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Metastatic in Biological News

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

... long-term survival rates in patients with metastatic melanoma whose disease had been minimized by ... Anti-Tumor Vaccines in Patients with metastatic Melanoma," was published in the June 2009 issue ... for melanoma patients with recurrent or distant metastatic disease at the time of diagnosis because there ...

Colorectal cancer

... genetic signature which distinguishes tumors with metastatic potential from those that do not metastasize. ... They discovered that this gene is more active in metastatic tumors and metastases than in non-metastatic ... will help determine early on whether a tumor has metastatic potential. The doctors could then adapt the ...

LSUHSC research describes function of key protein in cancer spread

... During the transition from a localized tumor to metastatic disease, cancer cells acquire the ability to ... According to the American Cancer Society, metastatic cancer is a cancer that has spread from its ... have metastases at the time of their death, and metastatic disease is directly responsible for the majority ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

... to significantly reduce the number and size of metastatic tumors in preclinical mouse models of lung and ... towards limiting tumor reoccurrence or metastatic disease." Immune response modifiers (IMRs) ... including progressive multiple sclerosis and metastatic disease," said Simon Wilkinson, Innate ...

New drug shows promise in treating drug-resistant prostate cancer

... A new therapy for metastatic prostate cancer has shown considerable promise in ... on survival in a large group of patients with metastatic prostate cancer. MDV3100 and RD162 are ... common treatment for the disease in its advanced, metastatic stage. Anti-androgen drugs, such as bicalutamide ...

New medications show promise in treating drug-resistant prostate cancer

... A new therapy for metastatic prostate cancer has shown considerable promise in ... on survival in a large group of patients with metastatic prostate cancer. The drugs are ... common treatment for the disease in its advanced, metastatic stage. Antiandrogen drugs, such as bicalutamide, ...

Metastatic bone disease patients can walk in Lazarus' footsteps

... procedure to treat the painful effects of metastatic bone disease by injecting bone cement to support ... of life can be severely affected when they have metastatic bone disease. Normal daily activities can become ... of their primary cancers," added Anselmetti. metastatic bone disease is a painful condition that can ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... called microRNA (miRNA) that is over-expressed in metastatic melanoma cell lines and tissues. ... may be an effective therapeutic strategy for metastatic melanoma, according to Eva Hernando, Ph.D., ... the first study to examine the role of miRNA in metastatic melanoma. "Melanoma becomes ...

Team finds breast cancer gene linked to disease spread

... and, at the same, time decrease the risk of metastatic dissemination," said Yibin Kang, an assistant ... illustrate the difference between localized and metastatic cancer: 98.1 percent of patients with localized ... by one, in breast tumor cells and tested their metastatic behavior in laboratory mice. The scientists ...

Expanding cell girth indicates seriousness of breast cancer

... and found cells that expanded the most were metastatic cancer, the term used when the disease has spread ... the cell's structure, or cytoskeleton. A metastatic cancer cell cytoskeleton is more prone to ... size, with the biggest deformity appearing in the metastatic cells. "Our approach - microfluidic ...

Weill Cornell science briefs June/July 2008

... New Cancer Stem Cell Identified A Potential metastatic Disease Target? Researchers from Weill ... a type of cancer stem cell that might initiate metastatic cancer, which spreads beyond the original, ... pave the way for research into a new subset of metastatic cancer stem cells, previously unidentified. ...

Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors

... to investigate the effects of chemotherapy on metastatic breast cancer in women with the BRCA1 or BRCA2 ... They matched 112 women with BRCA1-associated metastatic cancer and 29 women with BRCA2-associated metastatic cancer with 141 women with sporadic breast ...

CSHL scientists identify cells that promote formation of lethal lung metastases

... cancer patients. The cells that promote the metastatic transformation are called endothelial progenitor ... paper. Current efforts are focused on preventing metastatic spread, yet, paradoxically, insights have been lacking on how dormant metastatic lesions, after they have colonized distant ...

