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Modulation in Biological News

New insights into the regulation of PTEN tumor suppression function

... prevent its ability to act as a tumor suppressor," notes Pandolfi. "The modulation of the PML-HAUSP pathway offers us an exciting and unique approach to ... "Because PML is known to be 'druggable,' we believe that in cases of APL, modulation of PTEN function can be achieved with drugs already being used for the ...

Distinguishing between 2 birds of a feather

... as contextual modulation," explains Sharpee. To unveil how contextual modulation shapes the apparent profile of neurons specialized in recognizing ... that larger receptive field components were more susceptible to contextual modulation and adjusted more than smaller ones. But more importantly, they ...

BWF awards $7 million to infectious disease investigators

... Ph.D. University of Texas-Austin Mechanistic insight into host modulation of bacterial group activities Dong Yu, Ph.D. Washington University School of Medicine modulation of the DNA damage response by human cytomegalovirus ...

Stem cell research: From molecular physiology to therapeutic applications

... have not yet been clearly defined. In this review, Professor Robert Zhao summarizes the current literature on the complex mechanism of MSCs' immune modulation and clinical studies, and discusses future directions for utilizing MSCs for clinical treatments[2]. Professor Hongkui Deng from Peking University ...

Key protein regulating inflammation may prove relevant to controlling sepsis

... of the regulatory mechanisms of NFκB and expanded the functional scope of NFκB. More important, such findings offer new opportunities for modulation of the NFκB signaling pathway and for exploring new therapeutic strategies in various human diseases such as cancer and sepsis." ...

Breakthrough in the treatment of bacterial meningitis

... to cross the blood-brain barrier. Their findings, published today in The Journal of Clinical Investigation , suggest that disruption or modulation of this interaction of bacterial adhesins with the receptor might offer unexpectedly broad protection against bacterial meningitis and may provide a ...

Journal of General Physiology explores mysteries of TRP channels in latest Perspectives series

... and Sangsu Bang and Sun Wook Hwang (Korea University Graduate School of Medicine), who share their views about the questions concerning the modulation of the functional properties of the TRPA1 channel and, in particular, that regarding its temperature sensitivity. ...

JDRF-funded researchers discover proteins regulating human beta cell replication

... is a fundamentally important one for JDRF's Regeneration Program. Dr. Stewart and his colleagues address this question by demonstrating that modulation of specific cell cycle control proteins stimulates human beta cell replication. By identifying the control points for human beta cell cycle ...

Study first to pinpoint why analgesic drugs may be less potent in females than in males

... expression in a region of the brain called the periaqueductal gray area (PAG). Located in the midbrain area, the PAG plays a major role in the modulation of pain by housing a large population of mu-opioid receptor expressing neurons. Morphine and similar drugs bind to these mu-opioid receptors ...

TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims

... Dianna Boughter, who can be reached at 480-301-9875. "VTX-2337 is the first selective TLR8 compound to reach the clinic, and we are hopeful that modulation of the innate immune response will provide a benefit to patients in a number of oncology indications," said Dr. Robert Hershberg, Executive Vice ...

Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D

... fragility," the paper notes. The researchers were interested in looking at vitamin D levels because of the vitamin's presumed role in immune modulation and because it is thought to possibly play a role in the occurrence of type 1 diabetes. In addition, there has been a rise in vitamin D deficiency ...

Computation and genomics data drive bacterial research into new golden age

... response to different situations. Apart from bringing together experts from different fields to reveal new insights like the role of frequency modulation in gene expression, the ESF conference also achieved its other major objective of sustaining momentum in the field by establishing BacNet as an ...

From sheet metal elements to host cells: DFG launches 10 new collaborative research centers

... by host university) Collaborative Research Centre/Transregional Collaborative Research Centre 57, "Organ Fibrosis: From Mechanisms of Injury to modulation of Disease" deals with an extremely important scientific and clinical topic. Researchers at several sites study fibroses, i.e. the pathological ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... the removal of only Mfn2 produces insulin resistance in later experiments in a simple living model not only in individual cells - , would imply that modulation of this gene contributes to this pathology, thereby making Mfn2 a therapeutic target of interest", concludes Zorzano. Type 2 diabetes currently ...

Astrocytes and synaptic plasticity

... taken up by astrocytes. Astrocytes, previously thought to be unimportant in neuronal transmission, have recently been implicated in long-term modulation of neuronal synapses. For example, they release the neurotransmitter glutamate into the synapse prompting LTP. By specifically mopping up pro-BDNF, ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... cellular processes, led to a robust decrease in amyloid deposition in mice that develop plaque pathology commonly seen in Alzheimer's disease. modulation of neuronal calpain activity presents a potential therapeutic approach to Alzheimer's, they report. Presentation #P1-079 Partial ...

Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes

... N.Y. (Thursday, May 1, 2008) Recent discoveries have led to a revolution in the field of epigenetics, the study of gene regulation through the modulation of chromatin. These newly elaborated principles have brought the study of chromosomes and chromatin structure to the forefront of genetic research. ...

Biophysical Society announces winners of 2008 Student Travel Awards

... More Active Toward Pure POPC Membranes. Jill B. Jensen, University of Washington, FRET Reveals Kinetic Steps of Receptor-mediated modulation of Kv7 K+ Current and PIP2. Sarah G. Kamper, Calvin College, The Effect of Tether Length in Single Molecule Force Spectroscopy. Ann C. ...

Biophysical Society announces 2008 International Travel Awards

... towards Designing Dual LOX/COX Inhibitors as Potent Anti-Cancer Drugs. Shi-Qiang, Wang, Peking University, Beijing, China, B-adrenergic modulation of the Intermolecular Signaling Between a Single L-type Ca2+ Channel and Ryanodine Receptors in Rat Heart Cells. Xu-Long Wang, Shanghai Jiao ...

