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Pancreas in Biological News

Trio of signals converge to induce liver and pancreas cell development in the embryo

... and acute liver failure. Previous studies on pancreas and liver development have focused on individual ... that work simultaneously, converging to direct pancreas and liver progenitor cells to mature into their ... on genes that guide cells to ultimately become pancreas or liver tissue. The structure of the ...

Tiny samples could yield big predictive markers for pancreatic cancer

... distinguish between a harmless lesion in the pancreas and a potentially deadly one, say researchers at ... appear in the March issue of the journal pancreas , available online now. "New technologies ... have major surgery to remove the portion of the pancreas that contains the cyst, in hopes of eliminating ...

New regulatory mechanism discovered for cell identify and behavior in forming organs

... for example, how do we tell a cell to become a pancreas cell so it will produce insulin?" The study ... runs amok and the frog's foregut, liver and pancreas form improperly from a cascade of disorganized ... accurate foregut formation and initiate liver and pancreas development. Unknown before the study by Dr. ...

American Chemical Society's Weekly PressPac -- April 30, 2008

... can attack the insulin-producing cells of the pancreas and trigger diabetes, she says. MTS ARTICLE ... 5, 2008 No more needles: Toward an artificial pancreas for fighting diabetes Chemical & Engineering ... could be the key to developing an artificial pancreas to help millions of people with diabetes avoid ...

Elusive pancreatic stem cells found in adult mice

... the search, researchers have discovered that the pancreas does indeed harbor stem cells with the capacity ... of bona fide beta cell progenitors in the pancreas after birth. The elusiveness of this cell type ... injury led to a doubling of beta cells in the pancreas within two weeks, they showed. The animals ...

Leptin's long-distance call to the pancreas

... to prevent bone-making cells from releasing a molecule that prods the pancreas to discharge insulin. The study will appear online December 22, 2008 ( ... stimulates insulin release. Hinoi et al. tested whether leptin acts on the pancreas through osteocalcin. Leptin channels many of its effects through the ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... diabetes is the presence of insulin resistance. Insulin is produced in the pancreas and is the hormone responsible for ensuring that glucose reaches several ... counteracted by a greater production of insulin by the pancreas. When the pancreas does not have the capacity to produce the amount of insulin required for ...

Jefferson Department of Surgery announces new pancreas tumor registry

... Jefferson University, announces the establishment of the new Jefferson pancreas Tumor Registry (JPTR). "The purpose of the registry is to further study ... have been exposed." The JPTR modeled after the National Familial pancreas Tumor Registry is a longitudinal study in which participants may engage ...

Moderate use averts failure of type 2 diabetes drugs in animal model

... causes this shutdown doesn't kill the insulin-making beta cells of the pancreas or stop them from making insulin. Instead, it somehow stops them from ... dropped, and blood sugar levels rose dramatically. Examination of the pancreas showed that the animals' beta cells were still alive and contained normal ...

Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers

... mellitus, or type 1 diabetes, insulin-producing beta islet cells in the pancreas are attacked and destroyed by the bodys own immune system. Patients must ... potency declined with age, leaving potential autoimmune responses in the pancreas unchecked. It is likely, the researchers say, that certain genetic ...

Joslin researchers uncover potential role of leptin in diabetes

... receptors, which are found in tissues throughout the body including the pancreas as well as the brain, mediate leptin-induced inhibition of insulin ... the body. Researchers found that the mice lacking leptin receptors in the pancreas showed improved glucose tolerance and greater insulin secretion and beta ...

Breakthrough research identifies how cells from pigs may cure diabetes

... Society the Cell Transplant Society (CTS), the International pancreas and Islet Transplant Association (IPITA) and the International ... has shown that the transplantation of islet cells, harvested from the pancreas of a pig, yields a long-term reversal of diabetes in monkeys, opening the ...

'Normal' cells far from cancer give nanosignals of trouble

... made another important discovery: the abnormalities found in the nanoarchitecture of the colon cells are the same abnormalities as those found in the pancreas and lung, illustrating commonality across three very different organs. The results are published online by the journal Cancer Research . Authors ...

USC researchers present diabetes findings at American Diabetes Association Scientific Sessions

... the brain and the portal vein in sensing and regulating low blood sugar. Building on his research that determined the portal vein connecting the pancreas and liver has glucose sensors that alert the body to low blood sugar, Donovan will talk about different ways the portal vein sensors may connect to ...

Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics

... monitoring techniques, describes state-of-the-art CGM technology, and looks to the future and the ultimate goal of integrating CGM with an artificial pancreas to simulate normal blood glucose control systems in the body. Several articles focus on the challenges that CGM must still overcome, whether ...

Study shows CGM devices also benefit people with type 1 diabetes

... HbA1c levels less than 7 percent with intensive insulin therapy.) More information on the initial results of JDRF's CGM trials and on the Artificial pancreas Project is available online at http://www.artificialpancreas.org. Dr. Kowalski noted that over the past 15 years, the use of rapid and long-acting ...

New early detection studies of lung cancer in non-smokers launched today

... in never smokers as a separate category, it ranks as the seventh most common cause of cancer deaths worldwide, even before cancers of the cervix, pancreas and prostate," commented Adi Gazdar, M.B.B.S., of the University of Texas Southwestern Medical Center, Dallas, and team leader for the NCI-funded ...

LSUHSC student awarded top national honor for diabetes research

... Center. The research team previously demonstrated that glucose tolerance and fasting blood glucose levels in diabetic mice were improved when the pancreas overproduced Angiotensin-converting enzyme (ACE) 2. They hypothesized that the improvement in glucose stability could be achieved by enhancing ...

