Singapore nanotechnology combats fatal brain infections
... and fungal infections with novel peptide
nanoparticles developed by scientists at the ... and brain damage in patients.
nanoparticles, on the other hand, contain a ... that require treatment. The ability of IBN's peptide
nanoparticles to traverse the blood brain barrier ...
Tips from the journals of the American Society for Microbiology
Newly Developed Antimicrobial peptide
May Protect Mice from Lethal Bacterial Infections ... from Japan suggest that a synthetic antimicrobial peptide
identified as L5 may prevent death in mice ... researchers developed the cationic antimicrobial peptide
L5 out of antibacterial proteins from Sarcophaga ...
Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies
... designed to prevent build-up of amyloid, a toxic peptide
found in the brain. This peptide
clogs the brains of Alzheimer's patients but it ... the investigators sought to understand if amyloid peptide
contributed to secondary injury. Amyloid peptides ...
Peptides-on-demand: McGill researcher's radical new green chemistry makes the impossible possible
... "Currently, to generate peptides you must use a peptide
synthesizer, an expensive piece of high-tech ... to construct a single, simple "skeleton" peptide
which can be modified into any other peptide
needed with the addition of a simple reagent.
Common gene variants increase risk of hypertension, may lead to new therapies
... variants associated with changes in natriuretic peptide
levels were then tested in the same individuals ... the heart when it is stressed, and screening for peptide
levels is widely used to diagnose heart failure, ... premature to advocate screening natriuretic peptide
levels or gene variants to diagnose hypertension ...
Gene therapy reversed heart damage in heart failure
... rats were treated with a gene that generates a peptide
called ARKct, which was administered to ... show that beta blockers and the ARKct peptide
are compatible and can be given together," Dr. ...
In future trials in humans, the ARKct peptide
will be administered with beta blockers, which ...
Cancer cell 'bodyguard' turned into killer
... Research in La Jolla, Calif., have developed a peptide
that converts the Bcl-2 protein from a cancer ... in October.
The key to the conversion is peptide
NuBCP-9, a string of nine amino acids that bind ... outside the petri dish, researchers injected the peptide
and its mirror-image molecule into cancer tumors ...
Syracuse University researchers discover new way to attack some forms of leukemia
... identified a tiny component of the MLL proteina peptide
sequence that contains just six amino acidsthat ... in normal cells. The team members called this peptide
sequence the "Win" motif. They discovered that a synthetic version of this peptide
acts like a drug that breaks apart the MLL ...
Burnham researchers turn cancer friend into cancer foe
... today announced that scientists have created a peptide
that binds to Bcl-2, a protein that protects ... that usually keeps cancer cells in check. This peptide
(called NuBCP-9) and its enantiomer (mirror-image ... Satterthwait, Ph.D. and others.
The NuBCP-9 peptide
was created from Nur77, a potent pro-apoptotic ...
Discovery of natural compounds that could slow blood vessel growth
... by a number of proteins, like the sequence of the peptide
building blocks, the team first categorized the ... then used computer programs and compared the peptide
families to all of the proteins encoded by the ... and survival, they added different amounts of peptide
to dishes containing roughly 2,000 cells and ...
Chemists make beds with soft landings
... soft-landing can be used to prepare ultrapure peptide
layers on substrates. The question we faced was, ... the surface.
When the chemists examined the peptide
shapes in the solution and the resulting thin ... Wang.
Next, the team would like to create thin peptide
layers using different support surfaces and a ...
Researchers coat titanium with polymer to improve integration of joint replacements
... same type of fibronectin that included the RGD peptide
sequence as well as new sections also known to ... engineers Petrie and Garca modified them with peptide
Two-millimeter circular defects ... uncoated titanium, titanium coated with the RGD peptide
and titanium coated with different densities of ...
A molecular switch turns on the flame in 'nature's blowtorch'
... by a 180 degree rotation around a single peptide
bond. In one orientation, both oxygen and the ... This binding drives the reorientation around the peptide
bond, and moves the P450 from the form in which ... cycle can repeat. The reorientation of a single peptide
bond, an event called an "isomerization," thus ...
