The 21st century tomato
... Expression of certain genes may regulate metabolite
activity, but metabolites may also have a ... and followed the transmission of information from metabolite
to gene. In continuing research, Carrari and ... and nutrition, as well as to improve yield. metabolite
analysis also has possible applications in drug ...
First finding of a metabolite in 1 sex only
... development, the existence of a sex-specific metabolite
is a previously unrecognized and potentially ... that the presence or absence of a sex-specific metabolite
might affect an animal's development, anatomy and ...
Now that the existence of a sex-specific metabolite
has been proved for one animal, Kleps says ...
Birth control has long-term effect on hormone exposure
... postmenopausal phase of the study and frozen for subsequent analysis of metabolite
Lab results showed that the premenopausal use of oral ... isoflavones induced fewer significant effects on postmenopausal estrogen metabolite
"The magnitude and persistence of oral contraceptive ...
Healthy or diseased?
... concentrations." By a subsequent clustering of the test statistics of such metabolite
pairs, it is possible to identify groups of metabolites which discriminate ... of the metabolome. "With this recent quantum leap in the area of metabolite
analysis, the challenge to bioinformatics is to develop customized, ...
Chemicals in common consumer products may play a role in pre-term births
... samples collected during the third trimester and compared them to the control group who carried to term. They found significantly higher phthalate metabolite
levels in the women who delivered prematurely.
Premature birth is a significant risk factor for many health problems in childhood that can ...
Embryology study offers clues to birth defects
... that control the growth and differentiation of progenitor cells by regulating specific genes. One of these signaling molecules is retinoic acid, a metabolite
produced from vitamin A (retinol), which plays a key role in the development of limbs and other organs. Dr. Duester's lab was instrumental in ...
Simulating pharmaceutical and personal care product transport
... sorption in macropores using data from experiments on the transport of three PPCPs (atenolol, carbamazepine, and triclosan), the nicotine metabolite
cotinine, and the strongly sorbing dye rhodamine WT applied in LMB. The study was financed by grants from the European Union (ERAPharm, project no. ...
Genetic switch potential key to new class of antibiotics
... by the riboswitch.
In the current study, Wedekind and colleagues solved the crystal structure of a preQ1 riboswitch in complex with its precursor metabolite
preQ0. They chose to study the riboswitch from Thermoanaerobacter tengcongensis, a tough bacterium that lives at extreme temperatures and was first ...
Malaria parasite zeroes in on molecule to enhance its survival, team finds
... processes by simultaneously measuring the levels of all of the more than 500 core metabolites that make up an organism's "metabolic network." A metabolite
is a chemical involved in metabolism, the process by which an organism takes up nutrients from the environment and converts them to energy and the ...
Next generation microscopy: No stain, big gain
... about the ways in which SRS imaging will facilitate progress in many fields. "Applications of SRS imaging range from mapping distribution of small metabolite
and drug molecules in cells and tissues to medical diagnosis of cancer. Neuroimaging is another exciting area of application."
Gladstone scientists create Wikipathways to foster research collaboration
... dedicated wiki page, which displays the current diagram, description, references, download options, version history, and component gene, protein and metabolite
list. Any pathway can be edited from within its wiki page by activating an embedded pathway editor.
As the first wiki dedicated to biological ...
Researchers identify cancer preventive properties in common vitamin supplement
... two known risk factors for breast cancer.
Rogan said resveratrol works by inducing an enzyme called quinone reductase, which reduces the estrogen metabolite
back to inactive form. By making estrogen inactive, resveratrol decreases the associated risk.
The current study was conducted in laboratory ...
Genomics of large marine animals showcased in the biological bulletin
Cell-cell adhesion in the Cnidaria: Insights into the evolution of tissue morphogenesis, by Craig R. Magie and Mark Q. Martindale
flux to transcriptomics: Insights into the molecular mechanisms underlying primary productivity by the hydrothermal vent tubeworm Ridgeia piscesae, ...
A new gene trigger for pregnancy disorder identified
... catecholamine class of neurotransmitters.
Interestingly, this enzyme contributes to the breakdown of estrogen into 2ME (2-methoxyestradiol), a metabolite
that suppresses the activity of hypoxia inducible factor protein, explains Kalluri. We wondered if, in cases of preeclampsia, COMT was not ...
Crop scientists discover gene that controls fruit shape
... model Arabidopsis thaliana, which belongs to the same family as broccoli and cabbage. In Arabidopsis, AtIQD1 increases levels of glucosinolate, a metabolite
that Ohio State researchers are studying in broccoli for its possible role in inhibiting cancer (http://researchnews.osu.edu/archive/goodbroc.htm). ...
