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Necrosis in Biological News

Dangerous liaisons

... as hybrid necrosis. "We suspected that hybrid necrosis is always caused by the same biochemical ... more detail, they found that the gene that causes necrosis in hybrids, but not in the parents, is normally ... in contrast to many hereditary diseases, the necrosis is not due to each parent carrying a defective ...

How the plant immune system can drive the formation of new species

... as hybrid necrosis. We suspected that hybrid necrosis is always caused by the same biochemical ... more detail, they found that the gene that causes necrosis only in hybrids, but not in the parents, is ... In contrast to many hereditary diseases, the necrosis is not due to each parent carrying a defective ...

JCI table of contents: Aug. 9, 2007

... CARDIOLOGY: Cell death by necrosis leads to heart failure The prevalence of ... Investigation, indicates that cell death by necrosis also has a role in the cardiomyocyte loss that ... in cardiomyocytes causes the cells to die by necrosis and the mice to die of heart failure. Necrotic ...

Study reveals a key to blood vessel growth and possible drug target

... embryo. They showed that birc2 is needed for the formation of the tumor necrosis factor receptor complex 1, a group of proteins and peptides that activate cell survival by initiating signals. Tumor necrosis factor promotes activation of NF-kB, a protein complex transcription ...

Older men more likely than women to die after pneumonia

... School of Medicine and corresponding author of the study. The researchers measured blood levels of inflammatory indicators, including tumor necrosis factor (TNF) and interleukins 6 and 10, coagulation indicators including Factor IX, and fibrinolysis indicators including D-dimer concentrations. ...

Vitamin D deficiency related to increased inflammation in healthy women

... will determine the effectiveness of Vitamin D in reducing disease symptoms and reducing blood glucose levels in diabetics. The study, "Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH) D concentrations in healthy women," was published in the Journal of ...

Team identifies a molecular switch linking infectious disease and depression

... analysis of gene regulation in the mouse brains showed that exposure to BCG increased expression of IDO and two cytokines known to induce IDO: tumor necrosis factor-alpha and interferon-gamma. Because IDO degrades tryptophan, which is the precursor of serotonin, a brain chemical known to positively ...

A worm-and-mouse tale: B cells deserve more respect

... for the organism to fight off infection. Lund's team showed that the chemical messengers produced by B cells, such as interleukin-2 and tumor necrosis factor, are necessary for the immune system to protect mice against Heligmosomoides polygyrus . The team also showed that B cells must be present in ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... its receptor, can substantially suppress the lung inflammation and accompanying symptoms of an asthma attack. OX40 ligand is a member of the tumor necrosis factor (TNF) superfamily of molecules, which are signaling proteins used by inflammation-causing cells to communicate with the rest of the immune ...

Tips from the American Journal of Pathology

... also damages normal tissues. Autologous transplant of tissues such as fat tissue has often been used to prevent the fibrosis, organ dysfunction, and necrosis that result from radiation treatment; however, the effects of radiation on the transplanted fat tissue had not been studied. Dr. Cousin's group ...

Vitamin E shows possible promise in easing chronic inflammation

... research team examined the impact the Vitamin E or placebo treatment had on the mRNA and protein levels of three cytokines interleukin (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-1beta. "The mice were administered Vitamin E for three days prior to giving them what amounts to a minor systemic ...

Musculoskeletal center wins $2.2 million for drug safety

... focus on the use of eight biologics used for a range of autoimmune disorders. Among the studied drugs is what's called anti-TNF agents, or anti-tumor necrosis factor alpha agents. This category includes adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade). Five additional biologics will be ...

NSF, NIH award Ecology of Infectious Disease grants

... events (Rachel Noble, University of North Carolina at Chapel Hill); Virulence trade-offs in a vertebrate virus--infectious haematopoietic necrosis (IHN)--a disease of salmon and trout (Benjamin Kerr, University of Washington); Agricultural antibiotics and human health, using a multi-scale ...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

... Paul Janssen Research Center in Beerse, Belgium tomorrow. Feldmann and Maini received the $100,000 prize for their role in the discovery of tumor necrosis factor-alpha (TNF-alpha) as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions. "Thanks to their ...

New genes found for inflammatory bowel disease in children

... gene on chromosome 20 is a compelling candidate, because it is already known to participate in the biological pathway of a protein called tumor necrosis factor (TNF). TNF is a cytokine, a chemical messenger that plays a key role in the harmful inflammation characteristic of IBD. Some current ...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

... the clinics. Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)-α, IFN-γ, tumor necrosis factor-α (TNFα) interleukin (IL)-1α, and IL-12 as currently thought, an entirely new pathway - native to body chemistry - has been ...

Scientists suspect omega-3 fatty acids could slow acute wound healing

... during the inflammatory stage of wound healing. The primary cytokines in the process are interleukin-1 beta (IL-1b), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a). But research had not yet addressed how the interaction between fatty acids and these cytokines might affect human wounds. ...

Video released of rapid Alzheimer's improvement after new immune-based treatment

... previous work by the same authors, published in BioMed Central's Journal of Neuroinflammation, this study focuses on the effect of the anti-tumor necrosis factoralpha (TNF-alpha) drug, etanercept, on measures of verbal ability. TNF-alpha, a critical component of the brain's immune system, normally ...

Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment

... was published in the advance online publication of Nature Medicine yesterday. The team showed that a pro-inflammatory cytokine protein tumor necrosis factor-alpha (TNF-alpha) disrupts the localization of polycystin 2 the product of a gene mutated in ADPKD) to the plasma membrane and primary cilia ...

