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Microarray in Biological News

New tool probes function of rice genes

... The inexpensive, publicly-available rice DNA microarray covers nearly all the 45,000 genes in the rice ... Ronald and her colleagues used the new rice microarray to investigate gene expression changes when ... gene expression profiles across multiple rice microarray platforms, which will further accelerate this ...

New electrostatic-based DNA microarray technique could revolutionize medical diagnostics

... of silica (glass) across the surface of a DNA microarray and then observing the Brownian motion of the ... therapies that can stem from assays using a DNA microarray a thumbnail-sized substrate containing thousands ... grid. Often referred to as "gene chips," DNA microarray assays and their RNA counterparts have become one ...

Microarray sequence capture speeds large-scale resequencing of targeted genomic regions

... Direct Selection of Human Genomic Loci by microarray Hybridization, appears online (ahead of print) in ... genomes, such as human. The sequence capture microarray technology bridges the gap between ... of specific genes or loci using a single microarray hybridization-based enrichment process. The ...

Cancer Genomics Browser gives cancer researchers a powerful new tool

... the genome of a patient's cancer cells. Recent advances, such as microarray technology and high-throughput DNA sequencing, have made it possible to characterize tumor samples in exquisite detail. "You can run a microarray chip that analyzes a million points in the genome and can tell you about ...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

... multiforme, the deadliest of brain cancers. This technique uses a gene microarray that contains millions of probes that can stick to different regions of the human genome. The researchers purified DNA from tumors and then used the microarray chip to quantify genomic copy number. They found that PTPRD was deleted or ...

Rapid test for pathogens developed by K-State researchers

... of diagnostic medicine and pathobiology, use a device called a DNA spotted microarray to seek out the specific genetic markers that set one pathogen apart from ... technicians extract and fluorescently label total DNA, and run a microarray to check whether a particular gene is present. Narayanan said the next ...

'Smothered' genes combine with mutations to yield poor outcome in cancer patients

... appeared May 27 in PLoS Medicine . The team made their discovery using microarray technology - special silicon chips carrying pieces of genetic material ... that we must include both genetic and epigenetic changes when we do future microarray analyses to increase our understanding of the genetic basis of cancer," ...

Powerful integration of lipid metabolic profiling with gene expression analysis

... of thorough metabolic profiling with the unique and proprietary microarray analysis methods of Genomatix Software GmbH. The study elucidated the ... says Dr. Martin Seifert, co-author of the study and Vice President microarray Business and Collaborative Research at Genomatix. ...

Fungus genome yielding answers to protect grains, people and animals

... with plants, he said. "Because we now have the genome sequence and a microarray containing the whole genome, it will help us determine what genes allow ... genes involved in the infection process. "We are using the whole-genome microarray of Fusarium graminearum to identify the genes that are functional during ...

Spaceflight shown to alter ability of bacteria to cause disease

... gene expression at the mRNA level since the technique to do this, called microarray analysis, is a highly advanced and convenient way to quantitatively ... UA group was great and we obtained very nice data that complemented the microarray analysis very well, said Wilson. Keep in mind also that our body of mRNA ...

Putting stem cell research on the fast track

... in one experiment. Each of the teams developed separate specialized microarray platforms. Helping Develop Stem Cell Drugs A team led by Jonathan ... Those prongs imprint the surface of the corresponding slide, creating a microarray platform with thousands of individual cell-adhesive divots the perfect ...

ESHRE launches international study of polar body screening

... 24sure, the novel molecular technique to be used in both phases of the trial was developed by BlueGnome and is based on DNA amplification and microarray technology, which enables scientists to look at all the chromosomes at the same time. This is, in theory, far more powerful than the method ...

Researchers see evidence of memory in the songbird brain

... experience its brain is still trying to make sense of what it heard." The new study took a broad snapshot of gene activity in the brain. Using DNA microarray analysis, the researchers measured changes in levels of messenger RNAs in the auditory forebrain of finches exposed to a new song. These mRNAs are ...

