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Metabolism in Biological News

From the glass to the brain in 6 minutes

... in the Journal of Cerebral Blood Flow and metabolism . metabolism of brain cells affected The brain reacts ... Armin Biller of the working group for cerebral metabolism at the Department of Neuroradiology at Heidelberg ...

Researchers engineer metabolic pathway in mice to prevent diet-induced obesity

... in the June 3 issue of the journal Cell metabolism , chemical and biomolecular engineering professor ... pathway in mice that increased fatty acid metabolism and resulted in resistance to diet-induced obesity. "When we looked at the fatty-acid metabolism issue, we noted there are two aspects of the ...

Toward a systems biology map of iron metabolism

... to the survival of animal cells. When iron metabolism goes wrong the consequences can be devastating. ... researchers with a systems biology map of iron metabolism that would allow scientists to investigate ... "To build the systems biology map of iron metabolism described in this paper we have used the program ...

LSUHSC student awarded top national honor for diabetes research

... Mead Johnson Research Award in Endocrinology and metabolism by the American Physiological Society at the 2009 ... for research in the area of Endocrinology and metabolism at the Experimental Biology Meeting. She works in ... to Ang-(1-7)-mediated restoration of glucose metabolism in diabetic mice." She will present it on ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... he said. The enzyme is involved in the metabolism of arachidonic acid, a key signaling molecule ... focused on s-EH, an important enzyme for the metabolism of arachidonic acid that plays an essential role ... of concept that s-EH inhibition modulates glucose metabolism or blood pressure in patients with impaired ...

Disabling enzyme allows mice to gorge without becoming obese, new study finds

... within fat cells that is a key regulator of fat metabolism and body weight, making it a promising target in ... been that the major players in controlling fat metabolism and body weight were endocrine factors, primarily ... caution that previous discoveries in fat metabolism and appetite regulation have not always ...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

... Cytochrome P450 Assays for Assessing Drug metabolism and Drug Safety,' will support the Phylonix ... in multiwell plate formats, will accelerate drug metabolism and safety profiling and reduce the possibility ... vivo CYP assay will be useful for profiling drug metabolism prior to performing expensive mammalian testing. ...

Plants grow bigger and more vigorously through changes in their internal clocks

... many of their genes for photosynthesis and starch metabolism are more active during the day, report ... of genes involved in photosynthesis and starch metabolism in hybrids and polyploids. These genes were ... and polyploids. Circadian clocks control growth, metabolism and fitness in plants and animals. They found ...

Mysterious microbe plays important role in ocean ecology

... organisms. "For it to have such an unusual metabolism is very exciting," Zehr said. "We're trying to ... abundance. Zehr is also interested in how its metabolism differs from other known cyanobacteria. If it can ... may be ways to exploit this organism's unusual metabolism in biotechnology applications, he said. ...

Mysterious microbe may play important role in ocean ecology

... organisms. "For it to have such an unusual metabolism is very exciting," Zehr said. "We're trying to ... abundance. Zehr is also interested in how its metabolism differs from other known cyanobacteria. If it can ... may be ways to exploit this organism's unusual metabolism in biotechnology applications, he said. ...

Apelin hormone injections powerfully lower blood sugar

... mice, researchers report in the November Cell metabolism that they significantly lowered blood sugar ... in the control of skeletal muscle glucose and the metabolism of fatty acids. Moreover, they showed that ... insights into the physiology of glucose and lipid metabolism in health and disease. ...

Could Dr. House be replaced by a computer?

... genome-wide study of normal and abnormal human metabolism in a tissue-specific manner," says Prof. Ruppin. The computational model describes metabolism in ten different human tissues, exposing the functions in the body responsible for metabolism a set of chemical reactions occurring in living ...

For insulin sensitive overweight patients, 1 session of exercise improves metabolic health

... complications are associated with an abnormal fat metabolism in the muscle. As a result, accumulated fat ... Their research is entitled "Alteration in Lipid metabolism After One Day of Overeating Are Reversed by a ... study was to assess changes in fatty acid (FA) metabolism in response to acute overeating and exercise. ...

