Pulmonary hypertension in children may result from reduced activity of gene regulator
In a surgically created animal model of a congenital heart defect that causes too much pulmonary blood flow, they have already shown PPARs peroxisome
proliferator-activated receptors are down regulated. In these lambs, whose four-chambered hearts are essentially identical to humans, agonists to ...
Resveratrol prevents fat accumulation in livers of 'alcoholic' mice
... found that the increased expression of SIRT1 and AMPK led to:
Reduction of sterol regulatory element binding protein (SREBP-1)
Activation of peroxisome
proliferator-activated receptor gamma co-activator alpha (PGC-1α)
Elevation of circulating adiponectin, a hormone produced by fat cells, which ...
Biologists at UC San Diego identify key protein in cell's 'self-eating' function
... understand how and why they are selected by the lysosome for degradation.
What the biologists found, he said, is that this new protein can mediate peroxisome
selection during pexophagy that is, it is necessary for pexophagy, but not for other autophagy-related processes.
Suresh Subramani, a professor ...
Hormone helps mice 'hibernate,' survive starvation
... at play during starvation and fasting.
They focused on a nuclear receptor – a protein that turns genes on and off in the body – called peroxisome
proliferator-activated receptor alpha, or PPAR-alpha, which is known to control the use of fat as energy. Starving mice without PPAR-alpha become ...
Fat screen delivers plant-derived chemical with antidiabetic effects
... or TZDs, work through a counterintuitive mechanism: they restore insulin sensitivity by activating a central promoter of fat tissue production called peroxisome
proliferator-activated receptor ã (PPARã).
"The current explanation for this paradoxical mode of action is the idea that the body needs a place ...
Gut research yields new anti-cancer approach
... a new way to fight colorectal cancer, and potentially cancers of the esophagus, liver and skin. Early work shows that a group of compounds called peroxisome
proliferator-activated receptor-gamma (PPARgamma) inhibitors may have an unexpected cancer-fighting effect, according to research published today in ...
New understanding of parasite cell structures may provide treatments for serious tropical diseases
The new research will open areas for further investigation.
"Before this work in trypanosomes, there was no evidence that we could 'catch' peroxisome
proteins moving to the ER" said Mensa-Wilmot. "With better understanding of the process we could begin looking for compounds that may act as drugs by ...
Opposing fat metabolism pathways triggered by a single gene
... expression of another gene fat-7, which, by reducing acs-2, increases fat content. In its function, nhr-49 resembles a mammalian NHR, called peroxisome
proliferator-activated receptors (PPARs). Further investigation of this link may lead to better understanding of the functions of PPARs and provide ...