Seeing Alzheimer's amyloids
... three-dimensional picture of an Alzheimers peptide
aggregate using electron microscopy. The study, ... of how these fibrils are built from the A-beta peptide
(Alzheimer's peptide), said co-author Nikolaus ... an actual 3D image.
In healthy people A-beta peptide
does not aggregate, but in Alzheimers patients it ...
Taking the fight against cancer to heart
... vessels and lowers blood pressure
which increases potassium excretion
The hormones, called peptide
hormones because they are composed of amino ... such well-known hormones as insulin, are peptide
Started with congestive heart ...
Researchers reveal HIV peptide's possible pathway into the cell
... is the long-sought-after pathway that an HIV peptide
takes to enter healthy cells. The theorists ... the type of materials that can piggyback on the peptide
and also enter the cell. Researchers have proposed using the peptide
to deliver genes for gene therapy and drugs that ...
Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
... year, researchers at Weill Cornell manipulated a peptide
(protein) related to a third pathogen, ... However, the Weill Cornell team discovered that a peptide
specific to the parainfluenza virus "fusion ... too."
The team discovered just why the F peptide
works so well in a collaboration with Dr. Min Lu, ...
Scripps research team identifies key molecules that inhibit viral production
... the actual virus itself.
"We went for the simplest solution, taking a peptide
from core to see if we could block the interaction," Strosberg said, "and ... HCV production by 68 percent and 63 percent, respectively; a third related peptide
showed 50 percent inhibition. When added to HCV-infected cells, each of ...
Single virus used to convert adult cells to embryonic stem cell-like cells
... DNA, it begins making a protein. However, when it tries to read the 2A peptide
DNA that resides between the genes, the machinery momentarily stops, ... creates that gene's protein, stalls when reaching another piece of 2A peptide
DNA, and releases the second gene's protein. The process continues until ...
Epilepsy drug shows potential for Alzheimer's treatment
... to be caused by the gradual accumulation in the brain of amyloid-beta peptide
which is toxic to nerve cells. This is thought to be caused by a key ... switching off in later life. One of NEP's roles is to clear the toxic peptide
from the brain, and plaques begin to form as it gradually switches off, ...
UT Health Science Center researchers study diet and autism
... a protein in wheat; casein and whey are proteins in milk. Casomorphin, a peptide
in milk; and gliadomorphin, a peptide
in gluten, are thought to be related to changes in behavior in these ...
Treatment corrects severe insulin imbalance in animal studies
... or too high, resulting in diabetes.
The new study makes use of a peptide
(an amino acid compound) called exendin-(9-39) that blocks the action of a ... her study team expects to progress to a larger clinical trial. "If this peptide
can be developed into a treatment for children with this common form of ...
NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008
... in people with Alzheimer's disease, NYU researchers have found that the peptide
not only plays a toxic role in the neurodegenerative disease but also is ... memory consolidation in the normal brain. The rat study, which controlled peptide
levels in a region of the brain that is important in learning and memory, ...
Scientists reveal the key mechanisms for affinity between transient binding proteins
... that these relations are of short duration and there are few crystallized peptide
structures. Researchers at the Institute for Research in Biomedicine (IRB ... have detected all interactions possible between the globular domain and peptide
by exploring the 45,000 3D protein structures currently available on the ...
Duck-billed platypus genome sequence published
... contains expansions in the gene family that codes for a microbe-fighting peptide
called cathelicidin. Primates and rodents have only a single copy of the ... developmentally immature. Scientists postulate that the microbe-fighting peptide
may have been less critical for other mammals, whose offspring spend ...
Biomarkers allow doctors to match therapy to patient
... ER-positive disease, he said.
Response to preventive HER2/neu peptide
(E75) vaccine based on HER2/neu status: Abstract 2545
A HER2 peptide
E75 vaccine reduced mortality in patients with HER2-positive breast cancer ...
