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Malignant in Biological News

TGen researchers discover possible way to block the spread of deadly brain tumors

... be a serious target for drugs that could prevent malignant tumors from rapidly multiplying and invading ... and rapid division are key characteristics of malignant brain tumors known as glioblastoma multiforme, or ... as having a verified role in contributing to the malignant behavior of the disease," Dr. Berens said. ...

Twin nanoparticle shown effective at targeting, killing breast cancer cells

... targets the Her-2-positive tumor cell, a type of malignant cell that affects up to 30 percent of breast ... antigen, a protein located on the surface on the malignant cell. Put another way, the nanoparticle vehicle ... unloads its "passenger," the cisplatin, into the malignant cell. "It's like a magic bullet," said ...

As rates rise, researchers find better way to identify melanoma

... found a new protein produced excessively in malignant melanoma, a discovery that is particularly ... that IMP-3 is an important progression marker in malignant melanoma," said first author Jennifer G. Pryor, ... mistaken for melanoma but is not cancerous; and malignant melanoma, which has several phases of growth. ...

FSU researcher using computers to hone cancer-fighting strategies

... can best be modified in order to attack and kill malignant tumors while doing minimal harm to a patient's ... *The rate at which immunotoxins bind with malignant cells and the relative amount of antigens ... is possible: If not enough immunotoxins bind with malignant cells, too few cells will be killed with each ...

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

... disease, epilepsy, stroke/ischemia, dementia and malignant gliomas RICHMOND, Va. (May 9, 2008) Virginia ... disease, epilepsy, stroke, dementia and malignant gliomas. Neurodegenerative diseases are ... more clearly understand brain cancer, including malignant glioma, an invariably fatal tumor, and how it ...

PET/CT imaging proves golden for detecting cancer in children

... conventional imaging when it comes to detecting malignant tumors in children, according to research ... in children with a wide range of malignant cancers, explained the Hopkins professor of ... for patients with Ewing tumor. Ewings tumor is a malignant bone tumor occurring in children and young ....

GenWay Biotech obtains exclusive rights to AMDL's DR-70 cancer test in US and Canada

... Products (FDP) in the blood, which are elevated in the presence of a malignant tumor and increase as the malignancy grows. International studies have ... colon, rectal, ovarian, esophageal, cervical, trophoblastic, thyroid, malignant lymphoma, brain and pancreatic cancer making it one of the most versatile ...

Fluorescent cancer cells to guide brain surgeons

... Gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. ... The scientists tested the albumin method in thirteen patients with malignant gliomas. In nine cases it was possible to remove the fluorescent tumor ...

New tumor markers determine therapy intensity

... Characteristic changes in the DNA of medulloblastoma, the most frequent malignant brain tumor in childhood, indicate precisely how aggressively the tumor ... is the most frequent childhood brain tumor The most common malignant brain tumor in childhood is the medulloblastoma every year, more than 100 ...

Nearly a century later, new findings support Warburg theory of cancer

... as researchers instead found that genetic mutations within cells caused malignant transformation and uncontrolled cell growth. Many researchers argued ... defects could be found that were consistently associated with malignant transformation in cancers. Boston College biologists and colleagues at ...

Team finds breast cancer gene linked to disease spread

... scientists as a major signal that controls the biology of both normal and malignant cells. Breast cancer is caused by a malignant tumor that develops from cells in the breast. The most common sign of ...

Common food additive found to increase risk and speed spread of lung cancer

... of signaling pathways in those tissues can confer a normal cell with malignant properties," Dr. Cho explained. "Deregulation of only a small set of pathways can confer a normal cell with malignant properties, and these pathways are regulated in response to nutrient ...

New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume

... blend extracted from canola, Dermytol, produces a pronounced reduction of malignant melanoma cell growth. Dermytol, a proprietary compound developed by KGK ... of mice. After seven days of treatment, all of the mice were injected with malignant melanoma tumor cells. Dermytol or placebo treatments continued for 25 ....

