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Probes in Biological News

Nanocrystals reveal activity within cells

... within a cell. These ideal light emitting probes represent a significant step in scrutinizing the ... the Molecular Foundry. "These single-molecule probes will allow us to track proteins in a cell or ... remains constant." To study how these probes might behave in a real biological system, the ...

Ultrasound imaging now possible with a smartphone

... Engineering, have made commercial USB ultrasound probes compatible with Microsoft Windows Mobile-based ... 2008. In order to make commercial USB ultrasound probes work with smartphones, the researchers had to ... to build smartphone-compatible USB ultrasound probes for imaging the kidney, liver, bladder, and eyes, ...

6 young ASU faculty earn NSF Career awards

... fundamental questions about the use of molecular probes in biosensors. With such knowledge he will ... weight. Biosensors typically use molecular probes such as DNA, RNA, enzymes and antibodies to capture specific molecules. These probes offer selectivity but have many limitations. For ...

New high-throughput screening technique makes probing puzzling proteins possible

... but the basic ABPP premise is to develop probes that attach to proteins even when their targets, ... This allows scientists to build broad-spectrum probes that will work with a whole host of ... new technique relies on the same broad-spectrum probes previously used for ABPP, but instead of gel ...

International public-private partnership offers new paradigm for medicinal chemistry

... in epigenetic signalling, and to release these probes into the public domain with no restriction on use. Early stage information sharing on chemical probes is highly unusual and breaks with the tradition ... the role of these proteins in biology. The probes need to be highly selective for their target ...

Luminescence shines new light on proteins

... discovery by a team of scientists using optical probes means that changes in cells in the human body ... in the way that light was emitted by optical probes during a series of experiments. Light has ... information and the researchers used the optical probes to measure the behaviour of light and its ...

National Science Foundation grants Clemson professors award to develop nanoprobes

... $250,000 to research and develop nanofiber-based probes needles that are 10 times smaller in diameter than a human hair for medical diagnostics. The probes may save both money and time compared to more ... group will focus on the development of the fiber probes themselves, while Luzinov's will concentrate on ...

MIT probe may help untangle cells' signaling pathways

... technique allows researchers to tag proteins with probes that link together like puzzle pieces if the proteins interact inside a cell. The probes are derived from an enzyme and its peptide ... to are not interacting, said Ting. The new probes could be used to study nearly any protein-protein ...

UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system

... of California, San Francisco. "Dynamic probes like the one developed by UCLA scientists will ... prompted by the desire to add to a short list of probes now used in PET scanning and to develop new probes that monitor different molecular functions than ...

Fast AFM probes measure multiple properties of biomolecules or materials simultaneously

... to the standard AFM topography scan, these novel probes simultaneously measure material properties ... stiffness, elasticity and viscosity. Our probes attach directly to AFM systems currently on the ... were mapped in addition to topography. FIRAT probes made of dielectric materials with embedded ...

Harvard researchers publish MRI images of genes in action in the living brain

... is necessary to determine exactly how these gene probes reach brain tissue. In this report, Harvard ... Furthermore, the researchers believe that the probes may also help diagnose thinning of vascular walls ... Journal, but sometimes this is unavoidable. These probes of genes in action go a long way toward ushering ...

Going live with click chemistry

... extremely valuable for attaching small molecular probes to various biomolecules in a test tube or on ... but the means to tag glycans with imaging probes has been lacking, thereby prohibiting such ... permitting their chemical tagging with imaging probes through click chemistry, but the cytotoxicity of ...

Female human embryos adjust the balance of X chromosomes before implantation

... have started to differentiate into different cell layers). They used probes designed for detecting a gene called XIST (X chromosome Inactive Specific ... an inactive X chromosome and is transcribed (or copied) into RNA. Other probes were used to detect the sex and chromosomal status of each embryo. Ms ...

Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols

... ). The loading of individual cells with fluorescent probes via patch pipettes is regularly performed in neuroscience research ... A wide range of dyes can be loaded using this method, including probes for morphological reconstruction, ion-sensitive indicator dyes for ...

