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Repair in Biological News

Scientists track impact of DNA damage in the developing brain

... Switching off a key DNA repair system in the developing nervous system is linked ... of a pathway essential for single-strand DNA repair in the nervous system. The brain is thought to be ... cells do not divide, they cannot use the backup repair systems found in other tissues. Investigators ...

Researchers gain insight into mechanism underlying Huntington's

... "How these genetic changes escape normal DNA repair systems and become ingrained in an affected gene ... require DNA synthesis, DNA replication and/or DNA repair must be involved. Two key TNRs, CAG and CTG ... Li and his colleagues identified a novel DNA repair pathway referred to as DNA ...

Rampant helper syndrome

... function: deazaflavin is involved in DNA repair processes. ( PNAS Early Edition online, 1 July ... to demonstrate, the cofactor is involved in DNA repair processes. Specifically, repair of UV damage to the DNA molecule. Plants and ...

Genetically engineered mice yield clues to 'knocking out' cancer

... That's the conclusion of a recent study* in DNA repair by researchers at the National Institute of ... to several disease states. In humans, DNA repair genes produce enzymes called DNA glycosylases ... protect the genetic material. One of these repair genes, neil1, was identified and characterized in ...

MS study offers theory for why repair of brain's wiring fails

... because the body's natural mechanism for repair of the nerve coating called "myelin" stalls out. ... in mice and in human tissue, showed that repair of nerve fibers is hampered by biochemical ... known as oligodendrocytes, which function as repair workers in the brain. Oligodendrocytes form a ...

Researchers to reveal aging's origins on global stage

... or replaced frequently by our own extensive repair systems," Hayflick said. "These repair systems, which are also composed of complex ... would vanish." Hayflick also noted that these repair and maintenance systems are called "determinants ...

New center at Georgia Tech aims to improve recovery of soldiers with severe injuries

... and tissues. Technologies that could improve the repair and regeneration processes are being developed in ... of Mechanical Engineering. To enhance tissue repair and regeneration following a traumatic injury, ... at those sites long enough to participate in the repair process. While some cells certainly do migrate to ...

One size does not fit all

... that statin therapy in mice inhibits myelin repair or remyelination in the central nervous system. ... system-accessible immune therapies on the myelin repair processes in patients with MS and other ... These cells mature and produce new myelin to repair the damage. "Statins, which are known to ...

Award for pioneering stem cell research to mend broken bones

... tissue engineering to look at the development and repair of human skeletal tissue. Fractures, bone loss ... such as bone remain. Bone and cartilage tissue repair is a highly complex development process. A key ... and ultimately lead to more effective skeletal repair strategies. "We believe a paradigm shift in ...

Lithium may help radiation target cancer, spare healthy tissue

... and colleagues show that lithium promotes DNA repair in healthy cells but not in brain tumor cells. ... the body has several different ways to repair DNA damage. Xia, whose lab studies the mechanisms of DNA repair in normal cells and tumor cells, suspected that ...

CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die

... call a decision point as cells decide whether to repair broken DNA strands or commit suicide following ... gamma-H2A.X foci, which allow the cell to summon repair enzymes to the site of broken DNA strands. The ... The role of Eyes Absent in DNA damage repair EYA was shown to be a phosphatase by three ...

DNA repair mechanisms relocate in response to stress

... Like doctors making house calls, some DNA repair enzymes can relocate to the part of the cell that ... an image of yeast cells with fluorescent DNA repair enzymes for the cover. "DNA damage and ... and oxygen. Cells have an extensive set of repair enzymes that comb through DNA, continually ...

Interventional treatment can be recommended as first-line treatment for 'silent killer'

... (ages 40󈟉) who underwent endovascular repair for AAA over an eight-year period, studying the ... of secondary interventions after endovascular repair was 7.2 percent, which compares favorably to open ... 30-day mortality rate for endovascular aneurysm repair was 3.3 percent, compared to open surgery, which ...

