First genetically-engineered malaria vaccine to enter human trials
... scientists have created a weakened strain of the malaria
parasite that will be used as a live vaccine ... be trialled in humans from early next year.
kills more than one million people each year and ... falciparum parasite which causes the form of malaria
most deadly to humans. By removing the genes ...
Vaccine blocks malaria transmission in lab experiments
... Researchers at the Johns Hopkins malaria
Research Institute have for the first time ... cycle and necessary for continued transmission of malaria
from mosquitoes to humans. The study is published ... might become an important tool in the arsenal for malaria
control and progressive elimination ...
Tryptophan deficiency may underlie quinine side effects
... the principal mode of quinine action against the malaria
parasite is still largely unclear, as is the ... in yams, a staple food crop in the tropics where malaria
is prevalent. If quinine severely reduces ... tryptophan may affect quinine action against the malaria
Jeepers creepers: Climate change threatens endangered honeycreepers
... examining the present altitudinal range of avian malaria
and pox, honeycreeper distribution, and the ... the stage for epidemic transmission of avian malaria
and pox. Honeycreepers just like people faced ... numbers and geographic range. It was likely that malaria
swept rapidly across all of the lower Hawaiian ...
Old stain in a new combination
... of agents based on the oldest synthetic malaria
drug, the methylene blue stain, can curb the spread of malaria
parasites and make a significant contribution to ... called for by the international "Roll Back malaria
Initiative." In a study on 160 children ...
New lead on malaria treatment
... Approximately 350 million to 500 million cases of malaria
are diagnosed each year mostly in sub-Saharan Africa. While medications to prevent and treat malaria
do exist, the demand for new treatments is on the rise, in part, because malaria
parasites have developed a resistance to existing ...
$1.6 million grant to lead development of resistance-detecting field kit
The two principal methods for control of malaria
in sub-Saharan Africa are the use of ... staff in the regions of sub-Saharan Africa where malaria
and filariasis, a disabling and disfiguring ... in tropical diseases) and PMI (US President's malaria
Bacteria play role in preventing spread of malaria
... Plasmodium falciparum , the parasite that causes malaria
in humans, according to researchers at the Johns ... Health. Scientists with the Bloomberg School's malaria
Research Institute found that removing these ... the journal PLoS Pathogens .
As part of the malaria
transmission cycle, a mosquito acquires the ...
Penn State entomologists seek fungus to blunt mosquitoes' sense of smell
... insect pathogenic fungi.
"We will infect malaria
mosquitoes with an insect-specific fungus to ... malaria," said Thomas.
Mosquitoes transfer malaria
parasites to humans when the female mosquitoes ... to control locusts and grasshoppers and infect malaria
mosquitoes so that they no longer can smell and ...
New hope for advances in treating malaria
... According to the World Health Organisation (WHO), malaria
kills a million people across the globe each ... WHO also estimates that a child dies from malaria
every 30 seconds.
Dr McConkey says: "Our chemicals are particularly exciting as they kill malaria
parasites at low concentrations, something that ...
NIH funds development of resistance-breaking insecticides to reduce malaria transmission
... of resistance-breaking insecticides to reduce malaria
At present, the first line of defense against the malaria
mosquito in sub-Saharan African is insecticide ... and biologists in the United States with malaria
mosquito control experts in Kenya. The focus was ...
Locking parasites in host cell could be new way to fight malaria
... says Greenbaum. The team discovered that malaria
parasites depend upon an enzyme stolen from the ... report 350 million cases of malaria
occur worldwide, killing more than a million ... the infected cell, just as they had observed for malaria
Over the past 40 ...
Ecologists question effects of climate change on infectious diseases
... model estimations that the most dangerous kind of malaria
will gain 23 million human hosts outside of its ... current range.
"The dramatic contraction of malaria
during a century of warming suggests that ... could provide havens for mosquitoes, and thus malaria
parasites, to remain in areas that would ...
Malaria immunity trigger found for multiple mosquito species
... Plasmodium falciparum -the parasite that causes malaria
By silencing the gene, caspar, the ... mosquitoes-three mosquito species that spread malaria
in Africa, Asia and the Americas. Their findings ... development of Plasmodium berghei, which causes malaria
"When a mosquito is feeding on ...
