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Locus in Biological News

Evolution of fruit size in tomato

... vary up to 30% as a result of variation at this locus alone. Cloning and sequencing of this locus reveals that the wild type protein codes for a ... locule numbers. Further comparisons of this locus across different tomato cultivars, including wild ...

Concentrating on different aspects of pain leads to breakthrough in migraine genetics

... study. Researchers identified one gene locus on chromosome 10q23, which showed significant ... as well as in the replication study. The gene locus was especially strongly linked to female ... Verneri Anttila from Paloties group. This locus is thus linked to migraine in a total of 4000 ...

Does the desire to consume alcohol and tobacco come from our genetic makeup?

... in females and 28% in males) use a common locus (an identifiable location on a chromosome) for ... with diastolic blood pressure (DBP), they found a locus for smoking. on chr 3, in the area ... involved with pre-math stress DBP, they found a locus for alcohol on chr 4, inside gene GRID2, ...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

... reports steep changes in the frequency of genotypes at a single genetic locus with depth: a gradient of nearly one half percent drop in frequency per meter. The genotypes at the locus are directly related to behavioral types that select deep vs shallow water ...

New findings on immune system in amphibians

... characterized genetic variation and detected more than one MHC class II locus in a tailed amphibian. Unlike mammals, not much has been known until now ... the MHC has been studied, and the first one in which more than one MHC II locus has been found. The crucial role of the MHC in the immunity of ...

A tall story: New research adds to growing body of knowledge of genetics of height

... acting as switches to turn genes elsewhere in the genome on or off. One locus in particular is also implicated in osteoarthritis, the most common form ... involving the effects of wear and tear on the bodys structures. This locus reinforces a similar link identified by a previous study, and may be ...

UBC researchers help push for standard DNA barcodes for plants

... for Plant Research, and the Department of Botany. "Particular research projects with special needs could augment the system by adding a third DNA locus to their barcode if required." Theoretically, any DNA barcoding standard would have to accommodate over 400,000 species of plants, and would be a ...

Study finds genetic links to age of first menstrual period and menopause

... collaboration of the WGHS and the NHS represents a great example of how large cohorts with genome-wide data can complement each other. While only one locus reached near genome-wide significance in the NHS alone, the meta-analysis of combined data had much more statistical power and revealed a total of ...

Genetic irregularities linked to higher risk of COPD among smokers

... the notion that these variants influence risk independent of smoking behavior. The findings represent the discovery of the first major locus contributing to COPD in the general population. While Goldstein says the discovery may well open new therapeutic windows, it may also prompt ...

Easton honored with inaugural AACR Outstanding Investigator Award in Breast Cancer Research

... which impact breast cancer susceptibility, none of which had previously been associated with breast cancer: FGFR2, TNRC9, MAP3K1, LSP1 and a locus on 8q. Subsequently, he demonstrated how variations in these loci are associated with increased risk of breast cancer in BRCA mutation carriers. ...

Children's gardening programs grow environmental stewards

... In addition, this study evaluated the gardening program's effectiveness on promoting positive environmental attitudes and a high environmental locus of control with children." More than 80% of children who participated in the study had been previously involved in gardening, either through ...

Research pushes back history of crop development 10,000 years

... been reported on several occasions." "This process has similarities to the evolution of 'supergenes' in which many genes cluster around a single locus to contribute to one overall purpose." "We now need to move this research area to a new level. Domestication was a complex process and can now be ...

Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children

... of learning disabilities, autism, schizophrenia, or other neuropsychiatric disorders. This study, the authors said, adds 1q21.1 as a chromosomal locus to the growing list of structural variants that might eventually be included in genetic screening panels for people with developmental delays or ...

Ceramic material revs up microwaving

... are hot and will burn bare hands. Potholders are again necessary. Food preparation applications abound. A company in Arita, Japan -- long a locus of ceramic manufacturing -- called Asahi Ceramics Research Company is manufacturing microwave ware. The material's microwave heating properties ...

Plants in the fourth dimension

... they have shown that the nucleotides in the gene's DNA are replaced at a significant rate, resulting in greater genetic variation at this locus (chromosomal region). If plants have to respond to different conditions of light and temperature at different locations, then it makes sense for ...

Mate choice in plants

... S-specific matching between S-RNase and SLF, by itself is not sufficient for rejection of incompatible pollen. Other factors not linked to the S locus are also required in the genera Nicotiana (tobacco), Solanum (tomato) and Petunia. Three other glycoproteins, proteins with attached carbohydrate ...

Early origins of maize in Mexico

... information to track the evolution and dispersal of maize varieties as well as to reconstruct the history of maize domestication. For example, the locus teosinte glume architecture 1 (tga1), is important in determining phytolith formation and morphology and, along with other "domestication genes" can ...

Genome communication

... the process. The gene mediator of paramutation1 (mop1), an RNA dependent RNA polymerase is absolutely required for paramutation silencing at the b1 locus as well as for several other maize genes. In Arabidopsis, this RNA polymerase is associated with the production of small, interfering RNAs (siRNA) ...

Mapping the genetic locus for triglycerides

... scanned 714 Caucasians from 388 families with premature heart disease. They identified a novel region on chromosome 1, 1p31-32. While this genetic locus does contain 375 known genes, the researchers highlighted three genes that are especially promising candidates: angiopoietin-like 3, which inhibits ...