Human DNA repair process recorded in action

... A key phase in the repair process of damaged human DNA has been observed ... recorded a portion of the bacterial DNA repair process, a system considerably less complex than ... is that Rad51 doesn't fall away from the DNA when repair is complete. Instead, proteins that motor along ...

DNA repair patterns may predict risk of pancreatic cancer

... PHILADELPHIA Genetic variations in DNA repair patterns may increase risk of pancreatic cancer ... nine single nucleotide polymorphisms of seven DNA repair genes among 734 patients with pancreatic cancer and 780 people without cancer. DNA repair is the guardian of the genome. When ...

'Smart scaffolds' may help heal broken hearts

... disease or muscle loss that direct the body to repair damaged tissue rather than helping it cope with a ... attracts and supports cells necessary for tissue repair and can be directly injected into problem areas. ... "The scaffold materials would direct the repair process, and restore blood flow and function to ...

Potential therapy for congenital muscular dystrophy

... cells stick together, may lead to enhanced muscle repair in muscular dystrophy. The related report by ... of laminin-111, however, restored muscle repair and regeneration. The data from Rooney et al ... the alpha7beta1 integrin and laminin in muscle repair and suggest direct muscle injections of laminin ...

Breast cancer genome shows evolution, instability of cancer

... breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of ... We found that genes responsible for DNA repair are broken, explaining why the genome may be ... number repeats expose a particular defect in the repair mechanism for double stranded DNA. When that does ...

Superglue from the sea

... and hope it will be used within several years to repair shattered bones in knees, other joints and the ... bone in a joint, those fractures are difficult to repair because if they are not aligned precisely, you ... sandcastle worm glue would not be used to repair large fractures such as major leg and arm bones, ...

Repairing DNA damage: Researchers discover critical process in cancer treatment

... that can lead to cancer. Thanks to our body's DNA repair mechanisms, however, the effects of many ... role for the ATR protein in a specific DNA repair system, which is called nucleotide excision repair or NER," says Elliot Drobetsky, senior author and ...

Seemingly suicidal stunt is normal rite of passage for immune cells

... Sleckman says. "Not only is the cell's ability to repair DNA damage slowed down, the lymphocytes can't ... that regularly look for DNA damage. They can then repair it, or if that's not possible, push the cell to ... proteins, pushes for survival of the cell and repair of the damaged DNA. These groups of genes are ...

Closing the gap: Journal launch brings together wound-healing knowledge

... in the first issue of Fibrogenesis & Tissue repair , a new open access journal published by BioMed Central. CTGF is normally induced during tissue repair while elevated, prolonged CTGF expression is the ... of high quality research Fibrogenesis & Tissue repair will publish. The information provided by this ...

The structure of the Mre11 protein bound to DNA

... then launching the error-free method of DNA repair called homologous recombination. In an ... is important not only for error-free repair of DSBs but also for targeting genes to specific ... cells. But the deliberate inactivation of DNA repair pathways may be an even more powerful method of ...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

... skeletal muscleswhich allow the body to moveto repair and regenerate themselves. The study is ... (SC)) which play a key role in skeletal muscle repair and regeneration following exercise or injury. ... affect the muscle's ability to heal and/or repair itself. There was no change in the ...

Unique animal species can survive in space

... DNA damage, but that the animals managed to repair this damage. "All knowledge involving the repair of genetic damage is central to the field of ... that there are special molecules involved in DNA repair in multicellular animals like tardigrades, we ...

Stent grafts: a better way to treat blunt trauma injuries

... feel both legs), a complication of surgical repair for thoracic aortic aneurysms. "Analysis of ... provides unequivocal support for endovascular repair to replace open surgery as the procedure of choice for repair of the most common traumatic aortic injury," said ...

UGA researchers win $9.2 million stem cell grant from NIH

... to develop therapies for degenerative disease and repair of chronic injury. Focus areas include diabetes, ... involves finding ways to use stem cells to repair the human heart. "The heart is an organ that doesn't repair itself," said Dalton. "But we're studying a ...