Researchers identify new way the malaria parasite and red blood cells interact
... researchers have discovered a new mechanism the malaria
parasite uses to enter human red blood cells, ... cocktail to fight the mosquito-borne disease.
is transmitted to humans through bites from ... between 350 million and 500 million cases of malaria
occur world-wide annually, and more than 1 ...
LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug
... Steve Ward explained: "New drugs to treat malaria
are urgently required because the parasite has ... drugs and consequently more people die from malaria
now than they did twenty years ago. This project ... body thereby eliminating the clinical symptoms of malaria
and reducing the possibility of transmission to ...
Malaria parasite zeroes in on molecule to enhance its survival, team finds
... Medicine has found that the parasite that causes malaria
breaks down an important amino acid in its quest ... light on this poorly understood aspect of malaria
metabolism has given them new insights on the ... important because many of the drugs used to treat malaria
successfully in the past have targeted some ...
IRB Barcelona to coordinate two European projects on biomedicine
... of more than 5 million euros from 2009 to 2011. malaria
and diabetes will be the topics addressed by the ... Zorzano.
DISARMING THE PARASITE THAT CAUSES malaria
The consortium coordinated by Llus Ribas de ... in collaboration with laboratories in India". malaria
is caused by the parasite Plasmodium falciparum, ...
African thicket rat malaria linked to virulent human form
... Even though the most deadly form of malaria
for humans, Plasmodium falciparum , has been linked to malaria
found in chimpanzees, this group has been fairly ... and nuclear DNA.
"The link between human malaria
New papers offer insights into process of malarial drug resistance
... as it ages. More than 1 million children die from malaria
in sub-Saharan Africa each year, and in areas ... papers, Ferdig points out that development of the malaria
parasite Plasmodium falciparum in the blood is ... contribute to the drug-resistant phenomena in malaria
By uncovering the genetic ...
ASU researchers receive NIH awards for studies of malaria and emergent disease
... studies will examine the ecology and evolution of malaria
and a third will delve into the genetic mysteries ... parasite Plasmodium falciparum .
ranks with tuberculosis and HIV-AIDS among the most important causes of disease and death. malaria
kills a child from somewhere in the world every ...
New way to make malaria medicine also first step in finding new antibiotics
... compound, potentially making the treatment of malaria
Metcalf set out to ... make the compound even more effective against the malaria
parasite while remaining harmless to people.
This effort to help treat malaria
is just one facet of a major undertaking to find ...
Best way to treat malaria: Avoid using same drug for everyone, scientists say
... worldwide are recommending the wrong kind of malaria
Despite the availability of many ... Some 350 to 500 million people are infected with malaria
every year by being bitten by a mosquito carrying one of the four human malaria
parasites, P. falciparum, P. vivax, ....
Johns Hopkins scientists discover what drives the development of a fatal form of malaria
... people in tropical and subtropical regions, malaria
is one of the oldest recorded diseases and the ... that when red blood cells are infected with the malaria
parasite, they activate platelets to secrete the ... human red blood cells in culture with the malaria
parasite and found that this did, indeed, induce ...
Research exposes new target for malaria drugs
... The malaria
parasite has waged a successful guerrilla war ... Chemistry has exposed one of the tricks malaria
uses to hide from the immune proteins, which may aid in future drug development.
parasites (plasmodia) are transmitted to people ...
Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
... the possibility of preventing the human malaria
parasite, Plasmodium falciparum, which is responsible for more than a million malaria
deaths a year, from becoming sexually mature. ... sexual forms of the parasite do not contribute to malaria
symptoms, but are essential for transmission ...
American Chemical Society's Weekly PressPac -- March 19, 2008
Toward a new generation of vaccines for malaria
and other diseases
Accounts of Chemical ... involved in the complex infection process of the malaria
parasite, from which they designed, specifically ... synthesized chemically some of the most promising malaria
vaccine candidates that have been tested to date. ...
