Flow of potassium into cells implicated in schizophrenia
... implicated machinery that maintains the flow of potassium
in cells and revealed a potential molecular ... of a previously unknown form of a key such potassium
channel was found to be 2.5 fold higher than ... who carry the risk-associated version of this potassium
channel gene, even though they don't show any ...
Drug prevents seizure progression in model of epilepsy
... activity is associated with seizure disorders, a potassium
channel known as the BK channel.
"We have ... ion channels that allow
electrically charged potassium
ions to move out of cells, to sporadic epilepsy. ... to the same alterations in BK channel function. potassium
ions move through the channels, starting and ...
Many middle-aged and older Americans not getting adequate nutrition
... MO Micronutrients such as calcium, magnesium, potassium
and vitamin C play essential roles in maintaining ... Although dietary intake of calcium, magnesium, potassium
and vitamin C was similar between supplement ... users and non-users.
The study also found that potassium
intake was very much below the RDA whether ...
Cutting salt isn't the only way to reduce blood pressure
... of cardiovascular disease than sodium or potassium
"There isn't as much focus on potassium, but potassium
seems to be effective in lowering blood pressure and the combination of a higher intake of potassium
and lower consumption of sodium seems to be more ...
Forsyth scientists trigger cancer-like response from embryonic stem cells
... Biology, have identified a new function for a potassium
(KCNQ1) channel, mutations of which are known to ... syndromes. The team interrupted the flow of potassium
through KCNQ1 in parts of the Xenopus frog ... in embryonic development, and demonstrate that potassium
flows can be an important aspect of cellular ...
Site used by sodium to control sensitivity of certain potassium ion channels
... uncovered how sodium is able to control specific potassium
ion channels in cells, according to new study ... to control the opening and closing of certain potassium
channels. Using a computational-experimental ... the interaction between sodium and a group of potassium
channels known as Kir channel proteins. The team ...
New clues to how proteins dissolve and crystallize
... calcium and sodium out of cells and pumping potassium
Computer simulations and quantum calculations of how sodium and potassium
bind to proteins were performed by Lubo Vrbka and ... to measure the selective binding of sodium and potassium
to formate and acetate, two simple carboxylate ...
New regulations tighten controls on restricted chemicals
... nitric acid; nitromethane; hydrogen peroxide; potassium
nitrate; sodium nitrate; potassium
chlorate; sodium chlorate; and potassium
The regulations take effect for ...
Media highlights in the November issues of Biophysical Journal
... online. Topics of interest include voltage-gated potassium
channels that could payoff in synthetic drug ... a step closer to understanding how voltage-gated potassium
channels work. Vishwanath Jogini and Benot Roux, ... detailed atomic model of the Kv1.2 voltage-gated potassium
channel in an explicit membrane using the ...
New study finds lowfat chocolate milk is effective post-exercise recovery aid for soccer players
... Milk also provides fluids for rehydration and minerals like calcium, potassium
and magnesium that recreational exercisers and elite athletes alike need ... results in fluid losses, but also important minerals including calcium, potassium
and magnesium. The best recovery routine should replace fluids and ...
Ten genes identified in connection with sudden cardiac death
... existing medical theory. A number of the 10 genes help regulate human potassium
channels in the heart muscle, reinforcing the idea that the balance of sodium and potassium
moving in and out of the heart muscle is important, Abecasis said. ...
Calcium and vitamin D may not be the only protection against bone loss
... aged 50 and older were randomized to receive placebo or doses of either: potassium
bicarbonate, sodium bicarbonate, or potassium
chloride for three months. Researchers found that subjects taking ...
Researchers block damage to fetal brain following maternal alcohol consumption
... to cells in a key area of the fetal brain by blocking acid sensitive potassium
channels and preventing the acidic environment that alcohol produces. The ... demonstrated that the damage can be prevented by blocking acid sensitive potassium
channels, known as TASK channels, that lead into the Purkinje cells. The ...
