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Muscular in Biological News

ISU researchers find possible treatment for spinal muscular atrophy

... AMES, Iowa - Spinal muscular Atrophy is the second-leading cause of infant ... of Veterinary Medicine, would like to see Spinal muscular Atrophy lose its high ranking and even slide off the list altogether. Most Spinal muscular Atrophy sufferers -- more than 95 percent -- have ...

Sticky protein helps reinforce fragile muscle membranes

... occurs in certain congenital and limb-girdle muscular dystrophies. Specifically, the team ... findings may also have clinical implications for muscular dystrophies that are caused by abnormal dystroglycan." These congenital muscular dystrophies include Fukuyama ...

'Show me the money!' MDA greenlights grants

... for biomedical research have become scarce, the muscular Dystrophy Association reasserts its leadership in ... created the basis for progressive treatments of muscular dystrophy, amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, and spinal muscular atrophy. It also served as the basis for a ...

Robo-bats with metal muscles may be next generation of remote control flyers

... did extensive analysis of bats' skeletal and muscular systems before developing a "robo-bat" skeleton ... fabrication and assembly of the joints, muscular system and wing membrane for the robo-bat, which ... team is also using smart materials for the muscular system. "We're using an alloy that responds to ...

New therapy substitutes missing protein in those with muscular dystrophy

... shows potential to treat people with Duchenne muscular dystrophy, a fatal disease and the most common form of muscular dystrophy in children. In the mouse model, ... protein as a viable therapy for the treatment of muscular dystrophy as well as cardiac muscle diseases ...

Muscular dystrophy diagnosis delayed almost 2.5 years in boys

... Boys show signs of Duchenne muscular Dystrophy (DMD) for 2 years before they obtain a ... to have more children." DMD, the most common muscular dystrophy in children is a particularly ... of 453 boys born since 1982 with DMD or Becker muscular Dystrophy in ...

March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy

... and better ways to diagnose and potentially treat muscular dystrophy have been chosen to receive the 2009 ... identifying the genes and proteins that cause muscular dystrophy, a disorder in which the muscles ... Americans are affected by the nine forms of muscular dystrophy and other related neuromuscular ...

Cell 'anchors' required to prevent muscular dystrophy

... a laboratory mouse that seemed to have a form of muscular dystrophy. A group of proteins called ... wings, rather than lying flat, a symptom of a muscular problem. "I went back to my pediatric textbook and saw images of people with a form of muscular dystrophy who had splayed shoulder bones," said ...

Potential therapy for congenital muscular dystrophy

... together, may lead to enhanced muscle repair in muscular dystrophy. The related report by Rooney et al, ... issue of The American Journal of Pathology . muscular dystrophy is a group of inherited genetic ... progressive muscle weakness. In one type of muscular dystrophy, patients with mutations in the ...

The Burnham buzz

... Enzyme May Hold the Key to muscular Dystrophy A mutation in the gene coding the ... has long been known to be associated with muscular dystrophy, but the role the protein plays in the ... This advancement may lead to novel therapies for muscular dystrophy. Microscopic Race for New Cures ...

Caltech scientists show function of helical band in heart

... (Caltech) have created images of the heart's muscular layer that show, for the first time, the ... More precisely, they showed that the muscular band--which wraps around the inner chambers of ... configuration of the heart's myocardium--its muscular middle layer, the one that contracts with each ...

American Chemical Society's Weekly PressPac -- Nov. 19, 2008

... toward treatment for most common adult form of muscular dystrophy Journal of the American Chemical ... of a long-sought drug to treat myotonic muscular dystrophy (MMD), the most common form of muscular dystrophy in adults. MMD affects about 1 in ...

Scientist clears hurdles for muscular dystrophy therapy

... people in the United States have some form of muscular dystrophy. Duchenne muscular dystrophy (DMD) is the most common type of the ... "The difficult challenge with treating Duchenne muscular dystrophy, and other types of muscle-related ...

