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Mitochondrial in Biological News

Stress signals link pre-existing sickness with susceptibility to bacterial infection

... mitochondrial diseases disrupt the power generating machinery ... of a signaling protein that is associated with mitochondrial disease. Patients with mitochondrial disease exhibit a wide range of symptoms ...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

... yeast Saccharomyces cerevisiae, in order to study mitochondrial functions before going back to humans and ... Following this strategy, we first characterized a mitochondrial protein called Sdh5 in yeast and then moved on to ... potential role in human disease." Sdh5 is a mitochondrial protein that is highly conserved, meaning that it ...

Bad mitochondria may actually be good for you

... Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of ... slower rate and live longer than normal mice. mitochondrial oxidative stress is a popular theory explaining ... as they age a finding that seems to indicate the mitochondrial stress theory may not be correct. ...

How mitochondria get their membranes bent

... of great relevance to a better understanding of mitochondrial function in general. Recently, in cooperation ... Reichert, who has been appointed as professor for mitochondrial Biology to the Goethe University within the ... as we have for the first time found out how mitochondrial ultrastructure is regulated and which components ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... dismutase (Cu/Zn SOD) and glutathione, whereas mitochondrial SOD levels remained unaffected in pancreatic ... (INS-1 cells) exposed to nelfinavir. However, the mitochondrial uncoupling protein (UCP2) levels were ... component) it is likely that it may act as a mitochondrial antioxidant. Indeed pretreatment of pancreatic ...

UMMS researchers publish DNA identification of czar's children

... he and his colleagues completed basic studies of mitochondrial DNA inherited through the maternal lines and ... Yuri Moliaka, were able to determine the complete mitochondrial genome sequences from the remains. After doing ... Rogaev and colleagues reconstructed the complete mitochondrial genome sequences from the remains and, analyzing ...

Nearly a century later, new findings support Warburg theory of cancer

... argued, cancer should be interpreted as a type of mitochondrial disease. In the years that followed, ... effects, and not the causes, of cancer since no mitochondrial defects could be found that were consistently ... evidence to support Warburg's theory by examining mitochondrial lipids in a diverse group of mouse brain tumors, ...

African thicket rat malaria linked to virulent human form

... The analysis is based on amplification of entire mitochondrial genomes of malarial parasites that use humans, ... and a total of only about 6,000 nucleotides (the mitochondrial genomes of human and other animals are about ... These other phylogenies were based on both mitochondrial and nuclear DNA. "The link between human ...

New research helps explain genetics of Parkinson's disease

... exciting new discovery that links the fields of mitochondrial quality control and the genetics of Parkinson's ... suggest that Parkin loss is associated with mitochondrial dysfunction, but exactly how was unknown. To ... to mitochondria in cells that had undergone mitochondrial damage such as membrane depolarization. ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... that people resistant to insulin have altered mitochondrial capacity to "generate" energy through a process ... of energy only by regulating the expression of mitochondrial genes responsible for oxidative phosphorylation. ... discovered what the cell does to regulate this mitochondrial fusion gene and we explain why this gene is ...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

... D (CypD), and development of surrounding mitochondrial targets may be viable therapeutic strategies for ... This paper strengthens the concept that mitochondrial permeability pores may be central in mitochondrial and neuronal malfunction relevant to Alzheimer ...

A link between mitochondria and tumor formation in stem cells

... sorted mouse embryonic stem cells by their mitochondrial potential (the amount of voltage going across mitochondrial membranes, similar to how nerve activity is ... fact, when Finkel and colleagues administered the mitochondrial inhibitor rapamycin to high metabolism stem ...

Large reservoir of mitochondrial DNA mutations identified in humans

... United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. ... 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease. The ... new approaches to prevent the transmission of mitochondrial diseases, were published in The American Journal ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... describe how the increase of cholesterol in the mitochondrial membrane plays a key role in the resistance to ... toxicity. The supraphysiological level of mitochondrial cholesterol in hepatocarcinoma and in other cancers is well known, but its role in the mitochondrial regulation of cellular death and resistance to ...

Hebrew University develops novel approach for treating mitochondrial disorders

... A novel concept for the treatment of mitochondrial disorders using directed enzyme replacement ... damaged or deficient due to a genetic mutation, a mitochondrial metabolic disorder occurs. Modern medicine offers no cure for mitochondrial disorders (among which ...

