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Proliferation in Biological News

UCSB scientists show how certain vegetables combat cancer

... substances in these vegetables inhibit cell proliferation was unknown until now. Scientists in the UC ... the surprising discovery that SFN inhibits the proliferation of human tumor cells by a mechanism similar to ... cancer preventive agent because it inhibits the proliferation and kills precancerous cells," said Wilson. It ...

New molecular insight into vertebrate brain development

... central nervous system, as well as the controlled proliferation and differentiation of neural progenitor cells ... signaling serves as a brake on cell growth and proliferation by preventing another protein, YAP, from entering ... by restricting instructing the survival, proliferation and differentiation of neural precursor cells. In ...

Green tea may delay onset of type 1 diabetes

... be rapidly reproducing in the control group. The proliferation was suppressed in the EGCG-fed group. "It's kind of counterintuitive why would there be proliferation of the glandular cells occurring when the present ... for his master's research project at MCG. The proliferation phenomenon also can be observed in psoriasis, an ...

CSHL scientists identify new drug target against virulent type of breast cancer

... proteins. Brk acts as an accelerator of proliferation Further experiments by Muthuswamy's team revealed that although Brk does not induce cancerous proliferation on its own, it enhances the proliferation of cells that also express ErbB2 by speeding up ...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

... of apoptosis. The mechanism of imiquimod on cell proliferation is unclear. The research team, led by Dr. Ian ... inhibitory pathway is known to regulate cell proliferation by modulating cyclin dependent kinase inhibitors, ... chemistry - has been discovered to regulate cell proliferation by imidazoquinolines." Co-author, Moshe ...

A study reveals how cells communicate to activate the cell division machinery

... neighboring cells in order to activate the cell proliferation machinery that results in the organized growth of ... between the molecular elements that regulate proliferation for the correct development of the wing, explains ... could provide clues about how to repress the cell proliferation signals in cancer. The context is relevant ...

Yale scientists create artificial 'cells' that boost the immune response to cancer

... to cells that stimulate the activation and proliferation of antigen-specific T-cells . The boosted immune ... binding and signaling events that lead to T-cell proliferation in the body. It also causes a fast and effective ... Safe and efficient T-cell stimulation and proliferation in response to specific antigens is a goal of ...

Is hybridoma production about to take a quantum leap forward?

... greater secretion per cell, but rather greater proliferation of cells with a similar secretion. After ... conduct further tests: To what extent are cell proliferation rates affected by NPD-based media" Growing CHO ... researchers observed an unmistakable increase in proliferation when cells were incubated in NPD-based media, in ...

4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats

... to a REM sleep deprivation procedure reduces cell proliferation in the part of the forebrain that contributes to ... deprived rats and by 43 percent in YC rats. Cell proliferation was reduced by 63 percent in REM sleep deprived ... compared with YC rats. Across all animals, cell proliferation exhibited a positive correlation with the ...

St. Jude defines eye cancer gene's role in retinal development

... plays a central role in coordinating retinal proliferation with eye growth during development. Genes in ... However, the gene is crucial for the proper proliferation of retinal cells. In mice in which the scientists ... retinas likely resulted from an N-myc-related proliferation defect in the progenitor retinal cells. The ...

Why the switch stays on

... of its switches off, leading to uncontrolled cell proliferation one of the hallmarks of cancer. In a paper ... Mattos explains, instructions for the proliferation of cells are given by cascades of protein-protein ... when the proteins can interact resulting in cell proliferation and off when they cannot. If access to the ...

Cell response to stress signals predicts tumors in women with common pre-breast cancer

... high p16 and/or high COX-2 in the absence of cell proliferation reflected correct stress activation and a ... and/or high COX-2 in the presence of ongoing cell proliferation corresponded to a short-circuited response to ... distinguished by the absence or presence of a proliferation of cells, added Tlsty. We anticipate that these ...

