Navigation Links
Promoter in Biological News

UT Southwestern researchers identify new targets for RNAs that regulate genes

... interact with a non-gene region of DNA called a promoter region, a sequence of DNA occurring spatially in front of an actual gene. This promoter must be activated before a gene can be turned on. ... This type of RNA is found in association with the promoter regions that occur in front of the ....

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

... colleagues were interested in identifying how the promoter region of the EAAT2 gene controlled the ... examined all the regions and sequences in the promoter region and systematically eliminated them to then ... they identified critical regions in the EAAT2 promoter that might regulate activity, they found that ...

Regulation of TATA-less promoters

... machinery recognizes and binds to specific core promoter sequences in the gene. While some genes contain a TATA box core promoter element that is recognized by TBP (the TATA-box ... TRFs) have been identified, but their core promoter recognition functions have not yet been ...

NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness

... transcripts by SAGE and qRT-PCR methods. Then they employed extensive DNA promoter analysis based on the integrated Genomatix system in order to identify conserved cis-elements and putative trans-regulators. Framework analysis for promoter organization, as introduced by Genomatix, increased likeliness for ...

Media highlights in the January issues of Biophysical Journal

... variations in DNA accessibility between a non-promoter and two promoter nucleosomes were noted in the H2A-H2B depleted complexes. The ability of ... for differential recognition of specific nucleosomes, such as those on key promoter elements. Significant sequence-dependence nucleosome stability is not ...

Weizmann Institute scientists discover: A 'risk distribution law' for evolution

... They found that a genetic 'phrase' that regularly shows up in the promoter region of genes (the bit of genetic code responsible for activating the ... The expression of a gene that contains the sequence TATA in its promoter is more likely to have evolved than that of a gene that does not have TATA ...

Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis

... Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. The ... factor called TFIID is disassembled and replaced with an alternative core promoter recognition complex. The researchers determined that this alternative ...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... laboratory, used a luciferase assay developed from the luciferase enzyme fireflies use to make light to see exactly where DLX5 protein binds to the promoter region of the MYC gene. They found that there were two sites where DLX5 could bind to the MYC promoter, which is a section of DNA where certain ...

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

... spontaneous tumors than typical mice. PAPPA controls the availability in tissues of a hormone known as insulin-like growth factor (IGF) that is a promoter of cell division. Hence, IGF is required for normal embryonic and postnatal growth. But IGF also is associated with tumor growth, inflammation and ...

Scientists shed light on inner workings of human embryonic stem cells

... concentrations of transcription factors rise. They also show that the control between miR-145 and the "reprogramming factors" goes both ways. The promoter for miR-145 is bound and repressed by a transcription factor known as OCT4, they found. "It's a beautiful double negative feedback loop," Kosik ...

Using combinatorial libraries to engineer genetic circuits advances synthetic biology

... computer simulation, on its own, was unable to predict the behavior of this timing circuit. They then built a representative genetic timer using a promoter from each of their libraries and, over time, tracked its behavior. Based on information from one network, the research team was able to calibrate ...

New nucleotide could revolutionize epigenetics

... methyltransferase affixes a methyl group to cytosine, creating a different but stable nucleotide called 5-methylcytosine. This modification in the promoter region of a gene results in gene silencing. Some regional DNA methylation occurs in the earliest stages of life, influencing differentiation of ...

SIRT1 takes down tumors

... Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online April 13 ( www.jcb.org ) and will appear in the April 20 print issue of the ...

CFI awards $854,098 to University of Montreal and partners

... factor for insulin resistance and Type 2 diabetes. "My research explores a novel hypothesis that high concentrations of LDL particles may be a promoter rather than a consequence of Type 2 diabetes," says Dr. Faraj, adding she will investigate whether decreasing LDL particles by behaviour modification ...

Genetic variation may lead to early cardiovascular disease

... group further examined NPY levels in blood and found that, among the six NPY variants, there is a single-nucleotide change of the DNA code on the NPY promoter region of the gene the part of the gene that turns it on and off. This single-letter change was associated with higher NPY levels, suggesting that ...

Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

... and movement. "What is really interesting here is that p120 is acting like a tumor suppressor when it is bound to E-cadherin, and like a tumor promoter when it isn't," Dr. Anastasiadis says. The researchers believe these findings could help explain why in some solid tumors, such as breast, lung, ...

Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics

... percent of total soluble protein. Our results suggest that enzyme amount is affected by several factors including subcellular localization and the promoter used to drive gene expression. Southern hybridization analysis indicates that the gene is present at one copy per genome, simplifying breeding and ...

Scientists discover key patterns in the packaging of genes

... nearby genes. In particular, the team identified one combination of 17 modifications that was present in more than a quarter of the more than 12,000 promoter regions they examined. On average, the genes corresponding to this "backbone" set were expressed more actively. That is to say, they were ...

Texas A&M researchers develop tool to study complex clusters of genes

... Genes are controlled by a mechanism called a promoter, which turns the genes on or off. In higher organisms, like humans, there is usually a specific promoter that controls each gene separately, Sze explained. However, a bacteria's genome has to be compact, so there are a lot of genes clustered close ...

New paradigm for cell-specific gene delivery

... studies to determine how plasmids enter the nuclei of non-dividing cells, the group previously identified a region of a smooth muscle cell-specific promoter that was able to mediate nuclear targeting of any plasmid carrying this sequence uniquely in cultured smooth muscle cells but in no other cell type. ...

Stevens researchers provide oversight for three-year mariculture program in Egypt and Israel

... maintains the responsibility for the overall coordination of the project. Abel, the former Director of International Programs at CMS and a long time promoter of peace in the Middle East, managed 16 cooperative projects in the region during the past 25 years. He received two Distinguished Service Awards ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young investigators

... her sponsors Frederick R. Cross, PhD, and Eric D. Siggia, PhD, at The Rockefeller University, New York, New York, is investigating key features in promoter architecture and chromatin structure that govern the transcription of cell cycle-regulated genes, which is an important issue in understanding ...

International team compares 12 fruit fly genomes

... of messenger RNA. Researchers have long thought that the rate of transcription is limited by the time it takes Pol II to be recruited to the promoter region, where it copies a strand of DNA into RNA. But increasing evidence in Drosophila and other organisms indicates that Pol II frequently exists ...

Flies can turn off their immune response

... STAT form a complex HMG protein and HDAC, proteins known to be involved in DNA bending and chromatin structure. This complex is then recruited to the promoter regions of NF-B target genes, causing the chromatin structure near the NF- B target genes to contract and the expression of NF-B target genes to shut ...

Evolution is driven by gene regulation

... by aiming at their function, rather than their sequence. First, they isolated transcription factors that were specifically bound to DNA at their promoter sites. Then, they analyzed the sequences that were isolated to determine the similarities and differences in regulatory regions between the different ...

Effect on breast tumors of DNA alternations in 3 genes described

... promoters when exposed to a process called DNA promoter hypermethylation. Hypermethylation is a process ... or nuclear grade. "Our data suggested that promoter hypermethylation is common in breast cancer," Tao added. "Because promoter hypermethylation is potentially reversible, ...

How bad is malaria anemia? It may depend on your genes

... in response to infection. One version of the MIF promoter leads to less MIF protein made, while cells containing another version of the MIF promoter make much more MIF protein. Differences in the MIF promoter also have been linked to the severity of other ...

Basic work on E. coli identifies two new keys to regulation of bacterial gene expression

... underappreciated sections of both the DNA promoter region and RNA polymerase, according to work done ... of RNA, which are later translated into proteins. promoter regions are specific sequences within the DNA ... this case, regulation is achieved not because the promoter makes a special contact, but because it can't ...

Genomatix technology facilitates de novo identification of new renal disease associated genes

... approaches allow rapid characterization of shared promoter structures which can be used to find novel ... slit diaphragm. An evolutionarily conserved promoter model was generated. Genome-wide scans using this promoter model effectively predicted a previously ...

Dying of excitement

... mutation --- a single nucleotide change in the promoter region of the EAAT2 gene -- was equally prevalent ... for the repressor GCF2 -- a swap that inhibited promoter activity in transfected rat brain cells. Whether the mutant promoter decreases EAAT2 expression in the human brain, as ...

The urban evolution lab

... the amount of each protein that is produced. The promoter of a gene has the most important control function ... the researchers found genetic variations in the promoter that increased the gene expression and thus the ... precursor protein. These variations in the promoter that increase expression occur up to 20 times ...

Researchers discover a new genetic cause of Alzheimer's disease

... the amount of each protein that is produced. The promoter of a gene has the most important control function ... the researchers found genetic variations in the promoter that increased the gene expression and thus the ... precursor protein. These variations in the promoter that increase expression occur up to 20 times ...