Exercise could be the heart's fountain of youth

... on the heart." The researchers measured heart metabolism in sedentary older people both at rest and during ... women and men. In the men, the heart's fatty acid metabolism dropped in response to increased energy demand, ... The researchers tested the volunteers' heart metabolism before and at the end of their exercise programs ...

SEX4, starch and phosphorylation

... down to component sugars. Some aspects of starch metabolism have been known for many years, but regulation of ... mechanisms and regulatory components in starch metabolism have been identified by Dr. Samuel Zeeman and his ... of how these proteins coordinate starch metabolism are still unknown, the importance of phosphate ...

Monell scientist Mark Friedman awarded Guggenheim Fellowship to study diet and obesity

... Friedmans research focuses on how energy metabolism affects eating behavior. Studies in his ... and relaying information about the bodys fuel metabolism to the brain to control food intake. He has ... of dietary fat and carbohydrate affects metabolism to cause overeating and obesity. The findings ...

UT-Houston's Northrup and colleagues uncover genetic link to spina bifida

... an association between genes regulating glucose metabolism and spina bifida. The decade-long study looked at ... in a dozen genes that take part in glucose metabolism to look for a link between genetic variation in ... Sciences, the study titled Genes in Glucose metabolism and Association with Spina Bifida, found an ...

Story ideas from the Journal of Lipid Research

... Variants Affect Weight-Associated Cholesterol metabolism Researchers have found that variants in two ... genes alter how the body adjusts cholesterol metabolism in response to weight loss, a finding that may ... To study how these variants affect cholesterol metabolism in response to changes in weight loss from diet ...

Powerful integration of lipid metabolic profiling with gene expression analysis

... The study elucidated the effects on Mouse lipid metabolism by the disruption of hepatic Cytochrome P450 ... demonstrate that though gene expression and lipid metabolism in extrahepatic tissues being sensitive to ... the proper functioning of lipid mobilization and metabolism predominantly within the mouse liver with only ...

Cholesterol metabolism links early- and late-onset Alzheimer's disease

... prominent theory that abnormal brain cholesterol metabolism plays a role in the mental decline seen in ... partial defects in the regulation of cholesterol metabolism in the brain likely contribute to the development ... found an aspect of cholesterol transport and metabolism in the brain was a link between early- and ...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

... offspring's somatic cells other cells involved in all aspects of growth, metabolism and behavior, which have a set lifespan and new germline cells that ... Gary Ruvkun, PhD, whose work focuses on the development, longevity and metabolism of C. elegans , a tiny worm broadly used as a model for studying basic ...

Fatty foods -- not empty stomach -- fire up hunger hormone

... the foods we eatnot those made in the bodyin order to optimize nutrient metabolism and promote the storage of body fat. The findings, the study's author ... "This powerful obesity therapy frequently reduces appetite and improves metabolism before substantial weight loss occurs. Intriguingly, this procedure causes ...

Newly discovered reactions from an old drug may lead to new antibiotics

... that the gold drug Auranofin, used to treat arthritis, impacted selenium's metabolism process. The chemical reaction changes the selenium, which prevents ... approaches to preventing gum disease. "No one has tried to block the metabolism of selenium before as a therapeutic approach," Self said. "That's what's ...

A little java makes it easier to jive, researcher says

... edition of the International Journal of Sport Nutrition and Exercise metabolism . "This study looks at the effects of caffeine on muscle pain during ... But the tolerance effect is not ubiquitous across all stimuli. Even brain metabolism doesn't show this tolerance-type effect. That is, with individuals who are ...

UW-Madison study reveals new options for people with PKU

... to eat them throughout the day, which helps keep the body's protein metabolism running efficiently all day long," says Ney. "When he went back to the ... comparable in the two diets. Additionally, the GMP diet improved protein metabolism compared to the amino acid formula. Members of the PKU community have ...

Difference in fat storage may explain lower rate of liver disease in African-Americans

... "This seems to argue that there is a fundamental difference in the lipid metabolism between African-Americans and Hispanics or Caucasians, and this difference ... Dr. Browning said. Researchers next will study how differences in metabolism affect fatty liver disease. ...

