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Pulmonary in Biological News

Pulmonary hypertension in children may result from reduced activity of gene regulator

... flexible blood vessels into rigid pipes and the pulmonary hypertension that often results. "These drugs ... produce pummels the lungs, turning flexible pulmonary blood vessels into rigid pipes, said Dr. Black, ... of a congenital heart defect that causes too much pulmonary blood flow, they have already shown PPARs ...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

... scientists have linked with idiopathic pulmonary fibrosis, or IPF. The study appears online this ... die from the disease each year, according to the pulmonary Fibrosis Foundation. The disease typically ... medication that can stem the progression of this pulmonary condition. About one in 50 IPF patients have ...

American Chemical Society's Weekly PressPac -- Dec. 3, 2008

... toward early diagnosis of chronic obstructive pulmonary disease Journal of Proteome Research ... test for early detection of chronic obstructive pulmonary disease (COPD). That condition, which causes ... individuals, patients with COPD, and those with pulmonary fibrosis. They found that the lungs of COPD ...

Inherited genetic cause, possible treatment found for complex lung disorder

... that causes an inherited form of the lung disease pulmonary Alveolar Proteinosis (PAP). Reporting their ... to PAP. The lungs of people with PAP fill with pulmonary surfactant, a substance composed of lipids (fats) ... M.D., a physician/researcher in the division of pulmonary Biology at Cincinnati Children's and the report's ...

New cardiology research presented at CHEST 2008

... that the donor-derived tissue (atrial cuff or pulmonary vein) is a likely source of the arrhythmias ... #6363 TADALAFIL PROVES EFFECTIVE THERAPY FOR pulmonary HYPERTENSION (Tuesday, October 28, 10:30 AM ... be an effective adjunct therapy for patients with pulmonary arterial hypertension (PAH). Italian researchers ...

Gene with probable role in human susceptibility to pulmonary tuberculosis identified

... A new gene that may confer susceptibility to pulmonary tuberculosis has been identified by Genome ... our understanding of the disease process of pulmonary tuberculosis." GIS Senior Group Leader and ... are refractive to current treatment regimes." pulmonary tuberculosis is a contagious lung disease caused ...

African-Americans have unique lung cancer risks from chronic obstructive pulmonary disease

... suggests a greater risk from chronic obstructive pulmonary disease (COPD), according to a report published ... was the risk associated with chronic obstructive pulmonary disease. African American men with a prior history of chronic obstructive pulmonary disease had a more than sixfold increased risk of ...

Translational research patented first experimental treatment against idiopathic pulmonary fibrosis

... release is available in Spanish . Idiopathic pulmonary fibrosis is a disease with unknown cause with a ... suffering from it cannot develop with normality pulmonary gas exchange, and have a very reduced quality of ... survive 5 years after being diagnosed. Idiopathic pulmonary fibrosis affects 13 out of 100,000 men and 7 out ...

A step toward tissue-engineered heart structures for children

... published September 11, they describe making pulmonary valves through tissue engineering. These valves, ... flow from the hearts right ventricle into the pulmonary artery, are often malformed in congenital heart ... and growth factors, they were able to make pulmonary valve leaflets that had the right mechanical ...

Lecture to honor victim of Sept. 11 tragedy

... Hanson, MA, PhD 02, a former researcher in BUSMs pulmonary Center. Kim Hanson, along with her husband and ... 1992. After graduation, she joined the Schools pulmonary Center. She then concurrently entered the PhD ... Center, MD, Gordon and Ruth Snider Professor of pulmonary Medicine, Professor of Medicine and Biochemistry ...

NIH stimulus funding supports Emory biomedical scientists

... ranging from heart disease, cancer and neurology to organ transplantation, pulmonary diseases, addiction and epilepsy. In addition to research grants, NIH ... peoples' diets, may regulate inflammatory molecules that contribute to pulmonary fibrosis. Mechanisms of cardiac fibrosis: NADPH oxidases are enzymes ...

LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease

... as allergens, pollutants, and respiratory viruses during infancy leads to pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma later in life. Using protein profiling ...

Genetic irregularities linked to higher risk of COPD among smokers

... smokers at significantly higher risk of developing chronic obstructive pulmonary disease (COPD). The findings come from the first-ever genome-wide ... author of the study appearing in PLoS Genetics . Chronic obstructive pulmonary disease is one of the leading causes of death worldwide. While smoking is ...

RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report

... RSV. They then monitored the mice for 42 days, checking their pulmonary function and respiratory rate at set intervals. At the end of the study, ... in the other groups. While studies of adults with chronic obstructive pulmonary disease have suggested that RSV may persist, this is the first study to ...

Pivotal national trial uses newest interventional radiology treatment to bust blood clots in legs

... treatment with blood thinners is important to prevent a life-threatening pulmonary embolism, blood thinners alone do not dissolve the existing clot, which ... treatment with blood thinners is important to prevent a life-threatening pulmonary embolism, but blood thinners do not dissolve the existing clot, which ...

Key component of debilitating lung disease identified

... antioxidant defense system and the progression of chronic obstructive pulmonary disease (COPD) in humans. COPD is a degenerative condition that decreases ... School's Department of Environmental Health Sciences and the Division of pulmonary and Critical Care Medicine at the Johns Hopkins School of Medicine. ...

COPD? Eat your veggies

... inflammatory injury, is linked to the severity of chronic obstructive pulmonary disease (COPD) in smokers. Broccoli is known to contain a compound that ... School's Department of Environmental Health Sciences and Division of pulmonary and Critical Care at the Johns Hopkins School of Medicine. "Therapy ...

Infection blocks lung's protective response against tobacco smoke

... one mechanism that may cause smokers to develop chronic obstructive pulmonary disease. "Although smoking is the overwhelming cause of chronic obstructive pulmonary disease (COPD), only 20 percent of smokers develop the disease," said ...

RAND study finds evidence disease management programs

... artery disease, diabetes, asthma, depression and chronic obstructive pulmonary disease. With the exception of asthma and chronic obstructive pulmonary disease, which showed inconclusive results, researchers found consistent ...

Cleveland Clinic leading clinical program to improve early-stage lung cancer detection

... looks at the X-ray, identifies regions of interest (actionable/suspicious pulmonary nodules), and circles them for further analysis. The radiologist is then ... technology helped radiologists identify16 percent more 9-15 mm solitary pulmonary nodules that were early stage (1A) lung cancer than the radiologist would ...

Positive results for airway bypass

... lead author of the paper. These results reveal significant improvements in pulmonary function and reduction in breathing difficulties out to six months and ... is a potentially viable therapeutic option for patients with marked severe pulmonary destruction, whose only current option may be to wait for a lung ...

Placenta-derived stem cells may help sufferers of lung diseases

... , has found that stem cells derived from human placenta may ultimately play a role in the treatment of lung diseases, such as pulmonary fibrosis and fibrotic diseases caused by tuberculosis, chemical exposure, radiation or pathogens. These diseases can ultimately lead to loss of ...

UTSA infectious disease researchers advancing vaccine against Valley fever

... percent of infected individuals experience severe symptoms, such as chronic-progressive pneumonia or meningitis, the incidence of reported primary pulmonary infection cases in Arizona and California is on the rise, having significantly increased in the last decade. STCEID researchers at UTSA and ...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

... findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain them until life-saving transplants can ...

Genetically engineered mice yield clues to 'knocking out' cancer

... and brain. This indicates that there was a lack of DNA repair in these organs. During the second year of life, both types of mice also developed pulmonary and hepatocellular (liver cell) tumors. Double knockout mice had a higher incidence of tumors than the single knockouts. The researchers state ...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

... is asthma specialist and researcher Nicholas Kenyon, co-director of the UC Davis Asthma Network and associate professor of medicine, Division of pulmonary and Critical Care, UC Davis Medical Center. "We believe these pathways are very important in the airway inflammation that occurs in asthma ...

