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Mouse in Biological News

Protein handlers should be effective treatment target for cancer and Alzheimer's

... a viral immunologist, have developed 20 mouse models missing different molecular chaperones or ... chaperones. For contrast, they also have a mouse that over expresses heat shock factor 1, or Hsf1, ... breast cancers. By comparing the resulting mouse to one that just over expresses Her2/Neu, they ...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... cancer. Their studies were performed in mouse cancer models and in human cell cultures. ... and then proteins. Studies in both cells and a mouse model for cancer showed that they could promote ... act as a "first hit" that makes the inversion on mouse chromosome 6, which contains the DLX5 gene, more ...

Scientists track impact of DNA damage in the developing brain

... DNA strands in an organ system, in this case the mouse brain and nervous system. While the results ... a way to switch off Xrcc1 production in the mouse brain and nervous system as development began. ... system. St. Jude researchers then developed a mouse that carried an Xrcc1 gene outfitted with ...

Scientists closer to making implantable bone material, thanks to new research

... materials that were grown from bone cells from mouse skull and mouse bone marrow stem cells successfully mimicked many ... found that the 'bone-like' material grown from mouse embryonic stem cells was much less stiff and less ...

Scientists link immune system's natural killer cells to infant liver disease

... led the research team to experiment with a mouse model of biliary atresia. In the mouse experiments, the scientists used a rotavirus ... cells were the most abundant cells populating the mouse livers and bile ducts at the time of obstruction. ...

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

... according to researchers studying an "anti-aging" mouse model that lives longer than a typical mouse. ... of Pittsburgh of UPMC, reports that the novel mouse model has a thymus that remains intact throughout ... throughout life," said Dr. de Vallejo. The mouse model that Dr. de Vallejo's team studied was ...

Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system

... to maneuver a powered wheelchair or control a mouse cursor using simple tongue movements can be ... the user issued commands to move the computer mouse left and right. Using these commands, each ... and down -- the subjects were asked to move the mouse cursor through an on-screen maze as quickly and ...

Female human embryos adjust the balance of X chromosomes before implantation

... that major characteristics that are present in mouse pre-implantation embryos are present also in ... already have, or still have, a form of XCI. While mouse embryos reactivate the X chromosome in the inner ... embryos occur at a later stage than in mouse embryos. Thus, it is possible that reactivation ...

Mouse model provides clues to human language development

... journal Cell . Scientists of the German mouse Clinic at Helmholtz Zentrum Mnchen have generated and analyzed a mouse model in which parts of the human Foxp2 gene were ... now. The Helmholtz scientists in the German mouse Clinic conduct comprehensive analyses to ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

... located the genes for the subunits in both the mouse and human chromosomes. After coming to Penn State ... in mice. The Penn State researchers used a mouse model of IBD, replicating inflammation in the ... inflammation in the injured intestine. In the mouse model, it is possible to make detailed ...

UCSF discovers new glucose-regulating protein linked with diabetes

... the researchers. "Much has been learned from mouse models about glucose metabolism that is relevant ... she said, GLUT4 is stored inside both human and mouse muscles in a special compartment that releases it ... the Harvard team on this research produced the mouse capable of expressing CHC22 in its muscles and ...

A new mouse model provides insight into genetic neurological disorders

... altering a protein-making molecule, a mouse was made to help understand nervous system ... and legs in humans. Scientists have created a mouse to help understand human neuronal diseases that ... altering a protein-making molecule, a mouse was made with symptoms similar to the nervous ...

Tips from the American Journal of Pathology

... kidney disease progression, Ju et al screened a mouse model of progressive renal disease to identify ... AM80 is effective in treating early symptoms in a mouse model of multiple sclerosis (MS). They report ... in MS and other autoimmune diseases. Using a mouse model of MS, Klenmann et al found that AM80, a ...

Stanford scientists turn adult skin cells into muscle and vice versa

... point, they transformed human skin cells into mouse muscle cells and vice versa. This research shows ... cells that had nuclei from human skin cells and mouse muscle cells. By being encapsulated within the same cell wall, the human skin cells and mouse muscle nuclei could now "talk" to one another via ...

Diminuendo -- New mouse model for understanding cause of progressive hearing loss

... sensory hair cells in the inner ear, both in the mouse and in humans. The findings have been published ... of Experimental Genetics, have developed a new mouse model with a genetic mutant in which a single ... we were very surprised when with our new mouse model we discovered this new class of genes ...

New study overturns orthodoxy on how macrophages kill bacteria

... were much, much less likely to survive in the mouse than bacteria with only the SodB gene missing. ... mutants were less likely to survive in a mouse did not prove, however, that the missing enzymes ... protecting the bacteria from ROS generated in the mouse macrophages, Slauch said. "You get the same ...