Treatment corrects severe insulin imbalance in animal studies
... hyperinsulinism is caused by mutations in genes that encode important potassium
channels in the pancreatic beta cells." The study team, from Children's ... the drug diazoxide, which controls insulin secretion by opening up crucial potassium
channels in beta cells. However, this drug does not work in the most ...
Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
In the current study, the researchers examined two channels that allow potassium
ions to cross the cell membrane. The researchers genetically engineered ... Kv3.1 and Kv3.3, which normally open and close much faster than other potassium
These channels are common in a portion of the brain called ...
Story ideas from the Journal of Biological Chemistry
... do not have COX-2 enzymes. Rather, Celecoxib could directly inhibit the potassium
channels that help generate the electric current that drives heartbeat.
... that another mechanism is at work. The drug also inhibited rat and human potassium
channels expressed in a human cell line.
Singh and colleagues point out ...
New hypothesis for origin of life proposed
Mica layers are held together by potassium. The concentration of potassium
inside the mica is very similar to the concentration of potassium
in our cells. And the seawater that bathed the mica is rich in sodium, ...
Researchers' discovery may lead to hypertension treatment
... lower sodium levels all have serious side effects because they also reduce potassium
Researchers at Cornell and the Boyce Thompson Institute for Plant ... xanthurenic-acid, raised sodium levels in the rat's urine but kept potassium
levels constant. Schroeder said that while aldosterone (which does the ...
ADA releases updated position paper on vegetarian diets
... in vegetarian diets. An expanded section on osteoporosis includes roles of fruits, vegetables, soy products, protein, calcium, vitamins D and K and potassium
in bone health. "Registered dietitians can provide information about key nutrients, modify vegetarian diets to meet the needs of those with dietary ...
American Chemical Society's weekly PressPac -- May 27, 2009
... taste perception.
Despite this challenge, companies are forging ahead with salt reduction research. One of the most widely used salt replacers, potassium
chloride, resembles salt in terms of cooking performance but has a bitter taste that some consumers find unpleasant. Several companies are developing ...
People of higher socioeconomic status choose better diets -- but pay more per calorie
... and women, higher dietary energy density was associated with higher intakes of total fat and saturated fat and with lower intakes of dietary fiber, potassium
and vitamins A and C. Daily diet cost ($/day) was slightly higher for men ($6.72/day) than women ($6.21/day), reflecting the fact that men ate more ...
Uncooperative voltage sensors
... commentary on new experimental evidence that advances previous conclusions about the essential features of the Shaker K+ channel, a voltage-gated potassium
As Richard Horn (Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College) ...
Artificial cells, simple model for complex structure
... of the things we are looking into is how ions behave in the model cells," said Keating. "We want to take advantage of the effect common ions like potassium
and magnesium can have on protein and nucleic acid structures and function."
These polymer containing primitive artificial cells may offer a very ...
New method monitors critical bacteria in wastewater treatment
... transported into and out of the biofilm per minute.
"When bacterial biofilms are poisoned, sick and stressed they start to release ions, including potassium
and calcium, which is an early warning signal," Porterfield said. "The bacteria in wastewater treatment facilities often detach from surfaces, ...
2009 DOE INCITE projects allocated at ORNL
... of carbon dioxide sequestered from power plant emissions and pumped deep underground, the workings of a molecular machine known as the voltage-gated potassium
channel, and the evolution of dark matter in our Milky Way galaxy. These achievements pave the way for unprecedented advances in alternative energy ...
Researchers advance knowledge of little 'nano-machines' in our body
... ion channels because the malfunctioning of these channels is implicated in a number of diseases.
For this study, the research team investigated potassium
channels built out of four identical subunits, which form a pore through the membrane that can open and close in order to allow or block ion ...
Rare disease provides clues about enzyme role in arrhythmias
... CaM kinase II, you could directly affect pathways that cause unwanted developmental and neurological changes."
"In contrast to sodium channels or potassium
channels, there are very few diseases that cause mutations in calcium channels. Experts believe calcium is too important to 'futz' around with, ...
