Navigation Links
Metabolize in Biological News

Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants

... CINCINNATI Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at ... a specific point mutation in the gene that helps break down the drug, UGT, metabolize the drug slower. This point mutation, called UGT1A9-331, causes ...

Syracuse University scientists discover how some bacteria may steal iron from their human hosts

... the researchers observed that Streptomyces could ingest iron-citrate, metabolize the iron, and use the citrate as a free source of energy. Other ... additional energy to ingest the iron. Once in the cell, the bacteria metabolize the iron and, as an added bonus, use the citrate as an energy source. ...

Common allergy drug reduces obesity and diabetes in mice

... contrast, type 2 diabetes is a strictly metabolic condition in which cells grow increasingly deaf to insulin signals and thus lose their ability to metabolize glucose. In both cases, glucose mounts in the blood, at times to fatal levels. But it is becoming increasingly clear that we should also think of ...

Phthalic symbol

... as the only source of carbon for the microbes. Successive divisions of microbial cells quickly leads to the evolution of a strain that can quickly metabolize the phthalate and convert it into the raw materials for microbial growth and reproduction. The researchers then tested this phthalate-digesting ...

A little java makes it easier to jive, researcher says

... common for athletes before competing to consume a variety of substances that include caffeine, motivated by "the notion that it will help you metabolize fat more readily." "That research isn't actually very compelling," Motl said. "What's going on in my mind is people are doing it for that reason, ...

Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia

... Normally, bacteria use oxygen to breathe. But in an anaerobic environment, they can use other chemicals, including rust and arsenic. As the bacteria metabolize the iron and arsenic, they convert it to a form that readily dissolves in water. "As these sediments get buried very rapidly, the bacteria go ...

Fowl soil additive breaks down crude oil

... remediation exercise is complete. A more environmentally benign approach is to bioremediation, which uses natural or engineered microbes that can metabolize the organic components of crude oil. Stimulating such microbial degradation in contaminated soil often involves the use of expensive fertilizers ...

Great Lake's sinkholes host exotic ecosystems

... associated with rotting eggs. Where the sinkholes are deeper still and light fails, microorganisms use chemical means rather than photosynthesis to metabolize the sulfurous nutrients. Biddanda, Ruberg, and their team are probing the origins of ancient minerals flowing in from beneath this fresh inland ...

States expand newborn screening for life-threatening disorders

... was born in was part of a pilot program to expand newborn screening in California." 3MCC is a serious disorder that leaves newborns unable to metabolize leucine an essential amino acid found in many forms of protein. But because Giana, now age six, was diagnosed early, she was put on a special diet ...

MUHC and McGill scientists explain genetic disease first discovered in Quebec 24 years ago

... into its basic properties and how it behaves in healthy cells." The cblF idisease is a rare genetic disorder characterized by an inability to metabolize vitamin B12. Patients afflicted with this condition build up toxic levels of homocysteine and methylmalonic acid in their bodies. Vitamin B12, which ...

New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease

... recessive genetic disease that is characterized by a deficiency in an enzyme called phenylalanine hydroxylase (PAH). Without PAH, the body cannot metabolize the amino acid phenylalanine. It then builds up in the blood, crosses the bloodbrain barrier and causes severe brain damage. Fortunately, PKU can be ...

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

... Mayo and ABCSG highlight the emerging science of pharmacogenomics. Researchers in this field are studying whether genetic differences in how patients metabolize or process drugs can be used to individualize therapy. Additionally, in collaboration with bioTheranostics (a molecular diagnostics testing ...

Better beer: College team creating anticancer brew

... sample of the yeast from Houston's Saint Arnold Brewing Company, and they are modifying it with two sets of genes. The first set allows the yeast to metabolize sugars and excrete an intermediate chemical that the second set can later convert into resveratrol. "One set of genes gets you from A to B, and ...

Could Dr. House be replaced by a computer?

... which did not describe how the metabolism of different tissues work," says Shlomi. "Now we can provide large scale descriptions as to how tissues metabolize different compounds and how metabolism actually works in individual organs like the heart, liver, brain or pancreas." Towards Computerized ...

'Buckyballs' have high potential to accumulate in living tissue

... sugars because we process sugars, but we do bioaccumulate other compounds that we don't metabolize," Jafvert said. "If we have the ability to metabolize buckyballs, we won't bioaccumulate them." Findings were detailed in a research paper that appeared in August in the journal Environmental Science ...

Cyanobacterium sequenced features rare linear chromosome

... in a rice paddy in India, and three others from the deep ocean, are related, but each one comes from different environmental backgrounds and might metabolize differently. Thus, one or more strains might have biological gifts to offer that the others don't, or else combining traits of the different strains ...

