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Proteins in Biological News

Carnegie donates landmark clones to biology

... so little is known about the interactions that proteins have with each other and the protective membrane ... a cell. These interactive, so-called membrane proteins regulate nutrients and water fluxes, sense ... Biology have cloned genes to produce membrane proteins that may initiate the instructions for genes to ...

Protein handlers should be effective treatment target for cancer and Alzheimer's

... common and scientists say learning more about how proteins are made and eliminated will lead to better ... in the last 12 months to support studies of proteins and the molecular chaperones that manage them ... which prompt genes to make proteins, move proteins around the body, fold them up into the proper ...

UC San Diego engineer provides insights to decades-old DNA squabble

... Chromatin is a complex combination of DNA and proteins that makes up chromosomes. The function of ... most important features of DNA and the associated proteins in the model, using techniques called ... to cancer or you could have abnormalities in the proteins that regulate chromatin around these genes ...

Structure of protective protein in the eye lens revealed

... concentrated mix of several proteins. Protective proteins prevent these proteins from aggregating and clumping. If this protective ... Sciences ), shed new light on the work of these proteins and may be able to help in the development of new ...

New computer simulation helps explain folding in important cellular protein

... past three decades tried to understand what makes proteins fold into functional units and why it happens, ... this, we can learn about the characteristics of proteins including possible folding pathways and folding ... much is happening physically and biochemically as proteins fold into their functional shapes (called the ...

Reprogramming human cells without inserting genes

... human skin cells. Those genes began expressing proteins that changed the skin cells back to a more ... began expressing proteins, the team found those proteins migrated back into the nucleus of the skin cells, ... WPI and lead author on the paper. "Having these proteins localize to the nucleus is the first step of ...

Jet-propelled imaging for an ultrafast light source

... bodies are made. All living things are made of proteins and nucleic acids, but relatively few of the ... the thousands, perhaps millions, of varieties of proteins are known. The Linac Coherent Light Source ... structure. Unfolding the origami proteins begin as strings of amino acids that fold ...

ISU researchers find possible treatment for spinal muscular atrophy

... the mutated or malfunctioning SMN1 gene. All proteins in human bodies are made by copying genes. This ... sequence is blocked, SMN2 produces normal proteins and acts, in effect, like SMN1. "The ... if you think about it." The resulting proteins are normal just like a regular cell - free from ...

New windows opened on cell-to-cell interactions

... scales where the orientation of minuscule proteins is crucial, said Raghuveer Parthasarathy, who is ... molecules that mimic brush-like membrane proteins and contain tiny fluorescent probes at the outer ... may be possible. "There are brush-like proteins at cell surfaces that are really important for ...

Stunting plants' skyward reach could lead to improved yields

... work with an enzyme found to degrade parts of proteins that control life processes such as stem growth. ... can be applied across many other species. The proteins at issue in the research, called phytochromes, ... flowering time and other life processes. Those proteins are only responsive to certain parts of the light ...

LincRNAs serve as genetic air-traffic controllers

... have a global role in genome regulation, ferrying proteins to assist their regulation at specific regions of ... long been a mystery as to how widely expressed proteins shape the fate of cells. How does the same ... -- which is known to bind key chromatin modifier proteins and to assist in getting ...

Study by NTU professors provides important insight into apoptosis or programmed cell death

... cell's rescue mechanism is inhibited when certain proteins (i.e. 'anti-factors' that are necessary to keep a ... is involved in the transportation of certain proteins into and out of the cell's nucleus, is reduced ... serves as a track and directs the transport of proteins and other molecules into and out of the nucleus. ...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

... the phenomenon of "viral mimicry," in which viral proteins can resemble host proteins to hijack important cellular functions. His lab showed that host proteins can evolve to defeat viral mimicry, providing yet ...

Spontaneous assembly

... look at how thousands of bacterial membrane proteins are able to assemble into clusters that direct ... to show that the chemotaxis network of signaling proteins in E.coli bacteria is able to spontaneously form from clusters of proteins without being actively distributed or attached to ...

Plant protein 'doorkeepers' block invading microbes, study finds

... A group of plant proteins that "shut the door" on bacteria that would ... "In this study, we identified a complex of proteins in the common research plant Arabidopsis that ... 20 years, scientists have identified a number of proteins that are important for regulating the plant ...

GUMC discovery highlights new direction for drug discovery

... of a single protein, but our agent stops two proteins from interacting. This has never been shown ... say. Agents in use now that work against fusion proteins inhibit a single protein to stop intrinsic ... a rigid structure. A number of cancer-causing proteins are disordered. In their 15-year search for a ...

Rampant helper syndrome

... of their own. In the cells of living organisms, proteins perform this important function. They carry out the metabolism fundamental to all living processes. proteins are instrumental in cellular respiration, they ... are stored inside special pockets in the proteins and carry out essential metabolic functions. The ...

Biological warfare in bacteria offers hope for new antibiotics

... Scientists are to study a group of proteins that are highly effective at killing bacteria and ... Council (BBSRC) to find out how a family of proteins known as colicins force their way into bacterial ... bacteria. Understanding how this group of proteins work could help scientists develop new drug ...

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

... provides new insights into the scaffold of proteins that ensures accurate segregation of chromosomes ... segregating, chromosomes attach and move along proteins tracks (the mitotic spindle), from the centre of ... by controlling the assembly of a scaffold of proteins (called the kinetochore), which tether the ...

