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Monoclonal in Biological News

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

... Washington, DC - New research suggests that monoclonal antibody therapy of cancer can be improved to be ... recognized expert in development and use of monoclonal antibodies. "Treatment modifications might be ... on reviewing the last eight years of research on monoclonal antibody treatment, suggests that a new era in ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented ... methods. "There are clear settings where human monoclonal antibodies can be used strategically for both the ... mice that were exposed to H5N1 virus. "Our human monoclonal antibody protected mice from the lethal H5N1 ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented ... methods. "There are clear settings where human monoclonal antibodies can be used strategically for both the ... mice that were exposed to H5N1 virus. "Our human monoclonal antibody protected mice from the lethal H5N1 ...

UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology

... have developed a new, quicker way to sequence monoclonal antibodies a process that is many times faster ... titled, "Automated de novo protein sequencing of monoclonal antibodies." In it, the authors propose a new ... routinely used in the initial characterization of monoclonal antibodies, but subsequent mutations and other ...

Is hybridoma production about to take a quantum leap forward?

... have started to evaluate the use of fully human monoclonal antibodies as a complementary or primary ... benefits, the efficient production of human monoclonal antibodies is a high priority. But any attempt to ... human tissues. The capacity to humanize monoclonal antibodies in 1988 through hybridoma cell ...

First human gets new antibody aimed at hepatitis C virus

... of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody they developed that can neutralize the Hepatitis C virus (HCV). ... be neutralized and rendered unable to infect the new liver. Then, because monoclonal antibodies are highly specific and typically have little or no ...

Novel antibody prevents infection by hepatitis C virus

... University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV). The new antibody ... be neutralized and rendered unable to infect the new liver. Then, because monoclonal antibodies are highly specific and typically have little or no ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... of significant protection from relapse indicates that treatment with monoclonal antibodies against the toxins could reduce this significant and costly ... health problem." "These results highlight the exquisite specificity of monoclonal antibodies and their important role to save lives," said Howard H. Pien, ...

Galiximab in combination with rituximab in patients with previously untreated follicular lymphoma

... responded to treatment with galiximab, an investigational anti-CD80 monoclonal antibody, when given in combination with rituximab. Of the 61 patients in ... with this combination immunotherapy regimen. Galiximab is an anti-CD80 monoclonal antibody that has been studied as a single-agent in previously treated FL ...

Bright lights: Mystery of glowing antibody solved by Scripps research scientists

... scientists have shown that EP2-19G2, one of a panel of fluorescent monoclonal antibodies that were first reported in 2000, produces its distinctive ... to monitoring blood glucose levels for diabetic patients. When the monoclonal antibody EP2-19G2 is combined with stilbene, a hydrocarbon commonly used ...

Biotech Co. founded by UCLA Scientists to be acquired by Astellas, Pharma Inc.

... private biotech firms poised to tackle therapeutic, fully human monoclonal antibody oncology research and drug development. According to ... They were joined in 1999 by Dr. Aya Jakobovits, who helped develop monoclonal antibody technology at the company. Today, Agensys specializes in the ...

Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax

... New England Journal of Medicine of the results of two pivotal animal efficacy studies, which showed the life-saving potential of the Company's human monoclonal antibody drug raxibacumab (ABthrax), as well as the results of human safety studies, which supported the use of raxibacumab in the event of ...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... of invasive breast cancers. HER2 was chosen for the development of an entirely novel cancer therapy, culminating in the production of an anti-HER2 monoclonal antibody that since 1998 has been used successfully to treat patients with metastatic breast cancer. This was the first targeted therapeutic agent ...

Scientists develop a new HIV microbicide -- and a way to mass produce it in plants

... of which we address in this study." In the research paper, Ma and colleagues describe how they combined two protein microbicides (b12 monoclonal antibody and cyanovirin-N) into a single "fusion" molecule and showed that this molecule is more active against HIV than either of its individual ...

Novel vaccine approach offers hope in fight against HIV

... measure against HIV infection in people, Johnson said. "To ultimately succeed, more and better molecules that work against HIV, including human monoclonal antibodies, will be needed," he and his co-authors conclude. Finally, added Johnson, their approach may also have potential use in preventing other ...

NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA

... in the CMO market. The Rhobust® universal processing platform from Upfront Chromatography enables customers to efficiently capture and purify monoclonal antibodies, therapeutic proteins and other biomolecules directly from blood plasma or bioreactors, without the need for prior filtration.   ...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

... said than done--at least in the case of HIV. In their PNAS paper, Bjorkman and Klein looked at the neutralization capabilities of two different monoclonal antibodies isolated from HIV-infected individuals. One, called b12, binds a protein known as gp120, which forms the upper portion of an HIV's protein ...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

... an exclusive worldwide license agreement for CDA-1 and CDB-1 (also known as MDX-066/MDX-1388 and MBL-CDA1/MBL-CDB1), an investigational fully human monoclonal antibody combination developed to target and neutralize Clostridium difficile toxins A and B, for the treatment of C. difficile infection (CDI). ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... Colorado and TUSTIN, Calif., April 21, 2009--Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and serious virus infections, today reported that two preclinical studies presented during the AACR 100th ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... family, such as OX40L, might benefit some patients with inflammatory diseases, including asthma. MedImmune has a strong focus in developing human monoclonal antibodies for potential prevention and treatment of respiratory and inflammatory diseases, and currently has multiple programs underway targeting ...

Tailor-made recombinant proteins in mammals

... BERKELEY, CA A new way to direct chemical modifications to specific sites on recombinant proteins including the monoclonal antibodies so important in the pharmaceutical industry has been developed by Carolyn Bertozzi and her colleagues at the U.S. Department of Energy's ...

UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development

... infection-fighting agents, against the disease. Dr. Vitetta's research group will screen thousands of peptoids for their ability to bind to pre-made monoclonal antibodies that are already known to neutralize all varieties of a given pathogen. For example, the researchers will look for peptoids that bind to ...

New technique sees into tissue at greater depth, resolution

... by the National Institutes of Health. For their experiments, the Duke team attached nanospheres of gold to a targeting molecule known as a monoclonal antibody. Gold is a metal that not only is an efficient conductor of heat, but whose effects in the body are well known. The antibody they used ...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

... cytokine, TNF-alpha, was responsible for the debilitating symptoms of inflammatory disease. In seeking ways to block TNF-alpha, they studied a monoclonal antibody previously developed for an unrelated condition. Clinical trials revealed rapid and dramatic improvement of rheumatoid disease activity ...

New genes found for inflammatory bowel disease in children

... is a cytokine, a chemical messenger that plays a key role in the harmful inflammation characteristic of IBD. Some current treatments for IBD use monoclonal antibodies that selectively bind to a type of TNF involved in the disease (Among those drugs are infliximab, adalimumab and certolizumab). "As we ...

1918 flu antibodies resurrected from elderly survivors

... Crowe's team then fused cells showing the highest levels of activity against the virus with "immortal" cells to create a cell line that secretes monoclonal (or identical) antibodies to the 1918 flu. The antibodies reacted strongly to the 1918 virus and cross-reacted with proteins from the related 1930 ...

Leading researchers and experts gather to discuss latest advancements in drug discovery

... and Microbiome The meeting will also offer sessions on translational medicine, biomarkers and discovery, and the development of vaccines and monoclonal antibodies. ...

New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis

... been reported in some patients treated with Actemra. About Actemra Actemra is the first humanised interleukin-6 (IL-6) receptor inhibiting monoclonal antibody and represents a novel mechanism of action to treat RA, a disease with a high unmet medical need. The overall safety profile observed in the ...

Possible hepatitis C vaccine

... transplant in Britain. Now, in a collaborative effort with groups across Europe and the USA, scientists from The University of Nottingham have found monoclonal antibodies which may be a significant step towards a vaccine. Hepatitis C treatment is expensive and not successful in all patients. Untreated or ...

Mice stressed in simulated weightlessness show organ atrophy

... the same laboratory conditions. OPN is the continuing focus of Denhardts research interests. His long-term goal is to develop an OPN antibody a monoclonal or target-specific antibody that will inhibit OPN function in lab mice, and ultimately, in humans. This antibody could prove useful in treating the ...

Avian influenza survivors' antibodies effective at neutralising H5N1 strain

... Diseases in Bethesda, US, have shown that monoclonal antibodies generated from blood of human ... that allows them to rapidly reproduce human monoclonal antibodies starting from a small sample of blood. ... strain that we have been studying or that the monoclonal antibodies generated using our technique will be ...

Monoclonal antibody reduces exacerbations in asthmatics

... necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly fewer disease ... associates infused 14 patients with infliximab, a monoclonal antibody that binds and neutralizes tumor ... were no adverse events associated with using the monoclonal antibody for treatment. "Given that infliximab ...