Cause of mussel poisoning identified

... production in the laboratory. "We are able to produce so-called gene probes from our laboratory cultures with the help of molecular techniques", explains Tillmann. "These gene probes prove the existence of the toxin-producing algae in seawater samples and ...

Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors

... interventional cryoablation, which uses imaging to pinpoint tumors and probes to penetrate the skin to deliver freezing cold directly to a diseased ... Using computed tomography (CT) imaging, researchers could view tumors and probes in real time. Interventional cryoablation "has an excellent safety ...

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

... the nanocarrier and not endogenous changes in the tumor tissue, liposomal probes tagged with a fluorescent dye were injected into the animals. By looking ... regression, the researchers plan to investigate whether the liposomal probes can be used for this purpose in the future. To further develop and ...

Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo

... Researchers have created a new family of fluorescent probes called hydrocyanines that can be used to detect and measure the presence ... hydro-IR-783 and hydro-ICG but say that there are potentially 40 probes that could be created. The dyes vary in their ability to detect ...

Broad Institute awarded grant to develop chemical probes for human biology and disease

... undertake this work without them." The development of small molecule probes is an intensive effort that involves more than high-throughput screening ... required to develop promising small molecules into bona fide molecular probes of human biology. This requires modern organic synthesis, a scientific ...

MIT sculpts 3-D particles with light

... and tissue engineering. For example, they could be designed to act as probes to detect certain molecules, such as DNA, or to release drugs or ... graduate student Daniel Pregibon showed that the particles can be used as probes to identify DNA and other molecules. Other applications for the ...

Marine scientists warn human safety, prosperity depend on better ocean observing system

... Among technologies deployed by ocean observers: Diving Robotic probes Deployments today include some 3,000 small, drifting Argo probes that measure pressure, salinity and temperature at depths down to 2 km and ...

Human safety, prosperity depend on better ocean observing system: Scientists

... Among technologies deployed by ocean observers: Diving Robotic probes Deployments today include some 3,000 small, drifting Argo probes that measure pressure, salinity and temperature at depths down to 2 km and ...

Scripps scientists discover fluorescence in key marine creature

... research purposes, from markers for tracing molecules in biomedicine to probes for testing environmental quality. Until now, such proteins have been ... GFPs have been used as markers to examine gene expression as well as probes for tracking how molecules transfer energy. (GFP) is an easy protein to ...

Studying component parts of living cells with carbon nanotube cellular probes

... nanotubes induce little damage to cells upon penetration. By making these probes able to sense within the cells, information about chemical interactions ... The research found that carbon nanotubes and nanopipes can be used as SERS probes by two different methods that achieved identical results. Combining these ...

AGU journal highlights -- Sept. 6, 2007

... 2007, http://dx.doi.org/10.1029/2007GL030123 4. Robotic probes improve global ocean analysis Observations of the ocean are important ... open ocean, the Argo float network, a set of nearly 3000 oceanic robotic probes throughout the Earth's oceans that measure salinity and temperature at ...

Comet probes reveal evidence of origin of life, scientists claim

... Recent probes inside comets show it is overwhelmingly likely that life began in space, ... development of the theory. Now the team claims that findings from space probes sent to investigate passing comets reveal how the first organisms could ...

New windows opened on cell-to-cell interactions

... interactions. The six-member research team built tiny artificial molecules that mimic brush-like membrane proteins and contain tiny fluorescent probes at the outer end. These miniscule polymers were incorporated into artificial membranes placed on a silicon wafer that acts like a mirror, allowing ...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

... them with other inflammatory drugs to improve their efficacy and reduce their side effects," Hammock said. "Both the analytical and novel chemical probes will give us a better understanding of the basic causes of asthma." The enzyme is involved in the metabolism of arachidonic acid, a key ...

Rapid approach to identify influenza A virus mutations and drug resistance developed

... manufactured and shipped to Singapore just four days after the project was started. As the custom-developed high-density microarray contains probes which can reveal the complete sequence of the flu virus from patient samples, it enables the detection of any single base mutations in the regions of ...

