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Polymorphism in Biological News

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

... to treat anxiety and depression, harbors a common polymorphism in its gene. This polymorphism can come in two different versions that differ in ... motivation and seeking rewards. A specific polymorphism in this gene results in higher levels of ...

NMR researchers unlock hydrogen's secrets to spot polymorphism in pharmaceuticals

... companies are constantly battling the problem of polymorphism in which an active drug can actually exist in ... NMR equipment is already used to detect polymorphism in pharmaceuticals. However the standard ... which will bring immense benefits to the study of polymorphism in drugs and organic molecules in general. This ...

Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer

... they found no evidence that the -765G>C COX2 polymorphism played a role in cervical cancer, they found that ... of developing ovarian cancer. She said the polymorphism could enhance the expression of the COX2 gene, ... our findings are very interesting and this polymorphism seems to play an important role in cancer ...

DNA template could explain evolutionary shifts

... reasons for genetic mutations or changes looked at molecular "typos" in this process, tiny changes in the As, Ts, Cs or Gs called single nucleotide polymorphism (SNPs). They changed the message of the gene. However, in the early 1990s, Lupski was one of the early champions of a newly discovered mechanism in ...

Researchers gain genome-wide insights into patterns of the world's human population structures

... see significant variations. The UW researchers applied this method to a data set of almost 650,000 SNPs (pronounced "snips"). A single nucleotide polymorphism is a genetic variation in which the DNA code differs by only one "letter" in the same DNA sequence from two individuals of the same species. The data ...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

... Huntingtin . "Then, as he was leaving my office, it occurred to me that you could," he recalled. The key was something called a single nucleotide polymorphism or SNP. A SNP is any place on the genetic code that varies by a single unit. The genetic code is written with four letters, A, C, T, and G, which ...

Researchers identify 4 genetic hotspots associated with psoriasis

... Krueger said. "Second, it confirmed findings we reported in 2007 of polymorphisms (mutations) in the IL-12/23 pathways. Third, we now find a third polymorphism in this same cluster, IL-23A. Fourth, a treatment that knocks down IL-12 and IL-23 recently has been shown to be a very effective treatment for ...

Scientists uncover new genetic variations linked to psoriasis

... of Utah and colleagues in Canada and Europe, focused on sites within the genome where a single unit of DNA is changed, called a single nucleotide polymorphism (SNP). The researchers scanned nearly 450,000 SNPs in each of the genomes of 1,409 psoriasis patients and compared the DNA variations to those in ...

Human genomics in China

... diseases (such as deaf). Furthermore, substantial progresses were made in the development of technologies for human genome genotyping and genetic polymorphism detection, as well as for expressed sequence tag (EST) and full-length cDNA cloning and sequencing. All these achievements greatly strengthened the ...

Children's Hospital researchers identify genetic mutation that may predict organ rejection

... Pittsburgh of UPMC have identified a genetic mutation that identifies transplant recipients who experience rejection. Known as a single nucleotide polymorphism (SNP), the genetic mutation validates the effectiveness of the system the researchers developed to search the human genome, according to principal ...

TGen investigators devise faster, cheaper way of analyzing the human genome

... on whether the objective is: Discovering genetic variants for genotyping by a separate method such as custom SNP genotyping. Conducting polymorphism discovery and variant calling within one sequencing experiment. Exhaustively resequencing for all common and rare variants. The new method of ...

Gene associated with pair-bonding in animals has similar effects in human males

... an excellent job of linking this work to the work with voles by constructing the partner bonding measure that was then examined for associations with polymorphism in the gene AVPR1A," says Neiderhiser. The researchers caution that their findings do not suggest this genetic variation can be used to predict an ...

If your first cigarette gave you a buzz and you now smoke, a gene may be to blame

... which just one base-pair in the gene sequence was different from the more common form. This kind of genetic variation is called a single nucleotide polymorphism or SNP. Smokers were also eight times as likely to report that their first cigarettes gave them a pleasurable buzz. "It appears that for ...

Genetic variant increases triglyceride levels in Asian-Americans

... protein that likely plays an important role in metabolizing triglycerides. Some population studies with groups in China and Taiwan indicate that a polymorphism in the APOA5 gene (553 G>T shift) is associated with elevated plasma TG levels, which like cholesterol, increase the risk of heart disease. To get ...

Sociological research shows combined impact of genetics, social factors on delinquency

... number tandem repeat (VNTR) in the monoamine oxidase A (MAOA) gene, (2) the 40-bp VNTR in the dopamine transporter 1 (DAT1) gene and (3) the Taq1 polymorphism in the dopamine D2 receptor (DRD2) gene. MAOA regulates several brain neurotransmitters important in behavioral motivation, aggression, emotion and ...

Mapping the genetic locus for triglycerides

... protein 2, which helps convert cholesterol into bile acids. The researchers also note that another recent study identified a single nucleotide polymorphism associated with elevated TG levels in the exact same region, solidifying this part of chromosome 1 as the TG region. ...

UW launches cutting-edge DNA 'fin-printing' project for salmon

... Ocean and Bering Sea. The Seebs, who've been working for the Alaska Department of Fish and Game, are considered leaders in using single nucleotide polymorphism markers, referred to as SNPs and pronounced "snips." Identified by chemically treating a small bit of tissue, SNPs are differences along strands of ...