Sunburn alert: UVB does more damage to DNA than UVA

... which cover various aspects of DNA damage and repair and genetic alterations," said Ahmad Besaratinia, ... to our skin because our bodies are less able to repair the DNA damage it causes than the damage caused ... to analyze how well these cells were able to repair the damage. In addition, they analyzed published ...

Purple extremist thrives under inhospitable conditions

... of genetic material in dividing cells and the repair of genetic damage. All DNA ligases investigated ... contains metal ions that damage DNA for the repair of DNA seems contradictory," says project partner ... medicine a possibility: "The possibility of DNA repair under acidic conditions may ultimately provide a ...

Stem cell researchers give old muscle new pep

... pathways that control how well adult stem cells repair and replace damaged tissue. They then tweaked how ... the ability of muscle tissue in old mice to repair itself nearly as well as the muscle in the mice's ... If we can do that, we could rejuvenate tissue repair for a very long time." The researchers also ...

EuroDYNA takes lid off the genome

... are expressed and also the mechanisms used to repair DNA damaged by a variety of internal and external ... and elasticity. Indeed the ability of DNA to repair itself is essential for the long term survival of ... so important that a number of surveillance and repair systems have been put in place to ensure its ...

To fight the cancer before the tumor grows

... modified proteins in tumor cells in which a DNA repair defect has occurred. It is estimated that this repair defect is present in some 15 percent of all ... of these tumors, there is a defect in certain repair mechanisms of the DNA that leads mainly to ...

Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure

... injury that lead to heart failure and potential repair processes that occur in the adult failing heart. ... cellular and molecular mechanisms that promote repair for the damaged heart, said principal ... Too much expression of the latter can help repair a heart in failure. Dr. Feldmans research team ...

ASNTR awards go to Parkinson's Disease research and patient advocate at May meeting

... The American Society for Neural Therapy and repair (ASNTR) has awarded The 2008 Bernard Sanberg Memorial Award for Brain repair to neuroscientist Paul M. Carvey, PhD, dean of ... of the Center of Excellence for Aging and Brain repair and associate vice president for innovation at ...

Researchers reveal structure of protein that repairs damage to cancer cells

... scientists has shown how two proteins locate and repair damaged genetic material inside cells. One ... a molecule that could interfere with the repair process, making cancer treatment more effective. ... This is very bizarre, because most other DNA repair proteins prefer double-stranded, He said. The ...

Scientists uncover the potential to control adult stem cells

... towards the use of Adult Stem Cells (ASCs) to repair damaged tissue. Speaking at the conference in ... that instructs ASCs to contribute to tissue repair in response to chemical signals in the body. ... techniques by which ASCs could be instructed to repair damaged tissues. ASCs have potential for ...

Is DNA repair a substitute for sex?

... results have medical implications, because DNA repair capacity is an important factor in cancer, ... conditions. In animals that do have sex, DNA repair is accomplished during meiosis, when chromosomes ... genes on one chromosome can serve as templates to repair damaged genes on the other chromosome. The ...

Harvard researchers publish MRI images of genes in action in the living brain

... timemake it possible to monitor and detect tissue repair in the brain of living organisms using MRI. ... to proteins in cells responsible for brain tissue repair (glia and astrocytes). Then, researchers used the ... the animals brains were scanned using MRI, brain repair activity was visible. Glia and astrocytes ...

Protein protects lung cancer cells from efforts to fix or kill them

... If these damaged cells cant access their built-in repair system and subsequently survive long enough to ... But we found that Bc12 can block the DNA repair mechanism, which promotes tumor formation and ... that develops a genetic mutation and is unable to repair itself could be enough for a full-blown tumor to ...

Researchers probe a DNA repair enzyme

... in many molecular machineries orchestrating DNA repair in the cell. she said. Multiple diseases ... double-stranded DNA, allowing replication and repair of the strands. DNA is a fragile molecule that ... in the cells elaborate machinery to prevent and repair such damage. Mutations in the human members of ...
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