Two Hutchinson Center researchers named HHMI Early Career Scientists
... are critical for proper cell division. For example, to explore why humans are susceptible to HIV, Malik and his colleagues resurrected an extinct retrovirus
that infected chimps and gorillas, but not humans, 4 million years ago. Malik's research suggests that we may be vulnerable to HIV infection because ...
Evolutionary biologist will study HIV with grant from AIDS research foundation
... cells, the virus hijacks its host's genetic machinery to produce proteins and ultimately replicate itself. It has been recently found that the retrovirus
hijacks about 1,000 human genes.
"The big challenge now is to find which of these 1,000 genes and the proteins they encode are critical for HIV ...
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
... females under the age of 75 with a diagnosis of advanced rheumatoid arthritis. After tissue was removed from the subjects' knuckle joints, a harmless retrovirus
was inserted into the tissue cells, in order to serve as a "vector" to transport the gene into the patients' joints. After being placed in culture to ...
Body's anti-HIV drug explained
... for drug development.
APOBEC-3G is present in every human cell. It is capable of stopping HIV at the first step of replication, when the retrovirus
transcribes its RNA into viral DNA.
The study's authors, led by Xiaojiang Chen of the University of Southern California, were able to show the ...
Yamanaka eliminates viral vector in stem cell reprogramming
... as Shinya has shown, each step forward reveals a new set of challenges."
Dr. Yamanka's team began this series of experiments by replacing the retrovirus
with an adenoviral vector. While transfections with the genes on separate vectors didn't work, they did work when the genes were arranged in a ...
UT pathologists believe they have pinpointed Achilles heel of HIV
... the abzymes after decades of the infection. The immune system in some people can cope with HIV after all."
Carl Hanson, Ph.D., who heads the retrovirus
Diagnostic Section of the Viral and Rickettsial Disease Laboratory of the California Department of Public Health, has shown that the abzymes ...
UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
... and can give rise to bone, cartilage, fat, and muscle. Genes were inserted into the hematopoietic stem cells using one of two viral vectors either a retrovirus
or a lentivirus before they were transplanted into the mice, along with genetically modified mesenchymal stem cells.
Of the mice used in the ...
Ireland Cancer Center researchers advance stem cell gene therapy
... In the Phase I trial for patients with advanced malignancies, researchers collected peripheral blood stem cells from patients and exposed them to a retrovirus
containing the G156A-MGMT gene.
In addition to this promising research, Ireland Cancer Center scientists presented 24 oral and poster ...
New class of drug offers hope to treatment-resistant AIDS patients
... medicines, a discovery by a University of Georgia researcher may offer a new treatment option by targeting a previously elusive enzyme in the complex retrovirus
responsible for the devastating disease.
Approximately 40 million people worldwide have the infectious viral disease known as HIV-AIDS. Although ...
Ancient retrovirus sheds light on modern pandemic
... Human resistance to a retrovirus
that infected chimpanzees and other nonhuman ...
Evidence of human immunity to this ancient retrovirus
first emerged with the sequencing of the ... story of TRIM5a's role in battling one ancient retrovirus
while increasing human susceptibility to ...
Researchers discover that sheep need retroviruses for reproduction
... retroviruses related to Jaagsiekte sheep retrovirus
or enJSRVs, are critical during the early phase ... For instance, the exogenous Jaagsiekte Sheep retrovirus
or JSRV causes lung tumors in sheep and led to ... have shown that a protein of a human endogenous retrovirus
might have a role in development of the human ...
Scientists resuscitate a 5 million-year-old retrovirus
... the DNA sequence of a 5-million-year-old retrovirus
and shown that it is able to produce infectious ... which is the first to generate an infectious retrovirus
from a mobile element in the human genome, is considered a breakthrough for the field of retrovirus
research. The findings are reported in Genome ...
Scientists discover new regulating mechanism in cells
... RHA is knocked out, the spleen necrosis virus, a retrovirus
Boris-Lawrie and her collaborators were studying ... knocked out the RHA protein and learned that the retrovirus
stopped making several vital proteins.