Using nanotechnology, UCLA researchers discover cancer cells 'feel' much softer than normal cells

... of UCLA scientists were able to differentiate metastatic cancer cells from normal cells in patient samples ... procedure. One problem with diagnosing metastatic disease in this setting is that cancer cells and ... to find such striking characteristics between the metastatic cancer cells and normal cells, said Sarah Cross, ...

$2.7 million awarded for metastatic colon cancer research

... the 2007 Jeannik M. Littlefield-AACR Grants for metastatic Colon Cancer Research, totaling $2.7 million. Now ... discovery and development of new treatments for metastatic colon cancer. Colon cancer is the third most ... of treatment and potentially a poorer prognosis. metastatic colon cancer research will advance our ...

Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment

... the findings were pretty consistent. "When we looked at patients with metastatic disease, sarcosine levels were sky high compared to patients with ... increased tumor progression. A total of 89 metabolites were different in metastatic prostate cancer compared to localized disease. He's excited about what ...

Einstein researchers develop a new way to study how breast cancer spreads

... For 2007, the American Cancer Society reported that a woman with metastatic breast cancer had an average survival rate of two years. Using ... microenvironment of a tumor is to the behavior of a cancer cell and the metastatic outcome of the tumor itself. We can now look at the early steps of ...

New regulatory mechanism discovered for cell identify and behavior in forming organs

... in future studies looking for the causes of defective organs in fetuses, metastatic cancers and other diseases, according to researchers at Cincinnati ... Dr. Zorn and colleagues said their results have possible implications in metastatic cancer. For one, Sfrp proteins are already known to be tumor suppressors ...

Immunotherapy in high-risk pediatric sarcomas shows promising response

... was at the higher end of what is generally seen with recurrent and/or metastatic Ewing's sarcoma (ESFT) or alveolar rhabdomyosarcoma (AR) the two sarcomas ... 40 years, there has not been substantial improvement for patients with metastatic or recurrent disease. This study shows that immunotherapy is safe and ...

Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds

... in patients with esophageal cancer and are higher in patients with metastatic disease, the sensitivity and specificity of these markers in the diagnosis of recurrent cancer has not been compared. "The diagnosis of metastatic esophageal cancer prior to surgery and recurrent disease after surgery ...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

... in a heavily pretreated population of women with locally advanced or metastatic breast cancer, according to results of a multi-center Phase II clinical ... and safety of eribulin mesylate in patients with locally advanced or metastatic breast cancer who had received an anthracycline, a taxane and capecitabine ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... the enzyme plays a well-documented role in the formation of invasive and metastatic cancers, including pediatric neuroblastoma, the most common solid cancer ... has led to cure rates of 90 to 95 percent. In older children or those with metastatic disease, neuroblastoma is a much harder to fight. Tumor cells are often ...

Interleukin-8, key marker for colorectal cancer treatment

... unclear whether IL-8 expression is related to cancer progression and metastatic potential in colorectal carcinoma tissues. This issue was addressed by ... investigators report on a potential role of IL-8 in the development and metastatic spread of colorectal cancer in the October 7 issue of the World Journal of ...

NIBIB invests in quantum research

... groundbreaking technologies: disposable microchips for the diagnosis of metastatic lung cancer, a bio-artificial kidney to eliminate dialysis procedures, ... such low concentrations enables earlier intervention in the treatment of metastatic lung cancer, which remains the leading cause of cancer death in the U.S. ...

Dietary calcium could possibly prevent the spread of breast cancer to bone

... with breast cancer bone metastases or who are at high risk for developing metastatic disease, Dunstan said. Many older women in our community are known to be ... to investigate how calcium and vitamin D status influence progression to metastatic disease, and to determine if corrections of calcium and vitamin D ...

