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Metabolite in Biological News

The 21st century tomato

... Expression of certain genes may regulate metabolite activity, but metabolites may also have a ... and followed the transmission of information from metabolite to gene. In continuing research, Carrari and ... and nutrition, as well as to improve yield. metabolite analysis also has possible applications in drug ...

First finding of a metabolite in 1 sex only

... development, the existence of a sex-specific metabolite is a previously unrecognized and potentially ... that the presence or absence of a sex-specific metabolite might affect an animal's development, anatomy and ... Now that the existence of a sex-specific metabolite has been proved for one animal, Kleps says ...

Birth control has long-term effect on hormone exposure

... postmenopausal phase of the study and frozen for subsequent analysis of metabolite concentrations. Lab results showed that the premenopausal use of oral ... isoflavones induced fewer significant effects on postmenopausal estrogen metabolite concentrations. "The magnitude and persistence of oral contraceptive ...

Healthy or diseased?

... concentrations." By a subsequent clustering of the test statistics of such metabolite pairs, it is possible to identify groups of metabolites which discriminate ... of the metabolome. "With this recent quantum leap in the area of metabolite analysis, the challenge to bioinformatics is to develop customized, ...

Chemicals in common consumer products may play a role in pre-term births

... samples collected during the third trimester and compared them to the control group who carried to term. They found significantly higher phthalate metabolite levels in the women who delivered prematurely. Premature birth is a significant risk factor for many health problems in childhood that can ...

Embryology study offers clues to birth defects

... that control the growth and differentiation of progenitor cells by regulating specific genes. One of these signaling molecules is retinoic acid, a metabolite produced from vitamin A (retinol), which plays a key role in the development of limbs and other organs. Dr. Duester's lab was instrumental in ...

Simulating pharmaceutical and personal care product transport

... sorption in macropores using data from experiments on the transport of three PPCPs (atenolol, carbamazepine, and triclosan), the nicotine metabolite cotinine, and the strongly sorbing dye rhodamine WT applied in LMB. The study was financed by grants from the European Union (ERAPharm, project no. ...

Genetic switch potential key to new class of antibiotics

... by the riboswitch. In the current study, Wedekind and colleagues solved the crystal structure of a preQ1 riboswitch in complex with its precursor metabolite preQ0. They chose to study the riboswitch from Thermoanaerobacter tengcongensis, a tough bacterium that lives at extreme temperatures and was first ...

Malaria parasite zeroes in on molecule to enhance its survival, team finds

... processes by simultaneously measuring the levels of all of the more than 500 core metabolites that make up an organism's "metabolic network." A metabolite is a chemical involved in metabolism, the process by which an organism takes up nutrients from the environment and converts them to energy and the ...

Next generation microscopy: No stain, big gain

... about the ways in which SRS imaging will facilitate progress in many fields. "Applications of SRS imaging range from mapping distribution of small metabolite and drug molecules in cells and tissues to medical diagnosis of cancer. Neuroimaging is another exciting area of application." ...

Gladstone scientists create Wikipathways to foster research collaboration

... dedicated wiki page, which displays the current diagram, description, references, download options, version history, and component gene, protein and metabolite list. Any pathway can be edited from within its wiki page by activating an embedded pathway editor. As the first wiki dedicated to biological ...

Researchers identify cancer preventive properties in common vitamin supplement

... two known risk factors for breast cancer. Rogan said resveratrol works by inducing an enzyme called quinone reductase, which reduces the estrogen metabolite back to inactive form. By making estrogen inactive, resveratrol decreases the associated risk. The current study was conducted in laboratory ...

Genomics of large marine animals showcased in the biological bulletin

... Cell-cell adhesion in the Cnidaria: Insights into the evolution of tissue morphogenesis, by Craig R. Magie and Mark Q. Martindale Coupling metabolite flux to transcriptomics: Insights into the molecular mechanisms underlying primary productivity by the hydrothermal vent tubeworm Ridgeia piscesae, ...

A new gene trigger for pregnancy disorder identified

... catecholamine class of neurotransmitters. Interestingly, this enzyme contributes to the breakdown of estrogen into 2ME (2-methoxyestradiol), a metabolite that suppresses the activity of hypoxia inducible factor protein, explains Kalluri. We wondered if, in cases of preeclampsia, COMT was not ...

Crop scientists discover gene that controls fruit shape

... model Arabidopsis thaliana, which belongs to the same family as broccoli and cabbage. In Arabidopsis, AtIQD1 increases levels of glucosinolate, a metabolite that Ohio State researchers are studying in broccoli for its possible role in inhibiting cancer (http://researchnews.osu.edu/archive/goodbroc.htm). ...

100 percent of people carry at least 1 type of pesticide

... their life. Analysis of 6 POCs The researchers analyzed the samples and measured 6 different POC concentration levels: DDE, a principal metabolite in DDT (a pesticide used in Spain until the 80s); hexachlorobenzene, a compound used as fungicide and currently released by industrial processes; ...