The top 5 ways medical physics has changed health care

... machines that can now deliver beams of energetic electrons or X rays to malignant tumors -- at doses capable of killing cancerous cells and stopping the ... treating prostate cancer, cancers of the brain, head and neck and other malignant diseases, in children and in adults. 2) BETTER DETECTION OF BREAST ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... to study results published in the February 15 Cancer Research. malignant solid tumors are still very difficult to treat effectively, especially ... to help improve outcomes for patients with high-risk neuroblastoma. malignant peripheral nerve sheath tumors are cancers affecting the connective tissue ...

Contrast agent trials in swine

... a contrast agent that makes visible the microcalcifications related to malignant breast tumors. The researchers report in the journal Angewandte Chemie ... selectivity and sensitivity. This could allow it to selectively reveal malignant abnormal tissue. The swine trials demonstrated that the use of real-time ...

Interleukin-8, key marker for colorectal cancer treatment

... significant IL-8 up-regulation in all inflammatory, non-malignant and malignant colorectal entities compared to their corresponding normal tissues. ... specimens correlates with increasing tumor stages and, thus, also with the malignant status of colorectal cancer cells. Moreover, the investigators show for ...

'Normal' cells far from cancer give nanosignals of trouble

... that can detect features as small as 20 nanometers, validate the "field effect," a biological phenomenon in which cells located some distance from a malignant or premalignant tumor undergo molecular and other kinds of abnormal changes. The most striking findings were that these nanoscale alterations ...

New MRI technique could mean fewer breast biopsies in high-risk women

... a biopsy of a questionable lump or lesion. The universal technology will give radiologists greater confidence in visually classifying a lesion as malignant or benign. The American Cancer Society recommends that women with certain breast cancer risk factors including inherited genetic mutations, ...

UCLA cancer researchers develop model that may help identify cancer stem cells

... then validate these cells functionally. In an effort to find lung cancer stem cells, Batra and his team collected specimens from patients with malignant pleural effusions, a condition in which an abnormal amount of fluid collects between the thin layers of tissue lining the outside of the lung and the ...

University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease

... chemical biomarkers inside specific cells," says Dr. Quaroni, who conducted the synchrotron analysis. "Often the differences between healthy and malignant tissue can be quite small, but the differences seen here were quite striking. This is a good proof of concept for developing a traceable technique ...

Faculty of Translational Medicine boosts support for biomedical researchers

... 'The new Faculty will add support to an already flourishing research environment. My research involves investigating new potential treatments for malignant melanoma, a condition for which there are currently very few effective treatments once it has spread from the skin. The assistance provided by the ...

Tumor growth and chemo response may be predicted by mathematical model

... gleaned from cancer cells grown in the laboratory to determine whether a prescribed drug will reach the tumor in sufficient quantities to kill the malignant cells. "We seek to improve the precision of prescribing chemotherapeutic drugs, since it is sometimes hard to tell which will work and which will ...

Computer model predicts brain tumor growth and evolution

... quickly, often within 15 months of diagnosis. Massachusetts Sen. Ted Kennedy announced a year ago that he was suffering from this type of tumor, a malignant glioma of the brain. Details of the research were highlighted at an April meeting of the American Association for Cancer Research. The full ...

Lithium may help radiation target cancer, spare healthy tissue

... DSBs were repaired with greater efficiency in lithium-treated cells via the NHEJ pathway. However, none of these effects were observed in malignant glioma (brain tumor) cells, presumably because cancer cells generally utilize a different DNA repair mechanism, Xia said. The researchers ...

Publication sets guidelines across cancer therapies: Ensuring the best in patient management

... treatment and prognosis. "The literature in this publication suggests that FDG PET could play a significant role in personalizing the treatment of malignant tumors," said Wolfgang Weber, M.D., editor of the supplement and medical director with the division of nuclear medicine at the Albert-Ludwigs ...

