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Diminuendo -- New mouse model for understanding cause of progressive hearing loss

... forward in elucidating the common phenomenon of progressive hearing loss, opening up new avenues for ... Mice carrying this miR-96 mutation suffer progressive hearing loss as they get older. Moreover, if they ... and damage due to chronic noise. However, progressive hearing loss can also have genetic causes. ...

New insights into progressive hearing loss

... that a new kind of gene is associated with progressive hearing loss. The new gene - called a microRNA - ... new line of mice, called diminuendo, that showed progressive hearing loss from an early age. The two groups ... one copy of the gene variant they suffered progressive hearing loss, if they carried two variants they ...

Exercise after knee replacement critical

... knee replacements were given six weeks of progressive strength training two or three times a week ... and a six-minute walk. The group in the progressive strength-training program showed significant ... encouraging their patients to be compliant with progressive quadriceps strengthening during their ...

Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases

... Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, for instance, the "spikes," ... in the patient's mid-40s, the disease is rapidly progressive and fatal. In a subsequent study published in ... these disorders, with aging, may be caused by a progressive breakdown in this transport system." ...

The Parkinson's Disease Foundation awards $950,000 in seed grants

... PD one that would reproduce the age-dependent progressive loss of dopamine-producing neurons that underlies ... laboratory animals that spontaneously undergo progressive dopamine neuron loss by similar mechanisms. This ... treatments that might slow down or prevent the progressive loss of dopamine-producing neurons that results ...

Technique traces origins of disease genes in mixed human populations

... than Europeans to die rapidly of end-stage, progressive kidney failure. Many African Americans also have ... of the genome are associated with end-stage, progressive renal failure, said Alan R. Templeton, Ph.D., ... 575 cases of African-Americans with end-stage progressive renal failure and compared them to controls that ...

Paradigm shift in Alzheimers's research: new treatments

... Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by ... processing. Long-standing evidence shows that progressive cerebral deposition of A" plays a seminal role in ... form of A" species present in this model with progressive development of a complex pattern of N-truncated ...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... the brain enzyme, tissue-type plasminogen activator (tPA), prevents progressive brain damage triggered by the lack of oxygen and blood supply. The ... than other proteases, particularly matrix metalloproteinases, in the progressive molecular process that leads to brain injury. This makes it a better ...

Huntington's disease deciphered

... Huntington's disease is an adult onset neurodegenerative disease marked by progressive mental and physical deterioration. It has been known for more than a ... to maintain cell health." Brady's group has also linked this pattern of progressive neurodegeneration -- marked by a loss of signaling between neurons, a slow ...

Tips from the American Journal of Pathology

... of chronic kidney disease progression, Ju et al screened a mouse model of progressive renal disease to identify genes whose expression correlated with renal ... identified by Dr. Bttinger, Dr. Kretzler, and colleagues "predict progressive renal fibrosis in mice and may [therefore] be useful molecular predictors ...

Jefferson researcher awarded Landenberger Foundation grant for ALS research

... ALS, commonly known as Lou Gehrig's disease or motor neuron disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the ... cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. ...

Case Western Reserve University School of Medicine researchers receive $10.8 million

... Institutes of Health (NIH) to study how HIV infection results in the progressive immune deficiency that causes AIDS. The grant will fund four coordinated ... However in HIV infection, immune activation also appears to drive the progressive decline of an individual's immune system, eventually resulting in AIDS. ...

Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf

... hemoglobin (Hb) levels often decrease over time, splenomegaly appears, and progressive iron overload occurs from increased gastrointestinal iron absorption. ... activity, affected persons suffer from anemia, which is exacerbated by progressive splenomegaly and an increase in plasma volume as a result of shunting ...

Motor neuron disease and toxic substances: Possible link?

... yet know the exact manner in which toxic organophosphate exposure leads to progressive and permanent nerve damage, they have learned that this process involves ... contained within nerves. Fink examined members of two families who had progressive weakness and spasticity (tightness) in their legs, as well as muscle ...

Scientists track impact of DNA damage in the developing brain

... with oculomotor apraxia (AOA1) and spinocerebellar ataxia with axonal neuropathy (SCAN1). Both disorders are inherited and are characterized by progressive difficulty with walking and other movement. AOA1 is among the most common form of certain inherited movement disorders in Japan and Portugal. ...

Vaccine blocks malaria transmission in lab experiments

... booster given several months later. "This is an exciting beginning to what might become an important tool in the arsenal for malaria control and progressive elimination of malaria transmission," said Kumar. There is no animal reservoir for human malaria and in that regard it is possible to gradually ...

Scientists link immune system's natural killer cells to infant liver disease

... that blocking a gene that helps NK cells attack bile duct tissues lessens damage and may be a way to treat the most common cause of chronically progressive liver disease in children. The study, to be published in the Aug. 3 Journal of Clinical Investigation , is posted online on the journal's website. ...

'Show me the money!' MDA greenlights grants

... of the Board R. Rodney Howell. There are no cures yet for most muscle diseases, but the research MDA has funded has created the basis for progressive treatments of muscular dystrophy, amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, and spinal muscular atrophy. It also served as the ...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

... and training. The first ECNP School of Neuropsychopharmacology will be held in Oxford, UK, from 5󈝶 July 2009. ECNP is dedicated to the progressive integration of basic research, clinical neuroscience and medical practice, which can guide advances in neuropsychopharmacology and lead to a next ...

Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues

... to analyse genomes responsible for cancers of the prostate and breast. However, current genetic risk models do not predict who will get progressive disease. Promark, another consortium, searches for genetic variants that do associate with aggressive cancer forms. She also noted that the ...