Genetic contributions to human brain morphology and intelligence

... also needs investigation as the high heritability of a complex quantitative phenotype such as brain volume cannot be explained by a single-gene polymorphism Conclusion MRI studies in twins indicate that, given the basic additive genetic model, overall brain volume in adulthood is highly ...

Genome study shines light on genetic link to height

... such as height and weight. After scrutinizing the initial data, the scientists identified a single letter change known as a single nucleotide polymorphism or SNP in the HMGA2 gene as the most promising result. They collaborated with additional researchers to study this SNP through a second phase of ...

JCI table of contents: Aug. 9, 2007

... raises the possibility that genetic mutations in UREs might have a critical role in the development of cancer. TITLE: A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia AUTHOR CONTACT: Daniel G. Tenen Harvard Medical School, Boston, ...

'Personality-gene' makes songbirds curious

... free-living animal populations, it would help a lot to know the molecular genetic mechanisms behind the trait." Typing the behavioural relevant Drd4 polymorphism it should be possible to follow micro-evolutionary changes in populations, which would result from changing selection pressures on different ...

Horse genome assembled

... are available at the Broad Institute web site ( www.broad.mit.edu/mammals/horse/snp ) and will be available shortly from NCBI's Single Nucleotide polymorphism database, dbSNP ( www.ncbi.nlm.nih.gov/SNP ). The initial sequencing assembly is based on 6.8-fold coverage of the horse genome, which means, ...

Mapping the mouse genome

... two groups of mice: one consisting of outbred, heterogeneous stock (HS) and the other of recombinant inbred lines (RI). Using the single nucleotide polymorphism (SNP) data that resulted from physical mapping of the mouse genome, the authors were able to track the patterns of inheritance of >10,000 SNPs in ...

Fire ants: Their true story told by the scientist who loves them

... is inevitable. So are class, sex, betrayal and new beginnings. And size matters, says Tschinkel. In mature colonies, unusual variability known as polymorphism produces big-headed workers 20 times heavier than their smallest counterparts. Between chapters science-rich enough for biologists but accessible ...

Variations in detoxifying genes linked to Lou Gehrig's disease

... variations (polymorphisms) on the chromosome region encompassing PON2-PON3 were strongly associated with sporadic ALS. "Thus, single nucleotide polymorphism genotyping in the intergenic regions of the PON gene cluster, and replication, gene expression, gene-gene interaction and PON serum/enzymatic studies ...

History of human cannibalism eats away at researchers

... ritualistic mortuary feasts. A high-profile study published nearly three years ago suggested that individuals who were heterozygous for a common polymorphism in the PRNP gene were relatively resistant to the disease. Over time, homozygotes who participated in the cannibalistic rituals purportedly ...

Gene variation increases SIDS risk in African Americans

... One out of nine African Americans carries one copy of the common variant. One copy does not appear to increase risk for infants. "The common polymorphism alone does not cause SIDS," said Steven Goldstein, M.D., Ph.D., professor and chairman of pediatrics at the University of Chicago and director of the ...

Variation in bitter-taste receptor gene increases risk for alcoholism

... Goate. "I don't think our result has any implications for the levels of alcoholism within different populations," Goate says. "We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many ...

Alcoholism, smoking and genetics among Plains American Indians

... patterns of alcohol and tobacco use among Plains American Indians, as well as the influence that a catechol-O-methyltransferase (COMT) functional polymorphism called Val158Met may have on these behaviors. "The shared heritability between smoking and alcoholism, particularly in heavy smokers and heavy ...

New study explores beetle species with two forms of females

... species of diving beetles that have two forms of females ?for example, one with a smooth back and another furrowed ?the researchers found that this polymorphism is actually a stable state, that is, neither of the forms go extinct. "The results have implications for the understanding of how genetic ...

U-M scientists say fused genes trigger the development of prostate cancer

... to just 24 hours, NCBI can make it an integral part of the build cycle for dbSNP," said NCBI's Stephen Sherry. "Every time there is a new release of polymorphism and human variation information in our database, our colleagues in California will be able to re-compute the haplotypes and tag SNPs." To underscore ...

California computer scientists double volume of data in NIH biotech repository

... to just 24 hours, NCBI can make it an integral part of the build cycle for dbSNP," said NCBI's Stephen Sherry. "Every time there is a new release of polymorphism and human variation information in our database, our colleagues in California will be able to re-compute the haplotypes and tag SNPs." To underscore ...

NIH renews network focused on how genes influence drug responses

... of cardiovascular disease. (Ronald M. Krauss, M.D., University of California, Berkeley/Lawrence Berkeley National Laboratory) Functional polymorphism Analysis in Drug Pathways --$10.5 million provided by NIGMS and NCI for a multidisciplinary team to study genetic variation in the molecular pathways ...

Open microfluidic and nanofluidic systems

... classical Young equation but can vary over a wide range of values. A surprising prediction of the new theory is that the experimentally observed polymorphism of the wetting liquid depends only on two parameters: (i) the channel geometry, i.e., the ratio of the channel depth to the channel width; and (ii) ...

Novel technology detects human DNA mutations

... the medical analysis of human DNA. Nanosphere's nanoparticle-based technology allows for rapid, highly-sensitive and specific Single Nucleotide polymorphism (SNP) genotyping, which is the direct detection of a particular gene and the extent to which it is normal or mutated. The technology, reported in ...
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