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Lymphoma in Biological News

La Jolla Institute discovers novel tumor suppressor

... in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a ... marrow and include chronic myeloid leukemia. lymphoma and leukemia are cancers of the blood. ... Burkitt's lymphoma, an aggressive type of B-cell lymphoma that occurs most often in children and young ...

Galiximab in combination with rituximab in patients with previously untreated follicular lymphoma

... of patients with previously untreated follicular lymphoma responded to treatment with galiximab, an ... at the 10th International Conference on Malignant lymphoma (ICML). The results of this open label study ... a promising regimen for patients with follicular lymphoma (FL), a common type of ...

Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients

... the effect high dose vitamin C has on non-Hodgkin lymphoma patients. Researchers from the Jefferson-Myrna ... peroxide. When applied to certain non-Hodgkin lymphoma cells in the laboratory, the converted hydrogen ... intervention, the preliminary data on non-Hodgkin lymphoma cells is why we decided to start with this ...

University of Pennsylvania researchers zero in on the tiniest members in the war on cancer

... more than 300 miRNAs in both human and mouse lymphoma cells. Mendells team had previously found that ... miRNAs called the miR-17-92 cluster in lymphoma cells. In those cells that had high amounts of ... on." When they looked closer at the DNA of the lymphoma cells, the team also found that Myc was directly ...

Quantitative PET imaging finds early determination of effectiveness of cancer treatment

... patients response to chemotherapy for non-Hodgkin lymphoma (NHL) typically involves visual interpretation of ... response for patients with diffuse large B-cell lymphoma (DLBCL) is more accurate than visual analysis ... images, added Meignan. Diffuse large B-cell lymphoma is a fast-growing, aggressive form of non-Hodgkin ...

NC State first university in nation to offer canine bone marrow transplants

... Dogs suffering from lymphoma will be able to receive the same type of medical treatment as their human ... but it's never been feasible as a standard therapy until now." Canine lymphoma is one of the most common types of cancer in dogs, but the survival rate ...

New technology enhances therapeutic potential of cord blood stem cells

... of stem cells for the treatment of blood cancers, including myeloma, lymphoma and leukemia. The cells, which are collected from the umbilical cord after ... Christopherson will co-chair the session and review some of his Leukemia & lymphoma Society funded work at the symposium in a session entitled "Basic Science ...

Science expands Science Signaling, featuring research related to medical advances, and more

... of the insect repellent DEET. Science 319, 1838-1842 (2008). lymphoma Differentiation, survival, and growth of B cells, a particular type of ... molecules. Lenz et al. discovered that a common form of non-Hodgkins lymphoma in humans is caused by mutations in the CARD11 gene. These mutant forms of ...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

... methylated in the majority of the broad group of cancers called non-Hodgkin's lymphoma. This methylated DLC1 is detectable in the plasma samples of lymphoma patients, making it a good candidate for the screening, says Dr. Shi who also is looking for these types of biomarkers in breast cancer and the ...

Research uncovers clues to virus-cancer link

... KSHV miRNA. In second study, published June 4 in the journal Blood, the team looked for the presence of tumor suppressor mRNAs in primary effusion lymphoma and Kaposi's Sarcoma. "We chose these two cancers because, while they are both associated with the same virus, they occur in very different types ...

NC State researchers find soy may aid in treating canine cancers

... in soy that has been shown to be toxic to a wide variety of cancer cells in humans - to determine whether it would also inhibit the growth of canine lymphoma cells. The researchers found that a commercially available form of genistein called GCP was effective in killing canine lymphoid cells in a ...

Two Hutchinson Center researchers named HHMI Early Career Scientists

... mimicry," providing yet another nuance to a never-ending "arms race" between hosts and viruses. Taniguchi, as a physician in Tokyo, treated many lymphoma patients with DNA-damaging chemotherapy, only to watch the drugs lose their power as the tumors developed resistance. He then became a researcher in ...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

... to stave off cancer. "This is very promising research, but it is too early to say this is chemo-protective." Hematological cancers leukemia, lymphoma and myeloma accounted for an estimated 118,310 new cancer cases and almost 54,000 deaths in 2006, ranking these cancers as the fourth leading cause ...

