Protein handlers should be effective treatment target for cancer and Alzheimer's
... a viral immunologist, have developed 20 mouse
models missing different molecular chaperones or ... chaperones. For contrast, they also have a mouse
that over expresses heat shock factor 1, or Hsf1, ... breast cancers. By comparing the resulting mouse
to one that just over expresses Her2/Neu, they ...
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
... cancer. Their studies were performed in mouse
cancer models and in human cell cultures.
... and then proteins. Studies in both cells and a mouse
model for cancer showed that they could promote ... act as a "first hit" that makes the inversion on mouse
chromosome 6, which contains the DLX5 gene, more ...
Scientists track impact of DNA damage in the developing brain
... DNA strands in an organ system, in this case the mouse
brain and nervous system. While the results ... a way to switch off Xrcc1 production in the mouse
brain and nervous system as development began. ... system. St. Jude researchers then developed a mouse
that carried an Xrcc1 gene outfitted with ...
Scientists closer to making implantable bone material, thanks to new research
... materials that were grown from bone cells from mouse
skull and mouse
bone marrow stem cells successfully mimicked many ... found that the 'bone-like' material grown from mouse
embryonic stem cells was much less stiff and less ...
Scientists link immune system's natural killer cells to infant liver disease
... led the research team to experiment with a mouse
model of biliary atresia.
In the mouse
experiments, the scientists used a rotavirus ... cells were the most abundant cells populating the mouse
livers and bile ducts at the time of obstruction. ...
Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
... according to researchers studying an "anti-aging" mouse
model that lives longer than a typical mouse.
... of Pittsburgh of UPMC, reports that the novel mouse
model has a thymus that remains intact throughout ... throughout life," said Dr. de Vallejo.
model that Dr. de Vallejo's team studied was ...
Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system
... to maneuver a powered wheelchair or control a mouse
cursor using simple tongue movements can be ... the user issued commands to move the computer mouse
left and right. Using these commands, each ... and down -- the subjects were asked to move the mouse
cursor through an on-screen maze as quickly and ...
Female human embryos adjust the balance of X chromosomes before implantation
... that major characteristics that are present in mouse
pre-implantation embryos are present also in ... already have, or still have, a form of XCI. While mouse
embryos reactivate the X chromosome in the inner ... embryos occur at a later stage than in mouse
embryos. Thus, it is possible that reactivation ...
Mouse model provides clues to human language development
... journal Cell .
Scientists of the German mouse
Clinic at Helmholtz Zentrum Mnchen have generated and analyzed a mouse
model in which parts of the human Foxp2 gene were ... now.
The Helmholtz scientists in the German mouse
Clinic conduct comprehensive analyses to ...
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
... located the genes for the subunits in both the mouse
and human chromosomes. After coming to Penn State ... in mice.
The Penn State researchers used a mouse
model of IBD, replicating inflammation in the ... inflammation in the injured intestine.
In the mouse
model, it is possible to make detailed ...
UCSF discovers new glucose-regulating protein linked with diabetes
... the researchers.
"Much has been learned from mouse
models about glucose metabolism that is relevant ... she said, GLUT4 is stored inside both human and mouse
muscles in a special compartment that releases it ... the Harvard team on this research produced the mouse
capable of expressing CHC22 in its muscles and ...
A new mouse model provides insight into genetic neurological disorders
... altering a protein-making molecule, a mouse
was made to help understand nervous system ... and legs in humans.
Scientists have created a mouse
to help understand human neuronal diseases that ... altering a protein-making molecule, a mouse
was made with symptoms similar to the nervous ...
Tips from the American Journal of Pathology
... kidney disease progression, Ju et al screened a mouse
model of progressive renal disease to identify ... AM80 is effective in treating early symptoms in a mouse
model of multiple sclerosis (MS). They report ... in MS and other autoimmune diseases.
Using a mouse
model of MS, Klenmann et al found that AM80, a ...
Stanford scientists turn adult skin cells into muscle and vice versa
... point, they transformed human skin cells into mouse
muscle cells and vice versa. This research shows ... cells that had nuclei from human skin cells and mouse
muscle cells. By being encapsulated within the same cell wall, the human skin cells and mouse
muscle nuclei could now "talk" to one another via ...