Netting mosquitoes to prevent malaria
... to statistics from the World Health Organization, malaria
kills about 3,000 children each day in Africa. ... species that is responsible for transmitting malaria
to humans in Africa, hasn't demonstrated any ... Walker said. "So the parasites that cause malaria
shift into a different mosquito that feeds mainly ...
ETH Zurich researchers develop antibody test
... Peter Seeberger has been working on a sugar-based malaria
vaccine for years. The new test takes him one important step closer to his goal. The malaria
pathogen plasmodium falciparum carries poisonous ... a new method that demonstrates that the malaria
pathogens toxic sugar molecules trigger a ...
Monkey malaria widespread in humans and potentially fatal
... A potentially fatal species of malaria
is being commonly misdiagnosed as a more benign ... in Malaysia studied more than 1,000 samples from malaria
patients across the country. Using DNA-based ... Borneo, were infected with Plasmodium knowlesi, a malaria
parasite of macaque monkeys, and that the disease ...
CWRU School of Medicine has evidence vaccine against malaria will reduce disease
... impacting the three billion people exposed to malaria
every year. Brian T. Grimberg, Ph.D., Peter A. ... infection by the Plasmodium vivax (P. vivax) malaria
parasite. The research suggests a Duffy binding ... vaccine could provide protection against malaria
blood-stage infection. This specific protein is ...
Study of malaria parasite in patient blood finds distinct physiological states
... The malaria
parasite has been studied for decades, but ... identify three distinct biological states of the malaria
parasite: an active growth-based state, a ... first time, we have glimpsed the biology of the malaria
parasite in one of its most important ...
A genetic identity card for Plasmodium populations to improve control strategies
... WHO figures show that malaria
currently affects between 300 and 600 million ... and Anopheles funestus, two of the principal malaria
vectors in Sub-Saharan Africa. The work was done ... populations.
Moreover, in the zones where malaria
is endemic, infected individuals are bitten ...
NASA technology helps predict and prevent future pandemic outbreaks
... percent of the world at risk of infection. The malaria
Modeling and Surveillance Project utilizing NASA ... monitor environmental characteristics that effect malaria
transmission in Southeast Asia and other tropical and subtropical regions. malaria
surveillance provides public health organizations ...
MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
Every 30 seconds a child in Africa dies from malaria
- around 1 million every year, he said. Cerebral malaria
is a severe form of malaria
that affects the brain and is fatal in about 15 ...
MIT Holding, Georgia Southern University, and MEVLABS successfully test the PROVECTOR
... The two current principal methods of controlling malaria
are drug treatment of patients and the ... indicated a reduction in the dengue viruses and malaria
carried by mosquitoes. The Company is continuing ... carrying infectious disease pose to humans. malaria
currently infects over one hundred million people ...
Progress Against Malaria: Developments on the Horizon
... Street, 40th Floor
New York, NY 10007
Research Institute at the Johns Hopkins Bloomberg ... will also feature work from Macha, Zambia, where malaria
research is conducted in a unique rural setting. ... 2:45 pm KEYNOTE LECTURE
Current Developments in malaria
Product Innovation and Control
Chris Hentschel, ...
American Society for Microbiology honors Thomas E. Wellems
... E. Wellems, M.D., Ph.D., Chief, Laboratory of malaria
and Vector Research, National Institute of ... most of which he has devoted to the study of malaria
and its treatment. Resistance to chloroquine, a popular malaria
vaccine that was very successful in the 1950s, ...
Advance in effort to fight malaria by tricking the mosquito's sense of smell
... By mapping a specialized sensory organ that the malaria
mosquito uses to zero in on its human prey, an ... that the maxillary palps may serve as the malaria
mosquitos long-range detection system, says Tan ... a chemical strategy to combat the spread of malaria
by the Anopheles mosquito.
This paper marks a ...
Binghamton University researchers investigate evolving malaria resistance
... of New York, hope to understand how the malaria
parasite Plasmodium falciparum evolved resistance to the once-effective medication chloroquine.
is responsible for 1-3 million deaths a year, ... chloroquines treatment failure in the Pacific.
is relatively easy to eliminate in places that ...