Biochemists manipulate fruit flavor enzymes

... found in most bacteria and all known plants and animals. Although AOS or HPL are not found in humans, there are related P450 family members that help metabolize nearly half of the pharmaceuticals currently in use. In plants, AOS and HPL break down naturally-occurring, organic peroxides into GLV and jasmonate ...

Codeine not safe for all breastfeeding moms and their babies

... or transformed by the body into a more active pain relieving compound, morphine. Some individuals have a genetic variance which causes them to metabolize codeine at a rapid rate, producing significantly more morphine in their system than most of the population. While this genetic predisposition is ...

OU researchers isolate microorganisms that convert hydrocarbons to natural gas

... do this by studying the way microorganisms interact with hydrocarbons," says Suflita. OU researchers have isolated some interesting organisms that metabolize hydrocarbons in the absence of oxygeninsight that was lacking for a long time. OU researchers have extended their studies to how energy is ...

Analysis of Lake Washington microbes shows the power of metagenomic approaches

... DNA was then separated out and sequenced. In this way, microbial "subsamples" were produced that were highly enriched for organisms that could metabolize methane, methanol, methylated amines, formaldehyde and formate. The functionally enriched samples contained far fewer microbes than the total ...

New study shows compounds from soy affect brain and reproductive development

... various plants, including soybeans and soy-based foods. Equol is a hormone-like compound that is formed when bacteria found in the digestive system metabolize another phytoestrogen. However, only approximately a third of humans have the necessary bacteria to produce equol. The study shows that both ...

SEX4, starch and phosphorylation

... described in textbooks. Specifically, mutations at the Starch Excess 4 (SEX4), Maltose Excess 1 (MEX1) and other loci produce plants unable to metabolize starch to a usable form. When we use starch in the lab or cook with it, we tend to think of it as an amorphous mass, but it is really a complex, ...

Ecological genetics of freshwater bacteria surveyed

... although not all-powerful, influence. The newest techniques can analyze specific functional capabilities of bacteria, such as their ability to metabolize particular molecules. Moreover, some techniques can analyze multiple capabilities in parallel. These are being combined with accurate and sensitive ...

PET/CT imaging proves golden for detecting cancer in children

... is used to image cancer, a radiopharmaceutical (such as FDG, which includes both a sugar and a radionuclide) is injected into a patient. Cancer cells metabolize sugar at higher rates than normal cells, and the radiopharmaceutical is drawn in higher amounts to cancerous areas. PET scans show where FDG is by ...

Nationwide Children's Hospital involved in expanded access program for treatment of PKU

... Individuals with PKU are born with a deficient enzyme called phenylalanine hydroxylase (PAH). With little or no PAH activity, they are unable to metabolize an essential amino acid, called phenylalanine (Phe), which is found in most foods including meat, eggs, dairy, nuts, pasta, bread and all fruits and ...

Quantitative PET imaging finds early determination of effectiveness of cancer treatment

... is used to image cancer, a radiopharmaceutical (such as FDG, which includes both a sugar and a radionuclide) is injected into a patient. Cancer cells metabolize sugar at higher rates than normal cells, and the radiopharmaceutical is drawn in higher amounts to cancerous areas. PET scans show where FDG is by ...

OHSU turns innovations into commercial opportunities at record pace

... drug development. When new drug compounds are being developed they need to be tested on human liver cells to predict how the human liver will metabolize it. One in six compounds fail in the development stage because of liver toxicity. The market demand for such cells has reached an estimated $2 ...

Scientists ramp up ability of poplar plants to disarm toxic pollutants

... the carbon and hydrogen with oxygen to produce water and carbon dioxide. The transgenic poplar plants just do it a lot faster. The enzymes used to metabolize the contaminants are from a group called cytochrome P450 found in both plants and animals. Poplars have a lot of P450s and Doty said scientists hope ...

New genetic research into nicotine addiction shows promise for personalized treatment

... Addiction and Mental Health (CAMH). The study, published in the September issue of the journal Biological Psychiatry, found that the enzyme known to metabolize both the smoking cessation drug bupropion and nicotine is highly genetically variable in all ethnicities and influences smoking cessation. This ...

LSU professor looks for life in and under antarctic ice

... microbes are capable of metabolic activity when frozen down to -20 degrees Celcius. Our experiments have revealed the potential for microbes to metabolize under frozen conditions, but we still lack the smoking gun which proves this occurs in nature. We are now taking what we learned in the lab at LSU ...

Genetics determine optimal drug dose of common anticoagulant

... result represents one of the first applications of using an individuals genetic information to guide personal medical care. Because individuals metabolize drugs differently, varying doses of warfarin are needed for the drug to be effective in each patient. Too much warfarin can cause severe bleeding, ...