Change in gene may be underlying molecular defect in some colorectal cancers

... (MGMT) is often methylated--that is, the gene's promoter region has methyl groups added to it, which ... in Houston, and colleagues hypothesized that MGMT promoter methylation could be one of the characteristics ... defect in colorectal cancer, so they studied MGMT promoter methylation in the tumor, adjacent mucosa, and ...

Wheat can fatally starve insect predators

... so plants will produce useful nutrients for the insect. Instead, the promoter would be hooked up to a lectin or toxin gene and inserted into the cells. ... and location of those interactions would enable the scientists to use the promoter tactic only in the vegetative parts of the wheat plant rather than in the ...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

... correlations are impressive, given that several other factors like promoter effectiveness, promoter regulation, and mRNA half-life directly influence mRNA level, as well," ...

Scientists reveal structure of gateways to gene control

... an organism widely studied as a model of how human cells work. These promoter nucleosomes are the only ones in the yeast DNA that contain in their core ... that bind only to this H2A.Z protein as a tool for separating all these promoter nucleosomes from the other parts of the yeast's DNA. Next, the team used ...

'Perception' gene tracked humanity's evolution, scientists say

... is identical in humans and chimps. It's the prodynorphin gene's promoter sequence -- upstream DNA that controls how much of the protein is ... The researchers found that high genetic variation in the prodynorphin promoter was unique to humans. Other primates' promoters were far more homogeneous. ...

Gene therapy advance treats hemophilia in mouse models

... the part of the FIV that expresses the therapeutic gene so that its promoter that causes gene expression worked only when it was in a liver cell. ... virus goes to other organs of the body, it won't express well because its promoter is liver-specific," McCray said. "This modification helps prevent negative ...

Bioinformatics reveals new gene regulation system

... genes. The team observed that their signal always overlapped with the promoter signal, the region of DNA required for the initiation of the conversion of ... signals commonly work by allowing other proteins to bind on top of the promoter sequence and physically block promoters. Therefore, the duo predicted that ...
Other Contents
(Date:7/11/2014)... burning in eastern New South Wales, Australia when NASA,s ... 03:35 UTC on July 11 (12:35 p.m. local time/11:35 ... eastern New South Wales (NSW), the Moderate Resolution Imaging ... the region and spotted smoke (light brown) from various ... are outlined in red. , The New South Wales, ...
(Date:7/11/2014)... German . ... refraction of X-rays through a specimen instead of attenuation ... are often of much higher quality than those based ... Franz Pfeiffer are particularly interested in developing new approaches ... phase-contrast imaging. One main goal is to make this ...
(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2A new genome editing method brings the possibility of gene therapies closer to reality 2
(Date:7/13/2014)... identifies a novel genetic and molecular pathway in ... up potential new therapeutic strategies for an enigmatic ... a chronic inflammatory disorder of the esophagus. The ... foods and an over-accumulation in the esophagus of ... body,s immune system). EoE can cause a variety ...
(Date:7/13/2014)... July 13, 2014 Victorian Hotel has ... promoting the rental of bikes for its "Cycle the ... Victorian Hotel to tour the area using a rental ... Bicycle enthusiasts love to call Vancouver home, as it ... cycle travel and picturesque journeys through the countryside. Vancouver ...
(Date:7/13/2014)... Advanced boilers are preferred over conventional ... fossil fuels, produce high-capacity power, emit fewer pollutants, ... warming and climate change concerns, many countries have ... emissions and pollutants coming from fossilfuel-based power plants.North ... advance boilers market., The global power rental market ...
(Date:7/13/2014)... July 13, 2014 A Massachusetts couple ... the cancer risks associated with power morcellators ( http://www.gynecaremorcellatorlawsuit.com/ ... story to federal regulators, as they presented poignant testimony ... & Drug Administration (FDA) advisory panel meeting convened to ... to the Rochester Democrat and Chronicle, Dr. Hooman Noorchashm ...
(Date:7/13/2014)... New York, New York (PRWEB) July 13, 2014 ... mesh lawsuits ( http://www.transvaginalmeshlawsuithelp.com/ ) filed against ... the litigation’s second bellwether trial, which is expected to ... Control Order issued in the U.S. District Court, Southern ... Pretrial Conference will be held on August 7, 2014 ...
Breaking Medicine News(10 mins):Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4
Other TagsOther Tags