Findings show insulin -- not genes -- linked to obesity

... who is working with Cheng. "We found that the variability in fat storage is dependent on how 3T3-L1 cells process insulin, a hormone secreted by the pancreas after meals to trigger the uptake of glucose from the blood into the liver, muscle or fat cells." The findings are detailed in a research paper ...

Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases

... has been successfully used to regrow muscles in a mouse model, but it could be applied to all tissue-based illnesses in humans such as in the liver, pancreas or brain, the researchers say. The research team, which is based at UNSW and formerly from Sydney's Westmead Children's Hospital, adapted a ...

Study examining role of genetics and environment in type 1 diabetes

... stark contrast to how the autoimmune disease is typically diagnosed: gravely ill children are brought to an emergency room where parents find out the pancreas is essentially wrecked. The first children enrolled in TEDDY in 2004 and to date no Georgia participants have developed type 1 diabetes, although ...

IRB Barcelona to coordinate two European projects on biomedicine

... transforms molecules from the food we ingest into energy -, and that are responsible for insulin resistance. Insulin is a hormone generated by the pancreas and serves to allow glucose to enter cells. People who suffer from the so-called Insulin Resistance Syndrome generally present high levels of ...

Discovery of new gene associated with diabetes risk suggests link with body clock

... controlled by our body clock are connected to the machinery that keeps us metabolically healthy. It seems likely that the action of melatonin on the pancreas is being disturbed in this case, the researchers suggest. The international research collaboration combined ten genome-wide association scans ...

Master gene plays key role in blood sugar levels

... that potentially too much SRC-2 could raise the levels of glucose in the blood. That would call for increased production of insulin. Often, the pancreas fails after being forced to produce continuous, high levels of insulin. This can result in adult-onset diabetes. O'Malley and his colleagues plan ...

Researcher tricks immune system in diabetic mice

... it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the recipient -- often permitting independence from insulin therapy. However, the immune system tries to kill ...

New technique eliminates toxic drugs in islet transplant in diabetic mice

... it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the recipient -- often permitting independence from insulin therapy. However, the immune system tries to kill ...

Green tea may delay onset of type 1 diabetes

... a mouse model with the genetic defects that cause symptoms similar to human type 1 diabetes and Sjogren's syndrome, so the immune cells attack the pancreas and salivary glands until they are no longer functional." Another related finding was that even when salivary cells were under attack, they seemed ...

JDRF to provide $1M in funding to SmartCells, Inc.

... insulins, SmartInsulin is designed to maintain continuous, tight control of blood glucose levels while reducing the risk of hypoglycemia like the pancreas does automatically in the absence of diabetes. As part of the agreement, JDRF will provide $1 million in first-year funding to support preclinical ...

Where optics meets medicine

... a multidisciplinary team of researchers is investigating whether tissue optical spectroscopy can be employed for early cancer detection in the pancreas during minimally-invasive endoscopic diagnostic procedures. Their objective is to help physicians distinguish between cancerous tissue ...

Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential

... pericytes could then be coaxed into becoming whatever type of tissue the scientists desired. For instance, the researchers took pericytes from the pancreas and then reinjected them into an injured muscle. The cells immediately began regenerating muscle tissue. ...

'Friendly' bacteria protect against type 1 diabetes, Yale researchers find

... might actually help prevent onset of Type I diabetes, an autoimmune disease in which the patient's immune system launches an attack on cells in the pancreas that produce insulin. The root causes of autoimmune disease have been the subject of intensive investigation by scientists around the world. ...

JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control

... of regular CGM use among children and teenagers observed in this study underscore the importance of continued research into a closed-loop artificial pancreas a device that uses CGM data to administer appropriate doses of insulin through a pump without the need for involvement of the patient or for young ...

Battling diabetes with beta cells

... this method, which artificially replicates the insulin cells people need, could ensure that fewer people will die while waiting for a life-saving pancreas and kidney. Prof. Efrat's research paves the way for new and alternative forms of treatment in cases in which organ transplantation is not an option. ...

Treatment corrects severe insulin imbalance in animal studies

... leader in diagnosing such lesions and performing the curative surgery on newborns. However, when abnormal cells are distributed throughout the pancreas in so-called diffuse HI, surgeons must remove nearly all the pancreas. This relieves HI in about a quarter of cases, but leaves the majority of ...

Cellular self-eating promotes pancreatitis

... cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. In autophagy, a vesicle swallows a portion of cytoplasm and ferries it to the lysosome for digestion. ...

A single mechanism for hypertension, insulin resistance and immune suppression

... such as the insulin receptor, so that insulin can no longer bind and facilitate normal metabolism of glucose. Under normal conditions, the pancreas releases insulin in the bloodstream. The molecule then binds to insulin receptors on the cell-surface membrane, which signals the cells to absorb ...

Caution on stem cell therapy

... they are found. Medical researchers hope to transplant adult stem cells to treat various diseases. Examples include placing adult stem cells in the pancreas to replace damaged insulin-producing cells, in the heart to replace cardiac muscle cells killed by heart attack, and in the brain to replace ...

4 Stanford faculty named Howard Hughes Medical Institute Investigators

... addition to continuing his work in nematodes. Seung K. Kim, associate professor of developmental biology. His lab studies the development of the pancreas with the goal of translating that research into treatments for diseases, such as diabetes and pancreatic cancer. He works with stem and progenitor ...

2 new therapies show promise for cancer patients

... behind the combination of Gemcitabine plus Abraxane was based on careful science and was designed and executed by some of the leading experts in pancreas cancer in the world. While the data is preliminary and longer follow-up will be important, the biochemical and radiographic responses look very ...

Stem cell breakthrough offers diabetes hope

... become insulin-producing pancreatic cells, so the challenge has been to find a way of producing much greater quantities of these cells. The pancreas contains different types of specialised cells exocrine cells, which produce enzymes to aid digestion, and endocrine cells, including beta cells, ...
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