Researchers' discovery may lead to hypertension treatment

... subsequently synthesized and injected into rats. The rats' urine was then monitored. Two of the identified compounds, both derivatives of a common metabolite xanthurenic-acid, raised sodium levels in the rat's urine but kept potassium levels constant. Schroeder said that while aldosterone (which does the ...

Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage

... who take St. Johns Wort, a popular herbal supplement. These products have been shown to boost levels of the enzyme that produces the toxic liver metabolite NAPQI, an effect that will likely be heightened when taking both acetaminophen and caffeine together, he says. Likewise, people who drink a lot ...

Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring

... Signatures of Xenoestrogens to Assess Breast Cancer Risk $365,000 Bruce Kristal, Ph.D., Brigham and Womens Hospital, Boston Mitochondrial, metabolite and Protein Biomarkers of Effects of Diet $454,000 Coral Lamartiniere, Ph.D., University of Alabama at Birmingham Biomarkers of Biological ...

Study offers innovative profile of enzyme that aids tumor growth

... "Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose ... metabolic networks. A primary advantage of metabolite profiling in natural biological systems is that ... processes, specifically their small-molecule metabolite profiles-to begin to decipher the complex ...

Mining for gems in the fungal genome

... in certain scientific analyses, making secondary metabolite gene clusters easy to spot. Keller capitalized ... genes, which they knew were likely secondary metabolite gene clusters. The team's new approach ... species. The newly discovered secondary metabolite gene clusters are already beginning to yield ...

War on terror meets war on cancer

... and perhaps hydrogen isotope ratios in a common metabolite ?a product produced by most human cells as they ... would be asking whether the isotope ratio of the metabolite more closely matched the food that the individual ... involve taking a blood sample to collect some metabolite produced by the cancer cells. "If ...

Smoking changes brain chemistry

... in the smokers who did not use patches compared to those who did. The metabolite tCr plays an important role in supplying energy to the muscle cells. ... Upon follow-up after six months, the researchers found that most metabolite concentrations, including that of NAA, had normalized in the 25 ex-smokers ...

Indicators for risk of heart disease are higher in passive smokers

... level of cotinine in participants' blood, rather than relying on participants' self-reporting of exposure to second-hand smoke. Cotinine is the major metabolite of nicotine that indicates levels of nicotine intake. Since nicotine is highly specific for tobacco smoke, blood serum cotinine levels track exposure ...

Low levels of neurotransmitter serotonin may perpetuate child abuse across generations

... as they parented to note hitting and other negative behaviors toward their infants, and took samples of their cerebrospinal fluid to measure the metabolite concentrations of brain neurotransmitters such as serotonin every six months. They followed the infants until they became mothers themselves and ...

Tearing down the fungal cell wall

... is the first report that a fungal non-ribosomal peptide synthetase is associated with cell wall construction in fungal spores. The putative secondary metabolite produced by the protein encoded by this gene could serve as a physical bridge in the layers of the cell wall or function as a regulator of cell wall ...

Gene variation affects tamoxifen's benefit for breast cancer

... published in the Dec. 20 issue of The Journal of Clinical Oncology. "Our group has shown that CYP2D6 is responsible for activating tamoxifen to a metabolite called endoxifen that is nearly 100 times more potent as an anti-estrogen than tamoxifen itself," says Rae, research assistant professor of internal ...

Breaking the mold: Research teams sequence three fungus genomes

... Suspect genes encode proteins involved in central metabolic pathways, cell signaling, cell wall biosynthesis, pigment biosynthesis, and secondary metabolite production. In other words, A. fumigatus 's virulence genes are likely complex and mixed up with normal metabolic capabilities, Nierman says. He and ...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

... about what type of metabolism was going on in these abnormal cells compared to their normal non-cancerous counterparts, and used new, powerful metabolite detectors to verify that these compounds were actually being made. We then took information gained from the mouse and asked whether the same human ...

Product improves peptide identification for proteomics research

... manager of Agilent's Proteomics and LC/MS business. "The LC/MSD Trap XCT Ultra improves performance for a wide range of demanding applications in metabolite characterization, natural products screening, product degradation studies and food and environmental analysis, which require excellent sensitivity ...
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(Date:8/20/2014)... 20, 2014  The second annual Biometrics UnPlugged ... Tampa, Florida on September 15, ... Rahman, Director, Technology and Strategy at Samsung, and Philippe ... theme of this year,s event is Mobility at ... "Biometrics UnPlugged: Mobility at the Crossroads of ...
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(Date:8/19/2014)... a biomarker strongly associated with basal-like breast cancer, ... many types of chemotherapy. The biomarker, a protein ... therapeutics designed to treat this often deadly cancer. ... The Cancer Genome Atlas, molecular biologists Curt M. ... and bioinformatics techniques to detect patterns of gene ...
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