps link schizophrenia to specific DNA region

... of researchers has found genetic evidence linking schizophrenia to a specific region of DNA on chromosome 6. ... study participants, people with diagnoses of schizophrenia or schizoaffective disorder, plus controls from ... Genetics of Schizophrenia, International schizophrenia Consortium and SGENE data sets thousands of DNA ...

Flow of potassium into cells implicated in schizophrenia

... A study on schizophrenia has implicated machinery that maintains the flow ... could help correct disorganized brain activity in schizophrenia without risk of cardiac side effects associated ... game in linking genes with complex disorders like schizophrenia requires that we not only demonstrate statistical ...

Altered gene can increase risk of schizophrenia

... that is likely to increase risk for developing schizophrenia in some people. It provides a potential mechanism ... is an important step, but there are qualifiers. schizophrenia is not a single-gene disorder, and there are ... 1 percent of the general population has schizophrenia but not all of those with the illness will have ...

Researchers discover link between schizophrenia and diabetes

... AUGUSTA, Ga. People with schizophrenia are at increased risk for type 2 diabetes, ... In a study of 50 people newly-diagnosed with schizophrenia or a related psychotic disorder with no other ... or genetic factors between the development of schizophrenia and diabetes," he says. Dr. Kirkpatrick ...

Research supports toxoplasmosis link to schizophrenia

... parasite may trigger the development of schizophrenia and other bipolar disorders. The team from the ... a direct statistical link between incidences of schizophrenia and toxoplasmosis infection and our study is the ... and sleep patterns are well documented and schizophrenia has long been associated with dopamine, which is ...

Interaction between gene variants may alter brain function in schizophrenia

... reduced activity of important brain structures in schizophrenia patients but not in normal controls. The report ... known to be critical to working memory in 79 schizophrenia patients and 75 healthy controls as they ... folate metabolism and has been associated with schizophrenia risk, and COMT, which is involved with dopamine ...

Pitt research identifies new target in brain for treating schizophrenia

... could expand the options for controlling schizophrenia by identifying a brain region that responds to ... is an area that's been somewhat neglected in schizophrenia research. This study should encourage researchers ... the key to understanding the pathophysiology of schizophrenia and finding better treatments is to identify ...

NARSAD announces 2008 Prizes for Outstanding Achievement in Research on Mental Health Disorders

... the Lieber Prize for Outstanding Achievement in schizophrenia Research; Charles L. Bowden, M.D., of the ... will be awarded the Sidney R. Baer, Jr. Prize for schizophrenia Research. NARSAD began awarding prizes in ... Lieber Prize for Outstanding Achievement in schizophrenia Research, is the Irving and Dorothy Bernstein ...

Brain-nourishing molecule may predict schizophrenia relapse

... clues about whether patients suffering with schizophrenia are headed toward relapse, researchers say. ... factor, or BDNF, in the blood of patients with schizophrenia to see if the pattern of their rise and fall is a ... helpful," says Dr. Peter S. Buckley, schizophrenia specialist who chairs the Department of ...

Hopkins researchers piece together gene 'network' linked to schizophrenia

... first time molecular circuitry associated with schizophrenia that links three previously known, yet unrelated ... and also binds to PCM1. "But we weren't thinking schizophrenia at the time because BBS4 is involved in ... "Now that we know that that a subset of schizophrenia is related to centrosomes and these associated ...

Advances in the field of schizophrenia research: New genetic factors identified

... schizophrenia is one of the most serious mental illnesses and ... non-affected persons with persons suffering from schizophrenia in the hopes of discovering genetic variations ... to the further research concerning the causes of schizophrenia as well as the development of diagnostic testsand ...

Protein marker for schizophrenia risk

... in immune cells may be a reliable marker for schizophrenia risk, report researchers in a new proteomics ... issue of Molecular and Cellular proteomics. schizophrenia is a severe and complex psychiatric illness that ... As such, biomarkers that would indicate schizophrenia risk or onset would be extremely useful. ...

At Boston symposium, NARSAD researchers report on genes and family traits

... genes. Donald C. Goff, M.D., director of the schizophrenia Clinical and Research Program at Massachusetts ... Do genes explain why some people with schizophrenia are helped when they take supplements of the ... between low blood levels of folate and negative schizophrenia symptoms, folate is involved in many different ...

Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs

... behavioral and neuronal deficits associated with schizophrenia and possibly other brain disorders. In the ... deletions of 22q11.2 as a primary risk factor for schizophrenia in humans several years earlier. By digging ... as the one observed in some individuals with schizophrenia and examined what happens in the expression of ...

CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia

... individually rare gene mutations in people with schizophrenia that may help explain how that devastating ... three to four times more frequent in people with schizophrenia than in controls. CSHLs contribution to the ... which included 418 individuals, 150 of whom had schizophrenia or schizoaffective disorder. Instead of trying to ...

Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity

... Philadelphia, PA, January 8, 2008 schizophrenia is a developmental disorder with a large genetic ... medications for particular patients with schizophrenia is more art than science. We have been seeking ... that RGS4 contributes to both the severity of schizophrenia symptoms and the response to antipsychotic ...

New treatment mechanisms for schizophrenia

... Philadelphia, PA, January 8, 2008 The field of schizophrenia research has come alive with many exciting new ... a completely novel means of adjunct therapy for schizophrenia that is analogous to the use of SSRIs [selective ... drugs of neuropsychiatric diseases including schizophrenia and Alzheimers disease. Behavioral abnormalities ...

Feinstein researchers develop new genetic method and identify novel genes for schizophrenia

... markers from each parent, his or her risk for schizophrenia increases substantially, said Todd Lencz, PhD, ... they could open up new avenues for research in schizophrenia and severe mental illness, said Anil Malhotra, ... risk was large. In the study, 81 percent of the schizophrenia patients had at least one of these recessive ...

New studies on schizophrenia, depression, trauma and autism highlight annual meeting

... Study Finds Genetic Link between Cancer and schizophrenia A series of studies elucidates evidence that there is a genetic link between schizophrenia and cancer, providing a surprising possible ... for lower rates of cancer among patients with schizophrenia despite having poor diets and high rates of ...

How schizophrenia develops: Major clues discovered

... schizophrenia may occur, in part, because of a problem in an ... Studies have yielded very strong evidence that schizophrenia involves a decrease in the enzymes, like GAD1, ... precise molecular targets for development of new schizophrenia medications is a key effort, because it can lead ...

NARSAD presents 2007 prizes for outstanding achievement in neuroscience and psychiatric research

... Lieber Prize for Outstanding Achievement in schizophrenia Research: Eve C. Johnstone, M.D., is professor ... performed imaging and other anatomical studies of schizophrenia that have provided a substantial body of evidence ... abnormalities of brain structure in people with schizophrenia and on the mechanism of antipsychotic treatments. ...

MU brain imaging center provides research for autism, schizophrenia and Parkinson's disease

... that can have tremendous impact, including Parkinson's disease, autism, schizophrenia and other neurocognitive disorders using magnetic resonance imaging (MRI) ... and study of the causes of neurocognitive disorders such as autism, schizophrenia and Parkinson's disease," Christ said. "My laboratory recently initiated a ...

American Chemical Society's Weekly PressPac -- Sept. 10, 2008

... Chemical & Engineering News New scientific insights into schizophrenia are pointing toward new drugs that offer hope for millions of individuals ... 15 issue of Chemical & Engineering News, ACS' weekly newsmagazine. schizophrenia affects about 25 million people, or about one percent of adults, ....

Healthy Minds Across America features 48 public forums on mental health research, Sept. 14

... progression of such illnesses as depression, bipolar disorder, anxiety, schizophrenia and autism, and learn about current and potential treatments. In an ... when NARSAD began giving grants as the National Alliance for Research on schizophrenia and Depression, it has awarded more than $238 million in research funds to ...

A new gene trigger for pregnancy disorder identified

... BOSTON The COMT gene known already for its role in schizophrenia has been found to play a role in preeclampsia, according to a report in ... in preeclampsia, a gene commonly associated with schizophrenia which, under normal circumstances, inactivates the catecholamine class of ...

