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Protein in Biological News

New DNA and RNA aptamers offer unique therapeutic advantages

... strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and ... Aptamers offer several advantages compared to protein or small molecule drugs, most notably their ease ... used to identify aptamers that specifically bind protein drug targets of interest, the types of ...

Pitt researchers find promising candidate protein for cancer prevention vaccines

... naturally developed an immune response against a protein that is made in excess levels in many cancers, ... The finding suggests that a vaccine against the protein might prevent malignancies in high-risk ... a vaccine to boost response against MUC1, a protein that is abnormally produced in colon cancer and ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... of glioblastoma cells, preventing a growth factor protein from binding to it and activating growth pathways ... Lombardi. He adds that ALK receptors and the protein that binds to it, the growth factor pleiotrophin ... have hundreds of different areas on a receptor protein where its ligand could theoretically bind. We ...

Little-known protein found to be key player

... this week report that a little-understood protein previously implicated in a rare genetic disorder ... "It is fitting that the discovery of a new protein capable of fusing membranes comes 10 years after ... flies is very similar to the human version of the protein and serves the same function. "Prior to this, ...

New computer simulation helps explain folding in important cellular protein

... of the controlling mechanisms behind protein folding. "Our goal is to present the ... approach is to investigate the thermodynamics of protein folding through examining the energy landscape," ... for the Intel Corp.) GpA is a 131-amino acid protein that spans the human red-blood cell membrane and ...

Jet-propelled imaging for an ultrafast light source

... pulses offer a novel approach to the problem of protein structure. Unfolding the origami ... their work by attaching themselves to the larger protein molecules. A knowledge of the arrangement of a ... understand how a drug molecule will dock with a protein to promote or inhibit its activity, or cripple ...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

... facilitated by an increased amount of a signaling protein that is associated with mitochondrial disease. ... disease increase their production of a signaling protein called AMP-activated protein kinase (AMPK), to promote the generation of more ...

Discovery to aid in future treatments of third-world parasites

... Borstel in Germany had previously shown that a protein called alpha-1 can support Th2 responses but is ... Netherlands have now shown that omega-1, a single protein secreted from schistosome eggs, recapitulates the ... in vivo. This identification of a single protein will undoubtedly aid in unlocking the molecular ...

ISU researchers find possible treatment for spinal muscular atrophy

... gene. Humans need a certain level of SMN protein to ward off Spinal Muscular Atrophy. When SMN1 ... junk DNA. SMN2 normally doesn't produce normal protein because of the presence of a specific intronic ... SMN2 to restore the high levels of functional SMN protein could eliminate Spinal Muscular Atrophy caused by ...

Newly discovered gene fusion may lead to improved prostate cancer diagnosis

... group, this fusion, called NDRG1-ERG, produces a protein that may be a potential target for drug ... predicted to produce a protein. This fusion protein may be a target for drug therapy and could help ... NDRG1 and ERG, likely produce a cancer-specific protein through genetic rearrangements. This fusion ...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

... strategy, we first characterized a mitochondrial protein called Sdh5 in yeast and then moved on to study ... in human disease." Sdh5 is a mitochondrial protein that is highly conserved, meaning that it has ... colleagues discovered that, in yeast, the Sdh5 protein is needed for the SDH complex to function ...

Sticky protein helps reinforce fragile muscle membranes

... Specifically, the team identified a protein called alpha dystroglycan as the "glue" that ... alpha dystroglycan, leading to a version of the protein that does not attach properly to the basal ... the muscles from damage. "Injecting the protein helped us prove that glycosylated dystroglycan is ...

Vaccine blocks malaria transmission in lab experiments

... have for the first time produced a malarial protein (Pfs48/45) in the proper conformation and ... vaccine. Antibodies induced by Pfs48/45 protein vaccine effectively blocked the sexual ... vaccine. Previous attempts to fully express the protein had not been successful. The vaccine was first ...

University of Minnesota research leads to new technology to protect human health

... it was added to milk to increase its apparent protein content. Some children may have life-long chronic ... in the environment," says Joe Krebs, director of protein Chemistry and Engineering at Bioo Scientific. ... nutrient), is cheap, and is falsely recognized as protein by the most common chemical assay used to test ...

Promising new treatment for Alzheimer's suggested based on Hebrew University research

... effects of the disease, since the mutated protein (the enzyme that is the product of the gene) ... with the Alzheimer's disease β-amyloid protein and preventing it from precipitating and forming ... of this disease. To compare the normal protein to the K mutant, the researchers used synthetic ...

