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Probe in Biological News

New tool for next-generation cancer treatments using nanodiamonds

... functions in two different ways: in one mode, the probe acts like a fountain pen, wherein drug-coated ... online in the scientific journal Small . The probe could be used both as a research tool in the ... this issue, the team used the Nanofountain probe to target and inject single cells with a dose of ...

Ultrasound imaging now possible with a smartphone

... and computing by coupling USB-based ultrasound probe technology with a smartphone, enabling a compact, ... the researchers had to optimize every aspect of probe design and operation, from power consumption and ... never be the same. "You can carry around a probe and cell phone and image on the fly now," said ...

Making a point: Picoscale stability in a room-temperature AFM

... of nanotechnology. AFMs have a sharp, pointed probe fixed to one end of a diving-board-like cantilever. As the probe is scanned across a sample, atomic-scale forces tug at the probe tip, deflecting the cantilever. By reflecting a ...

Microscope reveals how bacteria 'breathe' toxic metals

... of a meter), and detect atomic forces between the probe tip and the surface material. They combined ... with the metal. The researchers coated their probe tip with antibodies for the protein OmcA, which ... would use to "breathe" the metal. Whenever the probe slid over an OmcA protein, the antibody coating ...

Luminescence shines new light on proteins

... has led to the creation of a new type of probe for examining protein interactions that could be ... the interaction at the molecular level between a probe (the optical probe, itself of one handedness) and ... Based on a chiral lanthanide complex, the probe emits circularly polarised light that inverts ...

Broad Institute awarded grant to develop chemical probes for human biology and disease

... tools known as "small molecules", which can probe the proteins, signaling pathways and cellular ... for novel disease therapies. "Small-molecule probe and drug discovery enables basic research to ... Screening Centers in the Molecular Libraries probe Production Centers Network (MLPCN), where vast ...

MIT probe may help untangle cells' signaling pathways

... researchers have designed a new type of probe that can image thousands of interactions between ... and senior author of a paper describing the probe published online June 27 by the Journal of the ... in cell division. They are currently using the probe to image the interaction of proteins involved in ...

UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system

... a common chemotherapy drug to create a new probe for Positron Emission Tomography (PET), an ... added a radiolabel so the cells that take in the probe can be seen during PET scanning. The probe is based on a fundamental cell biochemical ...

New gas sensors for monitoring carbon dioxide sinks

... The principle can also be used in liquids, so the probe is also useful for monitoring waterbodies, ... construction of the borehole and waterbody probe means that it can be used in gauges. The ... data capture/evaluation to take place while the probe is submerged. A device with these features has ...

Fast AFM probes measure multiple properties of biomolecules or materials simultaneously

... New research demonstrates that novel probe technology based on flexible membranes can ... sensing integrated readout and active tip (FIRAT) probe and its biological applications were presented at ... the topography of the surface. The new probe replaces the cantilever with a drum-like membrane ...

DOE-funded research projects win 46 R&D 100 Awards for 2009

... capabilities by combining full field transmission imaging with scanning probe capabilities. This technology will significantly improve the ability of ... Compact Gamma Camera This high-resolution nuclear medical probe can pinpoint the locale of cancer tissue in the prostate gland in detail ...

Nanocrystals reveal activity within cells

... it through a typical biological environment is fraught with issues: the probe can randomly turn on and off, competes with light emitting from the cell, ... a million times more efficient than traditional dyes," said Schuck. "No probe with ideal single-molecule imaging properties had been identified to ...

Colon cancer screening technique shows continued promise in new study

... used tissue samples near the location where doctors may ultimately use a probe to test technology. "If you have a precancerous lesion in one part of ... cancer screening technique. Further studies with a compatible fiber optic probe are under way for multicenter clinical validation. The work builds on ...

Hunt for 'climate-ready' crops accelerates as organizations search seed collections worldwide

... for Plant Breeding Capacity (GIPB). "We want to support scientists to probe crop genebanks for natural traits that will allow farm production to stay ... the support of the Bill & Melinda Gates Foundation, is supporting work to probe crop collections for critical traits such as drought or heat tolerance. ...

Breaking the ties that bind: New hope for biomass fuels

... Vgtales in France, Los Alamos researcher Paul Langan used neutrons to probe the crystalline structure of highly crystalline cellulose, much like an X-ray is used to probe the hidden structures of the body. Langan and his colleagues found that ...

Orientation of antenna protein in photosynthetic bacteria described

... amino acid residues, and some of those are reactive to the chemical probe we added into the system. The surface residues that react to the probe are then labeled, and we isolate the protein and characterize where the ...

New high-throughput screening technique makes probing puzzling proteins possible

... quite small, so their fluorescence is not very polarized. But, when a probe attaches to a protein, together they make a much larger molecule, ... unclear. "We didn't have any clue that emetine would be able to block probe labeling of RBBP9 until we did the screen," says Cravatt. Now the ...

Freezing prostate cancer does a man's body good

... added Onik. With cryoablation, interventional radiologists insert a probe through the skin, using imaging to guide the needle to the tumor; the probe then circulates extremely cold gas to freeze and destroy the cancerous ...

Breakthrough optical technology to assess colon cancer risk, accuracy

... Light Scattering Fingerprinting (4D-ELF)." This state-of-the-art light probe was developed by Vadim Backman, professor of biomedical engineering at ... with which these things can be measured." Researchers used the optic probe to measure oxygenated (Ohb) and deoxygenated (Dhb) hemoglobin (Hb) ...

Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more

... been done by lining up tiny electrodes within or near single neurons to probe their electrical activity. Though well established, this method is ... Nurmikko at Brown University have created a new type of dye-free optical probe that can directly sense naturally occurring neural activity. They have ...

