Evolutionary origin of bacterial chromosomes revealed

... I and III, Agrobacteria gene movements have produced second chromosomes derived from plasmids, while in the biovar II strain K84 the plasmid-based replicon has yet to reach second chromosome status." Derek Wood, associate professor at Seattle Pacific University, remarked: "The findings in this work ...

Hepatitis C complicated by morphine withdrawal

... withdrawal enhances hepatitis C virus (HCV) replicon expression, appears in the November issue of The ... measure HCV replication, they used a virus-like replicon that mimics the events that occur in liver cells ... RNA and proteins that HCV uses. Although the replicon does not produce the infectious virus, the ...

Cyclosporine inhibits hepatitis C virus in vitro

... on hepatitis C in vitro. For the in vitro study, the researchers, led by Roberto J. Firpi, M.D. of the University of Florida, treated the HCV replicon line, GSB1, with varying doses of Cyclosporine for 48 hours and examined the results. They found that Cyclosporine reduced HCV replication by 20 ...

Texas scientists discover how a hepatitis C protein promotes liver cancer

... hepatitis C genetic material that is able to reproduce itself in cultured cells and also able to produce proteins made by hepatitis C viruses. "The replicon experiments enabled us to identify a protein known as NS5B that attaches to the retinoblastoma protein, a critical tumor suppressor, and accelerates ...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

... the researchers inserted the gene for the HER2/neu protein in place of the deleted viral genes and then packaged the virus vector into virus-like replicon particles, referred to as “VRP-neu.?When these non-propagating particles are injected into an animal, the vector directs the animal’s cells to make ...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

... the researchers inserted the gene for the HER2/neu protein in place of the deleted viral genes and then packaged the virus vector into virus-like replicon particles, referred to as “VRP-neu.?When these non-propagating particles are injected into an animal, the vector directs the animal’s cells to make ...