Newly identified role for 'power plants' in human cells could lead to targeted therapies

... of proteins within mitochondria. If the mitochondrial tRNA genes are defective or missing, and proteins ... options for patients with diseases caused by mitochondrial defects. There appears to be no way to introduce ... called MERRF. This disease is characterized by a mitochondrial tRNA mutation leading to a drastic reduction in ...

Woolly-mammoth gene study changes extinction theory

... of extinct mammal by using the complete mitochondrial genome -- all the DNA that makes up all the genes ... population," Schuster said. Intriguingly, the mitochondrial genomes revealed by the researchers are several ... genomes of the extinct woolly mammoth using mitochondrial DNA, an important material for studying ancient ...

Long lost sisters

... teams research was based on a survey of African mitochondrial DNA (mtDNA) and is the most extensive survey of ... across the continent. How Old Was mitochondrial Eve" MtDNA, inherited down the maternal line, ... used in 1987 to discover the age of the famous mitochondrial Eve, the most recent common female ancestor of ...

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

... that atrial tachycardia is associated with mitochondrial dysfunction and oxidative stress followed by the ... and concomitant Ca2+-overload precede and induce mitochondrial dysfunction and oxidative stress in AF said ... by which calcium overload and resulting mitochondrial dysfunction and resulting oxidative stress impact ...

Ancient DNA: reconstruction of the biological history of Aldaieta necropolis

... ancient remains (normally by the sequencing of mitochondrial DNA, a molecule inherited maternally) of each ... obtained. Within the great homogeneity of the mitochondrial lines on the European continent, the genetic ... times. Besides the characterisation of the mitochondrial genome, they have carried out the ...

New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity

... a toolkit that isolates five primary aspects of mitochondrial function and analyzes how individual drugs affect ... of cellular health. On the other hand, mitochondrial dysfunction can lead to many neurodegenerative ... method for thoroughly interrogating all facets of mitochondrial activity. Historically, most studies on ...

Science casts doubt on famous British murder case

... to preserve the tissue in order to examine the mitochondrial DNA that could identify Cora Crippen based on the genetic history of her maternal relatives. mitochondrial DNA is the genetic blueprint that is passed down ... from the cells nucleus, Foran explained that mitochondrial DNA remains more stable in aged tissue and is ...

CU-Boulder worm study sheds light on human aging, inherited diseases

... therapies to reverse or lessen the effects of mitochondrial diseases, the largest family of human genetic ... for Behavioral Genetics. Diseases labeled as mitochondrial are those that affect the mitochondria, the ... find application in treating diseases linked to mitochondrial dysfunction such as Huntington's, Parkinson's and ...

Zebrafish to shed light on human mitochondrial diseases

... window to view the earliest stages of mitochondrial impairments that lead to potentially fatal ... them an ideal model for studying the effects of mitochondrial deficiencies on early development," said Baden, ... understanding of the mechanisms of mitochondrial associated pathology in people and speed the ...

Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes

... The study, which highlights the role of mitochondrial genome variation in the pathogenesis of common ... 2 diabetes cases may involve mutations in the mitochondrial genome. In the study published today, the ... virtually identical nuclear genomes but different mitochondrial genomes. This eliminated any complicating ...

Super-sleepers could help super-sizers!

... higher compared to that observed in active animals. This trick , known as mitochondrial coupling, allows these frogs to be extremely efficient in the use of the ... to cause most of the damage during periods of re-awakening, increasing mitochondrial coupling does not seem to be a particularly good idea for animals that ...

Embryonic heart exhibits impressive regenerative capacity

... onset cardiomyopathies. To investigate how mutations that interfere with mitochondrial function impact the heart during development, Professor Timothy C. Cox ... knockout approach in mice to inactivate a gene crucial for normal mitochondrial function. Their experimental methods established embryonic female mice ...

Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery

... and its potential to treat diseases of aging such as Type 2 Diabetes, mitochondrial disorders, inflammation, cancer, and heart disease. Entitled "SIRTUINS ... therapeutic promise. Such diseases of aging include Type 2 Diabetes and mitochondrial disorders, cardiovascular disease, cancer, neurodegeneration and ...