Flexible neck in cell-receptor DC-SIGN targets more pathogens

... survival against infection. A small cell-receptor protein called DC-SIGN is part of the immune system, and ... length between 20 and 30 nanometers. When the protein binds to a pathogen, binding sites on the cell ... in the neck, the researchers report. "The protein neck region acts as a stiff, but flexible, rod ...

Telomeres resemble DNA fragile sites

... our fragile telomeres from falling apart is a protein that ensures the smooth progression of DNA ... telomeres. At the center of the discovery is a protein known as TRF1, which de Lange, in an effort to ... Working with TRF1, the very first shelterin protein ever to be identified, de Lange and Sfeir have ...

Spontaneous assembly

... structures, such as membrane-bound organelles and protein transport systems, whose complex organization is ... we can examine a cell and see single proteins, protein dimers, and so forth, all the way up to large ... "Instead," said Liphardt, "random lateral protein diffusion and proteinprotein interactions are ...

Plant protein 'doorkeepers' block invading microbes, study finds

... system but still do not have a good sense of what protein complexes these proteins belong to and how they ... resistance. "Our ability to purify an immune protein complex will serve as a starting point to ... of the plant immune system in Arabidopsis. The protein is found in the permeable plasma membrane that ...

GUMC discovery highlights new direction for drug discovery

... a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer ... testing a small molecule that keeps the fusion protein from sticking to another protein that is critical for tumor formation. The ...

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

... to the spindle, and power its movement along the protein track. The location of the centromere on the ... of a protein, called CENP-A, but how this protein is recognised by the other components of the cell ... Lars and his colleagues were able to identify the protein that triggers the assembly of the centromere. ...

New biomarker method could increase the number of diagnostic tests for cancer

... that a new method for detecting and quantifying protein biomarkers in body fluids may ultimately make it ... one of the major hurdles in validating protein biomarkers for clinical use. Thousands of cancer ... (SID-MS), which is a technique used by protein scientists to measure the abundance of a ...

Natural-born divers and the molecular traces of evolution

... indicating that the net positive charge of this protein is increased in marine mammals compared with ... 29th June 2009. The net electric charge of any protein is directly related to the charge of its ... work will contribute to our understanding of protein solubility in general", explains Dr.Berenbrink. ...

Plant protein 'doorkeepers' block invading microbes, study finds

... system but still do not have a good sense of what protein complexes these proteins belong to and how they ... resistance. "Our ability to purify an immune protein complex will serve as a starting point to ... of the plant immune system in Arabidopsis. The protein is found in the permeable plasma membrane that ...

Xie Lab uncovers molecular machinery related to stem cell fate

... Institute's Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and ... of tumors. It has long been known that the BAM protein is necessary for germline stem cell ... by interfering with the function of the protein translation initiation factor eIF4A. EIF4A and ...

Structural biology scores with protein snapshot

... the structure of the largest membrane-spanning protein to date. Although NMR methods are routinely ... report the NMR structure of the large bacterial protein diacylglycerol kinase (DAGK), a complex of three ... years ago. DAGK is the smallest known kinase (a protein that adds chemical groups called phosphates onto ...

Computers aid in cracking deception in plants

... Korkin will narrow the field of potential protein candidates by identifying protein binding sites in the soybean that match with ... on. In our case, we're trying to find a specific protein binding site among a group of proteins from the ...

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

... in their genes that make a critical human protein called tyrosyl-tRNA synthetase. This came as ... for Chemical Biology at Scripps Research. This protein belongs to a class of molecules involved in one ... ribosome uses the mRNA as a template to make a protein by reading out its genetic sequence and then ...

How mitochondria get their membranes bent

... Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored ... mitochondria. Thereby, they discovered the protein Fcj1 ("Formation of criasta junction protein 1"), which is embedded in the inner membrane and ...

Proteins in gel

... a biochip, the structure can be destroyed and the protein cannot perform its function. Research ... and consists mainly of water. We thus make the protein believe that it is in a solution, even though it ... added from the outside very quickly reach the protein which is in and on this layer. For example, ...

Measuring intellectual disability

... of the fragile X mental retardation 1 (FMR1) protein (FMRP), which is mutated in fragile X syndrome. ... the lack of a quantifiable test to determine FMRP protein levels has prevented direct correlation between FMRP protein levels and clinical severity of disease. ...

