New trigger for chronic inflammation in rheumatoid arthritis discovered
... the immune system into action may be important in rheumatoid
arthritis, according to new research published ... develop more effective arthritis treatments.
arthritis is the most common autoimmune disease, ... joint leading to the persistent inflammation of rheumatoid
The molecular switch is called ...
Researchers identify new risk factor gene for rheumatoid arthritis
... have identified a new risk factor gene for rheumatoid
arthritis. The paper will be published in Nature ... investigators seeking to identify risk genes for rheumatoid
arthritis (RA). The hope is to figure out the ... About one percent of the population will develop rheumatoid
arthritis, which can be crippling.
REL is a ...
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
... gene therapy reduces symptoms in patients with rheumatoid
arthritis, an important milestone for this ... stem from a study of two patients with severe rheumatoid
arthritis conducted in Germany and led by an ... under the age of 75 with a diagnosis of advanced rheumatoid
arthritis. After tissue was removed from the ...
Anakinra for rheumatoid arthritis: A modest benefit with some risk
... a modest beneficial effect of anakinra for rheumatoid
arthritis patients, but warns against potential ... and its use with other biologic medications.
arthritis is a chronic inflammatory disease ... recommend caution with the use of anakinra for rheumatoid
arthritis, especially with the only modest ...
New therapeutic target identified for rheumatoid arthritis
... be used to treat inflammatory disorders, such as rheumatoid
The study, published online ahead ... in both pathways, could serve as a treatment for rheumatoid
"This is a basic science papers ... interleukin-6, which has been implicated in rheumatoid
arthritis, are produced. In another experiment, ...
Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
... prevent the onset of diabetes in patients with rheumatoid
arthritis, new Geisinger research shows.
... Geisinger patients who received treatment for rheumatoid
arthritis from 2000 to 2008. The study looked at, ... treat malaria but it has also been used to treat rheumatoid
arthritis and other autoimmune diseases.
Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
... as an effective therapeutic target for rheumatoid
arthritis and other chronic inflammatory ... trials revealed rapid and dramatic improvement of rheumatoid
disease activity with anti-TNF therapy, ... prevalent and debilitating conditions such as rheumatoid
"Advances in molecular medicine, ...
New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
... The innovative new rheumatoid
arthritis drug Actemra (tocilizumab) has been ... significantly improve the signs and symptoms of rheumatoid
arthritis (RA) in patients who failed to achieve ... Actemra is generally well tolerated.
Rheumatologists win $1.2M for arthritis research
... $1.2 million to study the underlying causes of rheumatoid
arthritis and to help find a cure for the ... explore more deeply the molecular development of rheumatoid
arthritis with the hope of finding new medicines ... have been made in the treatment and management of rheumatoid
arthritis, and build on that knowledge as we ...
Study identifies genetic risk factor for rheumatoid arthritis, lupus
... of two chronic, autoimmune inflammatory diseases: rheumatoid
arthritis (RA) and systemic lupus erythematosus ... the STAT4 gene as a susceptibility locus for rheumatoid
arthritis whether the presence of the variant ... in RA patient samples from the North American rheumatoid
Arthritis Consortium (NARAC) as compared with ...
Gene expression findings a step toward better classification and treatment of juvenile arthritis
... were more subgroups than originally thought. They included children with rheumatoid
factor (RF) positive JIA, meaning their blood tested positive for an antibody commonly seen in adults with rheumatoid
arthritis (RA). Surprisingly, the scientists found patterns of gene ...
Fireflies and jellyfish help illuminate quest for cause of infertility
... cells that produce a hormone linked to conditions, which include rheumatoid
arthritis and lupus.
The technique will help scientists track the ... It is believed to play a role in autoimmune diseases, such as lupus and rheumatoid
arthritis, as well as in the inflammation of cells and tissues.
LSUHSC awarded patent for compound inhibiting cancer and other diseases
... with proliferative retinopathies, skin disorders such as psoriasis, and rheumatoid
arthritis. Diseases that have been associated with abnormal blood vessel ... retinal detachment, hyperviscosity syndrome, toxoplasmosis, trauma, rheumatoid
arthritis, and post-laser complications.
