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Melanoma in Biological News

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

... survival rates in patients with metastatic melanoma whose disease had been minimized by other ... interest in developing new therapies for melanoma patients with recurrent or distant metastatic ... for the study. "Patients with metastatic melanoma are at high risk for additional metastases and ...

Zebrafish provide a model for cancerous melanoma in humans

... disease. Many of the changes they made caused melanoma in the zebrafish, indicating that zebrafish ... reminiscent of familial atypical mole and melanoma syndrome (FAMM) seen in humans. By producing ... that reduced the effects of RAS mutations on melanoma progression in zebrafish. ...

Skin cancer study uncovers new tumor suppressor gene

... The NIH analysis found that one-quarter of human melanoma tumors had changes, or mutations, in genes that ... that one of the most often mutated MMP genes in melanoma is not an oncogene at all. In its study, the team ... Consequently, in the estimated 6 percent of melanoma patients whose tumors harbor a mutated MMP-8 gene ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... 5, 2009)Scientists have long wondered how melanoma cells travel from primary tumors on the surface ... (miRNA) that is over-expressed in metastatic melanoma cell lines and tissues. The ... that the average survival for patients after melanoma metastasis occurs is only nine months. "Normal ...

Stress may hasten the growth of melanoma tumors

... aggressive form of skin cancer malignant melanoma stress, including that which comes from simply ... Research (IBMR), exposed samples of three melanoma cell lines to the compound norepinephrine, a ... us is that stress might have a worse effect on melanoma that is in a very aggressive or advanced stage, ...

Vitiligo skin disorder could yield clues in fight against melanoma

... it stops attacking pigment cells. Conversely, melanoma would be treated by revving up the immune system ... Chicago Stritch School of Medicine. Although melanoma accounts for less than 5 percent of skin cancers, ... cancer deaths. There will be more than 62,000 new melanoma cases in the United States this year, and more ...

More than skin deep: There's no such thing as a 'safe' suntan, researchers warn

... published in the October issue of Pigment Cell & melanoma Research , the official journal of The ... Cell Societies (IFPCS) and the Society for melanoma Research. The authors of the three review ... young women, are linked to an increased risk of melanoma (the most dangerous form of skin cancer), and do ...

Fish cancer gene linked to pigment pattern that attracts mates

... to male fish, it also has one perk: The black melanoma splotches arise from attractive natural markings ... Academy of Sciences this week shows that the melanoma gene can be conserved in swordtail fish because ... a lot of offspring, he noted. The swordtail melanoma has been studied since the 1920s, and scientists ...

As rates rise, researchers find better way to identify melanoma

... give doctors a new, objective way to distinguish melanoma from some benign moles that look like melanoma but are not cancerous. "We are very excited ... Medicine. "Although we have learned a lot about melanoma in recent years, it has unique biologic ...

New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume

... produces a pronounced reduction of malignant melanoma cell growth. Dermytol, a proprietary compound ... more than 62,000 Americans will be diagnosed with melanoma and one million Americans will be diagnosed with ... year. NCI expects more than 8,000 deaths from melanoma and less than 1,000 deaths from non-melanoma ...

New method for detection of phosphoproteins reveals regulator of melanoma invasion

... how proteins are modified in response to oncogenic B-Raf signaling in melanoma cells. In particular, identifying cellular targets for phosphorylation is ... phosphorylation of FAM129B and discovered its importance in controlling melanoma cell invasion." ...

Beach vacations may increase future skin cancer risk in children

... factor for malignant melanoma, the most dangerous form of skin cancer. melanoma rates have been rising dramatically over recent decades. More than 62,000 Americans are diagnosed with melanoma each year and more than 8,000 die. The study was conducted among ...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

... a laboratory technique known as copy number analysis to look for PTPRD in melanoma cell lines and in samples of human glioblastoma multiforme, the deadliest ... copy number. They found that PTPRD was deleted or mutated in 12 percent of melanoma tumors and in 14 percent of glioblastoma tumors examined. "That makes ...

