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Leukemia in Biological News

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

... yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic ... For this study, researchers analyzed leukemia cells from 111 St. Jude AML patients representing ... in contrast to pediatric acute lymphoblastic leukemia (ALL), AML is characterized by a very low burden ...

A miR boost enables acute leukemia cells to mature

... of a molecule called miR-29b in acute myeloid leukemia (AML) cells can reverse gene changes that trap ... says. "It shows that putting this miR back into leukemia cell lines and leukemia cells from patients causes a drop in global DNA ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... new mouse models for human acute myeloid leukemia (AML), an aggressive and devastating cancer of ... models also provide valuable insights into how leukemia develops and progresses. Their study traces the ... promoted the development of leukemia. To track leukemia onset and response to therapy, the scientists ...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

... An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to ... They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the ... they looked at the effect of the compound in leukemia cells. Using a commercially available grape ...

Tracking the molecular pathway to mixed-lineage leukemia

... and adults with the blood cancer mixed-lineage leukemia (MLL) typically have a poor prognosis, and most ... 169 genes, many of which are overexpressed in leukemia cells and encode hematopoietic stem cell ... linked chromatin misregulation to cancer and to leukemia disease progression. In MLL patients, it seems ...

Washington University scientists first to sequence genome of cancer patient

... and traced her disease - acute myelogenous leukemia - to its genetic roots. A large research team at ... died of her disease - and the genome of her leukemia cells, to identify genetic changes unique to her ... known genetic mutations that are common to her leukemia subtype but do not directly cause the disease) by ...

Syracuse University researchers discover new way to attack some forms of leukemia

... to a more effective way to treat some forms of leukemia and revolutionize the approach to treating other ... formed. The protein is called the Mixed Lineage leukemia (MLL) protein. In normal cells, the MLL protein, ... may help to reprogram the way DNA is packaged in leukemia cells and help convert the abnormal cells back ...

The MDS foundation supports vidaza's recommendation for European approval

... those with high-risk MDS, chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). The CHMP positive opinion was based ... delays the progression of MDS to acute myeloid leukemia (AML). Roughly 30 percent of patient diagnosed ...

Lab study shows methadone breaks resistance in untreatable forms of leukemia

... drugs, has surprising killing power against leukemia cells, including treatment resistant forms of the ... and radiation. "Methadone kills sensitive leukemia cells and also breaks treatment resistance, but ... Friesen and her colleagues tested methadone in leukemia cells in laboratory culture because this cancer ...

Tumor-inhibiting protein could be effective in treating leukemia

... and we chose leukemia." Tuszynski said leukemia cells arise from monocytes, a specific white ... macrophages. When the researchers treated the leukemia cells, "our molecule was able to induce a differentiation of these monocytic leukemia cells into a normal, macrophage-like phenotype," ...

UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells

... 600 mice. None of the transplanted mice developed leukemia or solid tumors caused by the gene therapy ... for human bone marrow stem cells to develop leukemia in long-term studies, not that the leukemia was caused by the genetic modification," Bauer ...

Gene therapy protocol at UCSD activates immune system in patients with leukemia

... reports that patients with chronic lymphocytic leukemia (CLL) who were treated with a gene therapy ... making antibodies that reacted against their own leukemia cells. The study will be published on line the ... making antibodies that reacted against their own leukemia cells. When tested in the lab, the antibodies ...

Ireland Cancer Center researchers advance stem cell gene therapy

... assessment of data over 30 years regarding acute leukemia and its management. He found that all avenues ... of a whole host of entities that provide leukemia care. Dr. Jonathan Kenyon and colleagues ... of anemias, myelodysplastic syndrome and acute leukemia in older individuals. Dr. Kevin Buntings ...

NCI renewal grant to develop new cancer therapies

... deacetylase inhibitors, in the treatment of leukemia and other blood malignancies. Through the ... histone deacetylase inhibitor activity against leukemia and related malignancies," Grant said. "We ... and IKK beta inhibitors in the treatment of acute leukemia and other hematologic malignancies." Grant ...

