Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... August Pi i Sunyer (IDIBAPS), is centred in the mitochondrion and its role in programmed cell death or apoptosis. The mitochondrion is the organelle in charge of the cell's ... its fluidity and response to several stimuli. The mitochondrion contains indispensable molecules so that the cell ...

Cutting calories could limit muscle wasting in later years

... found in every cell. The excess iron affects the chemistry inside the mitochondria, sparking the formation of harmful free radicals that can lead a mitochondrion straight to the emergency exit, said Christiaan Leeuwenburgh, Ph.D., a UF professor of aging in the UF College of Medicine and the Institute on ....

Boston College profs study oxidative stress subcellular to discover its role in diseases

... compounds that cause oxidative stress, the Boston College researchers have targeted specific locations within the cell notably the nucleus and mitochondrion and observed how these molecules interact with nucleic acids (DNA). This will make it easier to determine what parts of a cell are most likely to ...

Zebrafish to shed light on human mitochondrial diseases

... according to researchers at the University of Oregon. COX deficiencies refer to a breakdown of cytochrome coxidase, an enzyme located in the mitochondrion of every cell. Mitochondria are crucial cellular workhorses that provide chemical energy. Research of the deficiency has been stymied by a lack of ...

Hopkins researchers discover genetic switch that turns off an oxygen-poor cell's combustion engine

... that this genetic switch actively shuts off the mitochondrion under low oxygen conditions, apparently to ... of this link blocks the tendency of the mitochondrion to make toxic molecules as it struggles to ... into the TCA cycle within the mitochondrion. The mitochondrion then processes acetyl CoA using oxygen to obtain ...

Mitochondrial genes move to the nucleus -- but it's not for the sex

... or are capable of self-pollinating have transferred more genes from the mitochondrion to the nucleus," said graduate student Yaniv Brandvain, lead author of the ... genomes replicate separately, and a new and beneficial mutation in the mitochondrion could be separated from partner genes in the nucleus -- in the production ...

Researchers create artificial enzyme that mimics the body's internal engine

... Many organisms, including humans, derive their energy from tiny organelles in cells known as mitochondria. Embedded in the membrane of each mitochondrion is a structure called the electron transport chain, which produces adenosine triphosphate (ATP), a molecule that is the source of the cell's energy. ...

New protein vital for immune response is found in surprise location

... or activity may be a viable option for boosting immune responses against viral diseases." The fact that MAVS is located within the membrane of the mitochondrion makes sense for a couple of reasons, Dr. Chen said. First, proteins housed within the mitochondria have been shown by researchers, such as UT ...

A human parasite with a streamlined mitochondrion

... reactions within the mitosome but might not perform other functions. The work suggests that the Entamoeba mitosome may represent the simplest mitochondrion yet described, and thus it provides a model system for probing which mitochondrial functions are truly essential for eukaryotic cells. ...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

... state. Apparently, the rapidly growing cancer cells derive energy from an alternative source such as free glucose in the cell." Fortunately, the mitochondrion is nearly the same size as the light wavelength of about 800 nanometers, a frequency otherwise little absorbed by the body. Because of this close ...