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Phenotypic in Biological News

7th annual [BC]2 Basel Computational Biology Conference 'Molecular Evolution' June 18-19, 2009

... process. Richard E. Lenski, who will be speaking about the "Dynamics of phenotypic and Genomic Evolution During a 40,000-Generation Experiment with E. coli", ... findings in this project providing new insights on the dynamic coupling of phenotypic and genomic evolution and the role of complex mutations in the origin of ...

Researchers document rapid, dramatic 'reverse evolution' in the threespine stickleback fish

... a widely held theory behind rapid evolutionary change, the idea of phenotypic plasticity when an organism can take on different characteristics ... diet growing up, Peichel said. Our findings challenge the primary role of phenotypic plasticity in rapid evolutionary change. The gene that controls for ...

Tiny genetic differences have huge consequences: McGill researchers

... protein coding sequences could be responsible for the enormous variety of phenotypic differences between individuals. It had previously been shown that ... distinguish you and me, and yet it would be very hard to explain all the phenotypic differences in the way we look, grow, and behave just by the handful of ...

Measuring intellectual disability

... suggest that "[this] method should prove to be a powerful tool for further investigation of the relationships between FMRP and the diverse clinical phenotypic domains [of fragile X syndrome]." "Such domains include not only autism and autism spectrum disorders, but also developmental delay, behavioral ...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

... has, on average, decreased nearly one centimeter per year. The changes observed very likely are evolutionary genetic changes and not simply plastic phenotypic responses to the environment. They are comparable to changes that preceded the collapse of northern cod at Newfoundland. This finding further ...

The neurobiology of musicality related to the intrinsic attachment behavior?

... music together may add group cohesion. Thus, it is justified to hypothesize that music perception and creativity in music are linked to the same phenotypic spectrum of human cognitive social skills, like human bonding and altruism both associated with AVPR1A. We have shown for the first time in the ...

A genome may reduce your carbon footprint

... sequence assembly nor gene annotation is required to apply these techniques. In a species such as switchgrass there exists a great deal of phenotypic variation derived from latitudinal adaptation across its natural range and local adaptation to soil, temperature, and moisture conditions. It is ...

Color test enhances tomato analyzer software

... to analyze the morphology of tomato fruit. The researchers in this study developed a module for color measurement "to expand the array of objective phenotypic analyses implemented". TACT was applied to fruits and vegetables of various color and color uniformity. "TACT was designed to be user-friendly ...

Identifying mega-targets for high-yield plant breeding

... programs. Results from this research are published in the January 2009 issue of the journal Crop Science . The researchers found that all phenotypic traits had significant genetic diversity, but only seven of the 20 traits evaluated showed differences in the amount of diversity among the breeding ...

BioScience tip sheet, February 2009

... research articles: Biological Resource Centers and Systems Biology. Yufeng Wang and Timothy G. Lilburn. The authors propose leveraging phenotypic data from the few bacteria in resource collections that are well characterized with the larger numbers of bacteria for which there exist genetic ...

Pigs and dogs can bridge gap between mice and humans in developing new therapies

... (phenotypes), so that results can be compared across Europe. "The workshop showed that there is excellent expertise in individual labs, but the phenotypic tests need to be harmonised and standardised to facilitate comparison of results obtained in different labs," said Angelika Schnieke, one of the ...

Springer and the Physiological Society of Japan sign publishing agreement

... in Tokyo and Editor-in-Chief of The Journal of Physiological Sciences , said, "In the post-genome era, increasing interest is being devoted to phenotypic expression and the function of the organism. As a result, the body of new knowledge about physiology, which can be ultimately applied to improving ...

The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness

... appears to be an evolutionarily conserved regulatory factor, and may serve to globally modify bacterial responses to microgravity, regardless of the phenotypic outcomea decrease in virulence for M9 cultures grown in microgravity environments and an increase for bacteria steeped in the LB medium. But what ...

USC researchers head global effort to study genetic risks that contribute to psychiatric diseases

... in creating the Genomic Psychiatry Cohort. Blood and DNA from 40,000 subjects will be deposited in the NIMH repository, along with clinical and phenotypic data. Professors Michele T. Pato, M.D., holder of the Della Martin Chair in Psychiatry, and Carlos N. Pato, M.D., Ph.D., chair of the Department ...

December 2008 highlights from Biology of Reproduction

... context in the analysis of sex differentiation pathways. Susan Y. Park, Eun-Jig Lee, Donna Emge, Carolyn L. Jahn, and J. Larry Jameson. A phenotypic Spectrum of Sexual Development in Dax1(Nr0b1) -Deficient Mice: Consequence of the C57BL/6J Strain on Sex Determination. Biol Reprod 2008; ...

Prominent German biologist wins EMBO Communication Award

... prestigious journals, including Nature and Science, along with over 30 reviews and numerous book reviews. His focus is the speciation, genetics of phenotypic innovations and comparative genomics of fish. A prize of 5,000 euro and a handcrafted medal will be presented to Axel Meyer at the 7th Annual ELSO ...

ETH Zurich study on salmonella self-destruction

... specialises in salmonella infections; Professor Doebeli is a mathematician and theoretical biologist; and Professor Ackermann's group focuses on phenotypic noise. ...

The genetics of the white horse unraveled

... by Charles Darwin. The white horse is a beautiful illustration of the importance of regulatory mutations as a major underlying mechanism for phenotypic diversity within and between species. The Grey mutation does not change any protein structure but it affects the genetic regulation of two genes. The ...