UC San Diego researchers eliminate drug discovery bottleneck
... notoriously difficult to determine the structure of NRPs because the usual peptide
sequencing tools do not work. The cyclic structures of NRPs, the ... that it is possible to break NRP rings apart and then break the resulting peptide
strings into smaller and smaller subunits of the original ring using ...
Lipids in the brain an important factor for Alzheimer's disease?
... society. It is generally accepted that the disease is caused by Alzheimer peptide
(A -peptide) protofibrils. Until now, the conditions under which this type ... Belgium alone affects about 100,000 people misfolding of the A -amyloid peptide
leads in various stages to the formation of plaques. These plaques consist ...
Scientists discover novel way to remove iron from ferritin
... were open.
"We wanted to prove a hypothesis that a small protein or peptide
could bind to ferritin and could be used to regulate ferritin pores," said Dr. Theil. "Our hypothesis was correct. We proved that when a binding peptide
of seven amino acids, a heptapeptide, is coupled with Desferal the rate of ...
Paradigm shift in Alzheimers's research: new treatments
... significantly at the age of six months. Of all A" peptides studied, the peptide
that starts with pyro-glutamate (A"N3(pE)) at position 3 showed the ... enhanced stability and propensity to aggregate.
Therefore, this peptide
most likely seems to be responsible for the observed neuronal toxicity. ...
Toward an explanation for Crohn's disease?
... will recognize invading bacteria and then trigger the immune response. This study demonstrates that the NOD2 receptor preferentially recognizes a peptide
called N-glycolyl-MDP, which is only found in a specific family of bacteria called mycobacteria. When mycobacteria invade the human body, they cause ...
The battle for CRTC2: How obesity increases the risk for diabetes
... why thin people can become insulin-resistant.
The Salk team, led by Marc Montminy, Ph.D., a professor in the Clayton Foundation Laboratories for peptide
Biology, discovered how a condition known as ER (endoplasmic reticulum) stress, which is induced by a high fat diet and is overly activated in obese ...
Stress puts double whammy on reproductive system, fertility
... GnIH, discovered nine years ago in birds and known to be present in humans and other mammals. This small protein hormone, a so-called RFamide-related peptide
(RFRP), puts the brakes on reproduction by directly inhibiting GnRH.
The common thread appears to be the glucocorticoid stress hormones, which not ...
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
... have discovered that the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on shuttling of the peptide
and the OGF receptor from the cytoplasm to the nucleus. This discovery may provide valuable information to understanding the etiology and ...
LSUHSC student awarded top national honor for diabetes research
... research team found that ACE2 gene therapy improves pancreatic beta cell function and restores glucose stability by increasing the activity of a peptide
called Angiotensin (1-7), or Ang (1-7). ...
Our brains make their own marijuana: We're all pot heads deep inside
... proteins, called peptides, from the brains of mice and determining their amino acid sequence. The extracted proteins were then compared with another peptide
previously known to bind to, but not activate, the receptor (THC) affected by marijuana. Out of the extracted proteins, several not only bound to the ...
Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
... coral disease has resulted in thousands of new bacterial isolates producing highly selective antimicrobial compounds yielding highly selective small peptide
Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients
... role of CypD in Alzheimer's disease has not been elucidated.
In this paper, Dr. Yan and colleagues demonstrate that CypD interacts with Aβ peptide
within the mitochondria of Alzheimer's disease patients and a transgenic mouse model of Alzheimer's disease. The cortical mitochondria isolated from ...
Food for thought -- regulating energy supply to the brain during fasting
"We have all seen the sub-prime mortgage crisis," says Marc Montminy, M.D., Ph.D., a professor in the Clayton Foundation Laboratories for peptide
Biology who led the current study. "If you take out a loan, sooner or later you've got to pay your debt, and the same is true in fasting metabolism." ...
A second career for a growth factor receptor: keeping nerve axons on target
... show a direct interaction between these two systems."
Collaborating with Kuo-Fen Lee, Ph.D., professor in the Clayton Foundation Laboratories for peptide
Biology, the O'Leary team observed a defect in mice genetically engineered to lack p75. Through their synaptic connections, retinal axons develop a ...