AIDS interferes with stem cells in the brain

... novel molecular mechanism that inhibits stem cell proliferation and that could possibly be triggered in other ... or repair itself through neurogenesis, the proliferation and development of adult neural progenitor/stem ... behind the finding that HIV/gp120 reduced proliferation of aNPCs, the scientists studied the effect of ...

Protein that promotes cancer cell growth identified

... from the EGF receptor through the protein kinase Src to the master cell proliferation regulator protein, MAPK. This same signaling pathway stimulates ... complete understanding of the molecular mechanisms involved in cancer cell proliferation and migration, these results point to Caspase-8 as a novel therapeutic ...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

... and the nuclear compartments. The OGF-OGFr axis is known to regulate cell proliferation by modulating cyclin dependent kinase inhibitors, resulting in a ... up to 8 days. Transport through the nuclear pore and repression of cell proliferation required two of the three nuclear localization signals (NLS) in OGFr. ...

Time (and PPAR-beta/delta) heals all wounds

... important in early stages of wound healing," explains Tan. "But excessive proliferation isn't good: you can end up with hypertrophic scarring." This may also ... has already found that fibroblasts lacking the protein can increase the proliferation of squamous carcinoma cells; they now plan to investigate ...

Common food additive found to increase risk and speed spread of lung cancer

... those same pathways. "Lung cancer is a disease of uncontrolled cell proliferation in lung tissue, and disruption of signaling pathways in those tissues can ... are regulated in response to nutrient availability and, consequently, cell proliferation and growth. "Phosphate is an essential nutrient to living organisms, ...

Embryonic heart exhibits impressive regenerative capacity

... of the embryonic heart to replace diseased tissue through compensatory proliferation of healthy cells. Disorders of the mitochondria, a cell structure ... 10% of the cardiac tissue. The authors went on to show that increased proliferation of healthy heart cells was responsible for this change and led to a fully ...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

... The study is entitled "Simvastatin Reduces Human Primary Satellite Cell proliferation in Culture." It was conducted by Anna Thalacker-Mercer, Melissa Baker, ... simvastatin. The aim of the study was to determine SC viability during proliferation when treated with statins which may be indicative of the ability of SCs to ...

Novel anti-cancer mechanism found in long-lived rodents

... says Gorbunova. "Short-lived small species display continuous rapid proliferation of their cells, but these long-lived rodents have somehow found a way to slow down that proliferation when they need to." Gorbunova thinks that squirrels and similar rodents ...

Researchers identify cancer-causing gene in many colon cancers

... which genes control the production of beta-catenin and are involved in the proliferation of colon cancer cells, the research team ran three screening tests. In the ... "This study demonstrates that blocking CDK8 interferes with the proliferation of colon cancer cells that have high levels of the CDK8 protein and ...

Fat: Its not what you think!

... and obesity continue to plague the US, many people believe that the recent proliferation of high-fat diets is the major culprit. As a consequence, many people aim ... evidence that the over-consumption of carbohydrates and the past proliferation of synthetic transfata truly dangerous fatare actually to blame for the ...

JDRF awards University of Copenhagen professor with grant to conduct innovative diabetes research

... have shown that increased levels of pregnancy hormones are involved in the proliferation of beta cells. Dr. Nielsen will now study the effect of serum from pregnant women on human beta cell proliferation and survival in isolated islets. The successful identification of the ...

Cells united against cancer

... "Rogue cancer genes can force epithelial cells to proliferate and proliferation of malignant cells will certainly disrupt the organized epithelial ... genes and identifies LKB1 tumor suppressor gene as an architect of this proliferation resistant organizational plan. The ordered structure of epithelial cells ...

Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma

... in MM pathology. NF-κB target genes are known to be involved in cell proliferation and cell survival. Although there is significant overlap and interplay ... targeted disruption of the classical NF-κB signaling blocked myeloma proliferation and induced cell death. These genetic and functional data provide a ...

A study by the MUHC and McGill University opens a new door to understanding cancer

... itself to the surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms induced by the factor. However, in some cancer ... factor become much more pronounced, which results in an unrestrained proliferation of cells that can become a cancer. In the long term, this may serve as ...

