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Plaque in Biological News

Inflammation worsens danger due to atherosclerosis

... suggests that inflammation increases the risk of plaque rupture in atherosclerosis. The related report ... healthy individuals. One potential cause of plaque rupture is the thinning of the collagen fiber cap ... cells are often observed at the site of plaque rupture. Researchers led by Dr. Gran K Hansson ...

Eastman Dental Center awarded $1.6 million to find ways to prevent cavities

... reduce the ability of bacteria to form plaque and cause cavities. Most recently, Koo and his ... will better understand how these compounds affect plaque development and expand their potential usefulness to prevent plaque related diseases in humans," Koo said. ...

LIAI launches new division to look at novel approaches to heart disease and inflammation

... cause of most heart problems, was due to plaque formation caused solely by cholesterol buildup. ... community used to think cholesterol alone led to plaque formation," Ley explained. "While it is true ... immune system is also an important participant in plaque formation and weakening of the artery wall. As ...

Mutant gene identified as villain in hardening of the arteries

... or "furring" of the arteries is caused by plaque formation. In the vascular wall, Akt plays an ... regulating blood pressure, in blood clotting, in plaque formation in the arteries, and in formation of ... of lesions in the arterial wall and promote plaque stabilization to prevent an acute heart attack. ...

Trans fats hinder multiple steps in blood flow regulation pathways

... blood clots in the coronary arteries, and atherosclerosis, the buildup of plaque in the arteries to the point where it interferes with blood flow. "The ... the formation of plaques," Kummerow said. "They look corrugated, and this plaque buildup continues to the point where it will stop blood flow." Trans ...

Computational model examines the pathways of Alzheimer's that strikes at the young

... glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids that are found in large quantity in AD) were studied to ... to cause those changes. Nor was there any link found between amyloid beta plaque and tau tangles. The main conclusion of the model so far is that no single ...

Computational model examines the pathways of Alzheimer's that strikes at the young

... glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids that are found in large quantity in AD) were studied to ... to cause those changes. Nor was there any link found between amyloid beta plaque and tau tangles. The main conclusion of the model so far is that no single ...

Inhaling a heart attack: How air pollution can cause heart disease

... -- increase blood cholesterol levels and activate enzymes that cause plaque in the blood vessels to rupture. When plaque ruptures, it can cause a blood clot, which may block an artery and lead to ...

At risk for peripheral arterial disease? Simple quiz provides key so you can circulate better

... body and increases the risk for accelerated atherogenesisthe formation of plaque build up in the lining of the arteriesplacing 18.2 million Americans at ... narrows and clogs the arteries and slows blood flow to the legs. Since plaque blocks the smaller leg arteries first, PAD is considered a red flag for ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... led to a robust decrease in amyloid deposition in mice that develop plaque pathology commonly seen in Alzheimer's disease. Modulation of neuronal ... and cognitive deficits in mice that produced excessive amounts of the plaque forming protein. The approach poses a possibility to rescue ...

Mechanism explains link between apolipoprotein E and Alzheimer's disease

... lipidated forms of ApoE in a mouse model of AD resulted in reduced A? plaque levels and an improvement in contextual memory. The results of this ... of ApoE along with a seemingly paradoxical elevation of A? levels and plaque formation in mice. "Our data suggest that therapeutic agents that increase ...

Cigarette after Valentine snuggle deadlier for some

... good cholesterol. Unlike low-density lipoproteins (LDL), which build up plaque on artery walls and predispose a person to heart attacks or strokes, HDL helps filter LDL out of the blood and chips away at the plaque lining artery walls. When CETP has a common defect, it makes the ...

$13 million federal grant for research into vascular disease awarded to Weill Cornell

... that take place in arteries that predispose them to the formation of plaque and blood clots. The projects will continue investigations of the ... species and growth factors -- regulate blood-vessel cell activity and plaque formation, and that atherosclerosis acts like a blood clot, forming a ...

Lipids in the brain an important factor for Alzheimer's disease?

