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Lymphoblastic in Biological News

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

... mutations involve a single chemical change in the molecular building blocks of DNA. The data demonstrated that, in contrast to pediatric acute lymphoblastic leukemia (ALL), AML is characterized by a very low burden of mutations. The researchers found slightly more than two CNAs per AML patient, and less ...

St. Jude identifies genomic causes of a certain type of leukemia relapse

... Scientists at St. Jude Children's Research Hospital have identified distinctive genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The finding offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. ...

Lab study shows methadone breaks resistance in untreatable forms of leukemia

... culture because this cancer also expresses the opioid receptor. Theirs is the first study to look at use of the agent in leukemia, specifically in lymphoblastic leukemia T-cell lines and human myeloid leukemia cell lines. They found that methadone was as effective as standard chemotherapies and radiation ...

Ireland Cancer Center researchers advance stem cell gene therapy

... Group (ECOG) presented data that show that Imatninib (Gleevec) does not change outcomes on patients with Philadelphia Chromosome Positive Acute lymphoblastic Leukemia. Dr. Lazarus presented an assessment of data over 30 years regarding acute leukemia and its management. He found that all avenues ...

Daisies lead scientists down path to new leukemia drug

... end of 2007. Investigators expect to initially enroll about a dozen adult volunteers whove been diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) or other types of blood or lymph cancers, Jordan said. Under development is dimethylamino-parthenolide (DMAPT), a form of ...

St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia

... has revolutionized the treatment of chronic myelogenous leukemia, (CML) is often unable to prevent relapse of a particularly aggressive form of acute lymphoblastic leukemia (ALL). Targeted therapy drugs are designed to block the activity of a specific molecule, a strategy aimed at making treatments more ...

Retinol for combating leukemia cells

... of retinamide in certain types of leukemia - lymphoblastic leukemias. Nowadays, samples from the Hospital de ... in order to get these types of leukemia cells. lymphoblastic leukemias are, as their name indicates, a type of ... retinamide has great potential to eliminate the lymphoblastic cells without affecting healthy lymphocytes nor ...

Research shows cord blood comparable to matched bone marrow

... Blood Program at the New York Blood Center. The analysis included transplant outcomes in 785 children younger than 16 who had the diagnosis of acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). ...

Major gene study uncovers secrets of leukemia

... at St. Jude Children's Research Hospital have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children. The discovery not only suggests novel methods for treating pediatric ALL, but also provides a ...

Knocking out survival protein could aid leukemia treatment

... with several existing drugs might also offer an effective one-two punch against drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans yearly. The survival protein is called Mcl1. It usually helps keep normal ...

Leukemic cells find safe haven in bone marrow

... The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to investigators at St. ...

Researchers find docking sites for glucocorticoid receptor and Hsp90

... prescribed for such conditions as adrenal insufficiency as in Addison's disease, arthritis, asthma, inflammatory bowel disease and childhood acute lymphoblastic leukemia. "Glucocorticoids are very commonly used in the treatment of diseases," Darimont said. "They have a bunch of physiological activities ...

Scientists use gene signatures to match cancer and other diseases with potentially effective drugs

... author on a paper in Cancer Cell that describes how the method successfully identified a drug that can overcome therapy-resistant cases of acute lymphoblastic leukemia (ALL) in children. So-called "glucocorticoid" drugs like prednisone are very effective in many cases of ALL, but in some patients the cancer ...

St. Jude projects 90 percent cure rate for ALL

... The cure rate for the once almost universally fatal childhood cancer acute lymphoblastic leukemia (ALL) could reach 90 percent in the near future, thanks to improvements in diagnosis and treatment over the past four decades, according to ...

Single microRNA causes cancer in transgenic mouse

... designed molecules (called antagomirs) may be able to block miR 155 expression and be an effective therapeutic strategy in patients with acute lymphoblastic leukemia or high grade lymphomas. ...

Genes linked to treatment resistance in children with leukemia

... in the June 15, 2005, issue of Blood, the official journal of the American Society of Hematology. The researchers studied 246 children with acute lymphoblastic leukemia (ALL), all of whom were assigned to one of two groups that determined the intensity of therapy. Patients with poorer prognostic factors ?130 ...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

... A new study is providing scientists with a better understanding of why some pediatric acute lymphoblastic leukemia (ALL) patients fail to respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The ...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

... finding, from researchers at St. Jude Children's Research Hospital, suggests a way to improve the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. Jude study are published in the current online issue of Blood. The researchers ...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

... patients. Combined elevated TEL2 and MYC expression occurred in the B lymphocytes of over a third of patients with a B lymphoma called B-acute lymphoblastic leukemia. "These results offer new hope for improved diagnosis," said Monica Cardone, Ph.D., a postdoctoral student in Grosveld's laboratory who ...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

... researchers also tested 244 samples from 26 of the recipients themselves. The recipients had been treated for either white cell cancers (e.g., acute lymphoblastic leukemia) or red cell diseases (e.g., sickle cell disease). Because blood from the normal, healthy donors contained 1,200 to 155,000 sjTREC copies ...

Genetically modified natural killer immune cells attack, kill leukemia cells

... finding, from researchers at St. Jude Children's Research Hospital, suggests a way to improve the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. Jude study are published in the current online issue of Blood. The researchers ...

Genome-wide mouse study yields link to human leukemia

... and possibility, study authors say. Researchers in The Ohio State University Comprehensive Cancer Center bred a type of mouse that develops acute lymphoblastic leukemia (ALL). The mouse first goes through a pre-leukemic stage marked by rapidly expanding T cells and natural killer cells, both major components ...
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