Sustainable agriculture at the ESA Annual Meeting

... to kill crop-eating insects. But these insects have natural enemies, too, and new research is investigating what farmers can do to encourage the proliferation of these pest-eaters. One study, presented as a talk at the ESA meeting, shows that increasing the natural habitat in and around farms can boost ...

Key OSU water research receives national funding

... reduce stream flow production at the watershed level. Engle, who serves as director of the division's Water Research and Extension Center, said proliferation of woody plants is a challenge to rangeland managers across the globe. "It's both an economic and ecological issue, mainly because water-use ...

Dioxins in food chain linked to breastfeeding ills

... Sciences , researchers showed that dioxin has a profound effect on breast tissue by causing mammary cells to stop their natural cycle of proliferation as early as six days into pregnancy, and lasting through mid-pregnancy. In tissue samples from mice, exposure to dioxin caused a 50-percent decrease ...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... have been shown in the literature to be capable of reducing tissue injury, inhibiting fibrosis, promoting angiogenesis, stimulating recruitment and proliferation of tissue stem cells, and reducing inflammatory oxidative stress, a common cause of cardiovascular disease and heart failure. "Since skeletal ...

UNC study identifies genetic cause of most common form of breast cancer

... The discovery of tumor-suppressor genes has been key to unlocking the molecular and cellular mechanisms leading to uncontrolled cell proliferation the hallmark of cancer. Often, these genes will work in concert with others in a complex biochemical system that keeps our cells growing and ...

Stem cell focus for IBD wound healing

... Division of Pathology. He said: "The study will focus on the molecule CD24 which is a stem cell marker and which plays a key role in cell proliferation and the migration of healthy cells to a damaged area to restore normal tissue. "CD24 is a small molecule attached to the cell membrane which has ...

New hope for advances in treating malaria

... to grow and therefore it dies. The inhibitors developed at Leeds bind to the DHODH enzyme in the parasite and stop it functioning, preventing the proliferation of the parasites, which live in red blood cells. In addition, our chemicals are equally effective against parasites that have developed resistance to ...

New data on the breakdown of the KRas protein

... through the interior of the cell, which leads to the suspicion that it continues to exercise its influence on signalling pathways relating to cell proliferation and the appearance of cancers. The signalling pathways activated by KRas are highly complex. With the newly available data, it will be necessary ...

Scientists identify key gene that protects against leukemia

... San Francisco, demonstrates that the JunB gene is at the center of a complex network of molecular and environmental signals that regulate the proliferation and differentiation of hematopoietic stem cells, the multipotent, self-renewing cells that give rise to all blood cell types. In the study ...

Two-day symposium in Baltimore to tackle the promises and perils of proton radiotherapy

... proton therapy lowers the risk of secondary cancers later in life. What does the scientific evidence show about proton therapy? With the rapid proliferation of proton facilities in the United States, what will current and future practitioners of proton radiotherapy need to know? Now a panel of ...

University of Kansas graduate student researcher takes aim at deadly brain tumors

... very selective that we can use to target the cancer and not affect the normal cells of the brain." Cicaccio believes that ATF5 helps growth and proliferation of cancerous cells in brain tumors, where the protein is abundant. "It's known that ATF5 is required for brain development, but once we have ...

New drug agent knocks out multiple enzymes in cancer pathway

... a very low chemical affinity for bone. In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells called gamma delta T-cells, which aid in killing tumor cells. "The new drugs are about 200 times more effective than the drugs ...

Australia's most endangered snake might need burning

... in Morton National Park an area currently inhabited by broad-headed snakes has increased over the same 65-year interval. "The reason for the proliferation of vegetation is not known. In other parts of Australia, vegetation thickening has been attributed to altered Aboriginal fire regimes or to ...

Plant biologists discover gene that switches on 'essence of male'

... DUO1 is also related to a super class of Myb regulator proteins also present in animals that have an important role in controlling cell proliferation and that are implicated in certain human cancers such as leukemias. So like animal cell Myb proteins, DUO1 is needed for control of cell ...
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