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Neutrophil in Biological News

Apolipoprotein(a): A natural regulator of inflammation

... Hoover-Plow said "In this study apo(a) impeded neutrophil recruitment in two of the models of inflammation, ... induced peritonitis. Apo(a) also inhibited neutrophil chemoattractants, and neutrophil recruitment was restored in mice ...

UIC researchers make promising finding in severe lung disease

... barrier, no one has investigated how MYLK functions to regulate the neutrophil transmigration into tissues," said Xu. "We decided to look at this." ... endothelial barrier. It unleashes a cascade of molecular events inside the neutrophil that changes the cell's shape, which is necessary for adhesion and ...

Gene chips used to distinguish ventilator-associated pneumonia from underlying critical illness

... in number as bacteria invade the body. "We found genes that control neutrophil activation were turned on, and that is consistent with someone developing a bacterial infection," Cobb explains. "We did not find neutrophil genes being activated in patients who did not have infection, even though ...

Placenta-derived stem cells may help sufferers of lung diseases

... benefits for bleomycin-induced lung injury. While the severity of inflammation did not show an overall reduction, there was a marked reduction in neutrophil (white blood cell) infiltration after both xeno-and-allo-transplantation. "It is worth noting," says Dr. Parolini," that the presence of ...

Bypassing the insulin highway

... An immune cell known as a neutrophil releases a protein that can suppress glucose production in the liver without targeting insulin, researchers have found. Neutrophils, a type of ...

Researchers map out networks that determine cell fate

... that the cells activated both macrophage and neutrophil genes. "This showed for the first time how ... that activated macrophage genes and repressed neutrophil genes. Higher levels of C/EBPĄ tipped the ... Egr-1 and Egr-2 activate macrophage and repress neutrophil genes. Gif-1 is required to turn ...

Flesh-eating bacteria escape body's safety net

... nets, thereby allowing the organism to escape the neutrophil net and spread in body tissues. The UCSD team ... allowed these bacteria to degrade DNA, escape neutrophil killing, and produce a spreading ulcer in the ... simultaneously confirming just how important neutrophil DNA nets are to our normal immune defense," said ...

Why do aneurysms form? New studies suggest leading role for white blood cells

... that a certain type of white blood cell called a neutrophil appears to be crucial to AAA formation. ... what happened in the rodents that had altered neutrophil systems and in comparison rodents that were ... Gilbert Upchurch, M.D., the rodents that had low neutrophil levels or no neutrophil-attaching protein ...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

... feedback circuit regulating the balance between neutrophil production and destruction. The research, ... of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of ...

White blood cell waste disposal system plays critical regulatory role

... feedback circuit regulating the balance between neutrophil production and destruction. The research, ... of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of ...

Quitting smoking improves lung function considerably

... function test scores, the "quit" group also showed a reduction in sputum neutrophil counts when compared to those of smokers. Neutrophils are white blood ... and fungal infections, along with ingesting foreign debris. "Sputum neutrophil counts are reported to be increased in heavy smokers with asthma compared ...

Scientists reveal how disease bacterium survives inside immune system cell

... and pneumonia. In their experiments, the research team compared the neutrophil response to A. phagocytophilum with that of a weak strain of S. aureus. ... "This study has given us a global model of how bacteria can inhibit neutrophil apoptosis," says Dr. DeLeo. "Our next step is to look at specific human ...

Study finds adult stem cells can replicate

... secondary waves of other immune attack cells. "The contributions of the neutrophil weren't always appreciated by scientists," Pham notes. "When patients come ... AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, ...

Enzyme's newly discovered role may make it target for arthritis treatment

... secondary waves of other immune attack cells. "The contributions of the neutrophil weren't always appreciated by scientists," Pham notes. "When patients come ... AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, ...

Anthrax paralyzes immune cells with lethal toxin, UF research shows

... the transmission of signals within cells. But Dr. Southwick's study is the first to explain how anthrax can short-circuit a cell signal to block neutrophil movement, a realization that has eluded scientists for years. The finding almost escaped Southwick's research team as well, which was looking for ...

Molecule that destroys bone also protects it, new research shows

... diseases, white blood cells of the innate immune system called neutrophils play a critical role in fighting infections. In fact, humans with neutrophil defects usually lose all their teeth by the time they are 20 due to severe periodontal disease. "It turns out that IL-17 is really important in ...

White blood cells in lung produce histamine seen in allergies

... did much worse. Even though there were no mast cells, histamine levels rose up to 50 times normal." The reason was straightforward, Caughey says. neutrophil numbers increased in response to infection, and neutrophils in turn produced histamine. "It's a direct effect of the mycoplasma bacteria on ...

Proteins may predict lung transplant rejection

... of proteins at work in the lungs. Some promising results An earlier study from the laboratory had found that elevated levels of human neutrophil peptide (HNP), declining Clara cell secretory protein and some previously unidentified proteins were highly correlated with chronic lung rejection. ...

Soil-bound prions that cause CWD remain infectious

... "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote. Despite ineffective neutrophil immune cells, the patient's immune system still tagged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating ...

Scientists discover a new disease-causing bacterium in an immune-compromised patient

... "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote. Despite ineffective neutrophil immune cells, the patient's immune system still tagged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating ...

Disabling gene defuses rheumatoid arthritis in mice

... mice as potential anti-arthritis drugs. ### Jonsson H, Allen P, Peng SL. "Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis." Nature Medicine, June 2005. ...
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