QUT researchers develop smart instrument for tissue damage assessment

... instrument would reduce the dependence on surgical experience and guide them in the process of managing conditions such as osteoarthritis, avascular necrosis and osteochondritis dessicans." He said he hoped that a mock-up of the "smarthroscope", which is the subject of a QUT-owned patent, would be ready ...

Stopping unwanted cell death: Implications for drug discovery

... potent and selective inhibitors of RIP1 kinase, the authors write, including last author, Junying Yuan, PhD, professor at Harvard Medical School. necrosis is relevant to many diseases, particularly those that involve an acute event, such as heart attack or stroke. Cells are programmed to die when they ...

Synthetic compound promotes death of lung-cancer cells, tumors

... the Smac mimic only killed cancer cells when it was introduced along with another molecule often involved in the cell-death machinery, called tumor necrosis factor-a, or TNFa. In the current study, Dr. Wangs research group tested 50 human non-small-cell lung-cancer cell lines in culture and found that ...

Preventing tuberculosis reactivation

... Kirschner and colleagues, publishing in PLoS Computational Biology, conducts virtual clinical trials to examine the causes of reactivation. Tumor necrosis factor alpha (TNF) is a protein that facilitates cellcell communication during an inflammatory immune response. Animal models have shown that TNF is ...

Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients

... complications. The cause of UC is not known and there is no cure. About REMICADE REMICADE is the global market leader among anti-tumor necrosis factor alpha (TNF-alpha) therapies and is the only anti-TNF-alpha treatment approved in three different therapeutic areas: gastroenterology, ...

Depression, aging, and proteins made by a virus may all play role in heart disease

... Kiecolt-Glaser, a professor of psychiatry and psychology, initially focused on the role that two essential proteins interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) -- play in producing inflammation, a major part of the body's immune response. As the immune system ages, the levels of IL-6 ...

Turning viruses into allies against cancer

... trade name OncoVEX -- showed promise of causing necrosis (death) of tumors cells in most patients. "Tumor necrosis was evidenced clinically and/or by histology in ... who conducted much of the study. "In some cases necrosis was considerable." Like other oncolytic ...

Monoclonal antibody reduces exacerbations in asthmatics

... Patients with symptomatic moderate asthma who were treated with anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced ... with infliximab, a monoclonal antibody that binds and neutralizes tumor necrosis factor alpha (TNFá). Eighteen patients received placebo during the ...

Retinol for combating leukemia cells

... Clean and programmed death Two types of death occur in cells: necrosis and apoptosis. necrosis defines a pathological death, i.e. a death caused by a lack or deficit ...

Protein therapy may reduce infarct size in heart attack patients

... to assess the potential impact of KAI-9803 in this “first-in-human?study. Results indicate that KAI-9803 may be associated with less myocardial necrosis with lower CK-MB AUC values at all dose levels. Furthermore, improved tissue perfusion (measured during coronary angiography after stent implantation ...

SARS: No evidence that any of the treatments worked

... mouse model with arthritis. In testing, also in mice, phytol showed comparative effectiveness to standard therapies for arthritis such as anti-tumour necrosis factor-á and methotrexate. The authors conclude that these results "suggest a novel pathway of autoimmune inflammatory disease and possibly a novel ...

Key molecular signaling switch involved in allergic disease identified

... the epidermal growth factor receptor, an established target for the treatment of cancers, such as colon cancer. Moreover, ADAMs release tumor necrosis factor alpha, currently the major target for treatment of rheumatoid arthritis. Since the 1970s Conrad has been investigating the basic mechanism ...

Scientists discover new regulating mechanism in cells

... biosciences and a researcher with the OSU Comprehensive Cancer Center . The study shows, for example, that when RHA is knocked out, the spleen necrosis virus, a retrovirus Boris-Lawrie and her collaborators were studying as a vector for gene therapy, was unable to make certain proteins. Thus, RHA ...

UC Davis researchers reveal apples' protective ways

... cells to an extract of an apple mash made from different apple varieties. The researchers then challenged these cells by exposing them to tumor necrosis factor (TNF), a compound that usually triggers cell death and promotes inflammation via a mechanism called the "nuclear factor (NF) kappa B pathway." ...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

... case, the gene of interest produces IL-23, which appears to be very well suited for attacking gliomas. Earlier studies used IL-4, IL-12, and tumor necrosis factor related apoptosis inducing ligand (TRAIL). "Each cytokine has unique functions. What we want to do is marry the function with the ...

Infection 'alarm' yields clues to immune system behavior

... including septic shock, cancer, lupus and rheumatoid arthritis. Their findings, which focused on how a large protein molecule called tumor necrosis factor, or TNF, triggers an immune response, were reported in the February issue of the Journal of Biological Chemistry. "We were surprised by how ...

Synthetic Protein Eases Arthritis Symptoms in Mice

... might benefit people with rheumatoid arthritis, who suffer from excessive inflammation. A key promoter of inflammation is a chemical called tumor necrosis factor alpha (TNF-alpha). TNF-alpha starts a chemical chain reaction leading to inflammation by binding to two cell surface receptors, TNFR-1 and ...

Ants, not evil spirits, create devil's gardens in the Amazon rainforest, study finds

... is common in many ant species and, in fact, got its name from formica, which is Latin for ant. "Treatment of leaves with formic acid induced leaf necrosis on all the plants we tested," the authors write. "To our knowledge this is the first record of an ant using formic acid as a herbicide--although it ...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

... cells to release 40 times the normal levels of interleukin 10 (IL-10), which dampens down the immune response. LcrV also prevents secretion of tumor necrosis factor (TNF), which causes inflammation. "LcrV is secreted in massive amounts via the type-III pathway during an infection," Schneewind said. ...
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