Scientists track impact of DNA damage in the developing brain
... Switching off a key DNA repair
system in the developing nervous system is linked ... of a pathway essential for single-strand DNA repair
in the nervous system. The brain is thought to be ... cells do not divide, they cannot use the backup repair
systems found in other tissues.
Researchers gain insight into mechanism underlying Huntington's
... "How these genetic changes escape normal DNA repair
systems and become ingrained in an affected gene ... require DNA synthesis, DNA replication and/or DNA repair
must be involved.
Two key TNRs, CAG and CTG ... Li and his colleagues identified a novel DNA repair
pathway referred to as DNA ...
Rampant helper syndrome
... function: deazaflavin is involved in DNA repair
processes. ( PNAS Early Edition online, 1 July ... to demonstrate, the cofactor is involved in DNA repair
processes. Specifically, repair
of UV damage to the DNA molecule.
Plants and ...
Genetically engineered mice yield clues to 'knocking out' cancer
... That's the conclusion of a recent study* in DNA repair
by researchers at the National Institute of ... to several disease states. In humans, DNA repair
genes produce enzymes called DNA glycosylases ... protect the genetic material.
One of these repair
genes, neil1, was identified and characterized in ...
MS study offers theory for why repair of brain's wiring fails
... because the body's natural mechanism for repair
of the nerve coating called "myelin" stalls out. ... in mice and in human tissue, showed that repair
of nerve fibers is hampered by biochemical ... known as oligodendrocytes, which function as repair
workers in the brain.
Oligodendrocytes form a ...
Researchers to reveal aging's origins on global stage
... or replaced frequently by our own extensive repair
systems," Hayflick said.
systems, which are also composed of complex ... would vanish."
Hayflick also noted that these repair
and maintenance systems are called "determinants ...
New center at Georgia Tech aims to improve recovery of soldiers with severe injuries
... and tissues. Technologies that could improve the repair
and regeneration processes are being developed in ... of Mechanical Engineering.
To enhance tissue repair
and regeneration following a traumatic injury, ... at those sites long enough to participate in the repair
process. While some cells certainly do migrate to ...
One size does not fit all
... that statin therapy in mice inhibits myelin repair
or remyelination in the central nervous system. ... system-accessible immune therapies on the myelin repair
processes in patients with MS and other ... These cells mature and produce new myelin to repair
"Statins, which are known to ...
Award for pioneering stem cell research to mend broken bones
... tissue engineering to look at the development and repair
of human skeletal tissue.
Fractures, bone loss ... such as bone remain. Bone and cartilage tissue repair
is a highly complex development process. A key ... and ultimately lead to more effective skeletal repair
"We believe a paradigm shift in ...
Lithium may help radiation target cancer, spare healthy tissue
... and colleagues show that lithium promotes DNA repair
in healthy cells but not in brain tumor cells. ... the body has several different ways to repair
Xia, whose lab studies the mechanisms of DNA repair
in normal cells and tumor cells, suspected that ...
CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die
... call a decision point as cells decide whether to repair
broken DNA strands or commit suicide following ... gamma-H2A.X foci, which allow the cell to summon repair
enzymes to the site of broken DNA strands. The ...
The role of Eyes Absent in DNA damage repair
EYA was shown to be a phosphatase by three ...
DNA repair mechanisms relocate in response to stress
... Like doctors making house calls, some DNA repair
enzymes can relocate to the part of the cell that ... an image of yeast cells with fluorescent DNA repair
enzymes for the cover.
"DNA damage and ... and oxygen. Cells have an extensive set of repair
enzymes that comb through DNA, continually ...
Interventional treatment can be recommended as first-line treatment for 'silent killer'
... (ages 40) who underwent endovascular repair
for AAA over an eight-year period, studying the ... of secondary interventions after endovascular repair
was 7.2 percent, which compares favorably to open ... 30-day mortality rate for endovascular aneurysm repair
was 3.3 percent, compared to open surgery, which ...
Human DNA repair process recorded in action
... A key phase in the repair
process of damaged human DNA has been observed ... recorded a portion of the bacterial DNA repair
process, a system considerably less complex than ... is that Rad51 doesn't fall away from the DNA when repair
is complete. Instead, proteins that motor along ...