Study may explain exercise-induced fatigue in muscular dystrophies

... exercise that occurs in people with many forms of muscular dystrophy is distinct from the inherent muscle ... cause exercise-induced fatigue in mouse models of muscular dystrophy. Moreover, the study shows that Viagra ... was very similar to the fatigue experience by muscular dystrophy patients after a short period of ...

Mediator in communication between neurons and muscle cells found

... this piece may be mutated and/or attacked in muscular dystrophy. Agrin is a protein that motor ... signaling pathway has been implicated in muscular dystrophy, a group of genetic diseases that lead ... have implicated a mutant MuSK as a cause of muscular dystrophy and autoantibodies (antibodies the body ...

Robotics research: Enhancing the lives of people with disabilities

... that people with these types of ailments, such as muscular dystrophy, have extremely weak muscles that waste ... produced in muscles, could ultimately assist muscular dystrophy patients regain significant use of ... system on patients currently suffering from muscular dystrophy. The results from the project will be ...

Researchers discover molecular basis of a form of muscular dystrophy

... ) that people with limb-girdle muscular dystrophy are missing a protein called c-FLIP, ... new drugs to stop muscle wasting from limb-girdle muscular dystrophy and other conditions. Unfortunately, rare diseases like limb-girdle muscular dystrophy dont get the attention or funding they ...

Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report

... in mice afflicted with a human model of Duchenne muscular dystrophy. The study represents the first time ... function to defective muscles in a model of muscular dystrophy. The researchers newly developed ... developing a stem-cell therapy for humans with muscular dystrophy, if we are able to successfully combine ...

New clinical trial results show how personalized medicine will alter treatment of genetic disorders

... have the unprecedented ability to treat muscular dystrophies, and other disorders. In the ... trial involving a new treatment for Duchenne muscular dystrophy provides a proof-of-principle for ... areas of muscle tissue at the injection site of muscular dystrophy patients. "Dozens of specific ...

UVA reports surprising findings related to myotonic muscular dystrophy

... System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does ... surprising things. DM1 is the most common form of muscular dystrophy in adults and affects approximately ... response to potential therapies. Myotonic muscular dystrophy is recognized as the first example of a ...

Gene, stem cell therapy only needs to be 50 percent effective to create a healthy heart

... of life for individuals with specific forms of muscular dystrophy. Recent discoveries have demonstrated ... researchers have demonstrated that a muscular dystrophy patient should be able to maintain a ... the heart are healthy. Patients with Duchenne muscular dystrophy and ...

Massive microRNA scan uncovers leads to treating muscle degeneration

... activity linked to each of 10 major degenerative muscular disorders, opening doors to new treatments and a ... senior investigator. The disorders include the muscular dystrophies (Duchenne muscular dystrophy, ...

How to text message and avoid pain

... were also differences in terms of work technique, thumb movements and muscular activity. The thumb movements were assessed with a so-called electrogoniometer, and the muscular activity was analysed through electromyography (using electrodes to ...

Ultrasound imaging now possible with a smartphone

... Another promising application is for caregivers of patients with Duchene's muscular Dystrophy. A degenerative disease that often strikes young boys and robs ... A group at the Washington University Medical School studying Duchene's muscular Dystrophy is very interested in our devices and hope they can incorporate ...

Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases

... new hope to sufferers of muscle-wasting diseases such as myopathy and muscular dystrophy, according to researchers from the University of New South Wales ... researchers are looking to launch human trials treating specific forms of muscular dystrophy such as oculopharyngeal dystrophy within the next three to five ...

While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy

... 2009) Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers at Columbia University Medical Center have ... of experimental drugs for heart failure may also help treat the fatal muscular disorder. At first glance, heart failure and the muscle-wasting ...