Plant protein 'doorkeepers' block invading microbes, study finds

... A group of plant proteins that "shut the door" on bacteria that would ... "In this study, we identified a complex of proteins in the common research plant Arabidopsis that ... 20 years, scientists have identified a number of proteins that are important for regulating the plant ...

Trio of signals converge to induce liver and pancreas cell development in the embryo

... correct path is provided by genetic regulatory proteins that attach to chromosomes, marking part of the ... every cell must be loosened a bit. The regulatory proteins help with this, exposing a small domain near the ... They then act as a landing pad on which other proteins assemble to continue the gene activation process. ...

Structural biology scores with protein snapshot

... molecular pictures" of small proteins, large proteins and particularly those that reside within the ... receptors the largest family of cell signaling proteins are targets for about half of all ... pursuing structural studies of misfolded membrane proteins that cause diseases including peripheral ...

Cells use import machinery to export their goods as well

... function, importing life-supporting nutrients and proteins through an independent process. By using a finely ... the membrane and delivering their whole load of proteins and lipids, in contrast to the more discriminating process by which similar container ships import proteins from outside the cell, called endocytosis. But, ...

New nanoparticles could revolutionize therapeutic drug discovery

... (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug ... drug discovery. Understanding the structure of proteins is a vital first step in developing new drugs, ... has been slowed because due to their instability, proteins are difficult to work with in lab conditions. ...

Computers aid in cracking deception in plants

... part of its modus operandi, the nematode secretes proteins into the soybean that change the plant's cellular ... is difficult due to the sheer volume of proteins involved. By applying concepts of machine ... a specific protein binding site among a group of proteins from the nematode that match a particular binding ...

A Canada-wide technology platform for mapping the human interactome

... organization by mapping the dynamic networks that proteins form when they interact together and with other ... forefront of research aimed at deciphering how proteins inside the cell interact, and how errors in this ... greatly accelerate our ability to analyze the proteins within normal and diseased cells, and to ...

Molecular typesetting -- proofreading without a proofreader

... a model of how errors are corrected whilst proteins are being built. Ensuring that proteins are built correctly is essential to the proper ... must be happening. Otherwise, many more proteins in our bodies would malfunction," says Dr Cohen. ...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

... is hijacked by cancer," says Dr. Chadli. proteins that enable cancer basics such as endless cell ... of the ubiquitous heat shock proteins. These proteins are essential in the body, necessary to even digesting food. In healthy times they fold proteins properly so they'll do the right job, sometimes ...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... 8, 2009, emphasizes that such shape shifting by proteins is a common way of regulating cellular ... methods to show that both simple and complex proteins can swiftly change their structures. In March, ... shed light on how symmetry can result in proteins being able to populate structures that are ...

Cancer-causing protein can also help fight the tumors it causes

... review about such cell-to-cell transferring of proteins in FEBS Letters. Turning a cancer-causing protein against cancer itself The idea that proteins can transfer between cells challenges the ... in the immune system interact with other cells, proteins are exchanged without being secreted from the ...

TRAPping proteins that work together inside living cells

... DNA might be the blueprint for living things, but proteins are the builders. Researchers trying to understand how and which proteins work together have developed a new crosslinking ... new details about a well-studied complex of proteins known as RNA polymerase. The results suggest the ...

NIH funds $9.5 million for research on HIV and the human innate immune system

... projects, researchers will identify altered proteins in human epithelial cells from HIV-infected ... projects, researchers will identify altered proteins in human epithelial cells from HIV-infected ... eventually provide a firm understanding of what proteins are really important in maintaining health and ...

Protein that triggers plant cell division revealed by researchers

... cell division in animals, we know many of the proteins that control the process, but plants just don't ... discovered that BASL behaves like many of the proteins vital for animal asymmetric cell divisions, even ... They found that BASL behaved in some ways like proteins involved in asymmetric animal cell division--that ...

American Chemical Society's Weekly PressPac -- June 3, 2009

... by orchestrating how genes in the body produce proteins involved in arthritis, cancer and a range of ... medications might ratchet up the production of proteins in genes working at abnormally low levels or shut ... that cause genes to be active and churn out proteins so-called transcriptional activators. That's ...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

... Our ongoing studies suggest that a group of proteins that compromise the notch signaling pathway in ... discs are central to this process. These proteins regulate a variety of activities of stem cells ... engineered mouse model that lacks selected proteins of the notch signaling pathway in the ...

Scientists explain how 'death receptors' designed to kill our cells may make them stronger

... pathways activated by death receptors and the proteins involved in the process. Specifically, they looked at how these proteins interact with each other and how they ... are activated, including identifying key proteins involved in the processes, may allow researchers ...

Sugarcoating fruit fly development

... proteins are the executive agents that carry out all ... sugar residue, that is found on many different proteins across species. In the current online issue of ... report that the addition of this sugar tag to proteins in the nucleus of a cell is vital for normal ...

Understanding plants' overactive immune system will help MU researchers build better crops

... relies on the detection of pathogen effector proteins (proteins that are deployed by pathogens to ... After the detection of a pathogen, specific proteins in the plant, known as resistance proteins, ... defense response. The plants' resistance proteins are regulated by suppressors to achieve minimal ...

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

... Sections of proteins previously thought to be disordered may in fact ... an unexpected biological role providing certain proteins room to move -- according to a study published by ... between the outer membrane of a cell and the proteins found in the structures that form the cell's ...

The evolution of gene regulation

... to the technically inexplicable question of how proteins were regulated as a response to internal and ... is a decisive factor: it is mostly genes whose proteins are required most of the time that are directly activated. proteins such as lactase, on the other hand, which are ...
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