Harvard researchers publish MRI images of genes in action in the living brain

... ), Harvard researchers describe the development of gene probe eye drops thatfor the first timemake it possible to monitor and detect ... report, Harvard researchers describe how they link a relatively common MRI probe (superparamagnetic iron oxide nanoparticles) to a short DNA sequence that ...

Team IDs weakness in anthrax bacteria

... which can then survive the infection. With the aid of an intracellular probe developed in our laboratory, which fluoresces in the presence of NO, our ... With this knowledge in hand, the researchers are now using the fluorescent probe to screen libraries of chemicals for compounds that could potentially ...

Going live with click chemistry

... We are already using our copper-free click chemistry technique to probe glycan dynamics in living cells and in live zebrafish embryos, which serve ... Bertozzi says their copper-free click chemistry technique can be used to probe any biomolecule that can be labeled with an azide, including glycans, ...

Story tips from the US Department of Energy's Oak Ridge National Laboratory, September 2007

... A chorus of signals . . . Band excitation, a new family of scanning probe microscopy, moves the field towards probing energy transformation at the nanoscale, say the developers. Conventional scanning probe microscopes measure the cantilevers movements over the surface of a ...

Moving to the US increases cancer risk for Hispanics

... and differences in cancer prevalence among this population. "Don't assume that all Hispanics are the same," Ramirez said. "Physicians should probe Hispanic patients more on their background and family history to identify any problematic behaviors that could contribute to health problems." ...

Venomous sea snakes play heads or tails with their predators

... coral reefs. All sea snakes have extremely potent venom which is among the most toxic known in all snake species. When hunting for food sea snakes probe crevices and coral formations, temporarily forcing them to drop their guard to threats from the surrounding waters and making them highly vulnerable ...

Scientists open doors to diagnosis of emphysema

... looking inside the lungs," says Carsten Schultz, whose group carried out the research at EMBL. The researchers designed a special fluorescent probe that essentially allows MMP12 activity in macrophages to be quantified by the amount of fluorescence they take up. Applying this test to samples of ...

Scientists closer to making implantable bone material, thanks to new research

... the growth of different cell populations. They also used a nano-indenter and high resolution electron microscopy, which allowed the researchers to probe the samples so that they could understand how stiff the bone-like materials were and what their structure was at a microscopic level. ...

2000-year-old statue of an athlete sheds light on corrosion and other modern challenges

... biofouled manmade structures are limited, the finding of an ancient sculpture immersed for two millennia in the sea provided a unique opportunity to probe the long-term impact of a specific artificial substrate on biomineralizng organisms and the effects of biocorrosion," the report said. By evaluating ...

Will IVF work for a particular patient? The answer may be found in her blood

... the human genes with high density DNA microarrays, as used by Dr. Allen and her team. The advent of tools like microarrays that can simultaneously probe for up to 29,000 genes has radically changed scientific approaches to this type of research. "It's like looking at how a team of players perform ...

McGill University receives almost $63 million under CFI program to support five research projects

... and Cancer: from Obesity to Cachexia, is a major collaborative project teaming researchers doing fundamental research in metabolism and clinicians to probe the links between the progression of cancer, obesity and cachexia. The project is headed by Dr. Vincent Gigure of the Department of Biochemistry ...

Autonomous robot detects shrapnel

... site of the shrapnel." By proving that the robot could guide a needle to an exact location, it would simply be a matter of replacing the needle probe with a tiny tool, such as a grabber, the researchers said. Rogers worked in the laboratory of Stephen Smith, director of the Duke University ...

American Society for Microbiology honors Deborah T. Hung

... 2005 in Science. Currently, Dr. Hung's work focuses on tuberculosis (TB). She has already developed screens to identify small molecules that probe in vitro TB physiology and TB infection of macrophages. Her goal is to understand its persistent state by developing chemicals that can manipulate it ...

Small molecules mimic natural gene regulators

... factors (ATFs)---non-natural molecules programmed to perform the same function as their natural counterparts. These molecules can help scientists probe the transcription process and perhaps eventually be used to correct diseases that result from errors in gene regulation. In previous work, Mapp ...

NIH announces new program to develop therapeutics for rare and neglected diseases

... NCGC has developed a robotic high-throughput screening system and a library of more than 350,000 compounds that it uses to make basic discoveries and probe cellular pathways. NCGC also has developed a team of researchers skilled in developing assays representing disease processes that can be tested in ...

American Chemical Society's Weekly PressPac -- May 13, 2009

... insights into the mystery of how plants have managed to adapt and survive in the radioactive soil near Chernobyl. Their research is the first to probe how production of key proteins in plants changes in response to the radioactive environment, according to the report. It is scheduled for the June 5 ...

Nanoneedle is small in size, but huge in applications

... the cytoplasm or the nucleus of living cells. In addition to ferrying tiny amounts of cargo, the nanoneedle can also be used as an electrochemical probe and as an optical biosensor. "Nanoneedle-based delivery is a powerful new tool for studying biological processes and biophysical properties at the ...

MIT: Making waves in the brain

... Li-Huei Tsai, Picower Professor of Neuroscience and a Howard Hughes Medical Institute investigator. "This new tool will give us a great chance to probe the function of these circuits." Tsai co-authored a paper about the work that appears in the April 26 online issue of Nature. Gamma ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

... through a given material, the ocean for instance, the sound waves respond to the properties of the fluid. Scientists can use these responses to probe the characteristics of the medium -- the ocean or the atmosphere, for instance -- and one particularly powerful way of doing this employs a technique ...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

... at the G1-S interface of the cell cycle. To address the question of the location and temporal relationships of OGFr nucleocytoplasmic trafficking, a probe of OGFr fused to green fluorescent protein (eGFP) was constructed. Experiments with a human cancer cell, a squamous cell carcinoma of the head and ...
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