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Mad in Biological News

K-State professor's USDA research shows mad cow disease also caused by genetic mutation

... KAN. -- New findings about the causes of mad cow disease show that sometimes it may be ... spongiform encephalopathy -- also called BSE or mad cow disease -- was a foodborne disease. But his team's new findings suggest that mad cow disease also is caused by a genetic mutation ...

American Chemical Society's Weekly PressPac -- Aug. 6, 2008

... Test to protect food chain from human form of mad Cow Disease Journal of Agricultural and Food ... against possible spread of the human form of mad Cow Disease. The study is scheduled for the ... spongiform encephalopathy," better known as mad Cow Disease. "No currently available method ...

Prions show their good side

... Prions, the infamous agents behind mad cow disease and its human variation, Creutzfeldt-Jakob Disease, also have ... in the May 5th issue of the Journal of Cell Biology. Diseases such as mad cow result when the prion protein adopts an abnormal conformation. This ...

Iron is involved in prion disease-associated neuronal demise

... other neurodegenerative conditions, prion disorders are sporadic, inherited, and infectious, and affect both humans and animals; common examples are mad cow disease in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease in humans. The causative agent is a misfolded protein referred to as ...

Antibody key to treating variant CJD, scientists find

... through the consumption of cattle products contaminated with Bovine Spongiform Encephalopathy (BSE) a brain disorder in cows, commonly known as mad Cow Disease. Prion diseases can develop when a naturally occurring brain prion protein called, PrP, comes into contact with infectious prions. ...

Common soil mineral degrades the nearly indestructible prion

... pathogens that lack both DNA and RNA, prions are believed to cause such fatal brain ailments as chronic wasting disease (CWD) in deer and moose, mad cow disease in cattle, scrapie in sheep and Creutzfeldt-Jakob disease in humans. In addition to being perhaps the weirdest infectious agent know to ...

Girls have superior sense of taste to boys

... declare they are not fussy eaters. Past studies have shown that children who like sour things tend not to be nearly as fussy as children who are not mad about sour foods. Those who prefer sour flavours are also more open to tasting new foods. ...

'Fly guy' makes memory breakthrough

... their genes and then tests their mental abilities. He's called the "fly guy," and he may sound like a comic book villain, but Bolduc is no mad scientist. A new recruit to the University of Alberta's Faculty of Medicine & Dentistry, Bolduc has shown that genetically disrupting a specific ...

Tracking down the cause of mad cow disease

... prions seems to have a strong influence on the transformation of the normal form of the protein into its pathogenic form, which causes scrapie and mad cow disease. A team headed by Christian F. W. Becker at the TU Munich and Peter H. Seeberger at the ETH Zurich has now "recreated" the first ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... NYU researchers bolstered immunity against a toxic and infectious version of the prion protein, which causes a group of brain diseases, including mad cow's disease. By injecting a safe, reconfigured form of the protein into the body cavity of mice, in addition to orally delivering a neutral ...

Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination

... we currently manufacture heparin is simply unsafe," he said. "Because we rely on animals, we open ourselves up for spreading prions and diseases like mad cow disease through these animals. And because most of the raw material is imported, we often can't be sure of exactly what we are getting." ...

NIH recognizes Clemson nanotechnology for molecule tracking

... damage to healthy tissue. Other possible targets of investigation include plaques and fibrils in the brain associated with Alzheimer's disease and mad cow disease. For the last decade, scientists around the globe have worked to develop and refine highly fluorescent nanoparticles that light up ...

NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins

... one of the awards, won his grant with an original proposal to study prion diseases a group of deadly, brain-destroying disorders that include mad cow disease and its human version, Creutzfeldt-Jakob disease using genetically modified fruit flies and laboratory mice. I was totally surprised ...

Clemson scientists shed light on molecules in living cells

... says other possible targets of investigation include the formation of plaques and fibrils in the brain associated with Alzheimer's disease and mad cow disease. Graduate students Changfeng Wu, Craig Szymanski, Jennifer Grimland and Yueli Zheng contributed to the study, which the National Science ...

Thermochemical process converts poultry litter into bio-oil

... as land application and feeding to cattle, are under pressure because of pollution of water resources due to leaching and runoff and concern about mad cow disease contamination in the food chain. There are also concerns that poultry litter can harbor such diseases as avian influenza. While avian ...

Federal testing for mad cow disease a failure, law review editor says

... The U.S. Agriculture Department's mad cow disease-testing program is wholly inadequate ... with bovine spongiform encephalopathy, or mad cow disease, can cause Creutzfeldt-Jakob disease, ... The surveillance program found no cases of mad cow disease until June 24, 2005. "This cow was of ...

