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Mammary in Biological News

The way you eat may affect your risk for breast cancer

... provides protection against the development of mammary tumors should help us identify pathways that ... restriction provided greater protection from mammary tumor development than did the same overall ... in 10-week old female mice at risk to develop mammary tumors. Their hope was to explain why ...

Dioxins in food chain linked to breastfeeding ills

... pollutant has an adverse effect on the way mammary glands develop during pregnancy." Dioxins are ... that dioxin impairs the normal development of mammary glands during pregnancy. However, the underlying ... has a profound effect on breast tissue by causing mammary cells to stop their natural cycle of ...

Eating eggs when pregnant affects breast cancer in offspring

... with a chemical that causes cancer of the mammary gland (breast cancer). Although animals in all groups developed mammary cancer, the daughters of mothers that had ... affects modifications of the DNA within the mammary gland of fetuses as they develop in the womb. ...

Study links nicotine with breast cancer growth and spread

... the first to explore the effects of nicotine on mammary cells. "Although numerous studies indicate ... non-neuronal cells and tissues, in particular in mammary cells." "We were able to determine that mammary cells express different subunits of nAChR and ...

Stem cells may solve mystery of early pregnancy breast cancer protection

... Li and his colleagues compared the numbers of mammary or breast stem cells (early cells that can ... had had early pregnancies had half the numbers of mammary cells found in the mice that had never had ... They found that 1 in approximately 2,500 mammary cells were stem cells in the "virgin" mice while ...

Evidence now suggests eating soy foods in puberty protects against breast cancer

... are very consistent in showing a reduction in mammary cancer risk, she says. Exposure to soy in fetal ... are the structures that lead to growth of the mammary epithelium, which are the cells lining milk ... that genistein appears to activate in developing mammary glands are well known --- BRCA1, p53, and PTEN ...

Purdue research finds similarities in dog, human breast cancer pre-malignant lesions

... WEST LAFAYETTE, Ind. - Pre-malignant mammary lesions in dogs and humans display many of the ... said, they wanted to examine each type of mammary intraepithelial lesion for estrogen receptors ... of lesions, their association with spontaneous mammary cancer and the resemblance to human lesions, dogs ...

Protein linked to change in tissue that surround and support breast tumors

... can exist in a form that seems to change the structural composition of mammary tissue, potentially making it more conducive to tumor progression, say ... the AIB1delta3 slice variant gene were over-expressed. Upon examination of mammary tissue, they found that the tissue in mice with the splice variant of AIB1 ...

Statin therapy ineffective in breast cancer prevention

... of rats, and it did not alter the incidence of estrogen receptor-positive mammary cancers or its multiplicity. Similarly, no effect of atorvastatin was ... mg of bexarotene there was a significant reduction in the multiplicity of mammary tumors. Combining these regimens with atorvastatin did not augment the ...

T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role

... tumor angiogenesis by creating a strain of mice that develops spontaneous mammary gland tumors in the absence of T-cadherin. Their results appeared March 1 ... tumors were transplanted into normal and T-cadherin-deficient mammary glands the knockouts were deficient in growing new blood vessels to the ...

Key to evolutionary fitness: Cut the calories

... maximum capacity and shows that this is not due to any kind of physiological constraint, such as length of digestive tract or maximum capacity of mammary glands. Also, as the hares were provided with plentiful food, there could be no limitation of energy turnover due to food availability. The way ...

Dual role in breast tissue for a protein involved in leukemia

... in breast tissue. While it can contribute to the growth of one type of precancerous lesion in the breast, this protein also appears to protects mammary cells from carcinogenic exposure," says Miermont. These findings need to be validated and expanded, Furth says, but she adds that "while Stat5a is ...

Wildlife Conservation Society supports world's first study of egg-laying mammal

... which the female holds in a sticky pouch. The hatchling (known as a "puggle") resides in the pouch for between 40-50 days and receives milk from two mammary patches (echidnas have no teats). Once the puggle develops spines, the mother digs a nursery den that becomes the puggle's new home; the mother ...

Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair

... characteristics. For example, they are lean, resistant to diet-induced obesity, are more sensitive to insulin and leptin, and have abnormalities in mammary gland development and skin. When Gladstone researchers in the laboratory of Robert V. Farese, Jr. used genetic engineering to delete the enzyme in ...

Texas Medical Center researchers win collaborative grants

... Their project received $191,657 from the foundation. Separase is an enzyme that initiates the process of cell division. When over-expressed in mouse mammary cells, it has been found to cause the formation of tumors. Having discovered in a previous study that separase is significantly over-expressed in ...

UCSB scientists show how certain vegetables combat cancer

... of these compounds, called sulforaphane, or SFN," Azarenko added. "It has already been shown to reduce the incidence and rate of chemically induced mammary tumors in animals. It inhibits the growth of cultured human breast cancer cells, leading to cell death." Azarenko made the surprising discovery ...

Egg whites solve the 3-D problem

... to three," she said. "Understanding how the cell communicates, how protein work requires three dimensions." For example, breast cells in the mammary gland form ducts through which milk flows when a woman breastfeeds. "These are the same cells that cause cancer," said Oesterreich. "When you put ...

NTP finalizes report on Bisphenol A

... to those experienced by humans," Bucher said. The report also expresses "minimal concern" that BPA exposure will affect development of the mammary gland or accelerate puberty in females. The NTP expressed "negligible concern" that exposure of pregnant woman to BPA will result in fetal or ...

Breast cancer cells have to learn to walk before they can run

... influence a patients outcome, cautions Pearson. In their study, the Salk researchers used a tissue culture model that recreates the duct of the mammary gland. They embedded human cells, isolated from breast tissue, in a three-dimensional matrix that mimics their natural surroundings. These cells ...