Iron is involved in prion disease-associated neuronal demise

... the Singh laboratory suggests that accumulation of PrP-scrapie alters the metabolism of iron in diseased brains. The imbalance of brain iron homeostasis ... condition is loss of normal function of the prion protein in cellular iron metabolism demonstrated recently by Singh and colleagues, combined with gain of toxic ...

Malaria parasite zeroes in on molecule to enhance its survival, team finds

... believe that shedding light on this poorly understood aspect of malaria metabolism has given them new insights on the interactions between the parasite and ... the researchers said. Scientists are interested in studying the metabolism of P. falciparum to understand how organisms adapt to a parasitic ...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

... responses in the brain. Importantly, the AD brain exhibits impaired energy metabolism (a stressful situation) and it has been suggested that diminished cerebral ... "We have shown previously, using a pharmacological model of energy metabolism inhibition in pre-plaque transgenic mice with an excess of APP, that BACE1 ...

Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish

... and cancer cells do have something in common: relying extensively on the metabolism of glucose, a simple sugar. But until now, the advantages of this common ... levels of the antioxidant glutathione (GSH), which is generated by glucose metabolism through the pentose phosphate pathway. Thus, both neurons and cancer cells ...

Brain enzyme may play key role in controlling appetite and weight gain

... preventing weight gain and obesity. The findings were reported in Cell metabolism . To understand what drives hunger and causes metabolic disease, many ... thermostat in mammals, increasing or decreasing feeding behavior and metabolism to maintain a normal energy balance. "These findings show that it may be ...

Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers

... worm goes into a form of suspended animation called "dauer" that slows its metabolism and allows it to survive for extended periods without food. "When they ... Roy said. "However, that's not what kills them. They cannot adjust their metabolism correctly. They store up their six-month lipid reserves, but as soon as ...

Discovery of new gene associated with diabetes risk suggests link with body clock

... A connection between the body clock and abnormalities in metabolism and diabetes has been suggested in new research by an international team ... Mark McCarthy of the Oxford Centre for Diabetes, Endocrinology and metabolism at the University of Oxford. Melatonin is a hormone that is strongly ...

SNPs affect folate metabolism in study of Puerto-Rican adults

... have gained further understanding of the genomic basis for altered folate metabolism and the content of uracil in blood DNA. In a study published in October's ... and around Boston. In addition, four SNPs in two genes involved in folate metabolism previously associated with altered blood folate and homocysteine ...

Brandeis and Smart Balance team up to advance heart-healthy research

... will support continued research on diet factors that affect cholesterol metabolism and diabetes in the lab of nutritionist K.C. Hayes, who, along with ... better foods for healthier living," said Hayes, who has researched lipid metabolism for three decades. "It is a real vote of confidence to have Smart Balance ...

A new weapon in the fight against obesity and diabetes

... in French . A study appearing November 5 in the journal Cell metabolism demonstrates that a synthetic new chemical entity protects against ... intervention. The new chemical entity announced today in Cell metabolism was specifically designed to activate the SIRT1 pathway and assess its ...

Deprived of a sense of smell, worms live longer

... that the worms' sensation of food is critical to controlling their metabolism and life span." If roundworms sense that food is abundant, their metabolism adjusts accordingly. Their bodies respond to promote rapid ingestion, ...

A link between mitochondria and tumor formation in stem cells

... both visually and in the expression of key stem cell markers, low and high metabolism stem cells were indistinguishable. Yet, when transplanted into mice, ... and colleagues administered the mitochondrial inhibitor rapamycin to high metabolism stem cells, their teratoma capacity decreased significantly. While this ...

Biologists identify genes controlling rhythmic plant growth

... genome that deal with hormone biosynthesis, hormone signaling and hormone metabolism are all tightly correlated with rhythmic plant growth. This told us that ... questions about complex processes, such as how plants grow or how human metabolism goes awry." ...

OU researchers isolate microorganisms that convert hydrocarbons to natural gas

... and biodeterioration can be problematic, anaerobic hydrocarbon metabolism also has an upside. The OU researchers found that they can use their ... gas and create a new source of domestic energy. The concept of anaerobic metabolism is an innovative process and the OU initiative is the only one of its kind ...
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