UT Southwestern researchers probe kidney damage, protection in lupus

... Southwestern Medical Center have discovered in a mouse study. In a separate study with an ... caused by a different mechanism. For this mouse study, the researchers administered antibodies ... in the proteins encoded by the genes in normal mouse strains, compared with lupus-prone strains. When ...

New insights into progressive hearing loss

... in the equivalent genomic regions in human and mouse identified as implicated in hearing loss; the ... first and just one away from the mutation in the mouse gene. All three sit in a vital region of seven ... Researchers are using models of hearing in the mouse to understand human hearing deficits: by the age ...

Human ES cells progress slowly in myelin's direction

... stem (ES) cells, it's relatively easy to persuade mouse ES cells to turn into oligodendrocytes; it's ... it, 14 weeks as opposed to the 2 weeks taken by mouse ES cells. They also report another difference between mouse and human ES cells: a growth factor called Fgf2 ...

Stem cell therapy makes cloudy corneas clear, according to Pitt researchers

... indicate that after stem cell treatment, mouse eyes that initially had corneal defects looked no different than mouse eyes that had never been damaged," Dr. ... But three months after the lumican-deficient mouse eyes were injected with human adult corneal stem ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... goals for human cancer therapy by developing new mouse models for human acute myeloid leukemia (AML), an ... resistance or sensitivity to any cancer drug. The mouse models, the CSHL team notes, also serve as an ... effective use in the clinic." The Lowe team's mouse models also provide valuable insights into how ...

Brain building: Study shows brain growth tied to cell division in mouse embryos

... Cell Biology ( JCB ), Lake and Sokol report that mouse protein Vangl2 controls the asymmetrical cell ... fate. The research duo found that Vangl2-lacking mouse embryos had large numbers of early-born neurons ... progenitors in the brains of Vangl2-lacking mouse embryos. Also, Vangl2-lacking cells in culture ...

Targeted drug therapy prevents exercise-induced arrhythmias

... inside heart cells. Knollmann's team developed a mouse model for CPVT (by eliminating the calsequestrin ... prevented ventricular arrhythmias in the mouse model of CPVT. "So we knew that this ... calsequestrin gene, the same gene mutated in the mouse model; the woman has a mutation in the ryanodine ...

The host makes all the difference

... says Klaus Schughart, head of the Experimental mouse Genetics research group. In infection experiments ... the researchers injected seven different inbred mouse strains with the same quantity of type Influenza A flu viruses. All of the animals within one mouse strain are genetically identical, like identical ...

Tips from the American Journal of Pathology

... Am J Pathol 2009, 174: 1347-1357 mouse Model of Human Psoriasis Researchers led by ... University, Cleveland have developed a new mouse model to study human psoriasis. These findings ... been limited, however, due to the absence of a mouse model that adequately reproduces these symptoms. ...

Researchers piggyback to safer reprogrammed stem cells

... They successfully persuaded partly specialised mouse cells, called Epi-stem cells, to reprogram into ... mice when introduced into newly developing mouse embryos and can give rise to the offspring of ... this approach produces perfectly reprogrammed mouse cells. The Nature papers show that it can also ...

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

... and colleagues previously had created the hybrid mouse model by cross-breeding mice deficient in PKC ... their entire genome. "We are generating more mouse models to vary expression of this gene and study ... and related disorders," Mehta said. So far, mouse models lacking the protein have not shown any ...

Discovery could lead to a new animal model for hepatitis C

... a protein that allows the virus to enter mouse cells, a finding that represents the clearest ... a human protein, called occludin, that makes mouse cells susceptible to the virus. The discovery ... Rice's group found that even when they engineered mouse cells to overexpress all three proteins, the ...

Researchers iron out new role for serotonin

... author Ana Carnerio, Ph.D., discovered that a mouse strain they had been using to studying SERT ... By querying an online resource called the mouse Phenome Database, they found that most mouse strains possess a SERT version called "ER" which ...

New asthma research opposes current drug treatment, says UH prof

... shows the absence of asthma-like symptoms in a mouse model that lacks the key gene that produces the ... the development of asthma-like symptoms in a mouse model in which the beta-2 adrenoreceptor gene had been removed as compared to the mouse model with the intact receptor gene. "The ...

JCI online early table of contents: Jan. 19, 2009

... and using it to inhibit the growth of human and mouse prostate cancer cell lines in mouse models of prostate cancer. Further in vitro ... TITLE: Pim-1specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing ...