Researchers discover that growing up too fast may mean dying young in honey bees

... to trolox standards. Protein carbonylation, aconitase Vmax inhibition and mitochondrial H2O2 production were measured as markers of oxidative damage. The ... disappeared with age, which may explain the impairment of flight muscle mitochondrial function (elevated H2O2 production and reduced aconitase Vmax) and flight ...

Y chromosome study sheds light on Athapaskan migration to southwest US

... Athapaskan migrants. Previous genetic studies of this group focused on mitochondrial DNA, which is passed down exclusively from mothers to their offspring. ... gene pool. Consistent with a previous study of native North American mitochondrial DNA (also led by Malhi), the new analysis found a pattern that indicates ...

Nixing immaturity in red blood cells

... of these mitochondria. Nix accomplishes this task by disrupting the mitochondrial membrane potential (represented by difference in voltage across the inner ... this work. The next step is to identify proteins interacting with Nix for mitochondrial quality control by autophagy. Other factors may also regulate this ...

Kids with autism may have gene that causes muscle weakness

... at 37 children with autism spectrum disorders who were evaluated for mitochondrial disease, which causes muscle weakness and prevents a child from being able to participate in physical activities and sports. mitochondrial disease occurs when genetic mutations affect the mitochondria, or the part ...

Mounting evidence shows red wine antioxidant kills cancer

... which is likely the result of increased ROS. Depolarized the mitochondrial membranes, which indicates a decrease in the cell's potential to function. Radiation alone does not injure the mitochondrial membrane as much. The team also wanted to investigate why pancreatic ...

Global climate change: The impact of El Nio on Galpagos marine iguanas

... changes in levels of genetic variation in nuclear microsatellite DNA and mitochondrial DNA markers of samples collected before and after this El Nino event. ... before there is a significant loss of diversity in a population, whereas mitochondrial markers only show losses of diversity. Caccone said that although some ...

Global climate change: The impact of El Niño on Galápagos marine iguanas

... changes in levels of genetic variation in nuclear microsatellite DNA and mitochondrial DNA markers of samples collected before and after this El Nino event. ... before there is a significant loss of diversity in a population, whereas mitochondrial markers only show losses of diversity. Caccone said that although some ...

Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging

... SIRT 1 appears to mimic the beneficial effects of calorie restriction on mitochondrial and metabolic function in mammals in vivo and holds promise for treating ... are attractive drug targets because some have a specialized function in mitochondrial activity which may be therapeutically beneficial for metabolic and other ...

Sidestepping cancer's chaperone

... damaging healthy cells nearby. In Regulation of Tumor Cell mitochondrial Homeostasis by an Organelle-Specific Hsp90 Chaperone Network, published in ... of tumor cellsnot in those of normal cells. We have identified this mitochondrial accumulation of Hsp90 and TRAP-1 as a critical adaptive mechanism that ...

454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA

... have used the companys Genome Sequencer FLX system to sequence the entire mitochondrial genomes from 10 individual woolly mammoths. The study, entitled ... at room temperature. To put this new study in perspective, only seven mitochondrial genomes from extinct animals had been previously published, four from ...

Abnormal fat metabolism underlies heart problems in diabetic patients

... to produce too much of this enzyme in their hearts developed defects in mitochondrial function which became worse when they were fasted a condition that, like ... again implicating altered lipid metabolism, cardiolipin scarcity and mitochondrial impairment in heart disease using lipid as predominant fuel. Gross adds ...

$2 million grant aids study of lung cancer in people who never smoked

... and lung tissue, and blood specimens to conduct studies in proteomics, gene mutations and copy numbers, microRNAs (ribonucleic acid), methylation, mitochondrial mutations and gene expression. Many of these studies will examine the entire genome. "By pooling our talents we have a much better chance of rapid ...
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(Date:8/27/2014)... a rare, but deadly disease that exists as five ... the most lethal strains is the Sudan ebolavirus (SUDV). ... has caused widespread illness, even as recently as 2012. ... ACS Chemical Biology , researchers now report a possible ... SUDV. , John Dye, Sachdev Sidhu, Jonathan Lai and ...
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(Date:8/27/2014)... can be weaned later with no negative effects on ... at the University,s Roseworthy campus, published in the journal ... for pig producers. It allows improvements in piglet health ... usually start their oestrous cycles again during lactation, only ... says Ms Alice Weaver, PhD candidate with the School ...
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