Ripening secrets of the vine revealed

... when grapes slow down their growth and change colour, this study highlighted an oxidative burst involving hydrogen peroxide (H2O2), and an extensive modulation of the enzymatic anti-oxidative network. Meanwhile, Laurent G. Deluc and colleagues from the University of Nevada, Reno and the Boston University ...

A novel way found to prevent protein plaques implicated in Alzheimer's

... all body fluids and tissues of mammals. It is a jack-of-all-trades, playing a broad role in many functions, including cell proliferation and growth, modulation of the inflammatory response, and bone resorption. The protein also has been implicated in neuronal degeneration and repair of the nervous system. ...

The endocannabinoids: Functional roles and therapeutic opportunities

... neurological score. The authors concluded that the endocannabinoid system may play an important role in the pathogenesis of hepatic encephalopathy. modulation of this system either by exogenous agonists specific for the CB2 receptors or possibly also by antagonists to the CB1 receptors may have therapeutic ...

ASPB announces Summer Undergraduate Research Fellowship 2007 recipients

... endosperm ADP-GlcPPase Mentor: Dr. Miguel Ballicora Ashley Hipps, Cornell University Project: Determining the Molecular Mechanisms of Temperature modulation of Defense Responses in Arabidopsis thaliana through int Mutants Mentor: Dr. Jian Hua Charles Mason, Pennsylvania State University Project: ...

Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent

... itself," Berk said. "From our prior studies, this modulation appears to be concomitant with mood state ... Berk noted: "An area we will pursue is the modulation and change in Th1 and Th2 cytokine and ... understanding and the mechanism linkage modulation between anticipatory positive behaviors and ...

Flies on speed offer insight into the roles of dopamine in sleep and arousal

... that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep, wake, and arousal states. The work is reported by Dr. Ralph ... in humans and other animals, and many of these brain functions involve the modulation of neuronal activity and the ability to assign proper saliency (or ...

Human's ecological footprint in 2015 and Amazonia revealed

... healthy forests can degrade key ecosystem services, such as carbon storage in biomass and soils, the regulation of water balance and river flow, the modulation of regional climate patterns, and the amelioration of infectious diseases. ...

OHSU lab finds meth receptor that could lead to therapy

... put it all together, what you realize is that meth acts on several signaling systems and that a successful therapeutic treatment will likely require modulation of several targets simultaneously. We still have a lot to learn about how meth affects the body through this system," Grandy said. "We have our work ...

Zinc plays important role in brain circuitry

... that the findings "will certainly revive the flagging hopes of zincologists. This work provides a clear demonstration that interfering with zinc modulation of a synaptic pathway leads to a significant alteration in the phenotype of the animal." The three scientists added that the finding "puts a nice ...

New mechanism explains glucose effect on wakefulness

... subtle changes in glucose levels affect firing of orexin "raises the possibility that, besides being important for adaptive responses to starvation, modulation of orexin cells by glucose has a much wider behavioral role, contributing to the continuous daily readjustments in the level of arousal and ....

Increased sensitivity to nerve signals keeps diabetes at bay

... maintaining normal insulin release and blood glucose levels," Wess said. "It's also clear from our findings that the parasympathetic nervous system's modulation of blood sugar is not a transient event--its effects on the pancreas are sustained for a long time after a meal." ...

Malignant melanoma cells secrete protein required for embryo formation

... findings illuminate the remarkable plasticity of melanoma cells and the utility of the developing zebrafish as a model for studying the epigenetic modulation of tumor cells. Melanoma is one of the deadliest forms of cancer. The five-year survival rate for melanoma patients with widespread disease is ...

Face perception is modulated by sexual orientation

... has an important role in the processing of facial cues required for social communication. In this light, the researchers suggest that the observed modulation by sexual preference of the response to faces within the orbitofrontal cortex extends the role of this brain region in social behavior. Does the ...

Olfactory system detects pheromones that control reproduction

... dogmas is that LHRH neurons receive inputs from the vomeronasal system. For example, textbooks on reproductive physiology say that pheromonal modulation of reproductive behavior depends on these connections," said Dulac. "However, our studies show that this idea is wrong." Previous experiments ...

Meditation associated with structural changes in brain

... could reduce the thinning of the cortex that typically occurs with aging. "The area where we see these differences is involved in both the modulation of functions like heart rate and breathing and also the integration of emotion with thought and reward-based decision making ?a central switchboard ...

Penn study finds direct role for glial cells in brain cross-talk

... high adenosine levels can suppress epileptic seizures. In contrast, low levels of adenosine increased the transmission of nerve impulses. The modulation of neuronal activity through the regulation of the level of adenosine in the synapse may explain the nature of wake-to-sleep transitions during ...

Researchers track down cause of a disfiguring bone disorder

... mutations." "Human genetic diseases of the skeleton such as sclerosteosis and Van Buchem disease provide a starting point for understanding the modulation of anabolic bone formation," noted team members Michaela Kneissel and Hansjoerg Keller of Novartis, "and ultimately have the potential to identify ...

Excess liver gene protects against high-fat diet

... study elucidates a previously unrecognized role for these liver receptors in the links between diet, serum lipids, and atherosclerosis." Selective modulation of the LXR target genes in liver may therefore ameliorate high lipid levels and cardiovascular disease, the researchers said. The researchers ...

Study finds adult stem cells can replicate

... Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, 2005, 679-691. Funding from the Arthritis Foundation and the National Institutes of Health supported this ...

Enzyme's newly discovered role may make it target for arthritis treatment

... Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, 2005, 679-691. Funding from the Arthritis Foundation and the National Institutes of Health supported this ...
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(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ... and bring LaunchKey to market in 2015. ...
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