Rapid approach to identify influenza A virus mutations and drug resistance developed

... NimbleGen were designed, manufactured and shipped to Singapore just four days after the project was started. As the custom-developed high-density microarray contains probes which can reveal the complete sequence of the flu virus from patient samples, it enables the detection of any single base mutations ...

Society of Interventional Radiology Foundation awards $191,000 in grants

... "Analysis of Crossover and Blinding in the Investigational Vertebroplasty Efficacy and Safety Trial (INVEST)"; Valentin Lance, "Radiologic and microarray (Radiogenomic) Analysis of Gastric Adenocarcinoma: A Novel Classification of Tumor Subtypes and Prognosis," Natanel Jourabchi, "Microarray Analysis ...

New tool isolates RNA within specific cells

... Drosophila so that they would only express UPRT in specific target cells. The group tested the new approach in embryos, larvae and adults using microarray technology to detect cell type-specific gene expression. The researchers say the method should work in other systems, including vertebrates, by using ...

A biological basis for the 8-hour workday?

... 8-hour cycles. To uncover these shorter oscillations, the Hogenesch and Salk team isolated RNA from the livers of mice every hour for 48 hours. microarray analysis showed that more than 3,000 genes were expressed on a circadian rhythm which account for approximately 4% of all of the genes expressed in ...

FANTOM findings boost for biologists

... The international FANTOM4 research collaboration yielded a wide range of genome-scale data, including 24 million mRNA 5'-reads (CAGE tags) and microarray expression profiles along a differentiation time course of the human THP-1 cell line and data regarding chromatin status. These data are detailed in ...

Poison: It's what's for dinner

... Dearing says. "Prior to the advent of these microarrays, there haven't been techniques where we could look at detox genes comprehensively." The microarray analysis shows which genes in the woodrats have been "expressed" or activated to produce enzymes that make toxins in creosote and juniper water ...

Poison: It's what's for dinner

... Dearing says. "Prior to the advent of these microarrays, there haven't been techniques where we could look at detox genes comprehensively." The microarray analysis shows which genes in the woodrats have been "expressed" or activated to produce enzymes that make toxins in creosote and juniper water ...

Rensselaer receives more than $2 million from New York State to fund stem cell research

... new technologies that delve into molecular level changes that take place within the stem cells as they grow, including a cell-based, high-throughput microarray technology developed in the Dordick lab. Genetic Control of Stem Cells Ferland's lab will delve into the interior of the cell to understand ...

Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death

... for epidemiological studies to analyze the genomes of 15,842 individuals whose QT intervals had been measured by electrocardiogram. With DNA microarray chips, each able to assess hundreds of thousands of markers in each sample, followed by bioinformatic techniques to increase the number of markers, ...

Researchers identify gene linked to aggressive progression of liver cancer

... cells of patients with HCC, the team found that the expression of AEG-1 gradually increases as the tumor becomes more and more aggressive. Using microarray technology, they analyzed cDNA from the tumor cells and determined that AEG-1 modulates expression of genes relevant to the progression of HCC, ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... prodigious replication of the H5N1 virus. Respiratory tissues sampled on days 1, 2 4 and 7 post-infection were subjected to pathological, viral and microarray analysis. Although the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming ...

Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer

... Institute of Bioinformatics developed new computational methods to extract relevant gene patterns from the vast quantity of data generated by the microarray experiment. "In this study, we have mined the gene expression data in order to find a particular gene activity pattern, or gene signature, that would ...

Genomatix joins Illumina-Connect program

... efforts as well as help us keep up with the rapidly expanding portfolio of Illumina NGS applications". Besides the well established Genomatix microarray analysis pipeline which works with output from the Illumina BeadChip platform Genomatix delivers a complete solution for the analysis of Next ...

