New insight into the mechanisms of voltage sensing and transduction in biological processes
... Bioscience, examine a voltage-sensitive phosphatase
that converts an electrical to a chemical signal; ... were the major substrates of the phosphatase
activity, and whether depolarisation or hyperpolarisation induced the phosphatase
activity. By expressing phosphoinositide-specific ...
CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die
... transcription factor while, in other contexts, is also known to act as a phosphatase
that is, it can remove phosphate groups from other proteins."
The role of Eyes Absent in DNA damage repair
EYA was shown to be a phosphatase
by three separate groups in 2003. Although it was thought to be a PTP - ...
GUMC researchers find gene function 'lost' in melanoma and glioblastoma
... to cancer," Waldman says
PTPRD produces a receptor protein tyrosine phosphatase
that bisects the outer membrane of a cell. The part that protrudes outside ... yet in melanoma," Waldman says.
"Before this study, no single tyrosine phosphatase
was thought to play a generally important role as a tumor suppressor gene ...
Tumor suppressor gene in flies may provide insights for human brain tumors
... a counterpart in mammals, that can apparently prevent brain tumors from forming.
"Our data explicitly show that the fruitfly protein PP2A (protein phosphatase
2A) suppresses brain tumor formation and controls the balance of self-renewal and differentiation of neural stem cells," said Hongyan Wang, Ph.D, ...
Key protein regulating inflammation may prove relevant to controlling sepsis
... the severe inflammatory condition caused by bacterial infection that afflicts many patients in intensive care units (ICU).
In their paper, "WIP1 phosphatase
is a negative regulator of NFκB signaling," published in the May 2009 issue of Nature Cell Biology (NCB), the IMCB scientists described their ...
Decreasing insulin resistance prevents obesity-related cardiovascular damage
... disease is the biggest health threat of obesity and Medical College of Georgia researchers trying to understand why have knocked out protein tyrosine phosphatase
1B, or PTP1B, in genetically fat mice that get diabetes.
"Even before you have really bad diabetes, you are walking around obese with your glucose ...
Washington University scientists first to sequence genome of cancer patient
... novel mutations discovered, three were found in genes that normally act to suppress tumor growth. One of these mutations is in the PTPRT tyrosine phosphatase
gene, which is frequently altered in colon cancer.
Four other mutated genes appear to be involved in molecular pathways that promote cancer ....
SEX4, starch and phosphorylation
... across kingdoms. Amylopectin has similarities to glycogen, the soluble storage carbohydrate accumulated in animals, fungi, and bacteria. The SEX4 phosphatase
is related to laforin, a protein involved in animal glycogen metabolism. When laforin is missing, insoluble starch-like polyglucosans (Lafora ...
Biophysical Society announces 2008 International Travel Awards
Md. I. Hossain, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan, Voltage Range for Tuning of phosphatase
of Ci-vsp as Measured by Two PIP2-Sensors.
Naranamangalam R. Jagannathan, All India Institute of Medical Sciences, New Delhi, India, Role of ...
'Computer-chemistry' yields new insight into a puzzle of cell division
... the probable orientation required for a Cdc25B phosphatase
enzyme to "dock" with and activate a ... sites" -- where chemical reactions occur --on the phosphatase
and the kinase to link precisely, Rudolph said. ... residues the study identified, one residue on the phosphatase
and the other on the kinase. Both hot spots are ...
Natural tumor suppressor in body discovered by UCSD medical researchers
... Located on chromosome 18 and called PH domain Leucine-rich repeat Protein phosphatase
(PHLPP, pronounced "flip"), the tumor suppressor is described in the April ... Based on the chemical components of Akt, they specifically looked for a phosphatase
linked to the PH domain, a protein module found in a wide variety of ...
UCSD researchers discover variants of natural tumor suppressor
... research by Newton's lab, also published in Molecular Cell, described the discovery of an enzyme they named PH domain Leucine-rich repeat Protein phosphatase
(PHLPP, pronounced "flip") that turns off signaling of the Akt/protein kinase B, a protein which controls cell growth, proliferation and survival. ...
PTEN: the Treg's handbrake
... of Clinical Investigation, Laurence Turka and colleagues from the University of Pennsylvania have shown that Tregs from mice with T cells that lack phosphatase
and tensin homolog (PTEN) proliferate in response to IL-2. Importantly, PTEN-deficient Tregs retained their suppressive function in vitro and in ...
Rutgers researchers find fat gene
... fat metabolism; they just didn't know how.
The Carman team's first revelation came with the discovery that lipin is an enzyme (phosphatidic acid phosphatase
or PAP), a protein catalyst that is required for the formation of fats ?triglycerides, specifically.
The breakthrough for Carman's group grew out ...
Study uncovers placental microtransfusions lead to transmission of AIDS virus during childbirth
... medicine at the University of Melbourne.
The study involved measuring -- in umbilical cord blood samples -- a protein known as placental alkaline phosphatase
as an indicator of maternal-fetal microtransfusion.
"This enzyme, made in the placenta, is very big -- usually too big to pass through the natural ...
Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
... that Akt inactivation by dopamine involves the formation of a previously unidentified complex containing beta-arrestin 2, Akt and a third protein phosphatase
2A that inactivates Akt. Mice lacking beta-arrestin become less responsive to certain drugs and exhibit abnormalities in behaviors, such as ...