Meyskens honored with AACR-Prevent Cancer Foundation award

... of detailed laboratory work, he proposed a new conceptual framework for melanoma etiology, prevention, and treatment. Most recently, he has provided a major, new insight into the non-UVR causation of melanoma with suggestions for potential preventive strategies. Meyskens has ...

Variant of vitamin D receptor gene linked to melanoma risk

... risk of melanoma. The analysis revealed a significant association between melanoma risk and the BsmI gene. The researchers note that additional research ... whether any vitamin D receptor variant is independently associated with melanoma risk. "These findings prompt further investigation on this subject and ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... and the protein that binds to it, the growth factor pleiotrophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in ...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

... of TH-302 in patients with advanced solid tumors. After evidence of tumor activity was observed in the Phase 1 trial in patients with advanced melanoma both non-small cell lung cancer and small cell lung cancer the study was expanded to further investigate TH-302 anti-tumor activity in these ....

Implants mimic infection to rally immune system against tumors

... the skin can reprogram the mammalian immune system to attack tumors. The research -- which ridded 90 percent of mice of an aggressive form of melanoma that would usually kill the rodents within 25 days -- represents the most effective demonstration to date of a cancer vaccine. Harvard's David J. ...

Jefferson scientists discover a key protein regulator of inflammation and cell death

... Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation. The protein, AIM2 (absent in melanoma 2), is involved in the detection and reaction to dangerous cytoplasmic DNA that is produced by infection with viral or microbial pathogens, or by ...

Children's National researchers develop novel anti-tumor vaccine

... WASHINGTON, DCA novel anti-tumor vaccine for neuroblastoma and melanoma developed by scientists and clinicians at Children's National Medical Center in collaboration with investigators from the University of Iowa is ...

The genetics of the white horse unraveled

... of view since the mutation also predisposes for development of melanoma. About 75% of Grey horses older than 15 years of age have a benign form of melanoma that in some cases develops into a malignant melanoma. Thus, the study reported today has also given new insight in a molecular pathway that may lead ...

New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers

... half-life, selectively accumulated in tumor tissue, blocked angiogenesis, and significantly inhibited primary tumor growth in mouse models of melanoma and lung cancer, with no apparent side effects when used at effective doses. Subsequent tests suggest that Lodamin retains TNP-470's unusually broad ...

Synthetic compound promotes death of lung-cancer cells, tumors

... mimic alone, without having to add TNFa. The researchers also found that the Smac mimic alone was effective against some types of breast cancer and melanoma cells in culture. The apparent ability of a Smac mimetic, as a single agent, to induce cell death in nearly one-quarter of lung-cancer cell lines ...

Last chance for media to register for ECCO 14 -- the European Cancer Conference

... survival Couples more likely to divorce if one partner is diagnosed with certain types of cancer New type of drug shows promise in tackling melanoma in innovative way. . . . and much more. Press Office opening times: Sunday 23 September: 09.00 19.00 Monday 24 Wednesday 26 ....

Sun exposure early in life linked to specific skin cancer gene mutation

... The results indicate that different subtypes of melanoma are associated with different risk factors "The findings suggest that melanoma subtypes have different causes. This is important ... in melanomas. Researchers interviewed 214 melanoma patients in North Carolina about their risk ...

Dealing deadly cancers a knockout punch

... a standard chemotherapy agent, in a mouse melanoma model that included both cultured cells and live ... than cisplatin or reovirus alone at killing melanoma cancer cells in a mouse model. The investigators ... expected to begin in 2007, including a Phase II melanoma trial and a Phase I/II ovarian cancer trial. ...

'Guardian of the genome' protein found to underlie skin tanning

... light from the sun, it deters the development of melanoma skin cancer, the fastest-increasing form of ... of melanoma. "The number one risk factor for melanoma is an inability to tan; people who tan easily or ... author, David E. Fisher, MD, PhD, director of the melanoma Program at Dana-Farber and a professor in ...

