New cancer drug delivery system is effective and reversible
... molecules that target receptors on cancer cells, liposomes
can enter and dump their cancer-killing contents ... have spent more than a decade trying to direct liposomes
to specific cancer cells, with limited success. A ... however, and the process of attaching them to liposomes
is difficult to control. Antibodies spur an ...
Long-lasting nerve block could change pain management
... specially designed fat-based particles called liposomes
to package saxitoxin, a potent anesthetic, and ... various formulations -- various types of liposomes
containing saxitoxin with or without ... the action of encapsulated anesthetics. The best liposomes
produced nerve blocks lasting two days if they ...
Scientists can predict nano drug outcome
... agents encapsulated in tiny fat bubbles called liposomes
to determine if breast tumors in rodents could be breached by liposomes
loaded with a cancer drug called liposomal doxorubicin. The liposomes
were administered intravenously.
Nanoengineers mine tiny diamonds for drug delivery
... five times the amount of drug carried by conventional materials.
and polymersomes, both spherical nanoparticles, currently are used for ... even healthy cells that are encountered as they travel to their target. liposomes
and polymersomes also are very large, about 100 times the size of ...
Potential for non-invasive brain tumor treatment
... system in conjunction with chemotherapy drugs encased in heat-sensitive microbubbles called liposomes.
"Physicians would inject drug-carrying liposomes
into a patient's bloodstream, and then insert a catheter via a blood vessel to the site of the brain tumor," said Carl Herickhoff, fourth-year ...
Nanotechnology holds promise for STD drug delivery
... past work has focused on delivery of siRNAs with liposomes, bubble-like carriers made of phospholipids similar to those found in cell membranes, liposomes
are potentially more toxic to the mucosal tissues and are unable to provide sustained release. In the current work, the researchers demonstrated that ...
Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
... for chemotherapy resistance. In collaboration with the University of the Basque Country and the Swiss firm Merk Serono International, a model in liposomes
simulating the composition of the mitochondrial membrane was developed in order to check the effects of cholesterol on its fluidity and response to ...
Cells get sprayed
... way into the cell through a cell membrane that has been made porous, through treatment with electrical current or UV lasers, for example. Viruses and liposomes
can be used as genetic transporters and the genetic material can be injected or shot into the cell with a particle gun. These methods all have the ...
Sandia researchers discover way to see how a drug attaches to a cell
... nanoscopic, hollow platinum spheres by using liposomes
as blueprints. (Liposomes are microscopic, ... double layer of lipid (detergent) molecules. The liposomes
are placed in a solution containing a platinum salt. When these liposomes
are irradiated with light, photocatalysts located ...
Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
... cancer were treated for 3-5 weeks. They received liposomes
that contained either the FAK siRNA, a control siRNA, or were empty. Some mice received siRNA liposomes
plus the chemotherapy docetaxel.
Mice ... advantage over positively or negatively charged liposomes
when it comes to binding with and penetrating ...
Liposome finding implies electrical effect on cell development
... Experiments with liposomes
?cell-like "water balloons" composed of ... Mark Hayes and Michele Pysher have found that liposomes
have a tendency to form tube-like extensions in ...
In the experiments, the researchers placed liposomes
in a droplet of water and applied very low ...
'Micro-boxes' of water used to study single molecules
Water offers several advantages over other methods for containing single molecules, such as attaching them to surfaces or placing them inside liposomes
(artificial cells). The water droplets can be held far from any surface that might interfere, can readily encapsulate biomolecules (which prefer ...
Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
... and has been simulated with supercomputers by Michael F. Klein and Goundla Srinivas of Penn's Department of Chemistry. While cell membranes and liposomes
(vesicles often used for drug-delivery) are created from a double layer of fatty molecules called phospholipids, a polymersome is comprised of two ...