American Chemical Society's Weekly PressPac -- Aug. 8, 2007

... manufacturing sites. In addition to being explosive, TNT is toxic and a human health threat. Researchers knew that certain soil bacteria could metabolize and change trinitrotoluene (TNT) into nontoxic compounds. But those natural bacteria exist at levels too low to detoxify TNT. In the new study, ...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

... supply of an enzyme, called hexosaminidase ("hex"), used by brain cells to metabolize excess fatty material called lipids. Onset is typically at six months in ... are among a known group of about 50 diseases rooted in the inability to metabolize lipids or other materials. While Sandhoff and Tay-Sachs are relatively ...

Dragonfly's metabolic disease provides clues about human obesity

... an inflammatory response and immediate changes in metabolism. Unable to metabolize fat, the dragonflies accumulate fat around their muscles. This finding ... mix. A common symptom of metabolic syndrome is that muscles metabolize fewer lipids. The researchers also found that unused lipids accumulated ...

Did humans cause ecosystem collapse in ancient Australia?

... of carbon. All three animals were plant eaters. Different types of plants metabolize different forms of carbon in distinctive ways from the CO2 they take up ... all. "13C is the key," Fogel explained. "There are two main ways plants metabolize 13C . About 85% of plants belong to what is known as C3 photosynthesis ...

Genomics researchers discover protein deficit that causes drug toxicity

... mechanism decreases a protein and in turn causes certain individuals to metabolize thiopurine drugs differently. Thiopurine therapies are used to treat ... acids -- that results in the absence of the protein needed to properly metabolize thiopurine drugs. In patients with the genetic defect, instead of helping ...

Researchers identify protein pathway involved in Parkinson disease development

... neurons, they believe it is related to dysfunctional mitochondria and oxidative stress. Mitochondria are the cell's "power plants," which metabolize oxygen and generate energy. Oxidative stress is the damage caused to cells by reactive oxygen produced during oxygen metabolism. Although ...

Unraveling where chimp and human brains diverge

... 6-cylinder engine," explained Geschwind. "It's possible that our genes adapted to allow our brains to increase in size, operate at different speeds, metabolize energy faster and enhance connections between brain cells across different brain regions." Future UCLA studies will focus on linking the ...

Variations in detoxifying genes linked to Lou Gehrig's disease

... Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and ...
Other Contents
(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
(Date:7/10/2014)... N.Y. , July 2, 2014 It ... (ABD) to announce the appointment of the world-renowned Thoracic ... Board of Directors. Dr. Ginsburg, with over ... facilities: NY Presbyterian Hospital and Good Samaritan Regional Medical ... Pacemaker since the late 1980,s and is considered an ...
(Date:7/10/2014)... 7, 2014 According to a ... Access Control Systems Market Global Forecast, Market Share, Size, ... Electronic Access Control systems market was valued at USD ... at a CAGR of 12.6% from 2014 to 2019, ... in 2019. Browse the full Electronic Access ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
(Date:7/10/2014)... Adults with dyslexia are more likely to report that ... people who don,t have the learning disorder, according to ... to 10 percent of people, causes problems with reading ... with this condition said they suffered physical abuse during ... dyslexia. "Even after accounting for age, race, sex ...
(Date:7/10/2014)... News) -- Men who have a vasectomy may be ... study suggests. But the risk is comparatively small, ... the study said more research is needed to determine ... the study, Harvard researchers analyzed data from more than ... starting in 1986. During that time, 6,023 cases of ...
(Date:7/10/2014)... that the "Mississippi Baby," believed to have been functionally ... detectable levels of the virus, the Elizabeth Glaser Pediatric ... remains hopeful that the scientific breakthrough that allowed the ... two years will continue to help researchers understand how ... , "Although we had high hopes that the child ...
(Date:7/10/2014)... cells captured with a microchip-based device developed at the ... and the MGH Cancer Center can be cultured to ... In the July 11 issue of Science ... cells accurately reflect a tumor,s genetic mutation over time ... now can culture cells from the blood that represent ...
(Date:7/10/2014)... "Mississippi baby" an infant seemingly cured of HIV that ... of HIV infection in The New England Journal of ... more than two years of not taking antiretroviral therapy without ... researchers involved in the case. , "Certainly, this ... the medical staff involved in the child,s care, and the ...
Breaking Medicine News(10 mins):Health News:Researchers See Link Between Dyslexia, Abuse 2Health News:Study Links Vasectomy to Aggressive Prostate Cancer 2Health News:Study Links Vasectomy to Aggressive Prostate Cancer 3Health News:Despite setback, 'Mississippi Baby' represents significant breakthrough in effort to end AIDS 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3Health News:'Mississippi Baby' now has detectable HIV, researchers find 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 3
Other TagsOther Tags