Study calculates patient time costs associated with cancer care

... and 20.8 days) and shortest for patients with melanoma (2.2 days), prostate cancer (3.8 days) and breast ... medical care varied, ranging from 17.8 hours for melanoma to 351.3 hours for gastric cancer and 368.1 hours ... found that net patient time costs were lowest for melanoma ($271) and prostate cancer ($842) and highest for ...

Molecular differences between early and advanced melanomas could provide new drug targets

... introduced the gene for Akt into radial growth melanoma cells, the cells expressed nearly eight times as ... tumors and lead to unregulated cell growth. When melanoma cells overexpressing Akt were introduced into ... The scientists also found that the Akt-induced melanoma cells produced more of the enzyme NOX4, one of ...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

... In working to identify a key tumor antigen in melanoma and other cancers, scientists at The Wistar ... Immunology programs at Wistar. "Most of the melanoma vaccines currently in development work to ... T cell clones and lymphocytes in four out of nine melanoma patients. The antigen created no response in ...

Reversing cancer cells to normal cells

... Hendrix and colleagues discovered that aggressive melanoma cells (but not normal skin cells nor less aggressive melanoma cells) contain specific proteins similar to those ... the first molecular classification of malignant melanoma and may help to explain how, by becoming more ...

Science researchers genetically transform immune cells into tumor fighters

... in humans. Two of the 17 people with advanced melanoma who received the experimental treatment saw their ... therapy has only been used in this small group of melanoma patients, but Rosenberg says his team has ... researchers removed tumor-fighting T cells from melanoma patients and multiplied these cells in the ...

Speeding discovery of the 'human cancer genome'

... group examined genetically engineered mice with melanoma that had developed an increased potential to ... the protein in both mouse and human metastatic melanoma cells. Cancer cells without active Nedd9 lost ... invasive, identifying Nedd9 as a "bona fide melanoma metastasis gene." Nedd9's role appears to result ...

Malignant melanoma cells secrete protein required for embryo formation

... research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical ... embryonic growth factor by injecting aggressive melanoma cells into developing zebrafish embryos, which ... in 60 percent of cutaneous (skin) metastatic melanoma tumors but is absent in normal skin. They ...

Melanoma vaccine strategy shows promise in laboratory experiments

... A novel approach to creating a vaccine to treat melanoma has demonstrated promising effectiveness in a new ... at The Wistar Institute. About a third of melanoma patients might benefit from such a vaccine. The ... immune cells called killer T cells to attack the melanoma cells. Another type of immune cell called a ...

Canine cancer vaccine program shows early promise

... its anti-cancer activity. "Not all dogs with melanoma respond to this treatment," cautions Ilene ... treatment, 75 percent of dogs with oral melanoma will die within one year. But about 40 percent of dogs with a melanoma tumor present responded to a vaccine created from ...

Model identifies genes that induce normal skin cells to become abnormal

... with the microenvironment of metastatic melanoma cells induces normal skin cells to become similar ... collagen matrix preconditioned by malignant melanoma cells. Hendrix is president and scientific ... that the microenvironment of metastatic melanoma cells could induce benign skin cells to become ...

Stem cell microenvironment reverses malignant melanoma

... lines (federally approved) induced metastatic melanoma cells to revert to a normal, skin cell-like type ... to hESCs. The researchers also showed that these melanoma cells were less invasive following culture on the ... would influence the behavior of human metastatic melanoma cells ?since hESCs have the ability to develop ...

Researchers discover why melanoma is so malignant

... About 60,000 Americans will be diagnosed with melanoma this year, says the American Cancer Society, and ... will be fatal. If not caught in the early stages, melanoma can be a particularly virulent form of cancer, ... skin tumor is so ruthless. Unlike other cancers, melanoma is born with its metastatic engines fully revved. ...
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