Lamin A/C deficiency is 'unnerving'

... filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Mjat et al. show ... SUN2 are highly expressed in these tissues. Samples from Emery-Dreifuss muscular dystrophy patients exhibit similar hallmarks of skeletal muscle functional ...

Patient-derived induced stem cells retain disease traits

... type lost in patients with the devastating neurological disease spinal muscular atrophy confirmed that the University of Wisconsin-Madison stem cell ... cells by genetically reprogramming skin cells from a patient with spinal muscular atrophy, or SMA. In this inherited disease, the most common genetic cause ...

Sarcospan, a little protein for a big problem

... that adding it to muscle cells might ameliorate the most severe form of muscular dystrophy. In Duchenne muscular dystrophy (DMD), the mutated dystrophin protein fails to anchor correctly ...

Galloping and breathing at high speed

... secrets of equines. Their findings may provide a springboard for better muscular horse health, and a different approach to breathing devices for humans. ... efforts on understanding why this occurs. They found that two principal muscular factors in the fore limb guide a horse's forward movement. The first is ...

RNA emerges from DNA's shadow

... that cause genes to be incompletely read, including cystic fibrosis and muscular dystrophy. A drug based on the molecule is now entering trials that could ... Results so far indicate dramatic improvements in both cystic fibrosis and muscular dystrophy sufferers, although it is only suitable for those disorders ...

Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers

... connected to the Katholieke Universiteit Leuven have been able to prevent muscular tissue with severe hypoxia from dying. The muscles seem to adapt to the ... oxygen supply to the muscle - did not lead to the death of the surrounding muscular tissue. This was a very surprising result, since the muscle received too ...

Pittsburgh scientists identify human source of stem cells with potential to repair muscle

... be used to treat muscle injuries and diseases such as heart attack and muscular dystrophy. In a study using human muscle tissue, scientists in ... Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique ...

Avoiding hysterectomy: Major interventional radiology E-collection info available

... topic in one place, eliminating the need to search topics individually. Uterine fibroids are very common noncancerous growths that develop in the muscular wall of the uterus. Hysterectomy, surgical removal of the uterus performed by a gynecologist, is the most common treatment for symptomatic uterine ...

Triggering muscle development -- a therapeutic cure for muscle wastage?

... be ameliorated by the therapeutic application of mechano growth factor (MGF)?". There is hope that MGF can also help sufferers of diseases such as muscular dystrophy, ALS, renal disease or cancer, for whom intensive exercise is not an option. It may even prove useful to ameliorate muscle loss resulting ...

Stem cell surprise for tissue regeneration

... are surprisingly not needed in adult muscle stem cells to regenerate muscles after injury. The finding challenges the current course of research into muscular dystrophy, muscle injury, and regenerative medicine, which uses stem cells for healing tissues, and it favours using age-matched stem cells for ...

Brain-computer interface, developed at Brown, begins new clinical trial

... The new clinical trial is part of a larger BrainGate research effort, the ultimate goal of which is to help patients with spinal cord injury, stroke, muscular dystrophy, amyotrophic lateral sclerosis (ALS) or limb loss turn their thoughts into actions, restoring independence, mobility, and communication. ...

The secret to chimp strength

... all our muscle fibers at once," Walker writes. "So there might be a degree of cerebral inhibition in people that prevents them from damaging their muscular system that is not present, or not present to the same degree, in great apes." Walker says that testing his hypothesis that humans have more motor ...

Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle

... switch, or drug, that allows people to grow new muscle cells to replace those that are damaged, worn out, or not working for other reasons (e.g., muscular dystrophy). In addition, this same discovery also gives researchers a new tool for the study of difficult-to-treat muscle cancers. The full report ...

A splice of life

... actually looks like, thereby zeroing in on the process of genetic encoding. Importantly, 15 to 20 percent of all human genetic disorders, including muscular dystrophy, are caused by defects in this genetic encoding process known as RNA splicing. Using x-ray crystallography, the scientists for the first ...
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