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Malaria in Biological News

First genetically-engineered malaria vaccine to enter human trials

... scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine ... be trialled in humans from early next year. malaria kills more than one million people each year and ... falciparum parasite which causes the form of malaria most deadly to humans. By removing the genes ...

Vaccine blocks malaria transmission in lab experiments

... Researchers at the Johns Hopkins malaria Research Institute have for the first time ... cycle and necessary for continued transmission of malaria from mosquitoes to humans. The study is published ... might become an important tool in the arsenal for malaria control and progressive elimination ...

Tryptophan deficiency may underlie quinine side effects

... the principal mode of quinine action against the malaria parasite is still largely unclear, as is the ... in yams, a staple food crop in the tropics where malaria is prevalent. If quinine severely reduces ... tryptophan may affect quinine action against the malaria parasite. ...

Jeepers creepers: Climate change threatens endangered honeycreepers

... examining the present altitudinal range of avian malaria and pox, honeycreeper distribution, and the ... the stage for epidemic transmission of avian malaria and pox. Honeycreepers just like people faced ... numbers and geographic range. It was likely that malaria swept rapidly across all of the lower Hawaiian ...

Old stain in a new combination

... of agents based on the oldest synthetic malaria drug, the methylene blue stain, can curb the spread of malaria parasites and make a significant contribution to ... called for by the international "Roll Back malaria Initiative." In a study on 160 children ...

New lead on malaria treatment

... Approximately 350 million to 500 million cases of malaria are diagnosed each year mostly in sub-Saharan Africa. While medications to prevent and treat malaria do exist, the demand for new treatments is on the rise, in part, because malaria parasites have developed a resistance to existing ...

$1.6 million grant to lead development of resistance-detecting field kit

... The two principal methods for control of malaria in sub-Saharan Africa are the use of ... staff in the regions of sub-Saharan Africa where malaria and filariasis, a disabling and disfiguring ... in tropical diseases) and PMI (US President's malaria Initiative). ...

Bacteria play role in preventing spread of malaria

... Plasmodium falciparum , the parasite that causes malaria in humans, according to researchers at the Johns ... Health. Scientists with the Bloomberg School's malaria Research Institute found that removing these ... the journal PLoS Pathogens . As part of the malaria transmission cycle, a mosquito acquires the ...

Penn State entomologists seek fungus to blunt mosquitoes' sense of smell

... insect pathogenic fungi. "We will infect malaria mosquitoes with an insect-specific fungus to ... malaria," said Thomas. Mosquitoes transfer malaria parasites to humans when the female mosquitoes ... to control locusts and grasshoppers and infect malaria mosquitoes so that they no longer can smell and ...

New hope for advances in treating malaria

... According to the World Health Organisation (WHO), malaria kills a million people across the globe each ... WHO also estimates that a child dies from malaria every 30 seconds. Dr McConkey says: "Our chemicals are particularly exciting as they kill malaria parasites at low concentrations, something that ...

NIH funds development of resistance-breaking insecticides to reduce malaria transmission

... of resistance-breaking insecticides to reduce malaria transmission. At present, the first line of defense against the malaria mosquito in sub-Saharan African is insecticide ... and biologists in the United States with malaria mosquito control experts in Kenya. The focus was ...

Locking parasites in host cell could be new way to fight malaria

... says Greenbaum. The team discovered that malaria parasites depend upon an enzyme stolen from the ... report 350� million cases of malaria occur worldwide, killing more than a million ... the infected cell, just as they had observed for malaria parasites. Over the past 40 ...

Ecologists question effects of climate change on infectious diseases

... model estimations that the most dangerous kind of malaria will gain 23 million human hosts outside of its ... current range. "The dramatic contraction of malaria during a century of warming suggests that ... could provide havens for mosquitoes, and thus malaria parasites, to remain in areas that would ...

Malaria immunity trigger found for multiple mosquito species

... Plasmodium falciparum -the parasite that causes malaria in humans. By silencing the gene, caspar, the ... mosquitoes-three mosquito species that spread malaria in Africa, Asia and the Americas. Their findings ... development of Plasmodium berghei, which causes malaria in rodents. "When a mosquito is feeding on ...