Complexity of Crohn's disease revealed as 'gene' count tops 30
... to be implicated in a number of other common diseases including diabetes, rheumatoid
arthritis and psoriasis. However, the genetic relationship between Crohn's ... present in inflamed joints, implying that CCR6 may also be relevant to rheumatoid
arthritis, and therefore of added interest to the pharmaceutical industry. ...
Sugar linkage could lead to better treatment for autoimmune diseases
... that could lead to improved treatment of autoimmune diseases like lupus or rheumatoid
arthritis. The study, reported in a recent edition of the journal Science, ... material that is effective in relieving the inflammatory affects of lupus, rheumatoid
arthritis, asthma, and other autoimmune disorders. But because of the ...
Study helps explain how allergic reactions are triggered
... and are involved in diseases ranging from multiple sclerosis and rheumatoid
arthritis to cancer and atherosclerosis.
In order for mast cells to ... of several other debilitating diseases, including multiple sclerosis, rheumatoid
arthritis and cancer, an inhibitor of the CRAC channel could, in the ...
'Electronic switch' opens doors in rheumatoid joints
... for the development of new treatments for inflammatory diseases such as rheumatoid
Scientists at the University of Leeds have identified a ... diseases cause the production of high levels of thioredoxin in fact with rheumatoid
arthritis, its striking how much is present in affected joints. But we ...
Blood clotting protein linked to rheumatoid arthritis
... plays an important role in the inflammatory response and development of rheumatoid
arthritis. Inflammatory joint disease appears to be driven by the ... multiple sclerosis.
Affecting 2.1 million people in the United States, rheumatoid
arthritis is a painful and debilitating disease involving chronic ...
'Jumping genes' could make for safer gene delivery system
... treatment in which an engineered virus was injected into her knee to treat rheumatoid
arthritis. The viruses used were engineered to suppress the immune system only in the knee. In the case of rheumatoid
arthritis, the immune system is out of whack and is responsible for the ...
Aussie and Kiwi researchers make double MS genetic discovery
... says Professor Kilpatrick.
"They also reveal a link between genetic susceptibility to MS and other autoimmune diseases including Type 1 diabetes, rheumatoid
Arthritis and Graves' Disease and the also the potential involvement of Vitamin D metabolism in the risk of developing these diseases."
Scientists discover new genetic immune disorder in children
... Lebanon, and Puerto Rico. Those who were alive at the time of diagnosissix in allwere treated with anakinra, a drug that is normally used for rheumatoid
arthritis and is a synthetic form of human IL-1Ra. Although the patients were resistant to other medications such as steroids, most responded ...
UAB professor receives HudsonAlpha Innovation Prize
... bodies use T cells to protect against infections and cancer, but when T cells overreact and turn on the body, we see immune-mediated diseases such as rheumatoid
arthritis, inflammatory bowel disease, lupus and multiple sclerosis. "Our studies have contributed to the identification of a new class of T cells, ...
Limping rat provides sciatica insights
... a protein involved in regulating the inflammatory response. Elevated levels of IL-17 have already been implicated in such autoimmune diseases as rheumatoid
arthritis and asthma.
"This finding suggests a possible role for immune system activation in contributing to symptoms of sciatica," said Shamji, ...
KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex
... of celecoxib (Celebrex®, Pfizer). Celecoxib is a non-steroidal, anti-inflammatory Cox-2 inhibitor approved for the treatment of osteoarthritis, rheumatoid
arthritis and acute pain. In addition, celecoxib’s anti-proliferative effect has earned it a place in numerous clinical trials against several ...
Vitamin D deficiency related to increased inflammation in healthy women
... This may explain the vitamin's role in the prevention and treatment of inflammatory diseases, including heart disease, multiple sclerosis and rheumatoid
"The findings reveal that low vitamin D levels negatively impact inflammation and immune response, even in healthy women," said ...
Team identifies a molecular switch linking infectious disease and depression
... of chronic inflammation.
Doctors have known for decades that patients with chronic inflammation, such as that linked to coronary heart disease or rheumatoid
arthritis, are more likely than others to become depressed. Some pro-inflammatory drugs, such as interferon-alpha, which is used to treat Hepatitis C ...
