Navigation Links
Phosphatase in Biological News

New insight into the mechanisms of voltage sensing and transduction in biological processes

... Bioscience, examine a voltage-sensitive phosphatase that converts an electrical to a chemical signal; ... were the major substrates of the phosphatase activity, and whether depolarisation or hyperpolarisation induced the phosphatase activity. By expressing phosphoinositide-specific ...

CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die

... transcription factor while, in other contexts, is also known to act as a phosphatase that is, it can remove phosphate groups from other proteins." The role of Eyes Absent in DNA damage repair EYA was shown to be a phosphatase by three separate groups in 2003. Although it was thought to be a PTP - ...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

... to cancer," Waldman says PTPRD produces a receptor protein tyrosine phosphatase that bisects the outer membrane of a cell. The part that protrudes outside ... yet in melanoma," Waldman says. "Before this study, no single tyrosine phosphatase was thought to play a generally important role as a tumor suppressor gene ...

Tumor suppressor gene in flies may provide insights for human brain tumors

... a counterpart in mammals, that can apparently prevent brain tumors from forming. "Our data explicitly show that the fruitfly protein PP2A (protein phosphatase 2A) suppresses brain tumor formation and controls the balance of self-renewal and differentiation of neural stem cells," said Hongyan Wang, Ph.D, ...

Key protein regulating inflammation may prove relevant to controlling sepsis

... the severe inflammatory condition caused by bacterial infection that afflicts many patients in intensive care units (ICU). In their paper, "WIP1 phosphatase is a negative regulator of NFκB signaling," published in the May 2009 issue of Nature Cell Biology (NCB), the IMCB scientists described their ...

Decreasing insulin resistance prevents obesity-related cardiovascular damage

... disease is the biggest health threat of obesity and Medical College of Georgia researchers trying to understand why have knocked out protein tyrosine phosphatase 1B, or PTP1B, in genetically fat mice that get diabetes. "Even before you have really bad diabetes, you are walking around obese with your glucose ...

Washington University scientists first to sequence genome of cancer patient

... novel mutations discovered, three were found in genes that normally act to suppress tumor growth. One of these mutations is in the PTPRT tyrosine phosphatase gene, which is frequently altered in colon cancer. Four other mutated genes appear to be involved in molecular pathways that promote cancer ....

SEX4, starch and phosphorylation

... across kingdoms. Amylopectin has similarities to glycogen, the soluble storage carbohydrate accumulated in animals, fungi, and bacteria. The SEX4 phosphatase is related to laforin, a protein involved in animal glycogen metabolism. When laforin is missing, insoluble starch-like polyglucosans (Lafora ...

Biophysical Society announces 2008 International Travel Awards

... Md. I. Hossain, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan, Voltage Range for Tuning of phosphatase of Ci-vsp as Measured by Two PIP2-Sensors. Naranamangalam R. Jagannathan, All India Institute of Medical Sciences, New Delhi, India, Role of ...

'Computer-chemistry' yields new insight into a puzzle of cell division

... the probable orientation required for a Cdc25B phosphatase enzyme to "dock" with and activate a ... sites" -- where chemical reactions occur --on the phosphatase and the kinase to link precisely, Rudolph said. ... residues the study identified, one residue on the phosphatase and the other on the kinase. Both hot spots are ...

Natural tumor suppressor in body discovered by UCSD medical researchers

... Located on chromosome 18 and called PH domain Leucine-rich repeat Protein phosphatase (PHLPP, pronounced "flip"), the tumor suppressor is described in the April ... Based on the chemical components of Akt, they specifically looked for a phosphatase linked to the PH domain, a protein module found in a wide variety of ...

UCSD researchers discover variants of natural tumor suppressor

... research by Newton's lab, also published in Molecular Cell, described the discovery of an enzyme they named PH domain Leucine-rich repeat Protein phosphatase (PHLPP, pronounced "flip") that turns off signaling of the Akt/protein kinase B, a protein which controls cell growth, proliferation and survival. ...