100 percent of people carry at least 1 type of pesticide
... their life.
Analysis of 6 POCs
The researchers analyzed the samples and measured 6 different POC concentration levels: DDE, a principal metabolite
in DDT (a pesticide used in Spain until the 80s); hexachlorobenzene, a compound used as fungicide and currently released by industrial processes; ...
Researchers' discovery may lead to hypertension treatment
... subsequently synthesized and injected into rats. The rats' urine was then monitored.
Two of the identified compounds, both derivatives of a common metabolite
xanthurenic-acid, raised sodium levels in the rat's urine but kept potassium levels constant. Schroeder said that while aldosterone (which does the ...
Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
... who take St. Johns Wort, a popular herbal supplement. These products have been shown to boost levels of the enzyme that produces the toxic liver metabolite
NAPQI, an effect that will likely be heightened when taking both acetaminophen and caffeine together, he says.
Likewise, people who drink a lot ...
Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
... Signatures of Xenoestrogens to Assess Breast Cancer Risk
Bruce Kristal, Ph.D., Brigham and Womens Hospital, Boston
and Protein Biomarkers of Effects of Diet
Coral Lamartiniere, Ph.D., University of Alabama at Birmingham
Biomarkers of Biological ...
Study offers innovative profile of enzyme that aids tumor growth
... "Using a combination of enzyme activity and metabolite
profiling, we determined that this protein-whose ... metabolic networks.
A primary advantage of metabolite
profiling in natural biological systems is that ... processes, specifically their small-molecule metabolite
profiles-to begin to decipher the complex ...
Mining for gems in the fungal genome
... in certain scientific analyses, making secondary metabolite
gene clusters easy to spot. Keller capitalized ... genes, which they knew were likely secondary metabolite
The team's new approach ... species.
The newly discovered secondary metabolite
gene clusters are already beginning to yield ...
War on terror meets war on cancer
... and perhaps hydrogen isotope ratios in a common metabolite
?a product produced by most human cells as they ... would be asking whether the isotope ratio of the metabolite
more closely matched the food that the individual ... involve taking a blood sample to collect some metabolite
produced by the cancer cells.
Smoking changes brain chemistry
... in the smokers who did not use patches compared to those who did. The metabolite
tCr plays an important role in supplying energy to the muscle cells. ...
Upon follow-up after six months, the researchers found that most metabolite
concentrations, including that of NAA, had normalized in the 25 ex-smokers ...
Indicators for risk of heart disease are higher in passive smokers
... level of cotinine in participants' blood, rather than relying on participants' self-reporting of exposure to second-hand smoke. Cotinine is the major metabolite
of nicotine that indicates levels of nicotine intake. Since nicotine is highly specific for tobacco smoke, blood serum cotinine levels track exposure ...
Low levels of neurotransmitter serotonin may perpetuate child abuse across generations
... as they parented to note hitting and other negative behaviors toward their infants, and took samples of their cerebrospinal fluid to measure the metabolite
concentrations of brain neurotransmitters such as serotonin every six months. They followed the infants until they became mothers themselves and ...
Tearing down the fungal cell wall
... is the first report that a fungal non-ribosomal peptide synthetase is associated with cell wall construction in fungal spores. The putative secondary metabolite
produced by the protein encoded by this gene could serve as a physical bridge in the layers of the cell wall or function as a regulator of cell wall ...
Gene variation affects tamoxifen's benefit for breast cancer
... published in the Dec. 20 issue of The Journal of Clinical Oncology.
"Our group has shown that CYP2D6 is responsible for activating tamoxifen to a metabolite
called endoxifen that is nearly 100 times more potent as an anti-estrogen than tamoxifen itself," says Rae, research assistant professor of internal ...
Breaking the mold: Research teams sequence three fungus genomes
... Suspect genes encode proteins involved in central metabolic pathways, cell signaling, cell wall biosynthesis, pigment biosynthesis, and secondary metabolite
production. In other words, A. fumigatus 's virulence genes are likely complex and mixed up with normal metabolic capabilities, Nierman says. He and ...
Neurotransmitters signal aggressive cancer, offer potential for early diagnosis
... about what type of metabolism was going on in these abnormal cells compared to their normal non-cancerous counterparts, and used new, powerful metabolite
detectors to verify that these compounds were actually being made. We then took information gained from the mouse and asked whether the same human ...
Product improves peptide identification for proteomics research
... manager of Agilent's Proteomics and LC/MS business. "The LC/MSD Trap XCT Ultra improves performance for a wide range of demanding applications in metabolite
characterization, natural products screening, product degradation studies and food and environmental analysis, which require excellent sensitivity ...