Genetic variants of USF1 are associated with the increased risk for cardiovascular disease

... Public Health Institute and the University of Helsinki, Finland, has investigated variation within the upstream transcription factor 1 (USF1) gene locus in relation to CVD risk factors, atherosclerosis, and incidence and prevalence of CVD. USF1 gene was first identified in Finnish families ...

Making sense of antisense microRNAs

... Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. The studies from Drs. Alexander Stark and Manolis Kellis (MIT) and colleagues, and from Dr. Eric Lai (MSKCC) and colleagues, both ...

Evolution with a restricted number of genes

... structure in RNA polymerase II. They build on earlier observations that gene expression is not just regulated by binding of the enzyme to the gene locus to which it is recruited, but also during the phase of active transcription from DNA into RNA. During this phase, parts of the newly synthesised RNA ...

New genetic variant associated with prostate cancer in African-Americans

... -- which took advantage of genetic differences among African American men, who are at very high risk for this type of cancer -- led us to a different locus within that region and directly to a gene of interest. Prostate cancer is the most common male malignancy and the second leading cause of cancer ...

Study identifies genetic risk factor for rheumatoid arthritis, lupus

... and activation of certain cells of the immune system. "It may be too early to predict the impact of identifying the STAT4 gene as a susceptibility locus for rheumatoid arthritis whether the presence of the variant and others will serve as a predictor of disease, disease outcome or response to ...

Scientists unlock secret of what makes plants flower

... has led to the proposal that this signal is a protein known as Flowering locus T Protein (FT protein), which is produced in leaves by the Flowering locus T gene (FT gene). It travels through the plant's vascular system to the ...

Susceptibility to Crohn's disease -- an important new clue

... of a species ?Cécile Libioulle et al. identified a new susceptibility locus for Crohn’s disease. Their results are published online in the open-access ... colleagues applied this approach to Crohn’s disease and identified the key locus on chromosome 5. Individual susceptibility to many common diseases, ...

Leading reason for corneal transplants comes into focus

... most often in women, to chromosome 18. "Finding this chromosomal locus is putting us in the right neighborhood to find culprit genes," says ... with similar forms of Fuchs dystrophy, we believe we have the chromosome locus for the most common genetic mutation resulting in Fuchs," he said. "It's a ...

Same-sex mating by fungi spawned infection outbreak, evidence suggests

... remains to be discovered." Additional examination of the mating type locus provided evidence that the major outbreak isolate may have resulted from ... identical alpha genes from their alpha parent. However, the mating type locus of the two strains from Vancouver Island both of the alpha mating type -- ...

Research identifies protein that signals flowering in squash plants

... in plants. Some of the principal factors associated with the photoperiodic induction of flowering are proteins known as CONSTANS (CO) and FLOWERING locus T (FT). CO does not appear to travel long distances through the phloem, but rather, it strongly influences the production of another substance (i.e. ...

ASU researchers test antibacterial effects of healing clays

... been largely confined to amputations or surgical excision of the infected sites." This means if the clays are antibacterial in nature and the locus for that activity can be isolated, they may represent a new form of treatment, one that goes beyond the capacity of existing antibiotics. "And they ...

Scientists discover that ancient genes dictate flowering, fall bud set

... for initiation of flowering. In the annual plant Arabidopsis, the first plant to have its genome sequenced, the genes Constans (CO) and Flowering locus T (FT) induce flowering in response to day length. It turns out that Populus trees (aspens, cottonwoods, poplars), the first tree to have been ...

Links between DNA damage and breast cancer studied

... is the second leading cause of cancer-related death in women. Breast cancer detection and therapy generally target epithelial cells, the primary locus of breast cancers, but in recent years evidence has accumulated that genetic mutations that develop into cancer may occur initially in a deeper layer ...

Housecat-sized Siberian tiger cubs get collared

... upon several characteristics of the DNA markers, including allelic frequency and genomic coverage. In some cases, a particular variant at one locus is perfectly associated with a specific variant at another locus; in other words, the two markers are "genetically indistinguishable." Dr. Lon ...

Studies on human genome variation provide insight into disease

... upon several characteristics of the DNA markers, including allelic frequency and genomic coverage. In some cases, a particular variant at one locus is perfectly associated with a specific variant at another locus; in other words, the two markers are "genetically indistinguishable." Dr. Lon ...

A new molecule discovered in the battle between plants and disease

... acid peptide that was isolated from Arabidopsis thaliana (G. Pearce, A. Huffaker, C.A. Ryan, submitted). The peptide is encoded by a gene at the locus At5g64900 and is derived from the carboxyl terminus of a 92 amino acid precursor, proAtPep1, a scenario commonly found in both animal and plant ...

Improved statistical tools reveal many linked loci

... insights into the many interlocking pathways that make up the gene regulatory network. Citation: Storey JD, Akey JM, Kruglyak L (2005) Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol 3(8): e267. ...

The making and breaking of microtubules

... But these molecules also regulate enzyme activity and play a crucial role in controlling microtubule growth. When GTP binds to a particular locus on beta tubulin (the E-site or exchangeable site) polymerization occurs: tubulin dimers pile onto the protofilaments, and the microtubule grows. But ...
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