Epigenetic changes discovered in major psychosis

... changes to a gene that do not alter the DNA sequence) in individuals with schizophrenia and bipolar disorder. This is the first epigenome-wide investigation in ... an illness. The DNA sequence of genes for someone with an illness like schizophrenia and a for someone without a mental illness often look the same; there are ...

A genetic basis for schizophrenia

... Chicago, Illinois, July 21, 2009 schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major ...

Protein identified as critical to insulating the body's wiring could also become treatment target

... glutamate excites cells to action. Here, neuregulin-1 and ErbB4 suppress excitation. These findings have implications for conditions such as schizophrenia and seizures, where cell talk is out of control. ...

MIT: Making waves in the brain

... insights that could someday lead to new treatments for a range of brain-related disorders. "Gamma waves are known to be [disrupted] in people with schizophrenia and other psychiatric and neurological diseases," says Li-Huei Tsai, Picower Professor of Neuroscience and a Howard Hughes Medical Institute ...

Daily consumption of cannabis predisposes to the appearance of psychosis and schizophrenia

... whose psychosis is associated with a high consumption of cannabis. The results of this research work have been published in the journals schizophrenia Research and European Psychiatry , two of the most renowned worldwide publications in this research field. ...

'Neurological work-arounds' offer hope to people with monoamine-related disorders

... Professor at York College of the City University of New York were the two lead investigators on the study. "Illnesses such as depression, addiction, schizophrenia and Parkinson's disease devastate millions of lives each year. Current treatment strategies often fail and remain poorly understood," said Krantz. ...

Game of two halves leads to brain asymmetry

... efficient than fully asymmetric animals in which one eye specialises for one task and the other eye for the other task. In humans, people with schizophrenia have disrupted brain asymmetries but as yet, it is not clear if there is a causal link between the asymmetry and schizophrenia. "The direction and ...

Motor nerve targeting to limb muscles is controlled by ephrin proteins

... therapies that aim to rebuild damaged or diseased nerves. "The study of the ephrin proteins should help us understand diseases such as autism, schizophrenia as well as a number of neurological disorders," says Dr. Rmi Quirion, a scientific director at the Canadian Institutes of Health Research (CIHR). "We ...

MU researcher identifies possible genetic causes of borderline personality disorder

... COLUMBIA, Mo. According to the National Institute of Mental Health, borderline personality disorder (BPD) is more common than schizophrenia or bipolar disorder and is estimated to affect 2 percent of the population. In a new study, a University of Missouri researcher and Dutch team of ...

Rice University study finds possible clues to epilepsy, autism

... Rice University researchers have found a potential clue to the roots of epilepsy, autism, schizophrenia and other neurological disorders. While studying the peripheral nerves of the Drosophila, aka the fruit fly, Rice doctoral student Eric Howlett ...

USC researchers head global effort to study genetic risks that contribute to psychiatric diseases

... Health (NIMH) for a groundbreaking effort to collect genetic information on tens of thousands of patients in order to study the genetic risks for schizophrenia and bipolar disorder. The USC Center for Genomic Psychiatry and Massachusetts General Hospital (MGH) together received more than $25 million in ...

Claudin 11 stops the leaks in neuronal myelin sheaths

... found in the CNS, the authors speculate that defects in claudin 11 could be associated with deficits in cognition and perception, like those found in schizophrenia or neurodegenerative diseases. ...

The Rett Syndrome Research Trust launches operations

... the clinic. Thus, understanding the pathogenic mechanism underlying MECP2 disorders is likely to help us understand diseases ranging from autism and schizophrenia to cognitive disorders, epilepsy, and Parkinson disease." Monica Coenraads, Executive Director of the Trust, describes the work ahead. "This ...

Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children

... a heart defect that were previously undetected. Studies by other groups of researchers have also found a connection between 1q21.1 deletions and schizophrenia in some people, and parts missing in the reproductive tract in other people. These results, the authors of the Sept. 11 New England Journal of ...

Risks and benefits of antipsychotics in children and adolescents

... years old antipsychotics have been used for the treatment of conditions such as severe conduct disorders, Tourette syndrome, bipolar disorder and schizophrenia in children and adolescents. Treatment advances, particularly with the introduction of new-generation antipsychotic medications, have created a lot ...
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