A longer lasting tumor blocker

... they need to grow. Meanwhile, the scaffold of mice treated with anti-VEGF remained intact. M-CSF levels soar in patients with osteosarcoma (a malignant bone cancer), breast cancer and prostate cancer, making these cancers potentially the most responsive to M-CSF-blocking drugs Whether or not other ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

... as Toll-like receptor agonists or interferon alpha, each of which have a limited spectrum of activity and lack the ability to treat a broad range of malignant diseases, MIS416 acts on multiple pathways simultaneously to activate a broad range of innate immune cell types that are central to the development ...

UNC study: Scientists identify chemical compound that may stop deadly brain tumors

... treatment apply to a type of brain tumor called secondary glioblastoma multiforme (GBM). GBMs are part of a larger group of brain tumors called malignant gliomas, which is the type of cancer Senator Edward Kennedy suffers from. A report of the research will appear in the April 10, 2009 issue of the ...

Team identifies a molecular switch linking infectious disease and depression

... than others to become depressed. Some pro-inflammatory drugs, such as interferon-alpha, which is used to treat Hepatitis C and a cancer known as malignant melanoma, also induce symptoms of depression in a significant number of patients. In the new study, mice were exposed to Bacille CalmetteGurin ...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

... related receptors to shut down pro-growth signals, Weiner says. "For years it has been presumed that the ability of antibodies to interfere with malignant cell-related signaling is the dominant mechanism of anticancer activity, but we have also known that the normal job of an antibody is to deliver an ...

Tiny samples could yield big predictive markers for pancreatic cancer

... cysts are completely benign and have little or no risk of becoming cancerous. However, a subset of pancreatic cysts carry a real risk of becoming malignant over time," says co-author Jeffrey Tokar, M.D., Fox Chase gastroenterologist. "Many patients with pancreatic cysts are referred to us for endoscopic ...

Small molecules block cancer gene

... words, Tweardy and his colleagues identified an area on the Stat3 molecule that was important to its activity. Stat3 actually is critical in keeping malignant cells alive in the majority of cancers. Once Tweardy and his colleagues had identified a critical "pocket" on Stat3, they used the computer to ...

Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test

... more lethal castration-resistant prostate cancer in this trial suggest a fundamental difference in a patient's immune system's ability to deal with malignant tumors when confronted with more aggressive forms of prostate cancer," stated Karl Wassmann, Chief Executive Officer of Source MDx. "The Source MDx ...

Engineers create intelligent molecules that seek-and-destroy diseased cells

... Current treatments for diseases like cancer typically destroy nasty malignant cells, while also hammering the healthy ones. Using new advances in synthetic biology, researchers are designing molecules intelligent enough to ...

Beach vacations may increase future skin cancer risk in children

... Epidemiology, Biomarkers and Prevention , a journal of the American Association for Cancer Research. Number of nevi is the major risk factor for malignant melanoma, the most dangerous form of skin cancer. Melanoma rates have been rising dramatically over recent decades. More than 62,000 Americans are ...

Stress may hasten the growth of melanoma tumors

... COLUMBUS, Ohio For patients with a particularly aggressive form of skin cancer malignant melanoma stress, including that which comes from simply hearing that diagnosis, might amplify the progression of their disease. But the same new ...

New research findings may enable earlier diagnosis of uterine cancer

... 200 diseases, from arteriosclerosis and dementia to rheumatism, cerebral haemorrhage and cancer. The studies carried out by Sandra Karlsson on human malignant tumours have confirmed that changes in this gene are present in early as well as late stage cancer. "This shows that the identified gene has an ...

Implants mimic infection to rally immune system against tumors

... to cancer vaccination." Most previous work on cancer vaccines has focused on removing immune cells from the body and reprogramming them to attack malignant tissues. The altered cells are then reinjected back into the body. While Mooney says ample theoretical work suggests this approach should work, in ...

Phoenix conference highlights TGen's and Scottsdale Healthcare's contributions to molecular oncology

... and identifying new diagnostic tools. Assessing the effects and early clinical results of new, targeted drug therapies on solid tumors and malignant blood cancers. Identifying new drug therapies that optimize treatment results and minimize side effects in specific biologic and clinical ...
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