PTEN: the Treg's handbrake

... of Clinical Investigation, Laurence Turka and colleagues from the University of Pennsylvania have shown that Tregs from mice with T cells that lack phosphatase and tensin homolog (PTEN) proliferate in response to IL-2. Importantly, PTEN-deficient Tregs retained their suppressive function in vitro and in ...

Rutgers researchers find fat gene

... fat metabolism; they just didn't know how. The Carman team's first revelation came with the discovery that lipin is an enzyme (phosphatidic acid phosphatase or PAP), a protein catalyst that is required for the formation of fats ?triglycerides, specifically. The breakthrough for Carman's group grew out ...

Study uncovers placental microtransfusions lead to transmission of AIDS virus during childbirth

... medicine at the University of Melbourne. The study involved measuring -- in umbilical cord blood samples -- a protein known as placental alkaline phosphatase as an indicator of maternal-fetal microtransfusion. "This enzyme, made in the placenta, is very big -- usually too big to pass through the natural ...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

... that Akt inactivation by dopamine involves the formation of a previously unidentified complex containing beta-arrestin 2, Akt and a third protein phosphatase 2A that inactivates Akt. Mice lacking beta-arrestin become less responsive to certain drugs and exhibit abnormalities in behaviors, such as ...
Other Contents
(Date:9/12/2014)... an active role in the destruction and remodelling ... being an ,innocent bystander, as previously thought. , ... Lawler, Dr Ben Croker and colleagues from the ... while investigating the role of the protein SOCS3 ... was published in the journal Arthritis and ...
(Date:9/12/2014)... coccidiosis is a serious parasitic infection of young ... to diarrhoea and reduced nutritional intake. As the ... can result in increased mortality, the disease is ... farms., "The developing immune system of neonatal piglets ... the parasites. For this reason, an infection shortly ...
(Date:9/11/2014)... with autism often show a reduced frequency of ... in repetitive solitary behaviors. Autism has also been ... structure involved in processing emotions. Now Caltech researchers ... amygdala that control whether the animal engages in ... may have implications for understanding neural circuit dysfunctions ...
Breaking Biology News(10 mins):No innocent bystander: Cartilage contributes to arthritis 2Piglet health 2Piglet health 3Tipping the balance of behavior 2Tipping the balance of behavior 3
(Date:9/14/2014)... News) -- Getting enough sleep each night may mean you,re less ... new study suggests. The study included more than 3,700 people ... average of seven years. Those who slept less than six ... likely to have extended absences from work due to illness, the ... from work due to sickness were those who slept between seven ...
(Date:9/14/2014)... 2014 Top10BestSEOHosting.com always offers truly ... web host suppliers carefully, the site has announced ... are the Best WordPress Hosting suppliers in the ... a top web hosting provider, and the company’s ... web hosting provider known for its flexible hosting ...
(Date:9/14/2014)... A new DePuy Pinnacle hip lawsuit has ... behalf of a Franklin County, Ohio man who underwent hip ... metal-on-metal hip lawsuit filed against Johnson & Johnson and its ... 40 years old when the Pinnacle Hip device was surgically ... According to the hip implant lawsuit , the man underwent ...
(Date:9/14/2014)... School requires that children read at both near ... screened only for far vision when they enter school. , ... their eyes do not track effectively or focus (team) on ... avoid reading; at worst, they will think there is ... Children who cannot see cannot read. , On November ...
(Date:9/13/2014)... Recently, an experienced supplier of wedding ... its new collection of eggplant evening dresses . ... discounted rates, up to 58% off. According to the ... September 23. , The company’s new items are ... vintage, plus size, modest, sexy outfits and so on. ...
Breaking Medicine News(10 mins):Health News:A Good Night's Sleep May Mean a Good Day's Work 2Health News:Top10BestSEOHosting.com: The Best Linux Web Hosting Suppliers Now Unveiled 2Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 2Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 3Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 4Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 5Health News:Cheap Eggplant Evening Dresses Now Announced By Experienced Company iFitDress.com 2
Other TagsOther Tags