Researchers identify new way the malaria parasite and red blood cells interact

... researchers have discovered a new mechanism the malaria parasite uses to enter human red blood cells, ... cocktail to fight the mosquito-borne disease. malaria is transmitted to humans through bites from ... between 350 million and 500 million cases of malaria occur world-wide annually, and more than 1 ...

LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug

... Steve Ward explained: "New drugs to treat malaria are urgently required because the parasite has ... drugs and consequently more people die from malaria now than they did twenty years ago. This project ... body thereby eliminating the clinical symptoms of malaria and reducing the possibility of transmission to ...

Malaria parasite zeroes in on molecule to enhance its survival, team finds

... Medicine has found that the parasite that causes malaria breaks down an important amino acid in its quest ... light on this poorly understood aspect of malaria metabolism has given them new insights on the ... important because many of the drugs used to treat malaria successfully in the past have targeted some ...

IRB Barcelona to coordinate two European projects on biomedicine

... of more than 5 million euros from 2009 to 2011. malaria and diabetes will be the topics addressed by the ... Zorzano. DISARMING THE PARASITE THAT CAUSES malaria The consortium coordinated by Llus Ribas de ... in collaboration with laboratories in India". malaria is caused by the parasite Plasmodium falciparum, ...

African thicket rat malaria linked to virulent human form

... Even though the most deadly form of malaria for humans, Plasmodium falciparum , has been linked to malaria found in chimpanzees, this group has been fairly ... and nuclear DNA. "The link between human malaria and ...

New papers offer insights into process of malarial drug resistance

... as it ages. More than 1 million children die from malaria in sub-Saharan Africa each year, and in areas ... papers, Ferdig points out that development of the malaria parasite Plasmodium falciparum in the blood is ... contribute to the drug-resistant phenomena in malaria parasites. By uncovering the genetic ...

ASU researchers receive NIH awards for studies of malaria and emergent disease

... studies will examine the ecology and evolution of malaria and a third will delve into the genetic mysteries ... parasite Plasmodium falciparum . Worldwide, malaria ranks with tuberculosis and HIV-AIDS among the most important causes of disease and death. malaria kills a child from somewhere in the world every ...

New way to make malaria medicine also first step in finding new antibiotics

... compound, potentially making the treatment of malaria less expensive. Metcalf set out to ... make the compound even more effective against the malaria parasite while remaining harmless to people. This effort to help treat malaria is just one facet of a major undertaking to find ...

Best way to treat malaria: Avoid using same drug for everyone, scientists say

... worldwide are recommending the wrong kind of malaria treatment. Despite the availability of many ... Some 350 to 500 million people are infected with malaria every year by being bitten by a mosquito carrying one of the four human malaria parasites, P. falciparum, P. vivax, ....

Johns Hopkins scientists discover what drives the development of a fatal form of malaria

... people in tropical and subtropical regions, malaria is one of the oldest recorded diseases and the ... that when red blood cells are infected with the malaria parasite, they activate platelets to secrete the ... human red blood cells in culture with the malaria parasite and found that this did, indeed, induce ...

Research exposes new target for malaria drugs

... The malaria parasite has waged a successful guerrilla war ... Chemistry has exposed one of the tricks malaria uses to hide from the immune proteins, which may aid in future drug development. malaria parasites (plasmodia) are transmitted to people ...

Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature

... the possibility of preventing the human malaria parasite, Plasmodium falciparum, which is responsible for more than a million malaria deaths a year, from becoming sexually mature. ... sexual forms of the parasite do not contribute to malaria symptoms, but are essential for transmission ...

American Chemical Society's Weekly PressPac -- March 19, 2008

... Toward a new generation of vaccines for malaria and other diseases Accounts of Chemical ... involved in the complex infection process of the malaria parasite, from which they designed, specifically ... synthesized chemically some of the most promising malaria vaccine candidates that have been tested to date. ...