Diminuendo -- New mouse model for understanding cause of progressive hearing loss
... sensory hair cells in the inner ear, both in the mouse
and in humans. The findings have been published ... of Experimental Genetics, have developed a new mouse
model with a genetic mutant in which a single ... we were very surprised when with our new mouse
model we discovered this new class of genes ...
New study overturns orthodoxy on how macrophages kill bacteria
... were much, much less likely to survive in the mouse
than bacteria with only the SodB gene missing. ... mutants were less likely to survive in a mouse
did not prove, however, that the missing enzymes ... protecting the bacteria from ROS generated in the mouse
macrophages, Slauch said.
"You get the same ...
UT Southwestern researchers probe kidney damage, protection in lupus
... Southwestern Medical Center have discovered in a mouse
In a separate study with an ... caused by a different mechanism.
For this mouse
study, the researchers administered antibodies ... in the proteins encoded by the genes in normal mouse
strains, compared with lupus-prone strains. When ...
New insights into progressive hearing loss
... in the equivalent genomic regions in human and mouse
identified as implicated in hearing loss; the ... first and just one away from the mutation in the mouse
gene. All three sit in a vital region of seven ...
Researchers are using models of hearing in the mouse
to understand human hearing deficits: by the age ...
Human ES cells progress slowly in myelin's direction
... stem (ES) cells, it's relatively easy to persuade mouse
ES cells to turn into oligodendrocytes; it's ... it, 14 weeks as opposed to the 2 weeks taken by mouse
ES cells. They also report another difference between mouse
and human ES cells: a growth factor called Fgf2 ...
Stem cell therapy makes cloudy corneas clear, according to Pitt researchers
... indicate that after stem cell treatment, mouse
eyes that initially had corneal defects looked no different than mouse
eyes that had never been damaged," Dr. ... But three months after the lumican-deficient mouse
eyes were injected with human adult corneal stem ...
CSHL team develops mouse models of leukemia that predict response to chemotherapy
... goals for human cancer therapy by developing new mouse
models for human acute myeloid leukemia (AML), an ... resistance or sensitivity to any cancer drug. The mouse
models, the CSHL team notes, also serve as an ... effective use in the clinic."
The Lowe team's mouse
models also provide valuable insights into how ...
Brain building: Study shows brain growth tied to cell division in mouse embryos
... Cell Biology ( JCB ), Lake and Sokol report that mouse
protein Vangl2 controls the asymmetrical cell ... fate. The research duo found that Vangl2-lacking mouse
embryos had large numbers of early-born neurons ... progenitors in the brains of Vangl2-lacking mouse
embryos. Also, Vangl2-lacking cells in culture ...
Targeted drug therapy prevents exercise-induced arrhythmias
... inside heart cells. Knollmann's team developed a mouse
model for CPVT (by eliminating the calsequestrin ... prevented ventricular arrhythmias in the mouse
model of CPVT.
"So we knew that this ... calsequestrin gene, the same gene mutated in the mouse
model; the woman has a mutation in the ryanodine ...
The host makes all the difference
... says Klaus Schughart, head of the Experimental mouse
Genetics research group. In infection experiments ... the researchers injected seven different inbred mouse
strains with the same quantity of type Influenza A flu viruses. All of the animals within one mouse
strain are genetically identical, like identical ...
Tips from the American Journal of Pathology
... Am J Pathol 2009, 174: 1347-1357
Model of Human Psoriasis
Researchers led by ... University, Cleveland have developed a new mouse
model to study human psoriasis. These findings ... been limited, however, due to the absence of a mouse
model that adequately reproduces these symptoms. ...
Researchers piggyback to safer reprogrammed stem cells
... They successfully persuaded partly specialised mouse
cells, called Epi-stem cells, to reprogram into ... mice when introduced into newly developing mouse
embryos and can give rise to the offspring of ... this approach produces perfectly reprogrammed mouse
cells. The Nature papers show that it can also ...
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
... and colleagues previously had created the hybrid mouse
model by cross-breeding mice deficient in PKC ... their entire genome.