"That suggests that the retrovirus
needs RHA to make these essential proteins," says ...
Chimp genome reveals a retroviral invasion
... spread, but viral DNA will die with the host. A retrovirus
is called endogenous when it invades the germline ... of a subset of apes and monkeys revealed that the retrovirus
had integrated into the germline of African great ... and chimp than macaque and baboon.
When a retrovirus
reproduces, identical copies of LTR sequences are ...
New human retrovirus originated in mice
... Medical Institute researchers and their colleagues have discovered a new retrovirus
in humans that is closely related to a cancer-causing virus found in mice. ... findings describe the first documented cases of human infection with a retrovirus
that is native to rodents.
The researchers discovered the virus in ...
Performing monkeys in Asia carry viruses that could jump species to humans
... of the macaques tested positive for simian foamy virus (SFV), a primate retrovirus
that so far has not been shown to cause disease in humans, but that has ... settings in Asia. Two of the monkeys tested positive for simian retrovirus
(SRV), which, though it has been shown to infect humans in a laboratory ...
Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
... The ancestors of chimpanzees and gorillas were infected with a deadly retrovirus
about three to four million years ago, but there is no evidence it ... Evidence suggests that the 'retroelement' originated from an external retrovirus
that actively infected ape species in the past.
"The reason ...
Science study holds implications for gene therapy and stem cell biology
... study by Dr. Baum and team revealed that the insertion of several such retrovirus
vectors into a single blood-forming stem cell can lead to leukemia in ... found to be marked and activated by the random insertion of a disabled retrovirus
appear to have exactly this property: They can increase the multiplication ...
Can engineered immune cells stop AIDS?
... insert DNA that will counteract the infection.
The "Cadillac" of this gene delivery system is an HIV-based "lentiviral vector," a type of retrovirus
that uses the backbone of a virus to infect both dividing and nondividing cells. Wang says lentiviral vectors are very efficient delivery vehicles ...
'Virus chip' detects new virus in prostate tumors
... encephalitis, and hepatitis and leukemia.
Because the virus was probably originally acquired from another species, it is known as a xenotropic retrovirus
?in this case, a xenotropic murine-like retrovirus, or XMRV. This is not the first virus of this family to be discovered, but it appears to be the ...
Diabetes researchers pioneer islet cell xenotransplantation in primate studies
... and achieved sustained insulin independence (median survival >140 days with one animal now at 300 days) without evidence of porcine endogenous retrovirus
(PERV) dissemination. "This represents a major step forward and proves neonatal porcine islets can correct diabetes long-term in primates," said Drs. ...
Results of world's first gene therapy trial for arthritis show approach safe, feasible
... concern, the authors report no clinical side effects up to five years after the procedure and no evidence that the vector, a replication-defective retrovirus
called Maloney Murine Leukemia Virus, has since become capable of replication in their patients.
"At the outset, our primary objective was proving ...
Primate virus jumps species barrier to humans for first time in Asia
... Scientists have identified the first reported case in Asia of primate-to-human transmission of simian foamy virus (SFV), a retrovirus
found in macaques and other primates that so far has not been shown to cause disease in humans. The transmission of the virus from a monkey to a ...
Study reveals candidate targets for anti-retroviral therapeutics
... half of the genes identified in this study have at least one clear relative or homolog in the human genome, thus providing a rich source of candidate retrovirus
host genes. Sandmeyer and colleagues hope that this study, along with related studies of retrovirus-like elements in yeast, will ultimately lead to ...
Novel Enzyme Shows Potential As An Anti-HIV Target
... At just 9.8 kilobases, the HIV genome pales in comparison to the 3.2 gigabases of its human and nonhuman primate targets. The compact retrovirus
encodes just 14 proteins, which play different roles in promoting viral infection and virulence. As a retrovirus, HIV uses the host’s cellular ...