Netting mosquitoes to prevent malaria

... to statistics from the World Health Organization, malaria kills about 3,000 children each day in Africa. ... species that is responsible for transmitting malaria to humans in Africa, hasn't demonstrated any ... Walker said. "So the parasites that cause malaria shift into a different mosquito that feeds mainly ...

ETH Zurich researchers develop antibody test

... Peter Seeberger has been working on a sugar-based malaria vaccine for years. The new test takes him one important step closer to his goal. The malaria pathogen plasmodium falciparum carries poisonous ... a new method that demonstrates that the malaria pathogens toxic sugar molecules trigger a ...

Monkey malaria widespread in humans and potentially fatal

... A potentially fatal species of malaria is being commonly misdiagnosed as a more benign ... in Malaysia studied more than 1,000 samples from malaria patients across the country. Using DNA-based ... Borneo, were infected with Plasmodium knowlesi, a malaria parasite of macaque monkeys, and that the disease ...

CWRU School of Medicine has evidence vaccine against malaria will reduce disease

... impacting the three billion people exposed to malaria every year. Brian T. Grimberg, Ph.D., Peter A. ... infection by the Plasmodium vivax (P. vivax) malaria parasite. The research suggests a Duffy binding ... vaccine could provide protection against malaria blood-stage infection. This specific protein is ...

Study of malaria parasite in patient blood finds distinct physiological states

... The malaria parasite has been studied for decades, but ... identify three distinct biological states of the malaria parasite: an active growth-based state, a ... first time, we have glimpsed the biology of the malaria parasite in one of its most important ...

A genetic identity card for Plasmodium populations to improve control strategies

... WHO figures show that malaria currently affects between 300 and 600 million ... and Anopheles funestus, two of the principal malaria vectors in Sub-Saharan Africa. The work was done ... populations. Moreover, in the zones where malaria is endemic, infected individuals are bitten ...

NASA technology helps predict and prevent future pandemic outbreaks

... percent of the world at risk of infection. The malaria Modeling and Surveillance Project utilizing NASA ... monitor environmental characteristics that effect malaria transmission in Southeast Asia and other tropical and subtropical regions. malaria surveillance provides public health organizations ...

MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria

... Every 30 seconds a child in Africa dies from malaria - around 1 million every year, he said. Cerebral malaria is a severe form of malaria that affects the brain and is fatal in about 15 ...

MIT Holding, Georgia Southern University, and MEVLABS successfully test the PROVECTOR

... The two current principal methods of controlling malaria are drug treatment of patients and the ... indicated a reduction in the dengue viruses and malaria carried by mosquitoes. The Company is continuing ... carrying infectious disease pose to humans. malaria currently infects over one hundred million people ...

Progress Against Malaria: Developments on the Horizon

... Street, 40th Floor New York, NY 10007 The malaria Research Institute at the Johns Hopkins Bloomberg ... will also feature work from Macha, Zambia, where malaria research is conducted in a unique rural setting. ... 2:45 pm KEYNOTE LECTURE Current Developments in malaria Product Innovation and Control Chris Hentschel, ...

American Society for Microbiology honors Thomas E. Wellems

... E. Wellems, M.D., Ph.D., Chief, Laboratory of malaria and Vector Research, National Institute of ... most of which he has devoted to the study of malaria and its treatment. Resistance to chloroquine, a popular malaria vaccine that was very successful in the 1950s, ...

Advance in effort to fight malaria by tricking the mosquito's sense of smell

... By mapping a specialized sensory organ that the malaria mosquito uses to zero in on its human prey, an ... that the maxillary palps may serve as the malaria mosquitos long-range detection system, says Tan ... a chemical strategy to combat the spread of malaria by the Anopheles mosquito. This paper marks a ...

Binghamton University researchers investigate evolving malaria resistance

... of New York, hope to understand how the malaria parasite Plasmodium falciparum evolved resistance to the once-effective medication chloroquine. malaria is responsible for 1-3 million deaths a year, ... chloroquines treatment failure in the Pacific. malaria is relatively easy to eliminate in places that ...
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