Selective marker found to indicate aggressive form of breast cancer

... a highly aggressive cancer with similarities to mammary stem cells, the regenerative cells believed to be ... diagnostic tool for a cancer of regenerative mammary cells." According to the DiRenzo, another ... a non-invasive test that collects samples from mammary ducts may enable the development of a screening ...

How mammals fuel milk production may have implications for cancer

... offers insight into the manner in which the mammary glands of mammals meet the incredible metabolic ... “The developmental program that prepares the mammary gland for lactation is among the most critical ... changes in metabolism that occur in the mammary gland at the transition from pregnancy to ...

Pheromone from mother's milk may rapidly promote learning in newborn mammals

... of new odors, researchers have found that a mammary pheromone secreted in mother's milk may act as a ... in response to olfactory signals that include the mammary pheromone secreted in mother's milk. The ability ... work, the researchers investigated whether the mammary pheromone plays a role in the ability of newborns ...

Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

... development. "We've elicited a new pathway for mammary tumorigenesis," he says. "Before, we could say ... turned on cyclin D1, which was enough to cause mammary tumorigenesis. Now we've added another link: ... showed in laboratory studies that in mouse mammary cells lacking caveolin and certain ...

Compounds in plastic packaging act as environmental estrogens altering breast genes

... capable of affecting gene expression in the mammary glands of young female laboratory rats exposed to ... could alter the genomic signatures of the mammary gland during critical stages of development." BPA ... what effects, if any, each compound had on mammary gene expression during at different ages," said ...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

... ester, and the rexinoid, LG100268, synergize in the prevention of mammary tumors in a mouse model of estrogen receptor-negative breast cancer ... estrogen receptor, synergize in the prevention and treatment of certain mammary tumors in mice," said Liby. "This study takes our work further, ...

Mutant mouse provides insights into breast cancer

... By discovering a mutant mouse that is highly susceptible to mammary tumors, Cornell researchers have found a novel potential link between ... mice appear normal in every way, the females are highly predisposed to mammary tumors. "It's known that most cancers, by the time you look at them, ...

Temperament linked to onset of cancer and early death in female rats

... new experiences as infants maintain that temperament and die earlier from mammary and pituitary tumors than do their more adventuresome sisters, according ... by age 390 days, middle age for rats, 80 percent of the fearful rats had mammary cancer while only 38 percent of the adventuresome rats had the illness. ...

Study identifies new role for breast cancer susceptibility gene

... identify genes repressed by BRCA1 or a related tumor suppressor, CtIP, in mammary epithelial cells (MECs). Among the 12 genes inhibited by BRCA1 or CtIP was ... of capillary-like structures. Further studies demonstrated that mouse mammary tumors deficient in BRCA1 display high levels of ANG1 expression, ...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

... VRP-neu vaccine. Researchers then implanted a HER2/neu-positive tumor into mammary tissue in the mice. All of the control mice developed breast cancer but ... HER2/neu. These mice normally develop breast cancer in all ten of their mammary glands by the time there are 120 days old. In this experiment, they ...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

... VRP-neu vaccine. Researchers then implanted a HER2/neu-positive tumor into mammary tissue in the mice. All of the control mice developed breast cancer but ... HER2/neu. These mice normally develop breast cancer in all ten of their mammary glands by the time there are 120 days old. In this experiment, they ...

A genetic 'gang of 4' drives spread of breast cancer

... "We found that depriving aggressive metastatic tumor cells of these genes decreased both their ability to grow large aggressive tumors in the mouse mammary gland and also the ability to release cells from these tumors into the circulation," said Massagué. "The remarkable thing was that while silencing ...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

... formerly of the Department of Genetics at Harvard Medical School, and colleagues examined whether blocking the conversion of glucose to lactate in mammary tumor cells might help shed light on the association between tumor survival and the interplay between glycolytic phenotype and mitochondrial ...

Nanotechnology may find disease before it starts

... so it's not surprising that that's where we saw the particles," Rosol said. "But we ultimately want to be able to make these particles to go to the mammary glands or other tissues we're interested in." The ultrasound images grew brighter over the 90-minute period. The researchers compared these images ...

Chemotherapy gel may fight breast cancer and reduce breast deformity

... mixed them with a gelatin made of a polymer substance. Mice with breast cancer tumors were treated by inserting the gel under the skin next to the mammary gland. The researchers found that they could successfully control the delivery of chemotherapy over a period of 30 days and that the tumors were ...

Suppressing growth hormone in early adulthood may prevent cancer

... In a previous study, rats with high levels of growth hormone (a circulating factor that increases IGF-1 levels) exhibit an increase in spontaneous mammary tumors. Dwarf animals with 50 percent lower IGF-1 levels do not develop tumors in response to a chemical carcinogen. But Sonntag said that if these ...

Tamoxifen-like drug suggests new ways to selectively block estrogen

... which leads to its degradation. GW5638 fits somewhere in the middle, acting like a SERM in some tissues and more like a SERD in others, including mammary tissue, where it is a powerful estrogen antagonist. As a consequence, GW 5638 can inhibit the growth of breast cancers that have become resistant to ...

Venom doc tracks down snake bioweapons

... were shown to have been originally derived from proteins normally expressed in other body tissues, including brain, eye, lung, heart, liver, muscle, mammary gland, ovary, and testis. Only two of the toxins were derived from proteins presumably expressed in ancient reptile saliva. Both of these toxin ...

Hirsute Or Hairless? Two Proteins May Spell The Difference

... how hair develops sheds light on the fundamental processes that generate a wide range of tissues and organs, including the lungs, cornea, and mammary glands. How complex, three-dimensional structures emerge from single sheets of cells is a fundamental question in developmental biology. The ...
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