New gene variants present opportunities in nutrigenomics
... lipids measured to determine cardiovascular disease risk: low-density lipoprotein
(LDL) cholesterol, high-density lipoprotein
(HDL) and triglycerides. The discovery opens up new opportunities for ...
Macadamia nuts can be included in heart healthy diet
... Heart diet with macadamia nuts did reduce total cholesterol, low-density lipoprotein
cholesterol and triglyceride levels compared with the standard American ... macadamia nuts reduced total cholesterol by 9.4 percent and low-density lipoprotein
by 8.9 percent.
Individual calorie levels were used for each participant ...
LDL particle measurement by NMR recognized by ADA, ACC
... markers of CMR than LDL cholesterol or non-HDL cholesterol. Subsequently, lipoprotein
abnormalities are commonly found in patients with CMR. According to the ... with cardiometabolic risk," says Robert S. Rosenson, MD, Director of lipoprotein
Disorders and Clinical Atherosclerosis Research, University of Michigan ...
New genetic variants associated with lipid levels, risk for coronary artery disease
... between these genetic variants and risk of CAD. High levels of low-density lipoprotein
(LDL) (bad cholesterol) appear to increase the risk of CAD by narrowing or ... arteries that carry blood to the heart. High levels of high-density lipoprotein
(HDL) (good cholesterol) appear to lower the risk. High levels of ...
Scientists associate 6 new genetic variants with heart disease risk factor
... body. There are two main types of cholesterol in the body, low-density lipoprotein
(LDL) cholesterol and high-density lipoprotein
(HDL) cholesterol, which are commonly known as the "bad" and "good" ...
Oatmeal's health claims strongly reaffirmed, science shows
... cholesterol levels are lowered through oat consumption;
(LDL, the "bad" cholesterol) is reduced without adverse effects on high-density lipoprotein
cholesterol (HDL, the "good" cholesterol), or triglyceride concentrations. ...
GEN reports on strategies to overcome blood-brain barrier
... of biomolecules that are transported into the brain via RMT include insulin, insulin-like growth factor (IGF), leptin, transferrin, and low-density lipoprotein
In RMT, molecules in the circulation may bind to specific receptors on the luminal surface of brain capillaries (i.e., the surface that ...
Athletes not spared from health risks of metabolic syndrome
... had at least three risk factors indicating they had metabolic syndrome based on measures of waist circumference, glucose levels, high-density lipoprotein
(HDL, or good cholesterol), blood pressure and triglycerides.
Of those 34, one athlete had all five risk factors, and eight had four risk ....
Apolipoprotein(a): A natural regulator of inflammation
... of cytokine production. These effects of apo(a) are independent of its molecular mimicry of Plg.
Lipoprotein(a) (Lp(a)) is similar to low density lipoprotein
(LDL), but contains an additional apolipoprotein, apo(a). Numerous clinical studies conducted over the past 40 years have identified Lp(a) as a risk ...
New genes present drug targets for managing cholesterol and glucose levels
... disease and in a previous study, Abecasis, Boehnke, Willer and colleagues had shown that genetic variants that raise LDL cholesterol (low density lipoprotein
or so-called bad cholesterol) levels also increase the risk of heart disease. The current study describes the most detailed assessment of the ...
Mounting evidence shows health benefits of grape polyphenols
... their antioxidant effects, grape polyphenols help to slow or prevent cell damage caused by oxidation. Polyphenols decrease oxidation of low-density lipoprotein
cholesterol ("bad" cholesterol)a key step in the development of atherosclerosis (hardening of the arteries).
Grape polyphenols also have other ...
LSUHSC awarded patent for compound inhibiting cancer and other diseases
... to grow bigger than 2 mm, the diameter of a large grain of sand, it must a have blood supply. Application of Apoliporpotein A-1 and high density lipoprotein
has been proven effective in inhibiting tumor growth dependent upon angiogenesisthe process of developing new blood vessels. Studies have ...
Nutrition research unveiled this week shows pistachios are smart for the heart
... consumption. Compared to baseline, both the 1.5 and 3.0 ounce pistachio diets resulted in reduction of total cholesterol (TC) and low density lipoprotein
cholesterol (LDL-C). In addition to the beneficial effects of pistachios on cholesterol, including pistachios as part of a heart-healthy diet also ...
