Joint research into an enzyme that causes genetic diseases
... "natural" state).
Pyruvate carboxylase is a metabolic
enzyme that plays a fundamental role in the ... when mutations in the gene arise) diverse metabolic
diseases of genetic origin are triggered, amongst ... retardation. At the same time, being at a metabolic
crossroads, pyruvate carboxylase is potentially a ...
Common allergy drug reduces obesity and diabetes in mice
... the term "immunology" anywhere. This is because metabolic
conditions and immunologic conditions are, with a ... blood cells, also acts as a liaison between the metabolic
and immune systemsin this case, controlling ... In contrast, type 2 diabetes is a strictly metabolic
condition in which cells grow increasingly deaf ...
Scientists track chemical changes in cells as they endure extreme conditions
... molecular signatures of a cell's biochemical and metabolic
activity, such as spikes in levels of free ... as the surviving cells unleashed a series of metabolic
changes that enabled them to endure in the ... in the same bacteria, and watched their metabolic
response to stress and extreme conditions," says ...
Mosquito parasite may help fight dengue fever
... the insects' CO 2 production to find how their metabolic
rates respond to the parasite. Again, the insects' metabolic
rates were higher than those of the uninfected ... to change their behaviour and increase their metabolic
rate. McGraw suspects that the last explanation ...
Star Trek-like technology offers noninvasive monitor for patients and athletes
... draw blood and cumbersome equipment to determine metabolic
rate. The futuristic system, dubbed the Venus ... capability to measure blood and tissue chemistry, metabolic
rate (oxygen consumption) and other parameters. ... Systems and Technology team. "The measurement of metabolic
rate will let astronauts know how quickly they ...
Toward a systems biology map of iron metabolism
... we have used the program CellDesigner to map the metabolic
network in multiple types of cells. The modeling ... remarked: "We were able to construct an iron metabolic
network that comprised 151 different chemical ... first to use the CellDesigner program to map one metabolic
network in multiple types of cells."
Drinking 100 percent fruit juice is associated with lower risk of obesity and metabolic syndrome
... sensitivity and had lower risk for obesity and metabolic
syndrome a cluster of conditions that increases ... lower among 100% juice drinkers, while risk for metabolic
syndrome (defined as the presence of three or ... between 100% fruit juice consumption and metabolic
syndrome was no longer statistically significant. ...
Research suggests vegetable juice may help people with metabolic syndrome lose weight
... juice daily may help overweight people with metabolic
syndrome achieve better weight loss results. A ... same diet but drank no juice lost one pound.
syndrome is defined by a cluster of risk factors ... and abnormal blood lipids. If left uncontrolled, metabolic
syndrome increases risk for chronic diseases, ...
2009 ASPB Summer Undergraduate Research Fellowship award announcement
... Spectrometry Derivatization for metabolic
I am really excited to receive ... for this fellowship to continue my research in metabolic
engineering. My project involves improving the ... provide important insights toward quantifying metabolic
fluxes in plants. I am looking forward to a ...
Optimum running speed is stride toward understanding human body form
... the long-standing view that running has the same metabolic
cost per unit of time no matter the speed in ... were thought to balance out the difference in metabolic
cost, says Karen Steudel, a zoology professor at ... efficiency was determined by measuring runners' metabolic
rates at a range of speeds enforced by a ...
Reversing ecology reveals ancient environments
... The technique uses genomic data to examine metabolic
networks and pulls out proxies for reconstructing ... ecologically. But by looking at its genome and metabolic
network, you can recreate that past environment ...
Researchers have used genomic data to study metabolic
networks-the chemical reactions in metabolism ...
Malaria parasite zeroes in on molecule to enhance its survival, team finds
"The more we know about the parasite's metabolic
network, the more intelligent we can be about ... Metabolomics is a new field that aims to analyze metabolic
processes by simultaneously measuring the levels ... knowledge of the 'weak points' in the parasite's metabolic
network," Llins said.
According to the World ...
In India: A search for more effective tuberculosis drugs
... the molecule hits four of the bacterium's crucial metabolic
pathways at the same time, weakening and ... and his colleagues have studied the intricate metabolic
pathways that Mycobacterium tuberculosis ... the idea that a single drug can work on multiple metabolic
pathways, rather than making a molecule that acts ...