Newly created cancer stem cells could aid breast cancer research

... cells are more prone to become tumor-initiating cells and have a higher metastatic potential when they become cancer cells than other normal cells. The ... favors the growth of the human breast cells with high tumor-making and metastatic potential while the standard culture medium favors cells with low ...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

... a vector for the nanoparticle delivery of a DNA encoding diphtheria toxin suicide gene. These nanoparticles were injected into mice with primary or metastatic ovarian tumors. To test the efficacy of this technique, the researchers measured tumor volume before and after treatment. They found that while ...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... cancer therapy, culminating in the production of an anti-HER2 monoclonal antibody that since 1998 has been used successfully to treat patients with metastatic breast cancer. This was the first targeted therapeutic agent developed on the basis of a newly discovered gene with an oncogenic function in human ...

Green tea may affect prostate cancer progression

... growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and VEGF are good prognostic indicators of metastatic disease. The study included 26 men, aged 41 to 72 years, diagnosed with prostate cancer and scheduled for radical prostatectomy. Patients consumed ...

New method separates cancer cells from normal cells

... The vast majority of cancer deaths are due to metastasis, the spread of cancer cells from its primary site to other parts of the body. These metastatic cells tend to move more than their non-metastatic variants but this movement is poorly understood. Scientists are studying cancer cells intently with ...

First comprehensive guidelines for managing medullary thyroid carcinoma published in Thyroid journal

... for early disease, genetic testing, surgical management, post-surgical treatment and monitoring, management of persistent or recurrent MTC and metastatic disease, and long-term follow-up. The guidelines also propose directions for future research on MTC. "Medullary thyroid cancer is a rare and ...

Lithium may help radiation target cancer, spare healthy tissue

... brain tissue from damage that may occur during cranial radiation treatments. Cranial irradiation is part of standard therapy for both primary and metastatic brain tumors. However, as with all treatment modalities, radiation often causes long-term side effects. In particular, neurological impairments ...

Joining forces to improve lung cancer treatment

... of the reasons why we have organized this conference. We believe the result will be better outcomes for lung cancer patients." For patients with metastatic disease, targeted therapies have already entered clinical practice or have shown survival benefit in clinical trials. Combinations of chemotherapy ...

When cancer cells can't let go

... cells get traction by temporarily attaching to the ECM through focal adhesions. FAK spurs focal adhesions to disengage, and it is more abundant in metastatic tumors. Whether FAK also regulates invadopodia was unknown. When Chan et al. removed FAK, breast cancer cells were much less invasive. But to the ...

Cancer Genomics Browser gives cancer researchers a powerful new tool

... searching for all of the genes and mutations that contribute to the development of a cancer cell and its progression from a localized cancer to metastatic disease that spreads throughout the body. A genome is an organism's complete set of DNA, and researchers are now able to analyze the alterations that ...

Tips from the American Journal of Pathology

... They identified cleaved galectin-3 in later stage prostate cancer, and determined that reducing levels of galectin-3 inhibited the development of metastatic prostate cancer. Thus, cleaved galectin-3 may serve as a diagnostic marker and therapeutic target for prostate cancer progression. Dr. Raz's group ...

Freezing prostate cancer does a man's body good

... practice statement that indicated that cryotherapy is an option for men who have clinically organ-confined prostate cancer of any grade with negative metastatic evaluation. Since this interventional treatment is not widely known to doctors and patients, individuals will need to pursue it on their own, he ...

Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors

... rate of complications between percutaneous cryoablation and surgery, Georgiades said that none of the patients who had cryoablation developed new or metastatic disease and they had fewer complications. The minimally invasive nature of interventional cryoablation means that it can be performed with minimal ...

Society of Interventional Radiology hosts 34th annual scientific meeting

... Seeing "Lazarus Effect": Relieving Painful Bone Tumor Pain Often, individuals' quality of life can be severely affected when they have metastatic bone disease. Normal daily activities can become difficult when the metastases become painful, appetite diminishes and the need for pain medications ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators

... called macrophages in tumor progression and metastasis (cancer spread). His goal is to identify and characterize molecular pathways critical to metastatic cancers, particularly lung, breast, and skin cancers. These studies may lead to novel therapeutic targets to limit or prevent metastasis. Jason ...
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