Breast cancer cells recycle to escape death by hormonal therapy

... team led by Dr. Craig Thompson reported in 2007 in The Journal of Clinical Investigation that chloroquine increased death of suicide-resistant lymphoma cells being treated with chemotherapy. Dr. Schoenlein will give chloroquine along with an antiestrogen and measure cell death. "Most cancers ...

UC Davis researchers discover new drug target for inflammatory disease

... experiments using human cells to confirm the resulting predictions. The researchers conducted additional experiments using human leukemia and lymphoma cell lines, because they are known to express integrins, in order to measure changes in the inflammatory response due to sPLA2-IIA-integrin binding. ...

Children's national co-leads nationwide study of landmark sickle cell treatment

... cell patients. "Blood and marrow transplantation from unrelated donors has been routinely utilized to treat treatment-refractory leukemia and lymphoma for almost two decades," said Dr. Kamani , co-principal investigator of the study. "Preliminary results from the few unrelated donor transplants ...

Researchers find cancer-inhibiting compound under the sea

... and research dollars have only become available in the past 15 years. HDACs are already targeted by a drug approved for cutaneous T-cell lymphoma manufactured by the global pharmaceutical company Merck & Co. Inc. However, UF's compound does not inhibit all HDACs equally, meaning a ...

New guidelines for treating rheumatoid arthritis

... B, hepatitis C and active or latent tuberculosis. Doctors should not prescribe anti-TNF agents to patients with a history of heart failure, lymphoma or multiple sclerosis. ...

New treatment approach promising for lymphoma patients in the developing world

... Preliminary results suggest that patients with aggressive non-Hodgkin's lymphoma in the developing world might benefit from a modified chemotherapy regimen, researchers say. At the ESMO Conference Lugano (ECLU) organized by the ...

CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients

... patients had head and neck cancer (HNC), 31 percent had breast cancer, 13 percent had colon cancer, eight percent had lung cancer, six percent had lymphoma and 11 percent had other tumor types. All patients in this study received CAPHOSOL, administered as an oral rinse, four to 10 times daily for an ...

NCI renewal grant to develop new cancer therapies

... to lead a multi-institutional trial of vorinostat and bortezomib, a proteasome inhibitor, in patients with refractory diffuse lymphocytic B-cell lymphoma or mantle cell lymphoma. ...

Glue inside the cell

... to prevent an over-shooting activation of T cells. Unopposed lymphocyte activity is responsible for many chronic diseases, autoimmunity or even lymphoma development. Future work must address the status of Malt1 ubiquitination under pathological conditions, for instance in Malt1 dependent lymphomas. By ...

Antibiotic treats lymphoma of the eye

... doxycycline effectively treats a type of lymphoma associated with chlamydia infection, according to ... the National Cancer Institute. Ocular adnexal lymphoma of the MALT-type (OAL) is a kind of cancer of the ... authors found that doxycycline treatment caused lymphoma to regress in both patients who did not test ...

Spelling out cancer on the nanoscale

... protein detection. It was also tested on human lymphoma samples. In previous work, the Felsher ... to test their conditional model of MYC-induced lymphoma by using their nano-fluidic system to quickly ... was overexpressed in mantle cell and follicular lymphoma patients. In parallel, traditional Western blots ...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

... yielded an 89% survival rate in mantle cell lymphoma patients. The median follow-up was 3.8 years. Historically, patients with this type of lymphoma only have had a 50% chance of surviving 3 years ... patients with untreated mantle cell non-Hodgkin's lymphoma (NHL) were administered six cycles of ...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

... had lower risks of Kaposi sarcoma and non-Hodgkin lymphoma compared with those who did not use HAART, ... was not associated with lower risks of Hodgkin lymphoma or other cancers. Although people infected with ... and non-Hodgkin lymphoma, but not that of Hodgkin lymphoma or other non–AIDS-defining cancers," the authors ...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