Athletes not spared from health risks of metabolic syndrome
... underwent a battery of tests for the study had metabolic
syndrome. This means the players had at least ... health problems at the same time," Buell said.
syndrome is characterized by a cluster of ... that more than 50 million Americans have metabolic
Buell noted that the presence of ...
Control of blood vessels a possible weapon against obesity
... from 'white' fat to 'brown' fat, which has higher metabolic
activity and which breaks down more quickly.
... been shown that blood vessel growth affects the metabolic
activity of adipose tissue rather than vice ... open up new therapeutic avenues for obesity and metabolic
diseases like diabetes."
Brown fat releases ...
New scientific knowledge on juvenile diabetes
... physiological and environmental context. The metabolic
phenotype is sensitive to subtle factors such as ... Simell took part in the study, which investigated metabolic
profiles of DIPP children prospectively from ... 2008. The article reports the discovery of metabolic
disturbances that precede the autoimmune response ...
Brain enzyme may play key role in controlling appetite and weight gain
To understand what drives hunger and causes metabolic
disease, many scientists have focused on the ... other parts of the brain to adjust food intake, metabolic
rates, and physical activity accordingly keeping ... nutrient-sensing pathways and how they go awry in metabolic
disorders, researchers at Einstein focused on an ...
Apple or pear shape is not main culprit to heart woes -- it's liver fat
... in extreme cases, but more often it tends to have metabolic
Klein, who heads the Division ... without a fatty liver did not have markers of metabolic
problems. Whether shaped like pears or apples, it was fat in the liver that influenced metabolic
"Abdominal fat is not the best marker ...
Study identifies genetic variants giving rise to differences in metabolism
... induce major differentiations in the metabolic
make-up of the human population, according to a ... breakdown of fats. The resulting differences in metabolic
capacity can affect individuals' susceptibility ... in these genes have significantly different metabolic
capacities with respect to the synthesis of some ...
Systems biology brings hope of speeding up drug development
... against cancer, infectious diseases, or metabolic
conditions like diabetes, but these rarely ... notably the SBMS (Systems Biology to combat metabolic
Syndrome) initiative. metabolic
syndrome is the term for various conditions that ...
UC Davis researchers discover Achilles' heel in pancreatic cancer
... Davis Cancer Center researchers have discovered a metabolic
deficiency in pancreatic cancer cells that can be ... in that it is one of the first to identify a metabolic
pathway that can be leveraged to interrupt cancer ... cancer cells need to function," Bold said.
interruptions like this one are also being ...
Coping and copulation behavior may help calculate diabetes risk
Risk of developing type 2 diabetes and metabolic
syndrome is determined by an individual's genetic ... a test often used to diagnose diabetes and metabolic
syndrome, in a type of field mouse native to ... as behavior, when calculating risk of diabetes, metabolic
syndrome, and other common diseases.
A new weapon in the fight against obesity and diabetes
... and protect against diet-induced obesity and metabolic
diseases such as diabetes. A year ago, researchers demonstrated that these metabolic
benefits can also occur with large doses of ... by themselves in curbing obesity and associated metabolic
disorders, interest has increased in using the ...
Ecologists say metabolism accounts for why natural selection favors only some species
... To the researchers' surprise, they found the mean metabolic
rate of the species at rest fell on a narrow ... Academy of Sciences .
According to Li, the metabolic
optimum explains the ubiquitous and seemingly ... Unlike the genetic code and protein composition, metabolic
rate cannot be inherited from a common ancestor. ...
Biosynthetics production with detours
... an important advance in better understanding metabolic
pathways in bacteria and their use. Using ... created a network of individual genes and metabolic
processes in P. putida . "All of this is similar ... roads are blocked and then there are detours. The metabolic
paths in P. putida behave in exactly the same ...
Deprived of a sense of smell, worms live longer
... that sensory perception cues have important metabolic
consequences independent of what we actually eat.
"Emerging evidence suggests that core metabolic
pathways that modulate lifespan in worms also ... common ancestor, these pathways might have caused metabolic
adjustments that affect lifespan. That could be ...
