Scripps research team sheds light on immune system suppression

... of this immune response in mice infected with lymphocytic choriomeningitis virus, pointing to potential new ... San Diego, worked with mice infected with lymphocytic choriomeningitis virus, a model Oldstone ... then triggers other immune responses. But the lymphocytic choriomeningits virus, and presumably other ...

Study validates means to measure possible leukemia marker

... are spool-like proteins that help support and store DNA. The technology accurately detected differences in the composition of histones in chronic lymphocytic leukemia (CLL) cells compared with their healthy counterparts, immune cells called B lymphocytes. These variations are a promising molecular ...

Peering inside the skull of a mouse to solve meningitis mystery

... many critical experiments that supported the unexpected findings of the study. A Disease Driven by the Immune System The scientists used lymphocytic choriomeningitis virus (LCMV), which is relatively harmless in humans with a healthy immune system. Other viruses that cause meningitis usually are ...

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

... selectively rearm T cells while generally reinvigorating them." The researchers made their discoveries in a mouse model of chronic infection with lymphocytic choriomeningitis virus. They had earlier found that a receptor known as programmed death-1 (PD-1) was highly expressed by exhausted T cells from ...

The IMF says journal editorial documents dramatic increase in survival since the 1980s

... these achievements with myeloma are now benefiting a wide range of blood cancers as these drugs are being tested in non-Hodgkin's lymphoma, chronic lymphocytic leukemia and other blood cancers. In the editorial he says the next step is to identify new agents with "greater efficacy or lesser toxicities" in ...

Researchers find way to make tumor cells easier to destroy

... therapeutic, and it recently received clearance by the U.S. Food and Drug Administration to enter human phase I/II clinical testing in chronic lymphocytic leukemia. In some preliminary studies, GRN163L has been shown to be additive when used in combination with existing cancer drugs or radiation. ...

Two suppressor molecules affect 70 genes in leukemia

... that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model. The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules affects 70 genes, most of which are involved in critical functions such as cell ...

Gene therapy protocol at UCSD activates immune system in patients with leukemia

... A research team at the Moores Cancer Center at University of California, San Diego (UCSD) reports that patients with chronic lymphocytic leukemia (CLL) who were treated with a gene therapy protocol began making antibodies that reacted against their own leukemia cells. The study will be ...

NCI renewal grant to develop new cancer therapies

... received approval to lead a multi-institutional trial of vorinostat and bortezomib, a proteasome inhibitor, in patients with refractory diffuse lymphocytic B-cell lymphoma or mantle cell lymphoma. ...

University of Pennsylvania researchers develop formula to gauge risk of disease clusters

... eight cases of leukemia in Niles, Ill., in 1956-1960, which was reasonably assessed as a chance, random event. On the other hand, 12 cases of acute lymphocytic leukemia in Churchill County, Nev., in 1999-2001 was assessed not to be a chance event but due to a common, possibly environmental cause. Multiple ...

Pair of microRNA molecules controls major oncogene in most common leukemia

... for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia ... work as a future treatment for B-cell chronic lymphocytic leukemia, he said. These molecules could also be ... a number of miRNAs associated with B-cell chronic lymphocytic leukemia that appear to promote tumor ....

Researchers identify genes associated with lung transplant rejection

... California, San Francisco (UCSF) have identified six genes associated with lymphocytic bronchitis, which is thought to lead to obliterative bronchitis (OB), the ... tests in each patient. They identified six genes that correlate with lymphocytic bronchitis, potentially opening the way to a genetic test that would ...

The very unexpected life and death of a leukemic cell

... B cell chronic lymphocytic leukemia (CLL) is an incurable disease in which cells in the bone marrow ... In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells View the PDF of this article at: ...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

... journal recently invited three of the world's foremost experts on chronic lymphocytic leukemia (CLL) to write an authoritative update covering the ... "Previous theories about the development and progression of chronic lymphocytic leukemia require revision. With new molecular and protein markers now ...

Researchers discover inherited mutation for leukemia

... Researchers have discovered the first inherited gene mutation that increases a person's risk for chronic lymphocytic leukemia (CLL), one of the most common forms of the disease. The study shows that the inherited mutation greatly reduces the gene's protective ...

Synthetic peptide targets latent papilloma virus infections

... also prove useful against other infectious viruses, such as the related Epstein-Barr virus, the cause of mononucleosis and an aggressive form of lymphocytic leukemia called Burkitt's leukemia, and the Kaposi's sarcoma virus, which can develop to cancer in those with AIDS. ...

Massey researchers induce cell death in leukemia

... research at the American Association of Cancer Research's annual meeting suggesting the potential of a new combination treatment for chronic lymphocytic leukemia (CLL). In this study, led by Steven Grant, M.D., Massey's associate director of translational research, interactions between bortezomib ...

Knocking out survival protein could aid leukemia treatment

... But such a drug used in combination with several existing drugs might also offer an effective one-two punch against drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans yearly. The survival protein is ...

Scientists discover new virus caused deaths of transplant recipients from single donor

... of three transplant recipients who received organs from a single donor in Victoria, Australia. The previously unknown virus, which is related to lymphocytic choreomeningitis virus (LCMV), was found using rapid sequencing technology established by 454 Life Sciences and bioinformatics algorithms developed ...

Mouse mimics chronic leukemia, will aid drug development

... aid the development of new drugs for the disease. The mouse, called the TCL-1 transgenic mouse, develops a malignancy that closely mimics chronic lymphocytic leukemia (CLL). The lack of an animal model has greatly hampered the development of new treatments for CLL as well as research into its causes and ...

MiRNA fingerprint identified in platelet formation

... substantial evidence linking certain patterns of miRNA to both normal and abnormal blood cell development, especially in diseases like chronic lymphocytic leukemia and lymphoma. Relatively little was known, however, about miRNA functionality in platelet formation. Platelets are created from stem ...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

... ("cellular" immunity). B-cell lymphocytes can undergo malignant transformation to become non-Hogkins lymphoma, multiple myeloma or chronic lymphocytic leukemia. "This is the first human cancer vaccine study to see T-cell responses in the absence of B-cells," said the study's first author, Sattva ...

Enzyme allows B cells to resist death, leading to leukemia

... B cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in adults and is characterized by the progressive accumulation of mature B lymphocytes in the blood, ...