Stopping autoimmunity before it strikes
... organ systems," appears in the April 2009 issue of The American Journal of Pathology .
Autoimmune diseases such as lupus, multiple sclerosis, rheumatoid
arthritis and diabetes are caused when the immune system attacks the body's own cells. Normally, immune cells are prevented from attacking normal ...
CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
... stage, have shown protection against a number of diseases in animal tests and are being tested against diseases associated with bio-defense and rheumatoid
When used in this report, the words "intends," "believes," "anticipated" and "expects" and similar expressions are intended to identify ...
La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
... of interactions of TNF, the first member of the family to be discovered, with its receptors, is an approved treatment for several diseases, including rheumatoid
arthritis and inflammatory bowel disease. It is therefore possible that blockade of other members of this family, such as OX40L, might benefit some ...
Molecule that suppresses immune response under study in type 1 diabetes
... methods to get rid of IDO and observe what happens. He'll also enhance IDO expression in the females by giving a drug commonly used to treat rheumatoid
arthritis that the MCG team has learned can boost IDO expression. "The mouse has an endogenous mechanism; it's just defective," said Dr. Mellor. "If ...
Compounds could be new class of cancer drugs
... of biology in addition to studying the inhibitors in breast cancer models, they will explore how they work in cell systems that model brain tumors, rheumatoid
arthritis and viral infections.
Researchers identify 4 genetic hotspots associated with psoriasis
... of psoriasis and psoriatic arthritis. Polymorphisms of TNFAIP3 and TNI1 are also associated with two other autoimmune diseases, lupus and rheumatoid
The number of DNA sites discovered to have strong associations with psoriasis has increased from one to 10 in the past 18 months. But ...
Scientists uncover new genetic variations linked to psoriasis
... that some of the newly discovered variants have been associated with other inflammatory diseases such as Crohn's disease and autoimmune diseases like rheumatoid
arthritis and lupus. Additional studies will help to tease apart the ways in which these diseases are connected at the level of DNA. This information ...
Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
... published online in The FASEB Journal , may lead to entirely new therapies for a wide range of autoimmune disorders, such as colitis, lupus, rheumatoid
arthritis, inflammatory bowel disease, and multiple sclerosis, as well as new ways to prevent transplant rejection.
"The possibility that these ...
Vitamin D deficiency in infants and nursing mothers carries long-term disease risks
... hormone that helps to regulate immune system function. Long-term vitamin D deficiency has been linked to immune disorders such as multiple sclerosis, rheumatoid
arthritis, type I diabetes, and cancer.
"Vitamin D is a hormone not a vitamin and it is not just for kids anymore," writes Ruth A. Lawrence, MD, ...
Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
... interleukin-12 may play a role in the development of many diseases, including some cancers and auto-immune disorders like Crohn's, psoriasis, and rheumatoid
arthritis. In turn, modulating interleukin-12 levels could yield new therapies for those conditions.
In an effort to create a new and ...
Researchers learn that some 'good cholesterol' isn't good enough
... conclusion after reviewing published research on this subject. In their review, they found that the HDL from people with chronic diseases such as rheumatoid
arthritis, kidney disease, and diabetes is different from the HDL in healthy individuals, even when blood levels of HDL are comparable. They observed ...
Melatonin may save eyesight in inflammatory disease
... of cases of blindness in the US. Uveitis has a wide variety of causes, including eye injury, cancer, infection, and autoimmune diseases such as rheumatoid
arthritis and multiple sclerosis. There is currently no optimal treatment for uveitis. Corticoid steroid eye drops are often used; however, ...
Musculoskeletal center wins $2.2 million for drug safety
... of a newer class of medicines called biologics. These are genetically engineered therapies that target the immune system of patients who have rheumatoid
arthritis, Crohn's disease, psoriasis and other autoimmune disorders.
The award will allow the UAB CERTs to pinpoint which biologics have ...
Green tea may delay onset of type 1 diabetes
... affect about 8 percent of the population, says Dr. Hsu. Sjogren's syndrome can occur alone or secondary to another autoimmune disease, such as lupus, rheumatoid
arthritis or type 1 diabetes.
The study, published in the Oct. 24 issue of Life Sciences , supports earlier research showing EGCG's impact on ...