Omega-3 fatty acids appear to impact AMD progression

... adds the possibility that the timing of a dietary intervention as well as the combination of nutrients recommended may be important." AMD is a progressive disease that attacks central vision, resulting in a gradual loss of eyesight and, in some cases, blindness. The NEI reports that AMD is the most ...

Equity concerns raised by congestion pricing can be addressed to make approach viable

... individuals, congestion pricing is more likely to be progressive. If the toll revenues are used in other ways, then it can be regressive or progressive depending on local conditions and the specific details of the congestion pricing policy. Even if low-income groups and others who are ...

Combined stem cell-gene therapy approach cures human genetic disease in vitro

... were indistinguishable from human embryonic stem cells and iPS cells generated from healthy donors. Since bone marrow failure as a result of the progressive decline in the numbers of functional hematopoietic stem cells is the most prominent feature of Fanconi anemia, the researchers then tested whether ...

One size does not fit all

... need to monitor the effects of central nervous system-accessible immune therapies on the myelin repair processes in patients with MS and other progressive demyelinating diseases. Canadians have one of the highest rates of MS in the world. An estimated 50, 000 Canadians have MS, with approximately ...

Protein identified as critical to insulating the body's wiring could also become treatment target

... in a variety of neurological and psychiatric diseases including schizophrenia, multiple sclerosis and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens muscles. Cancer is an issue because the ErbB2 receptor also is an oncogene highly expressed in tumors. ErbB2 helps cancer ...

Scientists urge global action to preserve water supplies for billions worldwide

... of the climate- and societally induced stresses that will be exacerbated in the future under continuing climate changes, threatening massive and progressive disruptions in the availability of drinking water to more than a billion people in the two regions. The workshop was convened by UC San Diego and ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

... the drug has been used under compassionate release exemption to treat a small number of patients with chronic or life threatening illnesses including progressive multiple sclerosis and metastatic disease," said Simon Wilkinson, Innate Therapeutics' chief executive officer. "To date, MIS416 has shown itself to ...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

... that expresses sub-normal levels of ERCC1-XPF endonuclease, an enzyme that is important in DNA repair. Starting at 8 weeks of life, the mice display progressive symptoms associated with aging including muscle wasting, loss of vision and hearing, urinary incontinence, decreased liver and kidney function, and ...

Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease

... NEW ORLEANSAmyotrophic lateral sclerosis (ALS) is a fatal disease that damages key neurons in the brain and spinal cord. The disease causes progressive paralysis of voluntary muscles and often death within five years of symptoms. Although ALS (Lou Gehrig's disease) was discovered over a century ago, ...

Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease

... NEW ORLEANSAmyotrophic lateral sclerosis (ALS) is a fatal disease that damages key neurons in the brain and spinal cord. The disease causes progressive paralysis of voluntary muscles and often death within five years of symptoms. Although ALS (Lou Gehrig's disease) was discovered over a century ago, ...

Scaling the wall of deafness

... hair cells degenerated in the mouse ears. A few weeks later the mice became profoundly deaf, suggesting that a lack of normal microRNAs might lead to progressive hearing loss in people that were born with normal hearing, as well, says Prof. Avraham. The work in fish suggests that microRNA mutations may also ...

Scientists identify key gene that protects against leukemia

... in both the culture dish and when transplanted into mice. In every case in which engraftment of the HSCs occurred in the mice, the scientists noted a progressive expansion of the myeloid lineage, which constitutes a type of mature white blood cell that fights infection. This expansion led by 6 to 12 months ...

Redefining what it means to be a prion

... an unidentified disease infected more than 100,000 British cows and spread to humans, eventually killing more than 200 people. The disease causes progressive degeneration of physical and mental abilities, which ultimately lead to death. Scientists found the infectious agent was a prion, a misfolded ...

Gorilla gets MRI at Bronx Zoo

... us a better understanding of the possible causes of Fubo's problem and have helped to guide his care. It was a great opportunity to enlist the most progressive technology for the diagnosis of people with similar problems to our close relative the endangered gorilla. The procedure contributes to the knowledge ...

Rensselaer receives more than $2 million from New York State to fund stem cell research

... genes results in abnormal stem cell growth leading to nodules in the neurons of the brain, a condition known as periventricular heterotopia and a progressive shortening of bones known as skeletal chondrodysplasias. These genetic disorders, although rare in humans, provide important insight into how stem ...

Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes

... cells. "Overall, our results show that a close follow-up with intensive diabetic management alone could not be the only cause of the positive, progressive and consistent outcomes we obtained in this trial over one year of follow-up," said Dr. Estrada. "A decade ago, research had explored stem cell ...

Pitt researchers describe molecular '2-step' leading to protein clumps of Huntington's disease

... by the N-terminus in initiating aggregation gives us another possible molecular target." Huntington's disease is an inherited disease in which progressive degeneration of certain brain neurons causes uncontrolled writhing, twisting and jerking movements, and cognitive and psychiatric problems. It was ...

Antibody key to treating variant CJD, scientists find

... that could be key to treating patients with diseases such as variant CJD. Variant Creutzfeldt-Jakob Disease (vCJD) is part of a family of rare progressive neurodegenerative disorders, called prion diseases, which affect both animals and humans. It is thought that those who have developed vCJD became ...

TGen and ASU researchers find drug that could reduce risk of Alzheimer's

... Although far from proving anything about human use of the drug, the findings supports the scientific quest for a substance that could treat progressive cognitive impairment, cushion the impact of aging, or even enhance learning and memory throughout one's life span. "Fasudil shows great promise ...

UC Davis research shows that newly discovered drug reduces heart enlargement

... patients and reduce mortality." "By blocking the pathway that leads to overgrowth of cardiac cells, we have shown that it is possible to prevent the progressive deterioration of heart function and the development of abnormal hearth rhythms." The prototype drug published this week appears to be that ...
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