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Monocytes in Biological News

Peering inside the skull of a mouse to solve meningitis mystery

... experiments revealed that the real villains were monocytes and neutrophils, two types of white blood cells ... cells, the T-cells appeared to be summoning monocytes and neutrophils to the site of infection, like a ... a totally new targetthe neutrophils and monocytes recruited by the T-cells," Dr. Dustin says. "If ...

Tumor-inhibiting protein could be effective in treating leukemia

... "The Novel Angiogenic Inhibitor, Angiocidin, Induces Differentiation of monocytes to Macropahges," will be published in the July 15 issue of the journal ... against bloodborne pathogens and moves quickly to sites of infection. As monocytes enter tissue, they undergo a series of changes to become macrophages. ...

Lipoic acid could reduce atherosclerosis, weight gain

... disease, which begins when certain types of white blood cells called monocytes bind to adhesion molecules on the walls of arteries. This in turn allows the monocytes to enter the arterial wall, there they become inflammatory macrophages ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... human anti-PS antibody, PGN635, to confirm previous observations that in vitro, anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, most likely via cell-mediated mechanisms such as antibody-dependent ...

New origin found for a critical immune response

... other chemokines or chemokine receptors. They found that mice without the Ccr2 chemokine receptor that controls the migration of inflammatory monocytes had much lower accumulation of monocyte-derived dendritic cells and TH1 responses. The scientists concluded that there is a blood-derived lymph ...

New discovery may lead to new class of allergy drugs

... during an allergic reaction. Through a series of laboratory procedures, they tracked changes in immune cell type and found that eotaxin inhibits monocytes becoming dendritic cells (that find foreign invaders so other immune cells can neutralize them), resulting in more "fighter" cells being present ...

AVS 55th International Symposium & Exhibition, Oct. 19-24

... TRAP CELLS ... demonstrate the ease of trapping for bubbles, spheres, rod-like debris, non-spherical motile phytoplankton, macrophages, and monocytes in different fluid ... See: http://www.avssymposium.org/paper.asp?abstractID=1215 . GRAPHENE -- THE CARBON FLATLAND. Andrei Geim, ...

UC Davis researchers discover new drug target for inflammatory disease

... which are important first-line defenders for the immune system responsible for attacking foreign substances in the body. At elevated levels, monocytes indicate an overresponsive immune system. The involvement of integrins to the inflammatory process is of particular interest to study co-author ...

Biomarkers allow doctors to match therapy to patient

... with sunitinib, the ccEPC increases paralleled the rise in plasma VEGF levels; they decreased during the two-week off period, Vroling reports. monocytes and hematopoietic progenitor cells (HPCs) demonstrated the opposite pattern, according to Vroling. In a preliminary analysis, we found a ...

Teasing out tissue from blood

... produce stem cells from whiteblood cells called monocytes and develop them into many different tissue types ... because the idea that specialised cells like monocytes can be "de-differentiated" back to more primitive ... Cell Research meeting. Deriving "stem cells" from monocytes was originally reported in 2003 in Proceedings of ...

Leprosy microbes lead scientists to immune discovery

... The large white blood cells known as monocytes rapidly differentiated into the two distinct cell ... a trip-wire to raise the alarm. The TLRs spur the monocytes to differentiate into the two rapid response cell ... more severe leprosy infections, meaning that the monocytes hadn't succeeded in producing those key ...

Inflammation markers identify fatigue in breast cancer survivors

... monocytes. In some survivors, however, many of the IL-6R are shed from the monocytes and are soluble within the blood plasma. Those free-floating receptors can ... immune responses within people. "IL-6 contributes to an activation of monocytes in the blood, and enables antigen presenting cells to activate T cells as ...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

... a substance that binds to certain immune cells, and interferon gamma were added to dendritic cells. In the study, white blood cells called monocytes were obtained from both HIV patients and individuals not infected with the virus. In the laboratory, the researchers coaxed them to differentiate ...

Case Western Reserve University researchers find protein associated with brain cell death

... article, "Fibrillar Beta-Amyloid Stimulated Intracellular Signaling Cascades Require Vav for Induction of Respiratory Burst and Phagocytosis in monocytes and Microglia." The researchers discuss the role that the multi-domain protein Vav plays in the intercellular signaling of microglia, the brain's ...

US/African project deciphers deadly parasite genome

... a parallel report on the genome of the related cattle parasite T. annulata, which causes tropical theileriosis in cattle and transforms macrophages, monocytes and B-lymphocytes. That study was led by scientists at the Wellcome Trust Sanger Institute in Hinxton, UK. The lead author of Sanger's T. annulata ...

Scientists solve structure of key protein in innate immune response

... it presents the molecule to other proteins which initiate a strong pro-inflammatory response that stimulates host defenses. "Macrophages and monocytes can recognize distinct structural patterns in various molecules from pathogenic microorganisms," explains Dr. Jie-Oh Lee of the Korea Advanced ...
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