Lipoic acid could reduce atherosclerosis, weight gain
... research with lipoic acid research has been done in mouse models, scientists say, there should be a reasonable extrapolation to humans, because the lipoprotein
profile is similar, as well as the composition of the atherosclerotic lesions. These mouse models are routinely used in studies of human ...
Contribution of cholesterol transporter to vascular disease
... Low-density lipoprotein
(LDL), a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism, according to a report published ...
MIT links gene to cholesterol
... which the researchers found prevents cholesterol buildup by activating a cellular pathway that expels cholesterol from the body via HDL (high density lipoprotein
or good cholesterol).
SIRT1 is an important mediator of cholesterol efflux, and as such it's predicted to play a role in the development of ...
Corazonas Foods and Brandeis University partner to create cholesterol-reducing snacks
... first venture, Corazonas Heart-Healthy Tortilla Chips, are currently the first and only snack chips clinically proven to reduce low-density lipoprotein
(LDL) cholesterol, a.k.a. bad cholesterol, by up to 15 percent. The chips have been a huge hit since debuting in early 2006, further demonstrating ...
Mechanism for the in-vivo transport of siRNA
... High Density Lipoproteins (HDL) and Low Density Lipoproteins (LDL) as well as the albumin (protein) present everywhere in the blood. Without these lipoprotein
particles there is no uptake of siRNAs into the tissues, as became apparent from further experiments. In an additional experiment the scientists ...
American Chemical Society's Weekly Press Pac
... in Seattle, Wash.
Scientists long have suspected that there may be dysfunctional forms of so-called good cholesterol, also called high density lipoprotein
(HDL) cholesterol, that can lose their heart-protective effect. But the exact chemical composition of HDL, both good forms and bad, has remained ...
Pistachios lower cholesterol, provide antioxidants
... levels and the higher dose significantly reduced lipoprotein
ratios," says Sarah K. Gebauer, graduate student ... in the blood by 8.4 percent and low-density lipoprotein
(LDL), the so-called bad cholesterol, by 11.6 ... between the two doses of pistachios for the lipoprotein
ratios because it would appear that pistachios ...
Baby's genes affect mom's cholesterol levels
... as much influence as the mother's genes on her lipoprotein
levels. Because increased levels of lipoproteins ... interest to the medical community.
particle is composed of proteins called ... specific proteins involved in lipid metabolism, lipoprotein
lipase and apolipoprotein E. "Apolipoprotein E ...
Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
... The result is an upsurge in the liver's production of very low-density lipoprotein
(VLDL) cholesterol, the precursor of low-density lipoprotein
(LDL) cholesterol (known as the "bad" form of cholesterol) and ...
Hawaiian treasure, macadamia nuts good for the heart
... food provided by the researchers for another five weeks.
The Healthy Heart diet with macadamia nuts did reduce total cholesterol, low-density lipoprotein
cholesterol and triglyceride levels compared with the standard American diet.
"We observed a reduction in LDL similar to that seen with other ...
Light wine intake is associated with longer life expectancy in men
... among the survivors in 2000. "One can speculate that a protective effect of light alcohol intake could be due to an increase in high-density lipoprotein
(HDL) cholesterol, or to a reduction in blood clotting, due to an inhibition of platelet aggregation," Streppel said.
Furthermore, red wine ...
New study finds chocolate chip cookies lower cholesterol
... and coronary artery disease.
"Our results suggest dietary treatment with Right Direction Cookies significantly affected the total number of lipoprotein
particles and reduced plasma concentrations," said Jay Udani, a key researcher of the study and Medical Director of Medicus Research. "LDL levels ...
Key heart and Alzheimer's disease protein imaged for first time in native state
... crystallography, scientists at the Gladstone Institute of Cardiovascular Disease (GICD) have created the highest-resolution x-ray structure of a lipoprotein
particle to date.
The work focuses apoE4, one of three specific forms of apolipoprotein E, commonly known as apoE. The breakthrough has already ...
Ernst Mayr's theory illustrated in genetic epidemiology studies
... populations reveal interactions between two important genes involved in high cholesterol, the Apolipoprotein E (APOE) gene and the Low density lipoprotein
receptor (LDLR) gene. Interestingly, it has been found that the protein products of these genes physically interact. Both play a role in high ...
Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
... As plaque grows, it narrows the artery more and more. When the plaque ruptures, blood clots form that can block the artery entirely.
is transported inside arteries by macrophages, which engulf the cholesterol through a process called oxidation. Macrophages produce pro-inflammatory ...