... as it sounds. A new form of treatment for lymphoma that takes a fraction of the time of traditional ... found. Patients with advanced-stage follicular lymphoma ?a cancer generally considered incurable ?who had ... Program and the Multidisciplinary lymphoma Clinic at the U-M Comprehensive Cancer Center. ...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

... issue of Molecular Cell Biology (MCB). B-cell lymphoma is a cancer in which the antibody-producing cells ... "Instead, this gene promotes the development of lymphoma by enlarging the B lymphocyte population. This ... enough to turn these overactive lymphocytes into lymphoma cells. "The coup de grace consisted of a ...

Potential Cure for Lymphoma in HIV patients

... option for select patients with HIV-associated lymphoma will be published in the January 15, 2005, issue ... HIV-positive patients are more likely to develop lymphoma than HIV-negative individuals, and the treatment ... receives high-dose chemotherapy to kill any lymphoma in the body, and the autologous stem cells are ...

Risk of lymphoma increases with hepatitis C virus infection

... found that HCV infection increased the risk of developing non-Hodgkin's lymphoma by 20 percent to 30 percent. The risk of developing Waldenström's ... first, that the patients infected with HCV had a higher risk of developing lymphoma and, second, that HCV infection preceded development of the lymphoma. The ...

Researchers wake up viruses inside tumors to image and then destroy cancers

... associated with Epstein-Barr, including at least four different types of lymphoma and nasopharyngeal and gastric cancers. In the March 1 issue of Clinical ... of FIAU, but not in mice that weren't given Velcade. Mice whose Burkitt's lymphoma did not contain Epstein-Barr virus also did not respond to either Velcade ...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

... virus and an etiological agent for Kaposi’s sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time ... treatment option for cancers with wt p53. PEL is a non-Hodgkin type lymphoma latently infected with KSHV, and it manifests as an effusion malignancy in ...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

... study had ever before, and found that one-third of the animals developed lymphoma later in their life. This is the same gene being given to patients with ... life span, which is about one-and-a-half years. Mice that developed lymphoma did so at an average of 10 months of age. In the human gene therapy ...

Combination therapy improves AIDS-related lymphoma outcome

... risk" patients responded as well to therapy and survived as long as lymphoma patients without HIV. Lymphomas are cancers of the immune system's ... level of risk to rates comparable to those in non-HIV patients with lymphoma treated with CHOP and superior to previously published rates achieved by ...

Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue

... example is lymphoma, or cancer of the lymphatic system. Like many cancers, lymphoma cells have well-defined surface receptors that recognize unique ... antibody would play the role of a Trojan horse. Dai and Dean Felsher, a lymphoma researcher in the Stanford School of Medicine, have begun a collaboration ...

Specialized immune-system B cells play double-barreled role

... by the National Institutes of Health, the Arthritis Foundation, the lymphoma Research Foundation and the Leukemia & lymphoma Society. The researchers studied a particular type of B cell called the ...

Source of molecular triggers in cutaneous T cell lymphoma identified

... scientists identify the molecular triggers that stimulate Cutaneous T Cell lymphoma (CTCL) cells to clonally expand into large populations of malignant ... National Cancer Institute first identified CTCL as a separate category of lymphoma thirty years ago. The Yale research group reported that, like all T ...

New recommendations against a major opportunistic infection -- cryptococcosis

... is also more severe in HIV+ than in HIV- individuals. In terms of mortality, it is those patients suffering from a haematological malignancy (such as lymphoma or chronic leukaemia) in which cryptococcosis is the most serious. The study also demonstrates that between the two serotypes of C. neoformans ...

Antibody signal may redirect inflammation to fuel cancer

... said. The good news, she adds, is that potential drugs to block this pathway are already being tested in clinical trials to treat B cell lymphoma and auto-immune diseases made worse by inflammation, such as rheumatoid arthritis. "We already know that inflammation accelerates skin, ...
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