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Prion in Biological News

Redefining what it means to be a prion

... have quintupled the number of identifiable prion proteins in yeast and have further clarified the ... their set of tests, the researchers found 24 prion candidates meeting all three criteria. Included ... in some circumstances it's good to be in the prion state and in some cases it's not," says Whitehead ...

Iron is involved in prion disease-associated neuronal demise

... of iron homeostasis is a common feature of prion disease-affected human, mouse, and hamster ... insight into the mechanism of neurotoxicity in prion disorders, and novel avenues for the development ... Unlike other neurodegenerative conditions, prion disorders are sporadic, inherited, and ...

Antibody key to treating variant CJD, scientists find

... progressive neurodegenerative disorders, called prion diseases, which affect both animals and humans. ... in cows, commonly known as Mad Cow Disease. prion diseases can develop when a naturally occurring brain prion protein called, PrP, comes into contact with ...

Common soil mineral degrades the nearly indestructible prion

... gallery of microscopic infectious agents, the prion is the toughest hombre in town. Warped pathogens ... weirdest infectious agent know to science, the prion is also the most durable. It resists almost every ... disinfectants and autoclaving, which reduce prion infectivity but fail to completely eliminate it. ...

Tracking down the cause of mad cow disease

... cattle and CreutzfeldJakob disease in humans is a prion protein. This protein attaches to cell membranes ... Zurich has now "recreated" the first GPI-anchored prion in the laboratory. As they report in the journal ... anchored proteins. The isolation of a complete prion protein that includes the anchor has not yet been ...

K-State professor's USDA research shows mad cow disease also caused by genetic mutation

... ago, Richt said, it was thought that the cattle prion disease bovine spongiform encephalopathy -- also ... caused by a genetic mutation within a gene called prion Protein Gene. prion proteins are proteins expressed abundantly in the ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... Early Phases of Creating a Vaccine against prion Disease Thomas Wisniewski, MD, Department of ... against a toxic and infectious version of the prion protein, which causes a group of brain diseases, ... animals could produce more antibodies against the prion protein in the mouth and blood system, preventing ...

Tracking prions

... healthy proteins. The molecular bases for such prion diseases are not yet fully understood. Why are ... markedly in their molecular structure. The word prion is derived from the term Proteinaceous Infectious ... The spectra of the pH 7 and pH 3 versions of the prion differ significantly. Both are mainly arranged in ...

Prions show their good side

... Diseases such as mad cow result when the prion protein adopts an abnormal conformation. This ... new work, the authors found that mice lacking the prion protein had overactive brain cells. Their neurons ... stimulation than did neurons that had normal prion protein. This hyperactivity eventually led to the ...

New insights into the diversity of Creutzfeldt-Jakob disease agents

... that these subgroups could represent distinct prion strains in what is the most common human prion disease. prion diseases are transmissible neurodegenerative ...

Scripps scientists develop new tests that identify lethal prion strains quickly and accurately

... called the Standard Scrapie Cell Assay, measures prion infectivity levels in a highly accurate and ... to quickly distinguish between several prion strains in various cells lines. Using the new ... new assays vastly accelerate the measurement of prion infectivity and the determination of those cell ...

Penn biochemist receives NIH New Innovator's Award

... or even promote the formation of amyloid and prion fibers, extremely stable protein aggregates ... can be infectious, and are then termed prions. prion and amyloid formation are associated with some of ... sophisticated machinery to alleviate amyloid and prion aggregates, but these biological safeguards can ...

Lymph nodes can be key in spreading prion infectivity

... be crucial for spreading low doses of infective prion agents -the pathogens responsible for conditions ... sheds new light on the important issue of how prion agents are transmitted from the site of infection ... had been removed and the wound not yet healed, prion infection is substantially accelerated. The ...

NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins

... won his grant with an original proposal to study prion diseases a group of deadly, brain-destroying ... our innovative approach to understanding how prion proteins cause brain disease, and complement our ... has been genetically modified to produce hamster prion protein. In rodents, cows, humans and other ...

Prions and retroviruses -- an unholy alliance?

... whose make-up is changed as a result of a prion infection. In collaboration with colleagues from ... retroviruses is influenced by infectious prion proteins in tests with mouse cells. Prions an ... organism, they can modify the normal "healthy" prion proteins to create more infectious prions, and ...

Europe develops new technologies to boost health of livestock

... It is now possible to produce cattle lacking the gene that makes the prion protein responsible for BSE. Calves produced this way appear to be completely healthy, suggesting that the prion protein is not necessary, or that it has back up proteins that perform its ...

Canadian synchrotron conference sheds light on new biomedical research

... clean up and nanotechnology. Highlights include: Presentations by CLS users on using the synchrotron to study esophageal tumours, prion diseases such as BSE, watch nerves regenerate and treat tuberculosis Applications of synchrotron techniques to agricultural research, developing ...

Protein fibrils as alternative plastics?

... German . Amyloid deposits in tissues and organs are linked to a number of diseases, including Alzheimers, Parkinsons, type II diabetes, and prion diseases such as BSE. However, amyloids are not just pathological substances; they have potential as a nanomaterials. The potential applications of ...

Leroy Hood to receive 2008 Pittcon Heritage Award

... where he developed the ink-jet oligonucleotide synthesizer, which synthesizes DNA chips, and initiated systems studies on cancer biology and prion disease. In 2000 Hood cofounded the Institute for Systems Biology, a nonprofit research institute established to pioneer systems approaches to ...