... came as a surprise, for it had long been assumed that the fibrils and the plaque they cause are stable and that once they have formed they cannot ... occurring in the brain can destabilize the fibrils, and therefore also the plaque that is so typical of Alzheimer's disease. The liberated protofibrils are ...

Protein handlers should be effective treatment target for cancer and Alzheimer's

... tumor growth, Dr. Mivechi says. Essentially the opposite happens in Alzheimer's in which excess protein is a major component of the destructive brain plaque that is the disease's hallmark. Dr. Mivechi believes molecular chaperones, which typically slow in activity with age, are failing at their job so ...

PNNL scientist garners early career presidential award

... professor in civil and environmental engineering at Washington State University, Tri-Cities. Each PECASE award winner will receive a citation, a plaque and a commitment from their agency for continued funding of their work for five years. Tartakovsky is one of 12 recipients of the award through the ...

Kelvin Lee winner of Biochemical Engineering Journal Young Investigator Award

... contributed to the field of biochemical engineering by a young community member. The award consists of a cash prize of 2,500 U.S. Dollars and a plaque presented at the 2009 Biochemical Engineering Conference ( http://www.engconfintl.org/9am.html ). Professor Lee will present a lecture at the ...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

... proteins start unfolding, amino acids that shouldn't get exposed can interact with other proteins to form unhealthy aggregates, such as the brain plaque that is the hallmark of Alzheimer's, Dr. Chadli says. "The role of molecular chaperones like Hsp90 is to prevent this from happening." In the ...

Penn Medicine honored for its historic role in the history of microbiology

... (PHILADELPHIA) The University of Pennsylvania was honored by The American Society for Microbiology last Friday with a plaque dedication ceremony celebrating the designation of its third Milestones in Microbiology site. Formally known as the Laboratory of Hygiene, the ...

AIUM presents 2009 Memorial Hall of Fame awards

... and gynecology, served as chief of obstetrics and gynecology at Denver General Hospital, and operated a private practice in Denver, Colorado. A plaque honoring each member of the Hall of Fame is displayed in a designated place in the Executive Office of the AIUM. ...

Christopher McCulloch receives the IADR Research in Oral Biology Award

... is one of the 16 IADR Distinguished Scientist Awards and is one of the highest honors bestowed by IADR. The award consists of a monetary prize and plaque and recognizes outstanding research in the field of oral biology. ...

Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape

... research team is to figure out which form of alpha-synuclein may accelerate formation of the types of protein aggregates found in Alzheimer's disease plaque and in Parkinson's disease Lewy bodies. Using single-molecule methods to directly construct binding-folding maps (as in the current work) will be a ...

Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

... study's lead author, neuroscientist Mark Burns, PhD, an assistant professor at GUMC. "No one knows why it occurs, but abnormal amounts of amyloid plaque have been found during an autopsy in about a third of brain injury victims, some of whom were children who would ordinarily never have had these ...

International study identifies gene variants associated with early heart attack

... for the first time; and one of the novel regions also had been found, in a separate study by O'Donnell, to promote the buildup of atherosclerotic plaque in the coronary arteries. To analyze the effect of inheriting several risk-associated SNPs, participants were assigned a genotype score, which ...

American Chemical Society's Weekly PressPac -- Jan. 28, 2009

... reliable test for diagnosing CAD is angiography, an invasive test in which doctors inject special dyes into the body to visualize, via X-rays, fatty plaque deposits in the arteries of the heart. However, the technique is invasive, expensive, time-consuming, and may miss CAD in its earliest stages, they ...

JCI online early table of contents: Jan. 19, 2009

... where a blood clot (otherwise known as a thrombus) forms in a blood vessel supplying the heart at the site of a ruptured or eroded atherosclerotic plaque (the entity that causes hardening or furring of the arteries). Platelets have a key role in the development of these blood clots, and the development ...