BWF awards $7 million to infectious disease investigators

... David Artis, Ph.D. University of Pennsylvania Tracking helminth-specific immune responses in vivo Richard Bennett, Ph.D. Brown University phenotypic variation and host adaptation by the human fungal pathogen Candida albicans Miriam Braunstein, Ph.D. University of North Carolina-Chapel Hill ...

The sweet world of soil microbiology

... of several different shapes and sizes, each representing a unique soil microorganism. The physical appearance of the candy is a substitute for the phenotypic and genetic diversity that microbiologists would find in a soil microbial community. Small student groups work to organize the candy. They base ...

Biomarkers allow doctors to match therapy to patient

... CD34bright and CD133neg during sunitinib or bevacizumab treatment. They labeled them candidate cells because no data have proven definitively the phenotypic relationship between progenitor and blood-derived endothelial outgrowth cells, Vroling said. Their study included 23 patients with renal cell ...

Scientists unravel the genetic coding of the pea

... at different developmental stages, (from seedling through to fruit maturation), and also incorporates digital images of the plants. UTILLdb contains phenotypic as well as sequence information on mutant genes, and can be searched for TILLING alleles of genes of interest, using the BLAST tool, and for plant ...

Leading researchers and experts gather to discuss latest advancements in drug discovery

... challenges and automation solutions in the field. Topics and speakers scheduled for the St. Louis meeting this year include: Methods in phenotypic and mechanistic screening for primary cells and stem cells in drug discovery Latest techniques in targeting the appropriate genes in the human ...

Genomics throws species definition in question for microbes

... persisted and novel issues arose," says Roberts. "Conflicts exist between phenotypic and phylogenetic information, the means for classifying non-cultured ... the current paradigm, and microbial species do not always demonstrate the phenotypic or genetic cohesiveness expected of them. For these reasons and others it ...

Weapon performance determines mating success in the collared lizard

... species with polygynous mating systems, reproductive success reflects phenotypic variation. At the gross level, such phenotypic variation can include that of body size and weapon morphology, as well as ...

Evolution of influenza A virus

... virus evolution more difficult, as vaccine strain selection then becomes dependent upon intensive surveillance, whole-genome sequencing, and phenotypic ...

New technology used to construct the first map of structural variation in the human genome

... some forms of color blindness, and many other diseases. They lead to variation in gene expression levels and may account for a large amount of phenotypic variation among individuals and ethnic populations, including differential responses to drugs and environmental stimuli. Mechanisms underlying the ...

Mutant mice show key autism traits

... example, the Pten mutants do not display the expression of abnormal repetitive behaviors seen in ASD, although it is unreasonable to expect perfect phenotypic overlap of human ASD with any mouse model." Also, they wrote, "as appropriately pointed out by the authors, Pten deletion is restricted to ...

A new kind of mutation could explain numerous phenotypic variations in various species

... do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species ?among which humans ?including the hereditary predisposition to various diseases. Researchers at ULg have thus ...

Chimpanzee study reveals genome variation hotspots

... answer, but an exciting first step in studying the evolution of copy number variant regions and their downstream implications for disease and phenotypic variation," Perry says. In the study, researchers looked at the structural genomic variation in DNA samples of 20 wild-born male chimpanzees. ...

Relationship of brain and skull more than just packaging

... publication of the Journal of Experimental Zoology: Molecular and Developmental Evolution: "Our study represents the first empirical evidence of phenotypic integration of brain and skull in 3D, although indirect evidence has been accumulating for years." The researchers are also interested in ...

Interactive 3-D atlas of mouse brain now available on web

... in parallel with an international collaboration, the Mouse Phenome Database (MPD) project, which was created to establish a collection of baseline phenotypic data from commonly used inbred mice. The new brain atlas database consists of 3-D anatomical data from 10 adult male mice of the strain C57BL/6J, ...

Dog genome sequenced

... genetic studies along with the mouse, rat, and several insect species." phenotypic variation among dog breeds, whether it be in size, shape, or behavior, is ... the canine genome and describe the potential impact of these insertions on phenotypic diversity in dogs. "These SINEs are bimorphic, which means that at a ...

Scientists fetch useful information from dog genome publications

... genetic studies along with the mouse, rat, and several insect species." phenotypic variation among dog breeds, whether it be in size, shape, or behavior, is ... the canine genome and describe the potential impact of these insertions on phenotypic diversity in dogs. "These SINEs are bimorphic, which means that at a ...

Phenotype is influenced by nature, nurture and noise

... leads to oscillations in gene regulation that couldn't otherwise be predicted. Such noise is routinely described by cell biologists who record large phenotypic differences between supposedly identical cells in a single flask of growth medium. The mental picture most biologists have of a cell is of a ...

Optimizing cell therapy against tumors is a balancing ACT

... optimal for treating large, vascularized, established tumors. The authors use a mouse model that mimics the human clinical situation. They find that phenotypic and functional qualities of T cells are associated with the ability of ACT to cause regression of large, established melanomas. Seemingly ...

Researchers develop new method for facile identification of proteins in bacterial cells

... may be directed to Deborah Alper at the Johns Hopkins Bloomberg School of Public Health at dalper@jhsph.edu or 443-287-0402. "Identification and phenotypic Characterization of Sphingomonas wittichii Strain RW1 by Peptide Mass Fingerprinting Using Matrix-Assisted Laser Desorption Ionization-Time of Flight ...

Scientists document complex genomic events leading to the birth of new genes

... transcripts. This overexpression often alters the fragile molecular balance of gene products on a cellular level, ultimately resulting in deleterious phenotypic consequences. If these duplicated genes acquire new functions, however, they may confer a selective advantage to an organism, leading to the rise of ...
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