Daisies lead scientists down path to new leukemia drug

... that has already shown it can attack the roots of leukemia in laboratory studies is moving into human ... whove been diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) or other types of blood or lymph cancers, ...

JCI table of contents: Aug. 9, 2007

... ONCOLOGY: New SNP for acute myeloid leukemia Tumor suppressor proteins are so called ... expression of the PU.1 gene develop acute myeloid leukemia (AML). When researchers from Harvard Medical ... regulation of the PU.1 gene in acute myeloid leukemia AUTHOR CONTACT: Daniel G. Tenen Harvard ...

La Jolla Institute discovers novel tumor suppressor

... by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood. "PLC-beta 3 is an enzyme, but the function we ... cell testing in some other lymphomas and leukemias -- including myeloid leukemia -- indicating that these diseases also use this mechanism (low expression ...

Dual role in breast tissue for a protein involved in leukemia

... Washington, DC - A protein known to play a role in growth of some types of leukemia appears to have a mixed function in breast cancer development, say ... of leukemia, but add, "If Stat5a is to be used as a drug target for leukemia or other cancers, it is important to fully understand how altering its ...

Study validates means to measure possible leukemia marker

... variations in certain proteins that may make good biomarkers in chronic leukemia patients. The study shows that liquid chromatography-mass spectrometry ... detected differences in the composition of histones in chronic lymphocytic leukemia (CLL) cells compared with their healthy counterparts, immune cells called ...

Scientists identify key gene that protects against leukemia

... that could eventually open the door to more streamlined treatments for leukemia and other blood cancers, in which blood cells proliferate out of control. ... from other research, which has demonstrated that mutated HSC that cause leukemia burn out at a faster rate than normal HSCs. In contrast, this study shows ...

St. Jude identifies genomic causes of a certain type of leukemia relapse

... genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The finding offers a pathway to designing ... evolved from genetically distinct cells, indicating that the relapsed leukemia was actually an entirely new cancer. "The key finding in our work is ...

The MDS Foundation supports the FDA's decision to expand vidaza label to include survival data

... 30 percent of patients diagnosed with MDS will progress to acute myeloid leukemia (AML), but treatment with VIDAZA significantly delays this progression. ... azacitidine was shown to delay the progression of MDS to acute myeloid leukemia (AML). Roughly 30 percent of patient diagnosed with MDS will progress to ...

Two suppressor molecules affect 70 genes in leukemia

... in an animal model. The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules affects 70 genes, ... behavior. For the new study, the investigators first injected mice with leukemia cells in which they had restored the two microRNAs. This completely ...

St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia

... prevent relapse of a particularly aggressive form of acute lymphoblastic leukemia (ALL). Targeted therapy drugs are designed to block the activity of a ... of Genetics and Tumor Cell Biology, has shown that these two forms of leukemia part company in a crucial respect. Many Ph+ ALL cells lack a ...

University of Pennsylvania researchers develop formula to gauge risk of disease clusters

... The first was the classic case of a clustering of eight cases of leukemia in Niles, Ill., in 1956-1960, which was reasonably assessed as a chance, random event. On the other hand, 12 cases of acute lymphocytic leukemia in Churchill County, Nev., in 1999-2001 was assessed not to be a chance ...

Genetic factors implicated in survival gap for breast, ovarian or prostate cancer

... status, and found no statistically significant difference in survival based on race for a number of cancers including lung, colon, lymphoma, leukemia and multiple myeloma. However, African-American patients with breast, ovarian, or prostate cancers the gender specific tumors were found to face a ...

GUMC discovery highlights new direction for drug discovery

... that work against fusion proteins inhibit a single protein to stop intrinsic enzymatic activity; one example is Gleevec, used for chronic myelogenous leukemia (CML). The Ewing's sarcoma fusion protein, known as EWS-FLI1, lacks enzymatic activity, "and this difference is why our work is significant," ...