First high-res 3D structures of mammalian HSP90 protein solved

... cancer to sepsis, and drugs that stimulate HSP90 action may be appropriate therapies for diseases involving protein folding, such as cystic fibrosis, prion diseases , and Alzheimers Disease. Since 2001, Gewirth and his lab have been using the technique of X-ray diffraction to solve the first ...

Vaccine prevents prion disease in mice

... Annual Meeting in Boston, April 28 ?May 5, 2007. prion diseases, which include scrapie, mad cow disease, ... dementia and abnormal limb movements. prion is a protein that is also an infectious agent. ... the mice's immune system, researchers attached prion proteins to a genetically modified strain of ...

Scientists identify prion's infectious secret

... framework for us to begin exploring properties of prion biology that, up until now, have proven difficult ... (The brains of animals that have died from prion infections are literally packed with amyloid ... with peptides from baker’s yeast and then added prion protein to the array, also from the same yeast ...

Scripps research study reveals structural dynamics of single prion molecules

... protein-based inheritance in yeast. When this prion protein misfolds, it converts into ... Interestingly, the new study revealed that yeast prion protein Sup35 lacks a specific, static structure ... Deniz said that future work with yeast prion mutants might resolve some of the questions that ...

Brown team finds crucial protein role in deadly prion spread

... A single protein plays a major role in deadly prion diseases by smashing up clusters of these ... we studied has a big impact on how fast prion diseases spread and may also play a role in the ... propagation process ?fragmentation of existing prion complexes. Once converted, the thinking goes, ...

Prion disease treatable if caught early

... in mice have indicated that the effects of prion disease could be reversed if caught early enough. ... early treatments that aim to reduce levels of prion protein in the brains of people with prion disease. Also, they said that their findings ...

New approach to BSE successful in lab

... What is even more peculiar: exactly the same prion proteins occur in healthy animals. The only ... is an irresistible chain reaction. The malformed prion proteins can be deposited in the brain, thereby destroying brain tissue. prion diseases are always fatal, often, however, not ...

Brittle prions are more infectious

... Institute researcher have discovered that brittle prion particles break more readily into new "seeds," ... The discovery boosts basic understanding of prion infections, and could provide scientists with new ... for designing drugs that discourage or prevent prion seeding, said the study's senior author Jonathan ...

New evidence questions the simple link between prion proteins and madcow disease

... people do not absorb the disease-associated prion protein (PrP) from their guts. To test this, ... When they injected material containing abnormal prion protein (PrP) into the sheep's gut, it was ... to reappraise the fundamental understanding of prion diseases is enhanced by one more observation ...

Prions rapidly 'remodel' good protein into bad, Brown study shows

... when it comes in contact with the infectious prion form in yeast: The protein converts to the prion form, rendering it infectious. In an instant, ... using Sup35, a yeast protein similar to the human prion protein PrP. The researchers tagged a ...

New results validating Pall prion reduction filter disclosed at ISBT Congress

... the performance of its Leukotrap® Affinity prion Reduction Filter System, which was CE marked with a 99.9 percent prion removal efficiency in May 2005. It is the first ... discussions with potentially infected donors. prion Reduction Confirmed Sam Coker, Ph.D., ...

Variant prion protein causes infection but no symptoms

... Abnormal prion proteins are little understood disease agents ... research suggests that a variant form of abnormal prion protein--one lacking an "anchor" into the cell ... "This work provides novel insights into how prion and other neurodegenerative diseases develop and ...

Unweaving amyloid fibers to solve prion puzzles

... of low resolution tools to analyze varieties of prion strains and piece together the puzzle of how ... Prions are in the business of converting other prion molecules to join their ranks. And as they join ... To do this, Krishnan took a variety of yeast prion strains and modified them in such a way that if ...

Active Vaccine Prevents Mice From Developing Prion Disease

... both the United States and Europe are working on prion vaccines. But the NYU study is important because ... percentage of animals from developing symptoms of prion disease, explains Thomas Wisniewski, M.D., ... today provide such active immunization. The prion vaccine developed at NYU would most likely first ...

First technology to remove prions that cause vCJD from blood launched

... of Europe (CE) marking of its Leukotrap® Affinity prion Reduction Filter System. It is the first and only ... as Mad Cow Disease. The CE mark means the new prion reduction filter meets pan-European essential ... of medical devices. "The availability of our prion reduction filter is a seminal event heralding a ...

Strongest proof yet found for prion hypothesis

... test tubes, because what is needed to prove the prion hypothesis completely is to be able to produce ... of the paper. "The evidence in favor of the prion hypothesis was strong, but the final proof was ... Hetz. By mimicking the natural mechanism of prion formation but doing so at a much higher rate, ...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

... Since then, barriers to the transmission of prion diseases between species "have emerged as a major ... Surewicz of Case Western Reserve University. prion diseases are caused by misfolded variants of the normal prion protein, which aggregate into fibrous tangles ...

History of human cannibalism eats away at researchers

... with cannibalism has not been a major selective driving force on the prion protein gene, as has recently been proposed. Their work also has ... with diseases or to evaluate historical patterns of human migration. The prion protein gene ( PRNP ) encodes a protein that can abnormally fold and amass ...

New test to detect rare proteins in blood

... associated with cancers (such as breast cancer), Alzheimer's disease, prion diseases, and possibly psychiatric diseases relatively easy and more ... FACTT method on other rare, but medically important molecules, such as the prion protein (for mad cow disease with Mansun Sy at Case Western University) ...

Research into how prions act in the brain could hold the key to defeating diseases

... 'There is much we do not know about prions and prion diseases but our research teams are following several lines of investigation.' prion diseases are extremely complex and understanding ... no simple and accurate way to diagnose types of prion disease such as vCJD, no effective way of ...
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