DNA repair patterns may predict risk of pancreatic cancer
... PHILADELPHIA Genetic variations in DNA repair
patterns may increase risk of pancreatic cancer ... nine single nucleotide polymorphisms of seven DNA repair
genes among 734 patients with pancreatic cancer and 780 people without cancer. DNA repair
is the guardian of the genome. When ...
'Smart scaffolds' may help heal broken hearts
... disease or muscle loss that direct the body to repair
damaged tissue rather than helping it cope with a ... attracts and supports cells necessary for tissue repair
and can be directly injected into problem areas. ... "The scaffold materials would direct the repair
process, and restore blood flow and function to ...
Potential therapy for congenital muscular dystrophy
... cells stick together, may lead to enhanced muscle repair
in muscular dystrophy. The related report by ... of laminin-111, however, restored muscle repair
The data from Rooney et al ... the alpha7beta1 integrin and laminin in muscle repair
and suggest direct muscle injections of laminin ...
Breast cancer genome shows evolution, instability of cancer
... breaks and fusions of genes and a broken DNA repair
machinery, said researchers at Baylor College of ... We found that genes responsible for DNA repair
are broken, explaining why the genome may be ... number repeats expose a particular defect in the repair
mechanism for double stranded DNA. When that does ...
Superglue from the sea
... and hope it will be used within several years to repair
shattered bones in knees, other joints and the ... bone in a joint, those fractures are difficult to repair
because if they are not aligned precisely, you ... sandcastle worm glue would not be used to repair
large fractures such as major leg and arm bones, ...
Repairing DNA damage: Researchers discover critical process in cancer treatment
... that can lead to cancer. Thanks to our body's DNA repair
mechanisms, however, the effects of many ... role for the ATR protein in a specific DNA repair
system, which is called nucleotide excision repair
or NER," says Elliot Drobetsky, senior author and ...
Seemingly suicidal stunt is normal rite of passage for immune cells
... Sleckman says. "Not only is the cell's ability to repair
DNA damage slowed down, the lymphocytes can't ... that regularly look for DNA damage. They can then repair
it, or if that's not possible, push the cell to ... proteins, pushes for survival of the cell and repair
of the damaged DNA. These groups of genes are ...
Closing the gap: Journal launch brings together wound-healing knowledge
... in the first issue of Fibrogenesis & Tissue repair
, a new open access journal published by BioMed Central.
CTGF is normally induced during tissue repair
while elevated, prolonged CTGF expression is the ... of high quality research Fibrogenesis & Tissue repair
will publish. The information provided by this ...
The structure of the Mre11 protein bound to DNA
... then launching the error-free method of DNA repair
called homologous recombination.
In an ... is important not only for error-free repair
of DSBs but also for targeting genes to specific ... cells. But the deliberate inactivation of DNA repair
pathways may be an even more powerful method of ...
Cholesterol-lowering drugs and the effect on muscle repair and regeneration
... skeletal muscleswhich allow the body to moveto repair
and regenerate themselves.
The study is ... (SC)) which play a key role in skeletal muscle repair
and regeneration following exercise or injury. ... affect the muscle's ability to heal and/or repair
There was no change in the ...
Unique animal species can survive in space
... DNA damage, but that the animals managed to repair
"All knowledge involving the repair
of genetic damage is central to the field of ... that there are special molecules involved in DNA repair
in multicellular animals like tardigrades, we ...
Stent grafts: a better way to treat blunt trauma injuries
... feel both legs), a complication of surgical repair
for thoracic aortic aneurysms.
"Analysis of ... provides unequivocal support for endovascular repair
to replace open surgery as the procedure of choice for repair
of the most common traumatic aortic injury," said ...
UGA researchers win $9.2 million stem cell grant from NIH
... to develop therapies for degenerative disease and repair
of chronic injury. Focus areas include diabetes, ... involves finding ways to use stem cells to repair
the human heart.
"The heart is an organ that doesn't repair
itself," said Dalton. "But we're studying a ...