Report calls for improved monoclonal antibodies against solid tumors

... A new report by leading experts in monoclonal antibody research for oncology offers a ... manipulation of the physical properties of a monoclonal antibody as a potentially effective way to improve antibody treatments for solid tumors. monoclonal antibodies?ability to target a single specific ...

Researchers unveil strategy for creating actively-programmed anti-cancer molecules

... molecules and a non-targeting catalytic monoclonal aldolase antibody in a novel self-assembly ... recognize foreign pathogens harmful to the body; monoclonal antibodies are produced in the laboratory from a ... result of metastasis. The therapeutic use of monoclonal antibodies has expanded rapidly over the last ...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

... session include: A nanotube, combined with monoclonal antibodies, is detecting cancer cells, offering a ... Single Wall Carbon Nanotubes with Adsorbed monoclonal Antibodies Detect Breast Cancer Cells (Abstract ... an engineer have used tiny carbon nanotubes and monoclonal antibodies to detect cancer cells in the ...

Scientists turn tobacco against cancer

... College are using tobacco plants to produce monoclonal antibodies -- tiny guided protein missiles -- ... had previously shown that tobacco plant-made monoclonal antibodies could neutralize rabies virus and ... They first showed that plant-made monoclonal antibody purified from tobacco leaves could ...

Promising new West Nile therapy cures disease in mice

... to develop the potential treatment--known as a monoclonal antibody--after finding that antibodies taken ... The Washington University scientists made 46 monoclonal antibodies against West Nile virus and then ... virus into the scaffold of a human antibody. The monoclonal antibody was several hundred times more potent in ...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

... and chronic viral illnesses. Specifically, the article discusses using monoclonal antibodies in order to stimulate the immune system. In this therapy the ... predict. Aside from this, there are another four members of this monoclonal antibiotic family, which stimulate the immune system, currently being ...

Tiny Tampa Bay fish key to evolution of immune system

... proteins are susceptible to enzymes that break them down. A number of such monoclonal antibody-based drugs are in clinical use, such as Herceptin for breast ... core of this molecule, then we expect to design and produce more stable monoclonal antibodies for therapy," he said. Neil S. Greenspan, M.D., Ph.D., a ...
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(Date:9/30/2014)... Salk professor and Howard Hughes Medical Institute investigator, ... named recipients in the 2014 round of grants ... the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) ... announced September 30, provides more than $3 million ... years. , The BRAIN Initiative, launched last year, ...
(Date:9/30/2014)... water may increase the risk of stillbirth and ... by a Boston University School of Public Health ... Environmental Health , compared 1,091 PCE-exposed pregnancies ... Cape Cod, Ma., where water was contaminated in ... the installation of vinyl-lined asbestos cement pipes. PCE ...
(Date:9/30/2014)... live in almost any aquatic environment on Earth, but ... species are pushed to the limit. The amount of ... critical for how different species cope in the future, ... of Gothenburg, published in the scientific journal Proceedings ... continues apace thanks to increasing levels of greenhouse gases ...
Breaking Biology News(10 mins):Salk scientists receive $3 million for BRAIN Initiative grant 2Contaminated water linked to pregnancy complications, BU study finds 2Shape up quickly -- applies to fish, too! 2
(Date:9/30/2014)... By Alan Mozes ... 2014 (HealthDay News) -- Colon cancer patients who are ... slightly higher risk for developing a second weight-related cancer, ... to the risk of colon cancer recurrence, only the ... , "We found that colorectal cancer survivors who reported ...
(Date:9/30/2014)... leading cause of cancer death in women, according to ... professionals encourage women to get mammograms, even though the ... suspicious mammograms actually leads to a cancer diagnosis. , ... and their familiesnot to mention the time, discomfort and ... , Recently, a different type of test, ultrasound elastography, ...
(Date:9/30/2014)... September 30, 2014 Keystone Symposia will convene ... first in its 2014-15 Global Health Series on ... Sheraton Seattle Hotel immediately following the conclusion of ... four-day conference is part of the Keystone Symposia Global ... Foundation, which has also funded travel awards for 36 ...
(Date:9/30/2014)... 30, 2014 A new study ... studied the impact of stress on metabolism after eating a ... fries from a fast food restaurant, about 930 calories and ... for 20 minutes every hour for 7 hours, conducting the ... women who had experienced a stressful event in their lives ...
(Date:9/30/2014)... Integrated Medicine Alliance , Monmouth ... new medical specialty practice through a unique partnership with ... be located within the company’s Shrewsbury location and will ... Tawfik of American Heart Center, P.C., a highly regarded ... offer Integrated Medicine Alliance patients top notch cardiovascular care ...
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