CWRU receives $5 million from Ohio Third Frontier Commission

... jobs as well as by having access to leading-edge clinical therapies at our region's clinical institutions." The use of stem cells has focused on leukemia and myeloma treatments with recent applications in cardiovascular disease. Current healthcare is limited to the use of drugs or devices to treat ...

UCLA cancer researchers develop model that may help identify cancer stem cells

... select cells from a tumor have the ability to initiate a new tumor - the cancer stem cells. In the last decade, scientists have been able to isolate leukemia stem cells as well as brain and breast cancer stem cells. Many scientists believe that most, if not all, cancers will one day be traced back to these ...

University of Kansas graduate student researcher takes aim at deadly brain tumors

... by cancer patients. It's a motivating factor in making development of better cancer therapies the focus of her career. "My grandfather died of leukemia when I was in junior high and he was very sick the last year of his life," Ciaccio said. "I think a lot of it was the treatment that was making him ...

Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment

... pathways," Dr. Sreekumar says. His inspiration to follow those pathways is a fellow Ph.D. student who died too young and quickly of an aggressive leukemia and the fact that cancer is a leading cause of death worldwide. ...

Waking up dormant HIV

... the virus as some HIV always remains dormant in cells. But, a chemical called suberoylanilide hydroxamic acid (SAHA), recently approved as a leukemia drug, has now been shown to 'turn on' latent HIV, making it an attractive candidate to weed out the hidden virus that HAART misses. Matija ...

U-M researchers discover new genes that fuse in cancer

... rearrangements in chromosomes and fused genes in prostate cancer. Gene fusions had previously been known to play a role in blood cell cancers such as leukemia and lymphoma, and in Ewing's sarcoma. In the current study, the researchers showed that newer techniques could identify these gene fusions more ...

Human genomics in China

... molecular biology studies of mammalian reproductive system, signal transduction, immunology, microbiology, central nerve system, genetic evolution, leukemia pathogenesis and so on, were all somehow involved in genomics work to certain extent. The rise of other molecular "omics" further strengthened the ...

American Association for Cancer Research hosts Science of Health Care Disparities Meeting

... care because of the cost? Are rural patients less likely to be screened for cancer? Genetic polymorphisms that increase prostate cancer and leukemia risk When: February 3-6, 2009 Where: Carefree Resort and Villas Carefree, AZ AACR Press Room: Location: Cholla II Hours: 8:00 ...

Study links molecule to muscle maturation, muscle cancer

... COLUMBUS, Ohio Researchers at The Ohio State University Comprehensive Cancer Center have discovered that a molecule implicated in leukemia and lung cancer is also important in muscle repair and in a muscle cancer that strikes mainly children. The study shows that immature muscle ...

Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche

... in vivo," said Linheng Li, Ph.D., Investigator and senior author on the paper. "Furthermore, we will be able to use this technology to study leukemia (and other cancer) stem cells to better understand whether they use the same or different niches that normal stem cells use, and even to evaluate ...

Cancer cell 'bodyguard' turned into killer

... is for researchers to determine what types of cancer and what stages of the disease this deadly Bcl-2 converter would combat. Linda Wolff, a leukemia researcher at the National Institutes of Health's Center for Cancer Research in Bethesda, Md., said the researchers' discovery is "rare" in the world ...

UC Davis researchers discover Achilles' heel in pancreatic cancer

... function," Bold said. Metabolic interruptions like this one are also being studied for their potential in treating cancers of the blood, such as leukemia and lymphoma. In those cases, depleting the amino acid asparagine may be used in slowing cancer-cell growth. Bold and his colleagues are ...

Meyskens honored with AACR-Prevent Cancer Foundation award

... that may develop into cervical cancer in some women. Additionally, he promoted the idea that retinol could be used to affect chronic myelogenous leukemia (CML). Meyskens has re-examined the scientific basis for the etiology of melanoma. Based on 15 years of detailed laboratory work, he proposed a ...
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