Sunburn alert: UVB does more damage to DNA than UVA
... which cover various aspects of DNA damage and repair
and genetic alterations," said Ahmad Besaratinia, ... to our skin because our bodies are less able to repair
the DNA damage it causes than the damage caused ... to analyze how well these cells were able to repair
the damage. In addition, they analyzed published ...
Purple extremist thrives under inhospitable conditions
... of genetic material in dividing cells and the repair
of genetic damage. All DNA ligases investigated ... contains metal ions that damage DNA for the repair
of DNA seems contradictory," says project partner ... medicine a possibility: "The possibility of DNA repair
under acidic conditions may ultimately provide a ...
Stem cell researchers give old muscle new pep
... pathways that control how well adult stem cells repair
and replace damaged tissue. They then tweaked how ... the ability of muscle tissue in old mice to repair
itself nearly as well as the muscle in the mice's ... If we can do that, we could rejuvenate tissue repair
for a very long time."
The researchers also ...
EuroDYNA takes lid off the genome
... are expressed and also the mechanisms used to repair
DNA damaged by a variety of internal and external ... and elasticity.
Indeed the ability of DNA to repair
itself is essential for the long term survival of ... so important that a number of surveillance and repair
systems have been put in place to ensure its ...
To fight the cancer before the tumor grows
... modified proteins in tumor cells in which a DNA repair
defect has occurred. It is estimated that this repair
defect is present in some 15 percent of all ... of these tumors, there is a defect in certain repair
mechanisms of the DNA that leads mainly to ...
Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
... injury that lead to heart failure and potential repair
processes that occur in the adult failing heart. ... cellular and molecular mechanisms that promote repair
for the damaged heart, said principal ... Too much expression of the latter can help repair
a heart in failure. Dr. Feldmans research team ...
ASNTR awards go to Parkinson's Disease research and patient advocate at May meeting
... The American Society for Neural Therapy and repair
(ASNTR) has awarded The 2008 Bernard Sanberg Memorial Award for Brain repair
to neuroscientist Paul M. Carvey, PhD, dean of ... of the Center of Excellence for Aging and Brain repair
and associate vice president for innovation at ...
Researchers reveal structure of protein that repairs damage to cancer cells
... scientists has shown how two proteins locate and repair
damaged genetic material inside cells.
One ... a molecule that could interfere with the repair
process, making cancer treatment more effective. ... This is very bizarre, because most other DNA repair
proteins prefer double-stranded, He said. The ...
Scientists uncover the potential to control adult stem cells
... towards the use of Adult Stem Cells (ASCs) to repair
damaged tissue. Speaking at the conference in ... that instructs ASCs to contribute to tissue repair
in response to chemical signals in the body. ... techniques by which ASCs could be instructed to repair
ASCs have potential for ...
Is DNA repair a substitute for sex?
... results have medical implications, because DNA repair
capacity is an important factor in cancer, ... conditions.
In animals that do have sex, DNA repair
is accomplished during meiosis, when chromosomes ... genes on one chromosome can serve as templates to repair
damaged genes on the other chromosome. The ...
Harvard researchers publish MRI images of genes in action in the living brain
... timemake it possible to monitor and detect tissue repair
in the brain of living organisms using MRI. ... to proteins in cells responsible for brain tissue repair
(glia and astrocytes). Then, researchers used the ... the animals brains were scanned using MRI, brain repair
activity was visible. Glia and astrocytes ...
Protein protects lung cancer cells from efforts to fix or kill them
... If these damaged cells cant access their built-in repair
system and subsequently survive long enough to ... But we found that Bc12 can block the DNA repair
mechanism, which promotes tumor formation and ... that develops a genetic mutation and is unable to repair
itself could be enough for a full-blown tumor to ...
Researchers probe a DNA repair enzyme
... in many molecular machineries orchestrating DNA repair
in the cell. she said. Multiple diseases ... double-stranded DNA, allowing replication and repair
of the strands.
DNA is a fragile molecule that ... in the cells elaborate machinery to prevent and repair
such damage. Mutations in the human members of ...