"We are generating more mouse
models to vary expression of this gene and study ... and related disorders," Mehta said.
So far, mouse
models lacking the protein have not shown any ...
Discovery could lead to a new animal model for hepatitis C
... a protein that allows the virus to enter mouse
cells, a finding that represents the clearest ... a human protein, called occludin, that makes mouse
cells susceptible to the virus. The discovery ... Rice's group found that even when they engineered mouse
cells to overexpress all three proteins, the ...
Researchers iron out new role for serotonin
... author Ana Carnerio, Ph.D., discovered that a mouse
strain they had been using to studying SERT ... By querying an online resource called the mouse
Phenome Database, they found that most mouse
strains possess a SERT version called "ER" which ...
New asthma research opposes current drug treatment, says UH prof
... shows the absence of asthma-like symptoms in a mouse
model that lacks the key gene that produces the ... the development of asthma-like symptoms in a mouse
model in which the beta-2 adrenoreceptor gene had been removed as compared to the mouse
model with the intact receptor gene.
JCI online early table of contents: Jan. 19, 2009
... and using it to inhibit the growth of human and mouse
prostate cancer cell lines in mouse
models of prostate cancer. Further in vitro ...
TITLE: Pim-1specific mAb suppresses human and mouse
tumor growth by decreasing PIM-1 levels, reducing ...
Large DNA stretches, not single genes, shut off as cells mature
... previous studies have implied.
Working with mouse
brain and liver cells, as well as embryonic stem ... To find out, he and his team looked for LOCKs in mouse
embryonic stem cells. Unlike mature, adult liver ... the regions of DNA affected by LOCKs between mouse
liver and brain cells and their corresponding ...
Tips from the American Journal of Pathology
... that CXCL1 decreases the severity of disease in a mouse
model of multiple sclerosis (MS). They report ... specifically expressed in the nervous system in a mouse
model of MS. They observed decreased severity of ... the anti-inflammatory effects of annexin A1 in a mouse
model of peritonitis. FPR family members had ...
Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
... reactive oxygen species in cells, tissues and mouse
models were reported on December 8 in the online ... image reactive oxygen species production in live mouse
aorta tissue, which exhibit a physiological ... the researchers progressed to in vivo mouse
imaging studies. Hydro-Cy7 was selected for the ...
UC Davis researchers exploring gene therapy to fight AIDS
... present a poster detailing the development of a mouse
model that allows pre-clinical testing of their ... and efficacy trials. Researchers have created a mouse
model that replicates a normally functioning ... HIV infection," noted Anderson. "The humanized mouse
model is an important step toward bringing this ...
Gene therapy corrects sickle cell disease in laboratory study
... a harmless virus to insert a corrective gene into mouse
blood cells, scientists at St. Jude Children's ... Therapy , the researchers used a strain of mouse
with basically the same genetic defect and ... approaches."
While Persons believes that the mouse
experiments will lead to treatments in humans, he ...
Scientists shed light on evolution of gene regulation
... that bind to the GATA1 protein along most of a mouse
chromosome. The technique works by using an ... segments that are associated with GATA1 in the mouse
chromosome. They then compared the DNA sequences ... percent of the GATA1-bound DNA sequences from the mouse
were present in an identical form in other ...
Chicks to give scientists clearer picture of fetal development
... made available from the sequencing of the mouse
and chicken genomes. In particular, it will build on the pioneering Edinburgh mouse
Atlas at the MRC Human Genetics Unit in Edinburgh ... By cross referencing similarities with the mouse
atlas, scientists can identify the most relevant ...
Multiple sclerosis research charges ahead with new mouse model of disease
... , a team of Canadian researchers report on a new mouse
model of disease which will help in understanding ... in Ontario created a genetically modified mouse
expressing too much of an enzyme known as PAD2. ...
Not only does this work present a new mouse
model to study demyleinating disease, but it also ...
Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients
... brains from transgenic Alzheimer's disease type mouse
models suggest the role of mitochondrial Aβ ... of Alzheimer's disease patients and a transgenic mouse
model of Alzheimer's disease. The cortical ... and synaptic function of an Alzheimer's disease mouse
model and alleviated Aβ-mediated reduction ...