Large DNA stretches, not single genes, shut off as cells mature

... previous studies have implied. Working with mouse brain and liver cells, as well as embryonic stem ... To find out, he and his team looked for LOCKs in mouse embryonic stem cells. Unlike mature, adult liver ... the regions of DNA affected by LOCKs between mouse liver and brain cells and their corresponding ...

Tips from the American Journal of Pathology

... that CXCL1 decreases the severity of disease in a mouse model of multiple sclerosis (MS). They report ... specifically expressed in the nervous system in a mouse model of MS. They observed decreased severity of ... the anti-inflammatory effects of annexin A1 in a mouse model of peritonitis. FPR family members had ...

Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo

... reactive oxygen species in cells, tissues and mouse models were reported on December 8 in the online ... image reactive oxygen species production in live mouse aorta tissue, which exhibit a physiological ... the researchers progressed to in vivo mouse imaging studies. Hydro-Cy7 was selected for the ...

UC Davis researchers exploring gene therapy to fight AIDS

... present a poster detailing the development of a mouse model that allows pre-clinical testing of their ... and efficacy trials. Researchers have created a mouse model that replicates a normally functioning ... HIV infection," noted Anderson. "The humanized mouse model is an important step toward bringing this ...

Gene therapy corrects sickle cell disease in laboratory study

... a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's ... Therapy , the researchers used a strain of mouse with basically the same genetic defect and ... approaches." While Persons believes that the mouse experiments will lead to treatments in humans, he ...

Scientists shed light on evolution of gene regulation

... that bind to the GATA1 protein along most of a mouse chromosome. The technique works by using an ... segments that are associated with GATA1 in the mouse chromosome. They then compared the DNA sequences ... percent of the GATA1-bound DNA sequences from the mouse were present in an identical form in other ...

Chicks to give scientists clearer picture of fetal development

... made available from the sequencing of the mouse and chicken genomes. In particular, it will build on the pioneering Edinburgh mouse Atlas at the MRC Human Genetics Unit in Edinburgh ... By cross referencing similarities with the mouse atlas, scientists can identify the most relevant ...

Multiple sclerosis research charges ahead with new mouse model of disease

... , a team of Canadian researchers report on a new mouse model of disease which will help in understanding ... in Ontario created a genetically modified mouse expressing too much of an enzyme known as PAD2. ... Not only does this work present a new mouse model to study demyleinating disease, but it also ...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

... brains from transgenic Alzheimer's disease type mouse models suggest the role of mitochondrial Aβ ... of Alzheimer's disease patients and a transgenic mouse model of Alzheimer's disease. The cortical ... and synaptic function of an Alzheimer's disease mouse model and alleviated Aβ-mediated reduction ...
Other Contents
(Date:9/2/2014)... long, spiky legs and their propensity for eating anything, ... nightmares. And now research from North Carolina State University ... homes across the eastern United States. , "The good ... any kind of threat to humans," says Dr. Mary ... lead author of a paper about the research. , ...
(Date:9/2/2014)... are done in by it. New research at Rockefeller ... stress gap in mice with very similar genetic backgrounds ... understand the development of psychiatric disorders such as anxiety ... experiences as it goes through its life. And we ... of genes, and as a result, affect an animal,s ...
(Date:9/1/2014)... diet showed some modest improvement in the last decade ... consumption of unhealthy trans fats, but the gap in ... poor. , , An unhealthy diet is closely linked ... healthy diet is an important part of the strategy ... diet quality is important because it can offer guidance ...
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(Date:9/2/2014)... New York, New York (PRWEB) September 02, 2014 ... metal-on-metal version of the DePuy Pinnacle hip implant ... jury selection begins today in the U.S. District ... reports. According to court documents, Johnson & Johnson ... 6,000 lawsuits that allege the all-metal hip caused ...
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(Date:9/2/2014)... research shows a novel polypill increases patient adherence ... heart attack, according to new study results reported ... 2014 in Barcelona, Spain. According to Principal Investigator ... Heart at Icahn School of Medicine at Mount ... de Investigaciones Cardiovasculares Carlos III (CNIC) in Madrid, ...
(Date:9/2/2014)... San Diego School of Medicine have identified an enzyme ... findings, reported in the current issue of PNAS, offer ... worldwide. An estimated 40,000 women in America will die ... Cancer Society. , "The take-home message of the study ... breast cancer metastasis through a pathway regulated by an ...
(Date:9/2/2014)... associated with many health risks, including heart disease and ... possible way to mitigate one often-overlooked risk: not buckling ... by Sheldon H. Jacobson, a professor of computer science ... are associated with a decrease in seatbelt usage. However, ... in effect. , "Primary seatbelt laws lead to increased ...
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