Strongest proof yet found for prion hypothesis

... yet that infectious misformed proteins cause mad cow disease and other mysterious brain disorders ... afflict both human beings and animals, include mad cow disease, new-variant Creutzfeldt-Jakob ... improve current surveillance techniques for mad cow disease and its human form, new-variant ...

Vaccine prevents prion disease in mice

... oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American ... in Boston, April 28 ?May 5, 2007. Prion diseases, which include scrapie, mad cow disease, and chronic wasting disease, are fatal and there is no ...

Scientists identify prion's infectious secret

... have known for decades that certain neurodegenerative diseases, such as mad cow disease or its human equivalent, Cruetzfeldt-Jakob disease, result ... this process in mammalian prions, such as those responsible for mad cow and Cruetzfeldt-Jakob diseases, as well as in other non-prion proteins ...

Successful cell engineering may lead to mad cow prevention, say researchers

... that might cause bovine spongiform encephalopathy (BSE), commonly known as mad Cow Disease. Researchers Mark Westhusin and Charles Long in Texas ... resistance strategies in other animal species," Westhusin adds. BSE, or mad Cow Disease, is a fatal brain-wasting disease first identified in the ...

Unweaving amyloid fibers to solve prion puzzles

... such as Alzheimer's and Creutzfeldt-Jacob disease--the human analog of mad cow disease. But even though amyloids are common and implicated in a host ... prions can't cross the species barrier while others can--as they have with mad cows and humans.," says Lindquist. That gap has also been observed between ...

Beyond genes: Lipid helps cell wall protein fold into proper shape

... by misfolded proteins such as cystic fibrosis, Alzheimer's disease, and mad cow disease. The paper in today's Journal of Biological Chemistry by ... caused by misfolded proteins. "In cystic fibrosis, Alzheimer's disease and mad cow disease, the dysfunctional proteins are associated with membranes," ...

Active Vaccine Prevents Mice From Developing Prion Disease

... possibly prevent the onset of a brain disease in mice that is similar to mad cow disease. The new findings, published online this week in the journal ... prions. Although no cure for these diseases -- which include scrapie, mad cow disease, and chronic wasting disease -- is on the horizon, many ...

Brown team finds crucial protein role in deadly prion spread

... drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans. Because similar protein replication occurs ...

Biodegradable napkin -- featuring sensitive nanofibers -- may quickly detect biohazards

... Using this method we should, in theory, be able to quickly activate the fabric to detect whatever is the hazard of the week, whether it is bird flu, mad cow disease or anthrax." Frey and her colleagues are still working on ways, such as a color change, for the fabric to signal that it has ...

Blood transfusion-transmitted infections: A global perspective

... reduce that risk even further, particularly those due to emerging agents including variant Creutzfeldt-Jakob disease (vCJD) the human counterpart to mad cow disease. With regard to the emerging pathogens, several newly-developed pathogen-reduction technologies have been shown to be effective in ...

Prion find points way to test for human 'mad cow' disease

... describe experiments that may soon lead to a test that will enable medical science to estimate how many people are infected with the human form of mad cow disease, which can take as long as 40 years before manifesting itself. Such a blood test could also help prevent accidental transmission of the ...

History of human cannibalism eats away at researchers

... prion protein gene ( PRNP ) encodes a protein that can abnormally fold and amass in brain tissues to cause fatal neurodegenerative diseases such as mad cow disease. These diseases are cumulatively known as transmissible spongiform encephalopathies (TSEs) and in humans, include CJD ...

New test to detect rare proteins in blood

... says Greene. The researchers have also tried the FACTT method on other rare, but medically important molecules, such as the prion protein (for mad cow disease with Mansun Sy at Case Western University) and TNF-alpha (for autoimmune diseases), and will be developing tests for other cancer markers ...

Prions rapidly 'remodel' good protein into bad, Brown study shows

... maneuver sheds important light on the mysterious molecular machinery behind prions, infectious proteins that cause fatal brain ailments such as mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans. Because similar protein self-replication ...

New results validating Pall prion reduction filter disclosed at ISBT Congress

... (vCJD), emerge. An update on the latest measures to protect the public from the human form of Bovine Spongiform Encephalopathy (BSE), commonly called mad Cow Disease, and minimize risk of transmission through blood transfusion was presented here at the International Society of Blood Transfusion ...

Variant prion protein causes infection but no symptoms

... prion proteins are little understood disease agents involved in causing horrific brain-wasting diseases such as Creutzfeldt-Jacob disease in people, mad cow disease in cattle and chronic wasting disease in deer and elk. Now, new research suggests that a variant form of abnormal prion protein--one ...

First technology to remove prions that cause vCJD from blood launched

... blood component. Variant CJD, a fatal neurodegenerative disease, is the human form of Bovine Spongiform Encephalopathy (BSE), also known as mad Cow Disease. The CE mark means the new prion reduction filter meets pan-European essential requirements for safety of medical devices. "The ...
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