U-M researchers discover new genes that fuse in cancer

... is a more direct approach than the method Chinnaiyan's lab used to first identify gene fusions in prostate cancer, a process called microarray. Using microarray technology, researchers had to first know where they wanted to look. With gene sequencing, the researchers can find what's there without knowing ...

Team finds breast cancer gene linked to disease spread

... lymph nodes to bodily organs, according to the federal agency's statistics. In recent years, researchers have used advanced techniques such as DNA microarray technology to try and identify genetic profiles of the so called "poor prognosis" tumors -- those that are likely to come back after the initial ...

The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness

... to replicate elements of spaceflight. Nickerson was able to examine the activity of genes in fine-grained detail through a technique known as microarray analysis, which allowed for a complete profile of gene expression across the entire 4.8 million DNA base pairs that make up the circular Salmonella ...

UC San Diego researchers use metagene 'portraits' to reveal distinct stages of kidney formation

... neural networks, SOMs cluster genes with similar temporal expression profiles into metagene portraits. In this case, the SOMs were collected using microarray gene expression data and a high-dimensional data analysis program called Gene Expression Dynamics Inspector, or GEDI. UC San Diego scientists then ...

Einstein researchers develop technique to count messages made by single genes

... a single cell level reveals details that can advance the field of cancer and other disease research. "Cancer derives from a single cell. So current microarray technologies that are used on a tissue-wide level and are based on "grinding up a tumor" may be a good first step at directing us where to focus, but ...

New therapeutic target identified for rheumatoid arthritis

... that a protein called interferon gamma can increase inflammatory response, but they didn't know the exact mechanism. To find out, they turned to microarray analysis, a method of surveying an entire genome to determine which genes are being expressed or which are responsible for a certain condition. Using ...

GUMC researchers hone in on new strategy to treat common infection

... says. "We propose that this finding might lead to other, possibly more effective, treatment options." In this study, the researchers used a gene microarray analysis to further understand what knocking out the Ssk1 gene does to the organism, and they discovered that the gene is critical to the pathogenic ...

First comprehensive genomic study of common cold reveals new treatment targets

... and other cold viruses infect these nasal cells, which are the body's first line of defense against airborne pathogens. The researchers then used microarray gene chip technology to compare the gene expression levels between the infected volunteers and the control group. "Advances in genomics ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... response to therapy; in these cases antibiotic therapy is usually successful, and patients' clinical symptoms and FEV1 both improve rapidly. Using microarray gene analysis of the blood samples, the researchers identified 10 genes that differed significantly in their expression before and after therapy. ...

Breast cancer treatment resistance linked to signaling pathway

... to select appropriate patients for a Src inhibitor in the clinic. For the current study, Coughlin and colleagues performed quantitative tissue microarray sampling among almost 650 patient samples to analyze for the expression of markers of the Src pathway. According to Coughlin, the patients ...

Biologists identify genes controlling rhythmic plant growth

... exposed to day and night cycles of light, the scientists sought to determine which of its genes were being turned on during that period. Using DNA microarray chips, they were able to test thousands of genes at a time to determine which ones were active during that period. "We did many hundreds of ...

UCSF researchers identify virus behind mysterious parrot disease

... UCSF's patented ViroChip technology. The ViroChip, which DeRisi and Ganem developed, is a high-throughput screening technology that uses a DNA microarray to test viral samples. The team was able to recover virus sequence from a total of 16 diseased birds from two different continents. The complete ...

American Society for Microbiology honors D. Scott Merrell

... more infectious than those found in the environment. During his postdoctoral studies at Stanford University Medical School, Dr. Merrell mastered DNA microarray technology, first to continue his study of V. cholerae, and then to explore mechanisms used by Helicobacter pylori to survive within the human body. ...

New Web resource to improve crop engineering

... discovery of enzymes and the engineering metabolic pathways. The databases provide access to functional genomics data, such as those generated from microarray and metabolomic experiments. PMN is currently developing similar databases for important crop plants including poplar, soybean, wheat, and maize. ...
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