Could Dr. House be replaced by a computer?
... level, since they lacked information about the metabolic
processes of individual organs, such as the ... science gain a clearer overall picture of the metabolic
processes in our different tissues. Their model ... it to an existing model of the global human metabolic
network to ...
A link between mitochondria and tumor formation in stem cells
... relationship between stem cell potency and the metabolic
rate of their mitochondria a cell's energy ... had contrasting properties, as cells with lower metabolic
rates were more efficient at differentiating into other cell types while the highly metabolic
cells were more prone to keep dividing and form ...
Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
... fatty liver. This increases the risk of many metabolic
diseases, such as the metabolic
syndrome known as "deadly quartet". This ... head of the Junior Research Group "Molecular metabolic
Control" at the German Cancer Research Center ...
New evidence on the robustness of metabolic networks
... in areas where researchers want to manipulate metabolic
network structure, such as in bioengineering and ... titled "Cascading failure and robustness in metabolic
networks," are Lus A. Nunes Amaral, associate ... the size of these "cascade" events in simulated metabolic
networks, the Northwestern researchers were able ...
Bisphenol A linked to metabolic syndrome in human tissue
... plasticsbisphenol A (BPA)as a risk factor for metabolic
syndrome and its consequences.
In a laboratory ... puts people at a substantially higher risk for metabolic
syndrome is a combination of risk factors that ...
Risks and benefits of antipsychotics in children and adolescents
... months (Castro-Fornieles et al., in press).
and hormonal safety
Childhood obesity is ... about second-generation antipsychotics having metabolic
side effects such as weight gain, hyperglycaemia, ... study directly comparing weight gain and other metabolic
and hormonal risk factors after treatment with 3 ...
Research yields pricey chemicals from biodiesel waste
... research is available online in the journal metabolic
Engineering . The new paper and others published ... Chemical and Biomolecular Engineering. "The new metabolic
pathways we have uncovered paved the way for the ... Gonzalez's research revealed a previously unknown metabolic
pathway for glycerol fermentation, a pathway that ...
Hebrew University develops novel approach for treating mitochondrial disorders
DERT is a therapeutic approach to metabolic
disorders whereby the deficient or absent enzyme ... (Metabolites are substances produced by a metabolic
Inside the mitochondria there are ... due to a genetic mutation, a mitochondrial metabolic
disorder occurs. Modern medicine offers no cure ...
A single mechanism for hypertension, insulin resistance and immune suppression
... in a strain of rat that explains why such metabolic
disorders arise together in mammals.
The ... with hypertension also develop a variety of other metabolic
complications when high blood pressure strikes. ... for a common cause of diverse but concurrent metabolic
problems and we were testing our theory that ...
The 21st century tomato
... This systems approach in the new fields of metabolic
and functional genomics is producing the tools, ... genetic, and biochemical tools to model the metabolic
networks that interact in the process of tomato ... of this wealth of sequence data in functional and metabolic
analyses of tomato and other crops.
New Web resource to improve crop engineering
... materials, and new medicines. It is the Plant metabolic
Network (PMN) at http://www.plantcyc.org/
... understand the chemical reactions that happen in metabolic
processes, such as converting carbon dioxide to ... create a broad network of information about plant metabolic
pathways. A central feature is PlantCyc, a ...
Did walking on 2 feet begin with a shuffle?
... as a precursor to walking as a way of saving metabolic
energy is produced by what an animal eats, ... they go down and crawl, she said.
We think metabolic
energy is extremely important and we have only ...
Breaking news: Study revives Olympic prospects for amputee sprinter
... 400m, performance depends on both mechanical and metabolic
factors, said Herr, a bilateral amputee who heads ... the speed-duration relationship and rates of metabolic
Specifically, the ... as able-bodied sprinters.
Pistorius rates of metabolic
energy expenditure do not differ from elite ...
How and where fat is stored predicts disease risk better than weight
... obesity it causes, is the trigger for developing metabolic
syndrome, a collection of heath risk factors that ... when determining a persons risk of developing metabolic
syndrome, researchers at UT Southwestern Medical ... people today think that obesity itself causes metabolic
syndrome, said Dr. Roger Unger, professor of ...