A single mechanism for hypertension, insulin resistance and immune suppression
... CD18 gives these cells the ability to adhere to the walls of blood vessels as a way to home in on infections. With the loss of CD18 receptors, leukocytes
of the SHR animals are unable to bind to the wall of blood vessels, resulting in a compromised immune system.
These results point to a single ...
Antibody signal may redirect inflammation to fuel cancer
... turn on a dangerously different program: inducing leukocytes
to boost cell growth, increase the number of ... and in response, produce antibodies that signal leukocytes
to attack," said Coussens, associate professor of ... precancerous tissue in mice, we have found that leukocytes
apparently receive signals to switch programs, ...
A little stress gives beneficial oomph! to immune system
... mobilized all major types of immune cells, or leukocytes
to potential battle stations in the body. In ... number of immune cells may be advantageous, as leukocytes
fight infections and other diseases.
Stressed mice had much higher numbers of leukocytes
arriving at critical defense organs, such as the ...
Gene patterns in white blood cells quickly diagnose disease
... host cells initiate a unique response, turning specific genes on and off. leukocytes
in the bloodstream course throughout the body in a matter of minutes. If ... expression.
They first drew blood from healthy donors and screened leukocytes
to get a baseline for gene expression in unexposed samples. They then ...
Vital step in cellular migration described by UCSD medical researchers
... "Since cell migration plays an important role in the immune response, as leukocytes
move toward targets, a therapy that stops that movement could potentially ... alpha4 integrins are widely expressed in neural crest cells, immune system leukocytes
(such as T cells), striated and smooth muscle, and neurons. For this ...
Blame the brain for high blood pressure
... JAM-1 (junctional adhesion molecule-1), which is located in the walls of blood vessels in the brain.
JAM-1 traps white blood cells called leukocytes
which, once trapped, can cause inflammation and may obstruct blood flow, resulting in poor oxygen supply to the brain. This has led to the idea that ...
Infection detectives use disease 'fingerprints' to track common infections in children
... for the whole human genome and measures which genes are turned on or off.
In this study, researchers analyzed gene expression patterns in leukocytes
from 29 children at Children’s known to have one of four common infections: flu (influenza A); staph (Staphylococcus aureus); strep (Streptococcus ...
New imaging technique tracks traffic patterns of white blood cells
... Researchers at Mount Sinai School of Medicine have just developed an advanced imaging technique to capture the movement of the microdomains of leukocytes
or white blood cells. Microdomains are restricted areas on the surface of the cells in which receptors and signaling molecules accumulate during cell ...
UCSD researchers create roadmap to integrin activation
... inflammatory diseases. In addition, the ability to engineer these activation pathways may contribute to efforts to develop artificial platelets or leukocytes
that could be used in patients with suppressed bone marrow function, for example," said Mark H. Ginsberg, M.D., professor of Medicine at the UCSD ...
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal
... diseases, von Andrian said.
Dendritic cells teach, T cells learn
"We specialize in various types of intravital microscopy to find out how leukocytes
-- the white blood cells of the immune system that fight infection -- find their way around the body and how they communicate with other cells," von ...
First technology to remove prions that cause vCJD from blood launched
... methods to provide prion protection."
The Leukotrap Affinity Prion Reduction Filter removes all types of prions in addition to leukocytes
(white blood cells) from red blood cells. Prions can be either cell-associated (on white blood cells) or non-cell associated. Studies with the new ...