Gene therapy could expand stem cells' promise

... be dealt with and we have the technology to do that in the form of gene therapy," says senior author Dr. Ronald G. Crystal, chief of the Division of pulmonary and Critical Care Medicine at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, and the Bruce Webster Professor of Internal Medicine and ...

MCG researcher among first to receive NIH stimulus funding

... of Psychiatry and Health Behavior, Dr. Harold Szerlip, professor in the Sections of Nephrology, Hypertension and Transplantation Medicine and pulmonary Disease, and Dr. John Catravas, director of the MCG Vascular Biology Center and senior associate dean for basic science research. According to the ...

Allergy season: Cigarettes to the rescue?

... new study shows that cigarette smoke can prevent allergies by decreasing the reaction of immune cells to allergens. Smoking can cause lung cancer, pulmonary disease, and can even affect how the body fights infections. Along with many harmful effects, smoking cigarettes has a surprising benefit: cigarettes ...

Heart protein regulates blood vessel maintenance

... Tufts. The researchers have previously shown that BMPs (Bone Morphogenetic Proteins) play a role in the maintenance of smooth muscle cells in the pulmonary artery. In this study, the research demonstrates that FHL2 (Four-and-a-Half LIM Domain Protein 2) inhibits activation of genes that are involved in ...

Athletes with asthma need more help from their team trainers

... the study and a pulmonologist, critical care specialist and associate director of the Asthma Center at the Ohio State University Medical Center. pulmonary and sports medicine researchers sent electronic surveys, with questions related to the diagnosis and management of exercise-induced bronchospasm ...

Changes in gene may stunt lung development in children

... March 26 Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Research Center for ...

Researchers may have found why women have an edge on salt-sensitive hypertension

... tubules of the kidney. They also may help explain the swelling that occurs in some patients taking powerful new ETA antagonists, which are in use for pulmonary hypertension and under study for conditions such as diabetic nephropathy and uncontrolled hypertension. These antagonists block the action of ETA ...

Global warming linked to European viral epidemic

... with bleeding disorders). NE is a relatively mild hemorrhagic fever that causes flu-like symptoms often with renal complications, sometimes also with pulmonary problems, needing Intensive Care treatment, such as acute dialysis and/or mechanical ventilation. In some rare cases it can, moreover, cause the ...

Life Sciences Discovery Fund awards health research program grants

... sites of action inside the cells optimize drug therapy in defined cell populations and minimize damage to other areas of the body. Cancer and pulmonary trauma are leading causes of death in Washington and across the nation and result in millions of inpatient hospital days. Using polymer chemistry and ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

... are also likely to compromise telomerase function and may thus contribute to diseases such as dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis." ...

Montana State University researchers find gene that regulates mold's resistance to drugs

... pathogenesis in MSU's Department of Veterinary Molecular Biology. A. fumigatus can invade the lungs and cause dangerous diseases, including Invasive pulmonary Aspergillosis. Patients with a compromised immune system, especially organ transplant patients, are particularly at risk. "The incidence of ...

OSA's ISP launches with research on breathing disorders and congenital heart defects

... says McLaughlin. Other current clinical studies are testing whether aOCT can detect airway changes in people with asthma and chronic obstructive pulmonary disease. According to McLaughlin, this technology can also be used during sleep in patients with sleep apnea, to better understand why the upper ...

First comprehensive genomic study of common cold reveals new treatment targets

... is the major cause of the common cold, but it is also an important pathogen in more serious conditions, such as asthma and chronic obstructive pulmonary disease (COPD)," said David Proud, PhD, Professor, Department of Physiology & Biophysics, University of Calgary and senior author of the study. "The ...

National Jewish Health researchers evaluating treatment to help emphysema sufferers breathe easier

... help those who would not otherwise be considered for or benefit from lung volume reduction surgery." Emphysema, a component of chronic obstructive pulmonary disease (COPD), is a chronic, progressive and irreversible lung disease characterized by the destruction of lung tissue. The loss of the lungs' ...
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