Tumor suppressor gene in flies may provide insights for human brain tumors

... in Singapore have found a tumor-suppressing protein in the fly's brain, with a counterpart in ... "Our data explicitly show that the fruitfly protein PP2A (protein phosphatase 2A) suppresses brain ... Dr. Wang's previous work had identified a protein kinase called Polo as a tumor suppressor. Because ...

Fate in fly sensory organ precursor cells could explain human immune disorder

... An-chi found that mutations in the Actin-related protein 3 (Arp3), a component of the seven protein Arp2/3 complex, resulted in the loss of Notch ... This occurs because the ligand Delta a protein that activates the Notch pathway cannot travel ...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... fluorescence technique to find that a bacterial protein thought to exist in one "natural" ... form is active and the other is inactive, but the protein can easily morph from one state to another. ... study, also in PNAS , demonstrating how a simple protein associated with development of Parkinson's ...

The SIB recognizes the next generation of bioinformaticians

... how to predict physical interactions between protein residues entirely based on sequence data, using ... network methodology for the characterization of protein sequences that is extremely powerful and allows ... over the last years, multiple alignments of many protein families now contain more than 100 homologous ...

Scientists capture the first image of memories being made

... for the first time of a mechanism, specifically protein translation, which underlies long-term memory ... "Using a translational reporter, a fluorescent protein that can be easily detected and tracked, we directly visualized the increased local translation, or protein synthesis, during memory formation. Importantly, ...

Cancer-causing protein can also help fight the tumors it causes

... in FEBS Letters. Turning a cancer-causing protein against cancer itself The idea that proteins ... to discover the mechanisms by which the Ras protein is transferred, and initial results look ... all the news may be good. "It could be that a bad protein is able to transfer from cancer cells to immune ...

Infant formula adulteration with melamine underscores need for better detection methods

... better ways to detect deliberately falsified protein content in food ingredients. The presence of false protein can lead to illness and death, as with thousands ... and dietary supplements. "This Food protein workshop comes at a timely moment, as Congress ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

... of molecular biology, who co-ordinates the protein crystallography group at the University of Pavia. ... an opportunity for undergraduates to learn about protein engineering, how to develop assays, and to do protein purification," he said. Sobrado is affiliated ...

TRAPping proteins that work together inside living cells

... to make them thrive or fail. To learn about protein networks, scientists start with a familiar one ... be carefully controlled. To find coworkers of a protein of interest, Mayer and her colleagues build a ... factors. But they also found it on another core protein called the beta subunit, suggesting the tail of ...
Other Contents
(Date:10/22/2014)... Northwestern Medicine® scientists helps explain how bipolar disorder affects ... drug therapies to treat the mental illness. , ... same method recognized with the 2014 Nobel Prize ... tissue from mice with bipolar-like behaviors. In the synapses ... "nanodomain" structures with concentrated levels of ANK3 -- the ...
(Date:10/18/2014)... 2014 Psychological stress and stress-related psychiatric disorders are ... but the molecular mechanisms underlying this relation ... to the development of targeted preventive strategies ... devastating diseases. This work is presented at ... Berlin., Now an international group of researchers ...
(Date:10/17/2014)... University of Copenhagen have shown for the first time ... Cystic fibrosis patients, giving them the opportunity to get ... infections. , The study also discovered the bacterial growth ... was halted or slowed down by the immune cells. ... oxygen and helped "suffocate" the bacteria, forcing the bacteria ...
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(Date:10/25/2014)... Researchers who discovered antibiotics in farmed and wild ... The use of antibiotics in animals, including ... to the development of antibiotic-resistant bacteria that threaten ... study. Each year in the United States, ... kill about 23,000, according to the Infectious Diseases ...
(Date:10/25/2014)... 23, 2014 (HealthDay News) -- Current osteoporosis screening ... postmenopausal women at risk for osteoporosis-related fractures, a ... prevent fractures, we need tools that help us ... so that we can target these at-risk people ... professor of medicine in the division of general ...
(Date:10/25/2014)... October,s shorter, darker days can trigger a type of ... expert. People affected by seasonal affective disorder, ... and even have trouble getting out of bed. In ... Angelos Halaris, a professor in the department of psychiatry ... of Medicine. "Seasonal affective disorder should not be ...
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