New tool for next-generation cancer treatments using nanodiamonds

... cancer researchers investigate the efficacy of new drug-nanomaterial systems as they become available. The group also used the same Nanofountain probes to pattern dot arrays of drug-coated nanodiamonds directly on glass substrates. The production of these dot arrays, with dots that can be made ...

Public lecture at UC Riverside to discuss origin and fate of universe

... and leaders of the Cosmic Evolution Survey (COSMOS) projects, which is the largest single project performed on the Hubble Space Telescope and probes the formation and evolution of galaxies as a function of cosmic time. "The talk on May 28 is particularly timely, given the recent launch of the ...

Flow of potassium into cells implicated in schizophrenia

... studies. "Our study goes further, spanning discovery of a new gene variant, confirmation of its association with the illness, and multi-level probes into how it works in human post mortem brain tissue, the living human brain, and neurons," added Weinberger. By regulating the flow of potassium ...

Nanoneedle is small in size, but huge in applications

... also is a researcher at the Center for Nanoscale Chemical-Electrical-Mechanical Manufacturing Systems. "Nanoneedles can be used as electrochemical probes and as optical biosensors to study cellular environments, stimulate certain types of biological sequences, and examine the effect of nanoparticles on ...

Premier issue of Ecopsychology launched by Mary Ann Liebert Inc. publishers

... wilderness expedition program at the university and explores the development of an authentic language of human-nature relationships. Martin Jordan probes the link between how humans react to intimacy or early interpersonal attachments and their later relationship with nature. In the article entitled ...

Research plane Polar 5 on Arctic campaign

... vertical distribution of meteorological parameters like wind, temperature and humidity are carried out during the campaign by means of so-called drop probes sondes. The sondes are dropped from an altitude of five kilometres. "We will considerably improve regional Arctic climate models with our ...

Making a point: Picoscale stability in a room-temperature AFM

... noise cancellation headphones, but applied to atomic force microscopy, says Perkins. In its most recent work, the JILA team has controlled the probes position in three dimensions to better than 40 picometers (1 nanometer = 1000 picometers) over 100 seconds. In imaging applications, they showed the ...

New method for detecting explosives

... more portable device for detecting explosives. Much of this research focuses on "micromechanical" devices -- tiny sensors that have microscopic probes on which airborne chemical vapors deposit. When the right chemicals find the surface of the sensors, they induce tiny mechanical motions, and those ...

AGU journal highlights -- March 12, 2009

... that are shown through modeling and observation to be resonances of the magnetic field lines. They then use phase-difference calculations between probes to estimate the number of fluctuations present at a given time. The authors expect that further research will help understand the dynamics of the ...

Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims

... nearly 10 percent of deaths in the western hemisphere and about 5 percent of health-care costs. The device being developed uses embedded optical probes that are placed over major cortical blood vessels in each hemisphere of the brain. The technology, diffuse correlation spectroscopy is a non-invasive ...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

... and in samples of human glioblastoma multiforme, the deadliest of brain cancers. This technique uses a gene microarray that contains millions of probes that can stick to different regions of the human genome. The researchers purified DNA from tumors and then used the microarray chip to quantify ...
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(Date:10/14/2014)... A Mount Sinai-led research team has discovered a new kind ... or a cell that lines liver blood vessels, according to ... Reports . The existence of such a cell type contradicts ... the embryo, and may hold clues to origins of, and ... develop from a single cell into a complex being made ...
(Date:10/14/2014)... – A team of scientists led by researchers ... and the University of Miami Miller School of ... key genetic pathway underlying bipolar (manic depressive) disorder, ... for treating bipolar affective disorder, as well as ... new findings, published online this week in Nature ...
(Date:10/14/2014)... PA, October 14, 2014 – Over the past decades, ... of institutions to meet the needs of infants for ... of these infants to thrive. , Infancy ... development of the cortex. A generation of research suggests ... promote cortical development and cognitive function. In contrast, deprivation ...
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