New 'control knobs' for stem cells identified
... was functionally required for differentiation, the scientists depolarized the hMSCs by exposing them either to high levels of extracellular potassium
ions or to ouabain, a compound that blocks the transfer of ions in and out of cells. Both treatments disrupted the normal increase in negative ...
Where there's wildfire smoke, there's toxicity
... of particles during the fire episodes is different than that during 'normal' days impacted by traffic sources.
"Tracers of biomass burning (e.g. potassium
and levoglucosan) were elevated by two-fold during the fire periodm" he said. "Water-soluble organic carbon (WSOC) was also higher during the fire ...
Moderate use averts failure of type 2 diabetes drugs in animal model
... Physicians typically treat the condition with a sulfonylurea and metformin, a drug that increases insulin sensitivity.
Sulfonylureas bind to potassium
channels on the surfaces of beta cells. These channels normally control electrical activity and hence the levels of calcium in the cell; when the ...
Models of eel cells suggest electrifying possibilities
... nerve cells. The arrival of a chemical signal triggers the opening of highly selective channels in a cell membrane causing sodium ions to flow in and potassium
ions to flow out. The ion swap increases the voltage across the membrane, which causes even more channels to open. Past a certain point the process ...
Scientists identify the genes that cause blindness produced by corneal edema
... to a traumatism, cataract surgery, ageing, etc., the barrier of endothelial cells breaks, dispersed cells increase their volume and content in ions, potassium
and chlorine. The goal of these changes is to repair the endothelial barrier, prevent corneal oedema and, therefore, the loss of transparency and the ...
Researchers catch ion channels in their opening act
... to put the models of voltage sensor movement to the test.
They studied the voltage sensor segment in a specific ion channel called the Shaker potassium
channel. This protein was first discovered in fruit flies after researchers observed that a mutation in the channel caused the flies to vigorously ...
American Chemical Society's Weekly PressPac -- June 25, 2008
In the C&EN cover story, Associate Editor Bethany Halford points out that fireworks, flares and other so-called pyrotechnics commonly include potassium
perchlorate to speed up the fuel-burning process. But some studies have linked perchlorate, which can accumulate in the soil, air and water, to ...
Purple extremist thrives under inhospitable conditions
... that scientists find surprising about this survival expert: "All of the DNA ligases studied so far do not contain iron, but require magnesium or potassium
to function. Extraordinarily, the DNA ligase of Ferroplasma contains iron and does not need either magnesium or potassium. The iron is essential: ...
Silicon's effect on sunflowers studied
... with untreated controls. However, growth abnormalities were observed when concentrations of silicon at 100 and 200 mg per liter were supplied as potassium
silicate substrate drenches. In these treatments, plants appeared stunted with deformed flowers and were delayed in flowering. Consequently, the ...
Taking the fight against cancer to heart
... production and sodium excretion.
Vessel dilator which opens the blood vessels and lowers blood pressure
Kaliuretic peptide which increases potassium
The hormones, called peptide hormones because they are composed of amino acids, help regulate blood volume and blood pressure. Most ...
New process makes nanofibers in complex shapes and unlimited lengths
... the versatility of the drawing process, for which the U. of I. has applied for a patent, the researchers drew nanofibers out of sugar, out of potassium
hydroxide (a major industrial chemical) and out of densely packed quantum dots. While the nanofibers are currently fabricated from water-based inks, ...
Biophysical Society announces 2008 International Travel Awards
... By Cortical Actin Activity.
Vivian M. Gonzalez-Perez, Centro de Neurociencia de Valparaiso, Chile, Addition of a Charge to the Shaker potassium
Channel Voltage Sensor.
Manuel Gutierrez-Aguilar, Instituto de Fisiologia Celular, Mexico, In Yeast, Ca2+ and Octylguanidine Interact with ...
Kids eat more fruits, vegetables when schools offer salad bar
... disease, stroke and Type 2 diabetes. Eating a variety of fruits and vegetables can improve health by increasing amounts of vitamin C, phytonutrients, potassium
and fiber in the body and displacing energy-dense fatty foods.
The U.S.D.A. has reported that only 36.4 percent of U.S. children between the ...