Athletes not spared from health risks of metabolic syndrome

... include excess fat in the abdominal area (as measured by waist circumference), borderline or high blood pressure, cholesterol problems that foster plaque buildup in arteries, insulin resistance or glucose intolerance indicating the body can't properly use insulin or blood sugar, and the presence of a ...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

... induced increases in BACE1. The researchers went on to show that energy inhibition increased eIF2? phosphorylation, BACE1 levels and amyloid plaque formation in APP transgenic mice. In addition, phosphorylated eIF2? and BACE1 were elevated in an aggressive A? plaque-forming mouse model and in ...

A scientific breakthrough on the control of the bad cholesterol

... for eliminating LDL-cholesterol particles. Thus, the presence of PCSK9 leads to a surplus of bad cholesterol in the bloodstream and contributes to plaque formation, leading to blockage of blood vessels and arteries. This phenomenon is a major risk factor that can lead to cardiovascular diseases, such ...

Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?

... of rinsing with a cocoa flavanol extract without other oral hygiene methods (such as brushing or flossing) participants had decreased bacteria and plaque on their teeth*3. While some research is conducted with isolated properties and extracts from the cocoa bean, several of the studies showing ...

Aspirin and atherosclerosis

... seem to account for this. In a new study, though, researchers have uncovered the mechanism that may explain aspirin's ability to prevent arterial plaque buildup. Using cell culture and mouse models, Sampath Parthasarathy and colleagues observed that aspirin specifically its active byproduct ...

MSU biofilms research helps set standards for everyday products

... bacteria, it really does the job. Biofilms are the extremely common communities of bacteria that form on most wet surfaces. They range from the plaque on teeth to the slime on streamside rocks to the sludge that clogs pipes. Most biofilms are harmless, but some have been linked to ailments such ...

LSUHSC awarded $10M+ COBRE grant

... cardiovascular disease, diabetes, and sepsis. Dr. Bazan's project is designed to fill major gaps in our knowledge regarding the process of carotid plaque instability and rupture resulting in stroke. "In the state of Louisiana, the incidence rate for cardiovascular disease is disproportionately high, ...

The good and the bad of a potential Alzheimer's target

... did just that, using transgenic fruit flies expressing human NEP and/or amlyoid-beta protein. On the positive side, NEP expression did reduce plaque deposits and neuron damage in the flies as expected; on the other hand, NEP also reduced the activity of important neural proteins called CREB ...

Outstanding undergraduates recognized in agronomy, crop, soil, and environmental sciences

... and SSSA. Each year, top-notch seniors are selected for the award based on their scholarship, leadership, and participation. The students receive a plaque as part of their recognition and also become eligible to apply for the Frank D. Keim Fellowship if they are pursuing a graduate degree. The 2008 ...

AGU Journalism Awards won by Margaret Munro and Dr. Richard Smith

... late science editor of The New York Times, and David Perlman, science editor of the San Francisco Chronicle, respectively. Each award consists of a plaque and a $2,000 stipend. ...

Veterinary college researchers explore function of biofilm in bovine respiratory disease

... said Inzana. A biofilm is an organized community of bacteria that forms a glue-like substance that adheres to a variety of surfaces. The plaque on your teeth is a biofilm, as is the slime that often forms on meat that has been left out too long. While some biofilms are harmless, they can also ...

UTSA receives $822,000 from Kleberg Foundation to enhance scientific research

... Foundation and the only child of the Klebergs. Groves was joined by UTSA Development Board chairman Tom C. Frost in unveiling a commemorative plaque honoring the memory of her parents and celebrating the generosity of the foundation and its commitment to UTSA. George Perry, dean of the UTSA ...

New technology sharpens X-ray vision

... striking. The improved sensitivity in measuring bone density and hairline fractures could help diagnose the onset of osteoporosis. Because cancer or plaque cells scatter radiation slightly differently than normal cells, dark-field x-ray images can also be used to explore soft tissue, providing safer ...

Study locates cholesterol genes; finds surprises about good, bad cholesterol

... to reexamine the roles of good and bad cholesterol in susceptibility to heart disease," Abecasis said. Coronary artery disease, a condition where plaque accumulates on the walls of coronary arteries, is the most common type of heart disease and a leading cause of death in industrialized countries. The ...
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